Article
Clinical Neurology
John R. Younce, Meghan C. Campbell, Tamara Hershey, Aaron B. Tanenbaum, Mikhail Milchenko, Mwiza Ushe, Morvarid Karimi, Samer D. Tabbal, Albert E. Kim, Abraham Z. Snyder, Joel S. Perlmutter, Scott A. Norris
Summary: Resting-state functional connectivity MRI may predict motor response to subthalamic nucleus deep brain stimulation, with stronger connectivity between the left subthalamic nucleus and ipsilateral internal globus pallidus correlating with greater improvement in postsurgical motor outcomes. The integrity of pallidal-subthalamic nucleus circuits may be critical to motor benefits from deep brain stimulation.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Francesco Bove, Danilo Genovese, Martina Petracca, Tommaso Tufo, Danila Pisani, Maria Rita Lo Monaco, Anna Rita Bentivoglio, Paolo Calabresi, Carla Piano
Summary: This study aimed to assess the incidence rate and risk factors for sialorrhea in long-term follow-up of patients with advanced Parkinson's disease. The findings indicate that deep brain stimulation (DBS) does not increase the risk of developing sialorrhea.
NPJ PARKINSONS DISEASE
(2022)
Article
Clinical Neurology
Dejan Georgiev, Sanja Roskar, Anja Cus, Leonora Wilkinson, Marjan Jahanshahi
Summary: This study examined the acute effects of STN-DBS on proactive interference (PI) and retroactive interference (RI) during verbal learning in Parkinson's disease patients. The results showed that stimulation increased PI but had no effect on RI, indicating a role of STN in inhibitory control during memory encoding or recall.
MOVEMENT DISORDERS
(2021)
Review
Clinical Neurology
Gerard Saranza, Anthony E. Lang
Summary: This paper discusses the importance of drug challenge test in Parkinson's disease, especially the levodopa challenge test, and provides an overview of the different indications, commonly used protocols, and responsiveness or unresponsiveness to levodopa. Potential complications of the procedure are also highlighted.
JOURNAL OF NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Amir Ramezani, Seyed Reza Alvani, Meena Imma Saleh, Seyed Mehrshad Parvin Hosseini, Lama R. Alameddine
Summary: The study examines the factors that influence performance on the Persian MMSE among Iranians and provides normative and clinical data for the Iranian population. It also identifies demographic factors that may affect test performance and suggests a cutoff score for potential cognitive decline. The findings emphasize the importance of considering education level in interpreting MMSE scores for Iranian patients.
CURRENT PSYCHOLOGY
(2023)
Article
Neurosciences
Louise M. Jorgensen, Tove Henriksen, Skirmante Mardosiene, Ottilia Wyon, Sune H. Keller, Bo Jespersen, Gitte M. Knudsen, Dea S. Stenbaek
Summary: This study investigates the association between the cerebral 5-HT system and non-motor symptoms in patients with Parkinson's disease (PD), as well as the effects of turning deep brain stimulation (DBS) in the subthalamic nucleus (STN) on cognition and mood. The findings suggest that 5-HT1BR binding is related to working memory performance and affective bias, while the turning off of DBS can lead to decreased vigor in patients. The study also suggests that preservation of serotonergic functions may predict the effects of DBS-STN.
Article
Clinical Neurology
Eva Schaeffer, Thomas Vaterrodt, Laura Zaunbrecher, Inga Liepelt-Scarfone, Kirsten Emmert, Benjamin Roeben, Morad Elshehabi, Clint Hansen, Sara Becker, Susanne Nussbaum, Jan-Hinrich Busch, Matthis Synofzik, Daniela Berg, Walter Maetzler
Summary: Our independent analysis of three PD cohorts consisting of a total of 1124 PD patients found that patients taking Levodopa CR reported a significantly higher burden of nocturnal akinesia. Higher Levodopa intake and MDS-UPDRS part IV scores predicted worse quality of sleep and higher subjective nocturnal immobility scores, while disease duration and severity were not predictive. Levodopa intake was not associated with objectively changed mobility during sleep.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
P. Prendes Fernandez, M. Blazquez Estrada, J. Sol Alvarez, V. Alvarez Martinez, E. Suarez San Martin, C. Garcia Fernandez, J. C. Alvarez Carriles, B. Lozano Aragoneses, A. Saiz Ayala, E. Santamarta Liebana, L. Gonzalez Alvarez
Summary: This study compared the clinical and pharmacological response to subthalamic nucleus deep brain stimulation (STN-DBS) between patients with monogenic forms of Parkinson's disease (PD) and non-mutation carriers with idiopathic PD. The results showed no significant differences between the two groups, indicating that the effectiveness of STN-DBS is similar in patients with genetic mutations and those with idiopathic PD.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Pharmacology & Pharmacy
Johanna Weitzel, Angelika Wuensch, Olaf Rose, Klaus Langer
Summary: This study tested the dissolution profiles of bioequivalent levodopa combinations and found that there were significant differences between manufacturers. Carbidopa was found to be unstable in tap water and milk, while entacapone hardly dissolved in an acidic environment. It is important to ensure an acidic environment when using these drugs, and caution should be taken when considering the substitution of generic levodopa combinations.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Clinical Neurology
Haewon Roh, Jang Hun Kim, Seong-Beom Koh, Jong Hyun Kim
Summary: The study found that intraoperative recording of beta LFP using microelectrode is feasible, and intraoperative beta LFP can serve as a reliable surrogate for postoperative beta LFP, as well as provide information about the location with maximal power of beta oscillation within the subthalamic nucleus.
WORLD NEUROSURGERY
(2021)
Article
Chemistry, Multidisciplinary
Jong-Min Moon, Hazhir Teymourian, Ernesto De la Paz, Juliane R. Sempionatto, Kuldeep Mahato, Thitaporn Sonsa-ard, Nickey Huang, Katherine Longardner, Irene Litvan, Joseph Wang
Summary: Levodopa is the standard medication for symptomatic therapy of Parkinson's disease, but long-term use may lead to motor and non-motor complications. This study introduces an individualized therapeutic drug monitoring method that tracks the drug concentration in fingertip sweat, demonstrating a personalized dose-response relationship.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Review
Clinical Neurology
Ahmed Negida, Hazem S. Ghaith, Salma Yousry Fala, Hussien Ahmed, Eshak Bahbah, Mahmoud Ahmed Ebada, Mohamed Abd Elalem Aziz
Summary: This meta-analysis of six randomized controlled trials found that Mavoglurant was not superior to placebo in treating levodopa-induced dyskinesia in patients with Parkinson's Disease.
NEUROLOGICAL SCIENCES
(2021)
Article
Geriatrics & Gerontology
Ritesh A. Ramdhani, Jeremy Watts, Myriam Kline, Toni Fitzpatrick, Martin Niethammer, Anahita Khojandi
Summary: This study investigated the effects of high-frequency and low-frequency STN-DBS on spatiotemporal gait kinematics in patients with advanced Parkinson's disease. It was found that high-frequency STN-DBS significantly improved trunk and lumbar kinematics.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Johanna Philipson, Patric Blomstedt, Anna Fredricks, Marwan Hariz, Rasmus Stenmark Persson, Marjan Jahanshahi
Summary: Studies indicate that bilateral cZi DBS for PD patients generally do not have adverse cognitive effects, and cognitive function remains stable in both short and long term, although there may be declines in attention and self-reported executive function.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Isabel Wurster, Corinne Quadalti, Marcello Rossi, Ann-Kathrin Hauser, Christian Deuschle, Claudia Schulte, Katharina Waniek, Ingolf Lachmann, Christian la Fougere, Kathrin Doppler, Thomas Gasser, Benjamin Bender, Piero Parchi, Kathrin Brockmann
Summary: A family with SNCA triplication was identified, with the patient showing early onset, motor impairment, prominent non-motor symptoms, significantly elevated CSF α-Syn levels, and remarkable alpha-Syn seeding activity. PET-MRI revealed hypometabolism and atrophy in the brain, supporting the association between overexpression of α-Syn and PD.
NPJ PARKINSONS DISEASE
(2022)
Review
Clinical Neurology
Ji-Hyun Choi, Chaewon Shin, Han-Joon Kim, Beomseok Jeon
Summary: This review examined the placebo response in patients with degenerative cerebellar ataxias (CAs). The findings showed varying degrees of improvement in objective ataxia scales in the placebo groups. The study highlights the importance of considering placebo response in designing, analyzing, and interpreting clinical trials and in clinical practice for CA patients.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Hui-Jun Yang, Han-Joon Kim, Yu Jin Jung, Dallah Yoo, Ji-Hyun Choi, Jin Hee Im, Beomseok Jeon
Summary: This study conducted a data-driven subgroups analysis of patients with early multiple system atrophy (MSA) using latent class analysis (LCA). The results identified at least three different subgroups in early MSA. This is the first identification of disease subtypes in early MSA based on data, revealing heterogeneity within MSA-P and MSA-C subtypes.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Kyung Ah Woo, Han-Joon Kim, Seung-Ho Jeon, Hye Ran Park, Kye Won Park, Seung Hyun Lee, Sun Ju Chung, Jong-Hee Chae, Sun Ha Paek, Beomseok Jeon
Summary: This study investigated the long-term clinical outcomes of GPi-DBS in patients with PKAN. The results showed that the benefits of GPi-DBS on dystonia may persist for more than 5 years, but the effects on patient's subjective disability may have a shorter duration.
JOURNAL OF MOVEMENT DISORDERS
(2022)
Article
Neurosciences
Jung Hwan Shin, Han-Joon Kim, Chan Young Lee, Hee Jin Chang, Kyung Ah Woo, Beomseok Jeon
Summary: This study analyzed the relationship between blood biomarkers and survival in multiple system atrophy (MSA), and found that high absolute neutrophil count, red-cell distribution width, C-reactive protein, and other indicators were associated with higher mortality in MSA patients.
NPJ PARKINSONS DISEASE
(2022)
Letter
Clinical Neurology
Jae Young Joo, Jihoon G. Yoon, Seoungbok Lee, Jangsup Moon, Han-Joon Kim
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hee Jin Chang, Han-Joon Kim, Kyung Ah Woo, Jung Hwan Shin, Ki-Young Jung
Summary: This study evaluated the effect of CPAP on the quality of life in patients with MSA and their caregivers. The results showed that CPAP treatment had a beneficial effect on sleep complaints and QoL of the patients and improved caregivers' QoL.
SLEEP AND BREATHING
(2023)
Editorial Material
Clinical Neurology
Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Hyoshin Son, Jihoon G. Yoon, Man Jin Kim, Jangsup Moon, Han-Joon Kim
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Jae Young Joo, Hee Jin Chang, Kyung Ah Woo, Han Sang Lee, Han-Joon Kim
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Chaewon Shin, Seong-Ik Kim, Sung-Hye Park, Jung Hwan Shin, Chan Young Lee, Han-Joon Kim, Hyuk-Joon Lee, Seong-Ho Kong, Yun-Suhk Suh, Han-Kwang Yang, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Letter
Clinical Neurology
Sangmin Park, Jung Hwan Shin, Seung Ho Jeon, Chan Young Lee, Han-Joon Kim, Beomseok Jeon
JOURNAL OF MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Hee Jin Chang, Jiae Kim, Jae Young Joo, Han-Joon Kim
Summary: This study aimed to evaluate the feasibility and efficacy of online video-call speech therapy for patients with Parkinson's disease. By comparing two groups of patients who received online speech therapy and in-person therapy, it was found that online video-call therapy was as effective as traditional therapy in improving speech difficulties and was feasible.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Chan Young Lee, Hyesook Kim, Han-Joon Kim, Jung Hwan Shin, Hee Jin Chang, Kyung Ah Woo, Ki-Young Jung, Oran Kwon, Beomseok Jeon
Summary: The study found no significant association between diet quality and the probability of developing Parkinson's disease and its risk or prodromal markers in patients with isolated rapid eye movement (REM) sleep behavior disorder (iRBD). However, in patients under the age of 70, legume consumption was negatively correlated with the probability of developing Parkinson's disease, and patients with fewer prodromal markers had significantly higher legume consumption.
PARKINSONISM & RELATED DISORDERS
(2023)
Letter
Clinical Neurology
Hee Jin Chang, Kyung Ah Woo, Han-Joon Kim, Beomseok Jeon
JOURNAL OF CLINICAL NEUROLOGY
(2023)
Article
Clinical Neurology
Jung-Ick Byun, Kwang Su Cha, Minah Kim, Woo-Jin Lee, Han Sang Lee, Jun-Sang Sunwoo, Jung-Won Shin, Tae-Joon Kim, Jin-Sun Jun, Han-Joon Kim, Won Chul Shin, Carlos H. Schenck, Sang Kun Lee, Ki-Young Jung
Summary: This study suggests that cortical cholinergic activity may be impaired in iRBD patients, and functional connectivity between the nucleus basalis of Meynert and posterior regions may play a central role in the cognitive function of these patients.
JOURNAL OF CLINICAL NEUROLOGY
(2022)