Review
Economics
K. Achtert, L. Kerkemeyer
Summary: This systematic review collected and summarized 20 studies on the economic burden of amyotrophic lateral sclerosis. Most studies focused on costs per patient, ranging from euro9741 to euro114,605. Six studies demonstrated an increase in costs as the disease progressed, peaking near the patient's death. National costs for amyotrophic lateral sclerosis ranged between euro149 million and euro1329 million.
EUROPEAN JOURNAL OF HEALTH ECONOMICS
(2021)
Article
Psychology, Clinical
Aditi Kadakia, Maryaline Catillon, Qi Fan, G. Rhys Williams, Jessica R. Marden, Annika Anderson, Noam Kirson, Carole Dembek
Summary: The estimated economic burden of schizophrenia in the US doubled between 2013 and 2019, reaching $343.2 billion in 2019. Indirect costs accounted for the majority of the burden, with caregiving, premature mortality, and unemployment being the main drivers.
JOURNAL OF CLINICAL PSYCHIATRY
(2022)
Article
Public, Environmental & Occupational Health
May Phyu Sin, Md Zahid Hasan, Birger C. Forsberg
Summary: This study examined the change in the societal economic burden of under-five diarrhoea in Bangladesh from 2007 to 2018. It found a 36.4% reduction in the economic burden, but it still accounted for 0.29% of the country's gross domestic product in 2018. Premature deaths were the major contributor to the costs.
JOURNAL OF GLOBAL HEALTH
(2023)
Article
Nursing
Meng-Mei Yuan, Xi Peng, Tie-Ying Zeng, Mei-Li-Yang Wu, Ye Chen, Ke Zhang, Xue-Jun Wang
Summary: This study in China aims to understand the illness experience of ALS patients and the meaning they attach to it. Through qualitative research, three main themes and eight subthemes were identified, emphasizing the importance of the family self-help model in improving patient and family experiences.
JOURNAL OF CLINICAL NURSING
(2021)
Article
Cardiac & Cardiovascular Systems
Katarina Steen Carlsson, Kristoffer Nilsson, Michael Lyng Wolden, Mads Faurby
Summary: This study aims to investigate the direct and indirect costs, early retirement, cardiovascular events, and mortality in people with atherosclerotic cardiovascular disease (ASCVD) and matched controls over a 5-year period in Sweden. The results showed that individuals with ASCVD had significantly higher costs compared to the controls, with indirect costs and inpatient admissions being major cost drivers. ASCVD patients were also more likely to experience additional ASCVD events, such as stroke and myocardial infarction, and enter early retirement.
BMC CARDIOVASCULAR DISORDERS
(2023)
Article
Clinical Neurology
Mario Alberto Battaglia, Daiana Bezzini, Isabella Cecchini, Cinzia Cordioli, Francesca Fiorentino, Tommaso Manacorda, Mihaela Nica, Michela Ponzio, Daniela Ritrovato, Chiara Vassallo, Francesco Patti
Summary: This study estimates the burden and cost of illness of multiple sclerosis (MS) in Italy in 2019 from a societal perspective. The results show a significant impact of the disease on patients' daily activities and work, increasing with disability. Fatigue is identified as a major burden. The overall cost of the disease in Italy is estimated at 4.8 billion euros.
JOURNAL OF NEUROLOGY
(2022)
Article
Geriatrics & Gerontology
Bei Cao, Xiaojing Gu, Qianqian Wei, Chunyu Li, Yongping Chen, Ruwei Ou, Yanbing Hou, Lingyu Zhang, Tao Li, Wei Song, Bi Zhao, Ying Wu, Xueping Chen, Huifang Shang
Summary: Analysis of Chinese ALS patients revealed GLT8D1 gene as a potential causative gene in familial ALS, but may not play a significant role in sporadic ALS.
NEUROBIOLOGY OF AGING
(2021)
Article
Economics
David Holdford, Nicholas Vendetti, Daniel M. Sop, Shirley Johnson, Wally R. Smith
Summary: This study aimed to quantify the indirect costs of sickle cell disease in the United States and found that pain events had a significant negative impact on employment status, productivity, and daily lives of adults with the disorder.
Article
Clinical Neurology
Philippe Corcia, Pascal Lejeune, Patrick Vourc'h, Stephane Beltran, Anne-Sophie Piegay, Helene Blasco, Vincent Meininger
Summary: This study characterized the prototypical phenotype of patients with amyotrophic lateral sclerosis (ALS) associated with PFN1 mutations and identified clinical indications for testing mutations in this gene. The main clinical findings for familial ALS linked to PFN1 were identified as pedigrees with over five cases, an onset age around 50 years, onset in the lower limbs, and the absence of cognitive impairment. The similarities with other ALS mutations prompt a review of ALS classifications based on both phenotype and genotype.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Rheumatology
Martina D'Onghia, Jacopo Ciaffi, Piero Ruscitti, Paola Cipriani, Roberto Giacomelli, Jacob N. Ablin, Francesco Ursini
Summary: This review summarizes the available evidence on the economic impact of fibromyalgia and the specific cost drivers of healthcare expenditure for this syndrome. The findings suggest that fibromyalgia represents a substantial economic burden to healthcare systems and society. Medications were found to contribute significantly to the overall expenditures.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2022)
Review
Clinical Neurology
Thomas H. Julian, Sarah Boddy, Mahjabin Islam, Julian Kurz, Katherine J. Whittaker, Tobias Moll, Calum Harvey, Sai Zhang, Michael P. Snyder, Christopher McDermott, Johnathan Cooper-Knock, Pamela J. Shaw
Summary: Mendelian randomization studies on amyotrophic lateral sclerosis show a causal link between blood lipids and the disease risk, while factors like smoking and immune function require further investigation for confirmation. The use of high methodological standards and replication across different datasets are essential for reliable results in Mendelian randomization studies.
Article
Environmental Sciences
Angela M. Malek, Vincent C. Arena, Ruopu Song, Eric A. Whitsel, Judith R. Rager, James Stewart, Jeff D. Yanosky, Duanping Liao, Evelyn O. Talbott
Summary: This study investigated the relationship between long-term exposure to ambient particulate matter and gaseous air pollution and ALS mortality. The results showed that PM2.5 and PM10 were not significantly associated with ALS death risk, but PM10-2.5 was associated with increased risk. This study adds to the knowledge about the impact of long-term ambient pollution on ALS mortality. Further research on the relationship between air pollution and ALS is needed.
ENVIRONMENTAL RESEARCH
(2023)
Review
Medicine, General & Internal
Can Cui, Jiangwei Sun, Kyla A. McKay, Caroline Ingre, Fang Fang
Summary: This systematic review investigated the association between medication use and ALS risk, and found no strong evidence linking any medication use with the risk of ALS.
Article
Neurosciences
Shuangwu Liu, Yuying Zhao, Qingguo Ren, Dong Zhang, Kai Shao, Pengfei Lin, Ying Yuan, Tingjun Dai, Yongqing Zhang, Ling Li, Wei Li, Peiyan Shan, Xiangshui Meng, Qian Wang, Chuanzhu Yan
Summary: This study investigated amygdala abnormalities in ALS patients, revealing distinct patterns at different clinical disease stages and highlighting their impact on anxiety and cognitive dysfunction.
HUMAN BRAIN MAPPING
(2022)
Article
Clinical Neurology
Philippe Corcia, Christian Lunetta, Philippe Couratier, Patrick Vourc'h, Marta Gromicho, Claude Desnuelle, Marie-Helene Soriani, Susana Pinto, Mamede de Carvalho
Summary: The study found that PLS and ALS cases occurred in nine families, generally among first-degree relatives. Patients with both diseases exhibited typical disease characteristics, and genetic studies revealed mutations in specific genes in some patients. These results strongly support a phenotypic continuum between PLS and ALS.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Dermatology
L. Skov, S. F. Thomsen, L. E. Kristensen, R. Dodge, M. S. Hedegaard, J. Kjellberg
BRITISH JOURNAL OF DERMATOLOGY
(2019)
Article
Public, Environmental & Occupational Health
Thomas Bo Jensen, Espen Jimenez-Solem, Rikke Cortes, Cecilie Betzer, Sara Boge Breinholt, Kasper Meidahl Petersen, Tonny Studsgaard Petersen, Jakob Kjellberg, Hanne Rolighed Christensen, Jon Traerup Andersen
SCANDINAVIAN JOURNAL OF PUBLIC HEALTH
(2020)
Article
Endocrinology & Metabolism
Joachim Gaede, Jens Oellgaard, Rikke Ibsen, Peter Gaede, Emil Nortoft, Hans-Henrik Parving, Jakob Kjellberg, Oluf Pedersen
Article
Psychiatry
Lene Halling Hastrup, Erik Simonsen, Rikke Ibsen, Jacob Kjellberg, Poul Jennum
SCHIZOPHRENIA BULLETIN
(2020)
Article
Clinical Neurology
Poul Jennum, Rikke Ibsen, Jakob Kjellberg
Article
Medicine, General & Internal
Soren Thorgaard Skou, Ewa Roos, Mogens Laursen, Lars Arendt-Nielsen, Sten Rasmussen, Ole Simonsen, Rikke Ibsen, Arendse T. Larsen, Jakob Kjellberg
Article
Orthopedics
S. T. Skou, E. M. Roos, M. Laursen, L. Arendt-Nielsen, S. Rasmussen, O. Simonsen, R. Ibsen, A. T. Larsen, J. Kjellberg
OSTEOARTHRITIS AND CARTILAGE
(2020)
Article
Health Care Sciences & Services
Jakob Kjellberg, Christian K. Tikkanen
Summary: This study estimated the 3-year societal costs associated with the onset of cardiovascular comorbidities among individuals with obesity. The costs were mainly driven by healthcare expenses and productivity loss, emphasizing the importance of managing obesity and cardiovascular disease risk factors to prevent costly and debilitating comorbidities.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2021)
Article
Critical Care Medicine
Christine Marie Baeko Halling, Morten Hylander Moller, Soren Marker, Mette Krag, Jakob Kjellberg, Anders Perner, Dorte Gyrd-Hansen
Summary: Pantoprazole reduces clinically important gastrointestinal bleeding in ICU patients at risk, but does not significantly impact 1-year mortality, healthcare resource use, or employment status.
INTENSIVE CARE MEDICINE
(2022)
Article
Health Care Sciences & Services
Marie Lynge Buchter, Jakob Kjellberg, Rikke Ibsen, Catarina Sternhufvud, Birte Petersen
Summary: People with spinal cord injury or multiple sclerosis may experience bladder and bowel dysfunction due to acquired neurogenic damage, leading to significant personal and societal costs. Medical and social interventions are needed to reduce the burden of illness.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2022)
Article
Genetics & Heredity
Line Kessel, Jakob Kjellberg, Kamilla Nissen, Anette Rasmussen, Morten la Cour
Summary: A study on patients with childhood-onset inherited retinal dystrophies (IRD) showed that a few were able to achieve high educational levels, but many received disability pension or were unemployed in adulthood, resulting in markedly reduced lifetime income, despite comparable grade mark points from primary education.
OPHTHALMIC GENETICS
(2022)
Article
Oncology
Annika von Heymann, Emma Finsted, Mai-Britt Guldin, Elisabeth Anne Wreford Andersen, Jesper Dammeyer, Per Sjogren, Hans von der Maase, Kirstine S. Benthien, Jakob Kjellberg, Christoffer Johansen, Pernille Bidstrup
Summary: The Domus study, a randomized controlled trial, examined the impact of home-based specialized palliative care with a psychological intervention on advanced cancer patients' time at home and number of home deaths. However, the study found that this intervention did not significantly reduce caregiver burden.
Article
Health Care Sciences & Services
Marie Lynge Buchter, Jakob Kjellberg, Rikke Ibsen, Catarina Sternhufvud, Birte Petersen
Summary: This study examines the burden of illness among patients with urinary retention (UR) caused by non-neurogenic conditions. The results show that patients requiring intermittent catheterization (IC) have significantly higher healthcare utilization and costs compared to matched controls, primarily driven by hospitalizations. Urinary tract infections (UTIs) are the most frequent bladder complications often requiring hospitalization.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Psychiatry
Merete Nordentoft, Mikkel Rasmussen, Lene Hogh, Christian Legind, Jakob Kjellberg
Summary: Denmark has agreed on a 10-year plan for psychiatry, which was developed collaboratively by the Danish Health Authority and the Danish Authority for Social Services and Housing, involving various stakeholders. The government has recently proposed an investment plan to increase the overall budget in Danish regions and municipalities by nearly 20 percent over 10 years. The need for improvement in psychiatric services was emphasized by epidemiological research showing shortened life expectancy and high disease burden among individuals with mental disorders. The Psychiatry Alliance, a unified organization consisting of user organizations, trade unions, and scientific societies in the field of mental health, took a proactive approach to influence politicians and media, resulting in significant impact.
EUROPEAN PSYCHIATRY
(2023)
Article
Rheumatology
Bente Glintborg, Rikke Ibsen, Rebecca Elisabeth Qwist Bilbo, Merete Lund Hetland, Jakob Kjellberg