Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Psychology, Multidisciplinary
Sandro Iannaccone, Elise Houdayer, Alfio Spina, Gianluca Nocera, Federica Alemanno
Summary: This study investigated the use of electroencephalography quantified with statistical pattern recognition (qEEG-SPR) as a tool for diagnosing dementia and differentiating dementia with Lewy bodies (DLB). The results showed that qEEG-SPR had high sensitivity and specificity for identifying dementia and DLB. It is a non-invasive, low-cost, and environmentally friendly method that can be implemented in healthcare settings.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Clinical Neurology
Karri Kaivola, Zalak Shah, Ruth Chia, Sonja W. Scholz
Summary: The GBA gene is associated with risk for dementia with Lewy bodies (DLB) in patients without the APOE ε4 allele, while the APOE ε4 allele is associated with DLB co-pathology with Alzheimer's disease. APOE ε4 is not an independent driver of alpha-synuclein pathology in pure DLB, but GBA plays a significant role in the pure DLB subgroup.
Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Xudong Li, Miaoxin Shen, Ziling Han, Jinsong Jiao, Xiaopeng Tong
Summary: The gesture imitation test is a valuable tool for detecting DLB and differentiating DLB from ADD, especially in Items 1 and 4.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Matthew Ingram, Sean J. Colloby, Michael J. Firbank, Jim J. Lloyd, John T. O'Brien, John-Paul Taylor
Summary: In this study, the diagnostic characteristics of spatial covariance analysis (SCA) of FDG-PET and HMPAO-SPECT scans were investigated for the differential diagnosis of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The results showed that SCA of FDG-PET outperformed that of HMPAO-SPECT and had similar diagnostic performance to other analytical approaches.
PSYCHIATRY RESEARCH-NEUROIMAGING
(2022)
Article
Neurosciences
Yueyi Yu, Xinyi Xia, Xiaosheng Meng, Dan Li, Qi Qin
Summary: This study investigated the feasibility of using plasma p-tau181 and A beta(42) as potential biomarkers to differentiate AD and DLB. The results showed that plasma p-tau181 was significantly lower in DLB than in AD and healthy controls, while plasma A beta(42) was significantly higher in DLB than in AD but lower than in healthy controls. Both plasma biomarkers showed good accuracy in distinguishing DLB from healthy controls, while A beta(42) had better accuracy than p-tau181 in discriminating DLB from AD. These findings confirm the high diagnostic value of plasma p-tau181 and A beta(42) for distinguishing patients with DLB from healthy controls.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Guili Zhang, Shuai Liu, Zhichao Chen, Zhihong Shi, Wenzheng Hu, Lingyun Ma, Xiaodan Wang, Xudong Li, Yong Ji
Summary: Elevated plasma total homocysteine (tHcy) levels were independently associated with dementia with Lewy bodies (DLB) and Alzheimer's disease (AD). The association was stronger for DLB than for AD, and future longitudinal studies are needed to confirm the causative role of tHcy in DLB.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Psychiatry
Ming-Chyi Pai, Chiu-Jun Yang, Sheng-Yu Fan
Summary: This study investigated the differences in time perception performance between prodromal AD and prodromal DLB patients. The findings revealed that prodromal AD patients exhibited imprecision and overestimation of time, while prodromal DLB patients tended to underestimate time intervals. The study suggests that the clinical and pathological severity of these two prodromal dementia stages may differ.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Psychology, Clinical
Alan J. Thomas, Calum A. Hamilton, Sally Barker, Rory Durcan, Sarah Lawley, Nicola Barnett, Michael Firbank, Gemma Roberts, Louise M. Allan, John O'Brien, John-Paul Taylor, Paul C. Donaghy
Summary: Impaired olfaction may serve as a potential biomarker for early Lewy body disease, particularly in cases of mild cognitive impairment with Lewy bodies (MCI-LB). Olfactory function was significantly worse in individuals with probable MCI-LB compared to those with MCI-AD and healthy controls. A lower cutoff score of ≤ 7 on the SS-16 is recommended for identifying early LB disease in memory services.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Matthieu Lilamand, Josue Clery, Agathe Vrillon, Francois Mouton-Liger, Emmanuel Cognat, Sinead Gaubert, Claire Hourregue, Matthieu Martinet, Julien Dumurgier, Jacques Hugon, Elodie Bouaziz-Amar, Claire Paquet
Summary: This study found that cerebrospinal fluid levels of alpha-synuclein differ significantly between DLB and AD, suggesting its potential as a biomarker for distinguishing between these two diseases. CSF alpha-synuclein is associated with other AD biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neuroimaging
Wen-Ying Ma, Qun Yao, Guan-Jie Hu, Hong-Lin Ge, Chen Xue, Ying-Ying Wang, Yi-Xin Yan, Chao-Yong Xiao, Jing-Ping Shi, Jiu Chen
Summary: The study revealed different patterns of functional reorganization in DLB and AD patients, with the conversion and redistribution of rich club nodes possibly playing a causal role in disease-specific outcomes. This could serve as a potential biomarker for more accurate prevention and treatment strategies.
NEUROIMAGE-CLINICAL
(2022)
Article
Geriatrics & Gerontology
Pinar Soysal, Semen Gokce Tan
Summary: The study aimed to compare the prevalence of geriatric syndromes in early-stage Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Patients with DLB were more likely to experience orthostatic hypotension, fear of falling, depression, and insomnia compared to those with AD. The co-incidence of multiple geriatric syndromes is common in early-stage DLB and AD patients.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Psychology, Clinical
Hamish Naismith, Robert Howard, Robert Stewart, Alexandra Pitman, Christoph Mueller
Summary: This study examines factors associated with suicidal ideation around the time of dementia diagnosis. The findings suggest that depression, dementia with Lewy bodies, impaired activities of daily living, and vascular dementia are associated with a higher risk of suicidal ideation. The study highlights the importance of identifying and treating depressive symptoms in individuals with dementia and encourages further research on under-researched dementia subtypes.
INTERNATIONAL PSYCHOGERIATRICS
(2022)
Article
Clinical Neurology
Milan Nemy, Martin Dyrba, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Michael Ewers, Klaus Fliessbach, Wenzel Glanz, Doreen Goerss, Michael T. Heneka, Stefan Hetzer, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Matthias H. Munk, Robert Perneczky, Oliver Peters, Lukas Preis, Josef Priller, Boris-Stephan Rauchmann, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Bjorn H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Renat Yakupov, Maria Eriksdotter, Eric Westman, Olga Stepankova, Lenka Vyslouzilova, Emrah Duezel, Frank Jessen, Stefan J. Teipel, Daniel Ferreira
Summary: Nemy et al. investigate cholinergic white matter projections along the Alzheimer's disease continuum, finding that alterations in these pathways are present in individuals with subjective cognitive decline. These alterations precede the more widespread changes seen in mild cognitive impairment and Alzheimer's disease dementia. The study highlights the potential of using cholinergic white matter pathways as markers for the early stages of Alzheimer's disease.
Review
Clinical Neurology
Annegret Habich, Lars-Olof Wahlund, Eric Westman, Thomas Dierks, Daniel Ferreira
Summary: This systematic review summarizes findings on the structural and functional brain connectivity in patients with dementia with Lewy bodies (DLB). DLB patients show widespread abnormalities within and across brain networks, which are associated with core clinical features and cognitive impairments. Graph theoretical measures reveal disease-related decreases in local and global network efficiency. These connectivity characteristics may be particularly valuable at early stages of DLB and can help improve diagnosis, prognosis, and identify targets for future treatment.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Anna Marseglia, Gregoria Kalpouzos, Erika J. Laukka, Jane Maddock, Praveetha Patalay, Hui-Xin Wang, Lars Backman, Eric Westman, Anna-Karin Welmer, Serhiy Dekhtyar
Summary: This study investigates the interplay between social health and brain structural properties in relation to cognitive change in older adults. The findings suggest that both good social health and larger brain volume are associated with slower cognitive decline. Furthermore, good social health is related to higher cognitive levels in individuals with larger brain volume.
ANNALS OF NEUROLOGY
(2023)
Article
Behavioral Sciences
Gavin R. Stewart, Anne Corbett, Clive Ballard, Byron Creese, Dag Aarsland, Adam Hampshire, Helen Brooker, Rebecca A. Charlton, Francesca Happe
Summary: Cognitive differences in memory, information processing speed, and executive functions are common in autistic and high autistic trait populations. Older adults with high autistic traits experience more difficulties in memory, IPS, and EF tasks compared to those with low autistic traits. Further research is needed to examine age-related changes in cognitive profiles of older adults with autism traits.
Review
Geriatrics & Gerontology
Marianna Rogowska, Mary Thornton, Byron Creese, Latha Velayudhan, Dag Aarsland, Clive Ballard, Konstantinos Tsamakis, Robert Stewart, Christoph Mueller
Summary: Neuropsychiatric symptoms are common in patients with dementia and can lead to distress, rapid disease progression, and higher mortality. Non-pharmacological management should be the first-line treatment, but if medications are necessary, second-generation antipsychotics are commonly used. However, antipsychotic use in dementia is associated with adverse outcomes such as increased mortality, pneumonia, and cerebrovascular events. The risks are influenced by various factors, making individualized treatment decisions challenging. Close monitoring and early withdrawal of pharmacotherapy when possible can help mitigate these risks.
Article
Neurosciences
Jingru Fu, Antonios Tzortzakakis, Jose Barroso, Eric Westman, Daniel Ferreira, Rodrigo Moreno
Summary: Predicting brain aging is important for early detection and prognosis of neurodegenerative diseases. This paper proposes a methodology to fill missing data in longitudinal cohorts with anatomically plausible images. The proposed methodology uses deep learning-based diffeomorphic registration to simulate the aging process and rearrange the generated images to specific age ranges. The experimental results show that this methodology can produce anatomically plausible aging predictions and enhance longitudinal datasets.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Jessica Samuelsson, Anna Marseglia, Olof Lindberg, Eric Westman, Joana B. Pereira, Sara Shams, Silke Kern, Felicia Ahlner, Elisabet Rothenberg, Ingmar Skoog, Anna Zettergren
Summary: This study found associations between dietary patterns and dementia-related neuroimaging markers. Specifically, a high-protein and alcohol pattern was negatively associated with cortical thickness, while a Mediterranean-like pattern was positively associated with white matter microstructural integrity. No associations were found with a Western-like pattern.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Mans Gyllenhammar, Anna Rennie, Daniel Ferreira Padilla, John Wallert, Anders Rydstrom, Lars-Olof Wahlund, Maria Eriksdotter, Eric Westman, Urban Ekman
Summary: Education level is associated with atrophy in the medial temporal lobe and memory, with education moderating the effect of atrophy on memory.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Behavioral Sciences
Sara Pisani, Brandon Gunasekera, Yining Lu, Miriam Vignando, Dominic Ffytche, Dag Aarsland, K. Ray Chaudhuri, Clive Ballard, Jee-Young Lee, Yu Kyeong Kim, Latha Velayudhan, Sagnik Bhattacharyya
Summary: This study conducted a meta-analysis of MRI studies to explore the neuroanatomical alterations underlying psychosis in Parkinson's Disease (PDP). The results revealed widespread grey matter volume loss in the parieto-temporo-occipital regions of PDP patients, which was associated with the expression of serotonergic receptor genes (5-HT1a and 5-HT2a), but not dopaminergic receptors.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Clinical Neurology
Patricia Diaz-Galvan, Giulia Lorenzon, Rosaleena Mohanty, Gustav Martensson, Enrica Cavedo, Simone Lista, Andrea Vergallo, Kejal Kantarci, Harald Hampel, Bruno Dubois, Michel J. Grothe, Daniel Ferreira, Eric Westman
Summary: This study investigated the differential response of mild cognitive impaired (MCI) individuals with different magnetic resonance imaging (MRI) subtypes to donepezil treatment. Results showed that only MCI patients with minimal atrophy or hippocampal-sparing subtypes benefited from donepezil, as the drug slowed down the atrophy rate in these subtypes. The continuous subtyping approach, rather than the conventional categorical approach, captured this differential response.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Rosaleena Mohanty, Daniel Ferreira, Agneta Nordberg, Eric Westman
Summary: This study investigated the relationship between tau pathology and atrophy in Alzheimer's disease (AD) using tau-PET and structural MRI. The results showed that tau-PET patterns were associated with longitudinal atrophy in the AD continuum. Heterogeneity was also characterized as a continuous phenomenon, offering new insights into disease progression.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Maria Camila Gonzalez, Diego Alejandro Tovar-Rios, Guido Alves, Ingvild Dalen, Caroline H. Williams-Gray, Marta Camacho, Lars Forsgren, David Backstrom, Rachael A. Lawson, Angus D. Macleod, Carl E. Counsell, Claire Paquet, Carlo DeLena, Fabrizia D'Antonio, Andrea Pilotto, Alessandro Padovani, Frederic Blanc, Cristian Falup-Pecurariu, Simon J. G. Lewis, Konrad Rejdak, Ewa Papuc, Jakub Hort, Zuzana Nedelska, John O'Brien, Laura Bonanni, Marta Marquie, Merce Boada, Vanesa Pytel, Carla Abdelnour, Daniel Alcolea, Katrin Beyer, Ole-Bjorn Tysnes, Dag Aarsland, Jodi Maple-Grodem
Summary: This study compares the rate of cognitive and motor decline in patients with DLB and PDD, finding that both disorders show similar rates of decline. This has implications for future clinical trial designs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Clinical Neurology
Z. Pirtosek, V. Leta, P. Jenner, M. Verin
Summary: The standard of care refers to the level of care and treatment that healthcare providers should offer to patients, based on scientific evidence and medical knowledge. In the case of Parkinson's disease, the standard care is typically oral treatment with dopaminergic drugs. However, during the later stages of the disease, effective management with levodopa becomes more challenging, leading to the emergence of infusion therapies.
JOURNAL OF NEURAL TRANSMISSION
(2023)
Article
Geriatrics & Gerontology
Mariola Zapater-Fajari, Patricia Diaz-Galvan, Nira Cedres, Therese Rydberg Sterner, Lina Ryden, Simona Sacuiu, Margda Waern, Anna Zettergren, Henrik Zetterberg, Kaj Blennow, Silke Kern, Vanesa Hidalgo, Alicia Salvador, Eric Westman, Ingmar Skoog, Daniel Ferreira
Summary: This study found a significant association between depressive symptomatology and SCD-memory and SCD-concentration. Depressive symptomatology was not associated with AD and CVD biomarkers. The phosphorylated tau biomarker and depressive symptomatology predicted SCD-memory, while the A beta 42/40 ratio and depressive symptomatology predicted SCD-concentration.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Anna Rennie, Urban Ekman, John Wallert, J-Sebastian Muehlboeck, Maria Eriksdotter, Lars-Olof Wahlund, Daniel Ferreira, Eric Westman
Summary: This study compared three different approaches to subgroup SCI and MCI patients and investigated their capacity to disentangle cognitive and biomarker heterogeneity. The three approaches identified individuals with different biomarkers and captured some neuropsychological differences. The study helps advance understanding of the clinical and biological heterogeneity within SCI and MCI.
NEUROBIOLOGY OF AGING
(2023)