Article
Biochemistry & Molecular Biology
Yutong Shi, Caiyun Qi, Ying Bai
Summary: This study analyzed the metabolism of bone marrow cells from patients with multiple sclerosis (MS) at the single-cell level and found activated metabolic pathways and altered cell-cell communication in the plasma cell population. These findings provide insights into the pathogenesis of MS and may contribute to the development of novel immune therapies.
Article
Biochemistry & Molecular Biology
Yutong Shi, Caiyun Qi, Ying Bai
Summary: This study investigates the metabolic landscape of bone marrow cells in patients with MS, shedding light on the unique metabolic characteristics of immune cells and plasma cells in this context. The findings provide new insights into the pathogenesis of MS and may contribute to the development of future immune therapies.
Article
Clinical Neurology
Antonio Uccelli, Alice Laroni, Rehiana Ali, Mario Alberto Battaglia, Morten Blinkenberg, Lou Brundin, Michel Clanet, Oscar Fernandez, James Marriot, Paolo Muraro, Seyed Massood Nabavi, Roberto S. Oliveri, Ernst Radue, Cristina Ramo Tello, Irene Schiavetti, Johann Sellner, Per Soelberg Sorensen, Maria Pia Sormani, Jens Thomas Wuerfel, Mark S. Freedman
Summary: The MESEMS study aimed to evaluate the safety and activity of autologous bone marrow-derived MSCs in patients with active multiple sclerosis. The results showed that MSC treatment did not affect GELs and does not support its use in treating multiple sclerosis.
Article
Hematology
Hannah Kinoshita, Mamatha Mandava, Mariah Jensen-Wachspress, Haili Lang, Elisabeth Joy, Jay Tanna, Chase D. McCann, Samuel O'Brien, Sianna Burnett, Abeer Shibli, Fahmida Hoq, Monica Bhatia, Patrick J. Hanley, Blachy Davila Saldana, Kris M. Mahadeo, Catherine M. Bollard, Michael D. Keller, Allistair Abraham
Summary: Hematopoietic stem cell transplantation (HSCT) is increasingly used to treat sickle cell disease (SCD). However, this treatment increases the risk of viral infection. This study explores the use of virus-specific T-cell (VST) therapies after HSCT to prevent or treat viral infections in SCD patients.
Article
Hematology
Soung-Min Lee, Chae Eun Kim, Ha Young Park, Eun Hye Yoon, Hae Jeong Won, Joo Mi Ahn, Nu Zen Na Nguyen, Minji Kim, Won Hee Jang, Won-Sik Lee, Mi Seon Kang, Myeonggyo Jeong, Hwayoung Yun, Suhyun Park, Sangwook Wu, Dong Hyun Kim, Byungsuk Kwon, Su-Kil Seo
Summary: By studying the AHR axis, we found that a specific AHR agonist can inhibit the further development of idiopathic pneumonia syndrome (IPS) and promote the differentiation of regulatory T cells. This research provides a new therapeutic target for treating inflammatory and autoimmune diseases.
Article
Medicine, General & Internal
Sergio Gomez, Carmen Salaverria, Erin Plenert, Gisela Gonzalez, Gisela D'Angelo, Allison Grimes, Aaron Sugalski, Anne-Marie Langevin, Lee Dupuis, Lillian Sung
Summary: The study successfully translated the pediatric cancer therapy symptom screening tool SSPedi into Argentinian Spanish and evaluated its understandability and cultural relevance among relevant patients. Results showed no difficulty in understanding the translated version and it was well-received in terms of cultural relevance.
Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Hematology
Swetha Kambhampati, Ying Sheng, Chiung-Yu Huang, Sophia Bylsma, Mimi Lo, Vanessa Kennedy, Kelsey Natsuhara, Thomas Martin, Jeffrey Wolf, Nina Shah, Sandy W. Wong
Summary: B-cell maturation antigen-targeted chimeric antigen receptor T-cell therapy is an effective treatment for relapsed refractory multiple myeloma. This study analyzed the infection outcomes of 55 MM patients treated with BCMA CAR-T and found that despite multiple risk factors, severe infections were relatively rare.
Article
Multidisciplinary Sciences
Miaomiao Sun, Xiaoqian Wang, Yuwei Shou, Chao Chen, Chenbo Yang, Yinghao LIang, Yichen Hong, Jiao Shu, Kuisheng Chen
Summary: Multiple myeloma (MM) is the second most common hematological malignancy, and angiogenesis determines its progression. Research on the relationship between tumor angiogenesis and miR-21 is rare. Our study found that miR-21 was abundant in cancer-associated fibroblasts (CAFs)-derived exosomes and could enter multiple myeloma endothelial cells (MMECs), regulating angiogenesis in MM.
SCIENTIFIC REPORTS
(2023)
Article
Cell & Tissue Engineering
Yuki Saito, Maki Miyajima, Sena Yamamoto, Norihiro Miura, Tsukasa Sato, Arisa Kita, Shogo Ijima, Mineko Fujimiya, Takako S. Chikenji
Summary: Up to 60% of SLE patients experience autonomic symptoms, and damage to the sympathetic nervous system can result in bone marrow dysfunction and multiple organ damage. This study shows that therapy targeting the nervous system can improve multiple organ damage in SLE, and the administration of BMSCs cultured on a 3D fiber scaffold can improve bone marrow neuropathy, skin lesions, kidney function, and mortality.
STEM CELLS TRANSLATIONAL MEDICINE
(2022)
Article
Microbiology
Shiela McCollam, James S. Lewis, Joseph Bubalo, Amber Diaz
Summary: This study aimed to evaluate the efficacy and safety of 300-mg once-monthly intravenous (IV) pentamidine prophylaxis in 702 adult allogeneic hematopoietic stem cell transplant (HSCT) patients. The results showed that IV pentamidine administration effectively prevented Pneumocystis jirovecii pneumonia (PJP), but breakthrough Nocardia and Toxoplasma infections were observed in a certain percentage of patients.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Biophysics
Patrick J. Hayden, Dirk-Jan Eikema, Liesbeth C. de Wreede, Linda Koster, Nicolaus Kroger, Hermann Einsele, Monique Minnema, Alida Dominietto, Michael Potter, Jacob Passweg, Arancha Bermudez, Stephanie Nguyen-quoc, Uwe Platzbecker, Johanna Tischer, Fabio Ciceri, Joan Hendrik Veelken, Per Ljungman, Nicolaas Schaap, Edouard Forcade, Angelo Michele Carella, Virginie Gandemer, William Arcese, Adrian Bloor, Attilio Olivieri, Laure Vincent, Meral Beksac, Stefan Schonland, Ibrahim Yakoub-Agha
Summary: For patients with relapsed multiple myeloma, receiving a second allo-HCT from a HLA-identical sibling donor for both transplants is associated with higher overall survival rates. Additionally, an interval of more than 2 years between transplants is associated with superior 5-year survival rates.
BONE MARROW TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Alice Bertaina, Paul C. Grimm, Kenneth Weinberg, Robertson Parkman, Karen M. Kristovich, Giulia Barbarito, Elizabeth Lippner, Girija Dhamdhere, Vasavi Ramachandran, Jordan M. Spatz, Sahar Fathallah-Shaykh, T. Prescott Atkinson, Amira Al-Uzri, Geraldine Aubert, Kim van der Elst, Sean G. Green, Rajni Agarwal, Priscila F. Slepicka, Ami J. Shah, Maria G. Roncarolo, Amy Gallo, Waldo Concepcion, David B. Lewis
Summary: This study aimed to find a new approach to eliminate immune rejection and the need for post-transplantation immunosuppression. By performing bone marrow and kidney transplantation on three patients with a specific genetic condition, the researchers successfully achieved the goal of normal renal function without the need for immunosuppression.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Medicine, Research & Experimental
Steven D. Schutt, Yongxia Wu, Arjun Kharel, David Bastian, Hee-Jin Choi, Mohammed Hanief Sofi, Corey Mealer, Brianyell McDaniel Mims, Hung Nguyen, Chen Liu, Kris Helke, Weiguo Cui, Xian Zhang, Yaacov Ben-David, Xue-Zhong Yu
Summary: This study investigates the role of Fli-1 in graft-versus-host disease (GVHD) and identifies it as a potential therapeutic target. Fli-1 regulates different T cell subsets and pathogenicity in the development of acute and chronic GVHD. Inhibiting Fli-1 with low doses of specific drugs attenuates GVHD severity without compromising the graft-versus-leukemia (GVL) effect.
JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Cell Biology
Yang Cao, Huizhuang Shan, Meng Liu, Jia Liu, Zilu Zhang, Xiaoguang Xu, Yue Liu, Hanzhang Xu, Hu Lei, Miao Yu, Xingming Zhang, Wanting Liu, Zhilei Bu, Zhixiao Fang, Yanjie Ji, Hua Yan, Weiying Gu, Yingli Wu
Summary: The study demonstrates that anlotinib exhibits significant anti-myeloma effects by inducing cell cycle arrest, apoptosis, and inhibiting multiple signaling pathways. Notably, it also targets c-Myc and enhances ubiquitin proteasomal degradation, leading to apoptosis. Additionally, anlotinib shows cytotoxicity against bortezomib-resistant MM cells, suggesting its potential clinical application for human MM treatment.
CELL DEATH & DISEASE
(2021)
Review
Immunology
Yarne Klaver, Andre Kunert, Stefan Sleijfer, Reno Debets, Cor H. J. Lamers
Review
Biochemistry & Molecular Biology
Cor H. J. Lamers, Yarne Klaver, Jan W. Gratama, Stefan Sleijfer, Reno Debets
BIOCHEMICAL SOCIETY TRANSACTIONS
(2016)
Article
Hematology
Cor H. J. Lamers, Rebecca Wijers, Cornelis A. M. van Bergen, Judith A. E. Somers, Eric Braakman, Jan Willem Gratama, Reno Debets, J. H. Frederik Falkenburg, Jan J. Cornelissen
Article
Immunology
Yarne Klaver, Sabine C. L. van Steenbergen, Stefan Sleijfer, Reno Debets, Cor H. J. Lamers
CLINICAL IMMUNOLOGY
(2016)
Article
Immunology
Andre Kunert, Mandy van Brakel, Sabine van Steenbergen-Langeveld, Marvin da Silva, Pierre G. Coulie, Cor Lamers, Stefan Sleijfer, Reno Debets
JOURNAL OF IMMUNOLOGY
(2016)
Article
Immunology
Yarne Klaver, Sabine C. L. van Steenbergen, Stefan Sleijfer, Reno Debets, Cor H. J. Lamers
FRONTIERS IN IMMUNOLOGY
(2016)
Article
Biophysics
Lucia E. Duinhouwer, Nick Beije, Bronno van der Holt, Anita Rijken-Schelen, Cor H. Lamers, Judith Somers, Eric Braakman, Jan J. Cornelissen
BONE MARROW TRANSPLANTATION
(2018)
Article
Immunology
Pauline L. de Goeje, Yarne Klaver, Margaretha E. H. Kaijen-Lambers, Anton W. Langerak, Heleen Vroman, Andre Kunert, Cor H. J. Lamers, Joachim G. J. V. Aerts, Reno Debets, Rudi W. Hendriks
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Andre Kunert, Edwin A. Basak, Daan P. Hurkmans, Hayri E. Balcioglu, Yarne Klaver, Mandy van Brakel, Astrid A. M. Oostvogels, Cor H. J. Lamers, Sander Bins, Stijn L. W. Koolen, Astrid A. M. van der Veldt, Stefan Sleijfer, Ron H. J. Mathijssen, Joachim G. J. Aerts, Reno Debets
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2019)
Letter
Hematology
Burak Kalin, Elisabetta Metafuni, Mariette ter Borg, Rebecca Wijers, Eric Braakman, Cor H. J. Lamers, Andrea Bacigalupo, Jan J. Cornelissen
Article
Oncology
Yarne Klaver, Maud Rijnders, Astrid Oostvogels, Rebecca Wijers, Marcel Smid, Dirk Grunhagen, Kees Verhoef, Stefan Sleijfer, Cor Lamers, Reno Debets
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Daan P. Hurkmans, Els M. E. Verdegaal, Sabrina A. Hogan, Rik de Wijn, Lies Hovestad, Dianne M. A. van den Heuvel, Rob Ruijtenbeek, Marij J. P. Welters, Mandy van Brakel, Edwin A. Basak, Herbert M. Pinedo, Cor H. J. Lamers, Harmen J. G. van de Werken, John P. Groten, Reno Debets, Mitchell P. Levesque, Reinhard Dummer, Ellen Kapiteijn, Ron H. J. Mathijssen, Joachim G. J. Aerts, Sjoerd H. van der Burg
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2020)
Article
Oncology
Erik H. P. van Putten, Anne Kleijn, Victor W. van Beusechem, David Noske, Cor H. J. Lamers, Anna L. de Goede, Sander Idema, Daphna Hoefnagel, Jenneke J. Kloezeman, Juan Fueyo, Frederick F. Lang, Charlotte E. Teunissen, Rene M. Vernhout, Cathy Bakker, Winald Gerritsen, David T. Curiel, Arnold Vulto, Martine L. M. Lamfers, Clemens M. F. Dirven
Summary: The purpose of this study was to test the safety of locally delivering Delta24-RGD, an oncolytic adenovirus, through convection enhanced delivery (CED) in the tumor and surrounding brain of patients with recurrent glioblastoma. The results showed that Delta24-RGD was safe and feasible, induced a local inflammatory reaction, and demonstrated promising clinical responses.
CLINICAL CANCER RESEARCH
(2022)
Letter
Hematology
Burak Kalin, Mariette ter Borg, Rebecca Wijers, Judith A. E. Somers, Bronno van der Holt, Cornelis A. M. van Bergen, Eefke J. Petersen, Jurgen Kuball, Ellen Meijer, Nicolaas P. M. Schaap, Sacha S. Zeerleder, Annoek E. Broers, Eric Braakman, J. H. Frederik Falkenburg, Cor H. J. Lamers, Jan J. Cornelissen
Review
Oncology
Andre Kunert, Matthias Obenaus, Cor H. J. Lamers, Thomas Blankenstein, Reno Debets
CLINICAL CANCER RESEARCH
(2017)