期刊
JOURNAL OF NEUROLOGY
卷 260, 期 8, 页码 2073-2077出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00415-013-6944-9
关键词
Multiple system atrophy; Progressive supranuclear palsy; Corticobasal syndrome; Autonomic dysfunction; Ghrelin; Gastrointestinal symptom
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [21591109]
- Japan Health Foundation
- Kato Memorial Trust for Nambyo Research
- Nestle Nutrition Council, Japan
- Research Committee for Ataxic Diseases of the Ministry of Health, Welfare, and Labour of Japan
- Grant for Promotion of Niigata University Research Projects
- Grants-in-Aid for Scientific Research [21591109, 24591290] Funding Source: KAKEN
Patients with multiple system atrophy (MSA) often have evidence of compromised gastrointestinal motility. Ghrelin is a gut hormone that influences gastrointestinal motility in humans. The aim of this study was to determine whether ghrelin secretion is affected in MSA patients, and to investigate the relation between ghrelin secretion and gastrointestinal symptoms. Plasma levels of active ghrelin and unacylated ghrelin were measured in patients with MSA (n = 30), other atypical parkinsonian disorders including progressive supranuclear palsy-Richardson syndrome and corticobasal syndrome (n = 24), and control subjects (n = 24) using enzyme-linked immunosorbent assays. Gastrointestinal symptoms were quantified in all subjects using a self-report questionnaire. The ratio of active ghrelin to total ghrelin in the plasma (active ghrelin ratio) was lower in patients with MSA (mean: 8.0 %) than in patients with other atypical parkinsonian disorders (mean: 13.7 %, P = 0.001) and control subjects (mean: 13.9 %, P = 0.001). The active ghrelin ratio was correlated with the severity of gastrointestinal symptoms in MSA (r = -0.5, P = 0.004). Our observations indicate that ghrelin secretion is affected in patients with MSA. The low active ghrelin ratio may contribute to gastrointestinal symptoms in MSA.
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