Article
Infectious Diseases
Yunwen Qi, Zongze Jiang, Daixin Xie, Na Lei, Zhiyou Cai
Summary: In this study, a patient with neurosyphilis presenting with status epilepticus, hemiplegia, and aphasia was reported. After diagnostic tests and analysis, the patient was diagnosed with general paresis of the insane and showed significant recovery after high-dose intravenous penicillin therapy. Early diagnosis plays a crucial role in the effective treatment of neurosyphilis.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Psychiatry
Wietse A. Wiels, Mandy M. J. Wittens, Dieter Zeeuws, Chris Baeken, Sebastiaan Engelborghs
Summary: The study suggests that as cognitive impairment progresses, neuropsychiatric symptoms such as apathy, agitation, aggression, and activity disturbances increase, while affective symptoms like anxiety and depressive symptoms remain relatively stable. The research findings also indicate that there are no significant differences in neuropsychiatric symptoms between pure AD and AD with a significant vascular component.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Neurosciences
Kerriann K. Badal, Sathyanarayanan Puthanveettil
Summary: Axonal transport plays a crucial role in normal neuronal function, plasticity, and memory storage, while disruptions in this process are associated with neurodegenerative disorders. However, there is limited understanding of axonal transport deficits in neuropsychiatric disorders.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2022)
Review
Chemistry, Multidisciplinary
Yulei Wang, Suman Dana, Hao Long, Yang Xu, Yanjun Li, Nikolaos Kaplaneris, Lutz Ackermann
Summary: Late-stage functionalization (LSF) is a powerful strategy to accelerate the development of medicinally relevant compounds, crop protecting agents, and functional materials. Electrochemical late-stage functionalization (eLSF) has emerged as an environmentally friendly platform and has gained significant momentum in the past decade.
Review
Biochemistry & Molecular Biology
Melina Decourt, Haritz Jimenez-Urbieta, Marianne Benoit-Marand, Pierre-Olivier Fernagut
Summary: Parkinson's disease is associated with a variety of non-motor symptoms, including olfactory and autonomic dysfunction, neuropsychiatric issues, and cognitive impairments. These symptoms can worsen significantly over the course of the disease and may manifest before motor symptoms appear. Rodent models have shown that dopaminergic loss contributes to anxiety, apathy, depression-like behaviors, as well as learning and memory deficits in PD.
Article
Neurosciences
Dheeraj S. Roy, Ying Zhang, Tomomi Aida, Soonwook Choi, Qian Chen, Yuanyuan Hou, Nicholas E. Lea, Keith M. Skaggs, Juliana C. Quay, Min Liew, Hannah Maisano, Vinh Le, Carter Jones, Jie Xu, Dong Kong, Heather A. Sullivan, Arpiar Saunders, Steven A. McCarroll, Ian R. Wickersham, Guoping Feng
Summary: The study identified specific gene expressions in the anterior thalamic nuclei related to autism and schizophrenia, affecting memory functions. Different areas within the nuclei have distinct functions in memory encoding, with regulation of neuronal excitability playing a role in memory deficits. The findings suggest converging cellular mechanisms underlying cognitive deficits in certain neuropsychiatric disease models.
Review
Chemistry, Multidisciplinary
Elvira Romero, Bethan S. Jones, Bethany N. Hogg, Arnau Rue Casamajo, Martin A. Hayes, Sabine L. Flitsch, Nicholas J. Turner, Christian Schnepel
Summary: Enzyme catalysis plays an increasingly important role in synthetic chemistry, offering opportunities for late-stage modifications with high applicability in drug development. Enzymes can effectively introduce functional groups and diversify compound libraries in a fast and direct manner.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Editorial Material
Clinical Neurology
Bo Zhao, Zonghong Zhu, Jinjing Zhao, Miao Yang, Yimo Zhang, Hang Li, Shuyi Pan, Xiaokun Qi, Yingxin Yu
Summary: This article reports the clinical symptoms, diagnosis, and imaging findings of a 17-year-old girl. She presented with cognitive impairment, personality and behavioral changes, dysarthria, and paroxysmal lower-extremity weakness. Initial suspicion was mitochondrial encephalomyopathy, but pathogenic mutations were not found through genetic testing, and blood and cerebrospinal fluid lactate levels were normal.
Review
Chemistry, Multidisciplinary
Peter Bellotti, Huan-Ming Huang, Teresa Faber, Frank Glorius
Summary: The emergence of modern photocatalysis has revolutionized late-stage C-H functionalization, offering unprecedented regio- and chemoselectivities. This Review focuses on the strategies of small-molecule drugs, agrochemicals, and natural products, highlighting the main mechanistic scenarios and comparing established ionic chemistry and photocatalyzed radical-based manifolds. The authors aim to provide a comprehensive overview of the current state-of-the-art and address the challenges and future directions in this field.
Review
Chemistry, Multidisciplinary
Celena M. Josephitis, Hillary M. H. Nguyen, Andrew McNally
Summary: Azines, such as pyridines, quinolines, pyrimidines, and pyridazines, are widely used in pharmaceuticals due to their physiochemical properties and tunability. Synthetic methods for installing groups from azine C-H bonds are valuable, especially in late-stage functionalization reactions. This review highlights recent advances in azine late-stage functionalization reactions.
Article
Chemistry, Organic
Maxwell O. Bowles, Caroline Proulx
Summary: Azapeptides can undergo late-stage N-alkylations on-resin to selectively install side chains on the hydrazide nitrogen atoms. The major product is the N1-alkylated azapeptoid, while only a small amount of alkylation occurs on the other aza-amino acid nitrogen (N2). Site-selectivity was determined using various analytical techniques.
Review
Chemistry, Multidisciplinary
Jeroen B. I. Sap, Claudio F. Meyer, Natan J. W. Straathof, Ndidi Iwumene, Christopher W. Am Ende, Andres A. Trabanco, Veronique Gouverneur
Summary: This review discusses recent advances in difluoromethylation processes, focusing on X-CF2H bond formation and the development of various difluoromethylation reagents. Metal-based methods have shown promise in transferring CF2H to C(sp(2)) sites, while Minisci-type radical chemistry has been successfully applied to difluoromethylate C(sp(2))-H bonds.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Medicine, General & Internal
Kristin Carr, Onyema Ogbuagu
Summary: The incidence of syphilis has been on the rise, likely due to improved screening methods leading to the diagnosis of chronic untreated infections. Patients with syphilis can present with severe or subtle neurological symptoms, which may be missed and only detected when evaluating for other neurological infections.
Article
Chemistry, Multidisciplinary
Julia R. Dorsheimer, Tomislav Rovis
Summary: Stable isotopes have significant applications in chemistry and drug discovery. This study presents a method using a simple benzophenone imine as the N-15 source to access N-15-labeled primary amines through late-stage isotopic exchange.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Takafumi Ide, Kaibo Feng, Charlie F. Dixon, Dawei Teng, Joseph R. Clark, Wei Han, Chloe Wendell, Vanessa Koch, M. Christina White
Summary: A sustainable manganese perchlorophthalocyanine catalyst has been found to achieve selective intermolecular allylic C-H amination, including substrates with key sites and competing sites.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2021)
Article
Immunology
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Rebecca Rogall, Stefan Blaschke, Judith Kleinhaus, Noemie Reinert, Annika Bach, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
JOURNAL OF NEUROINFLAMMATION
(2018)
Article
Cell & Tissue Engineering
Stefan Blaschke, Sabine Ulrike Vay, Niklas Pallast, Monika Rabenstein, Jella-Andrea Abraham, Christina Linnartz, Marco Hoffmann, Nils Hersch, Rudolf Merkel, Bernd Hoffmann, Gereon Rudolf Fink, Maria Adele Rueger
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
(2019)
Article
Neurosciences
Monika Rabenstein, Marcus Unverricht-Yeboah, Meike Hedwig Keuters, Anton Pikhovych, Joerg Hucklenbroich, Sabine Ulrike Vay, Stefan Blaschke, Anne Ladwig, Helene Luise Walter, Magdalena Beiderbeck, Gereon Rudolf Fink, Michael Schroeter, Ralf Kriehuber, Maria Adele Rueger
FRONTIERS IN CELLULAR NEUROSCIENCE
(2019)
Article
Immunology
Monika Rabenstein, Sabine Ulrike Vay, Stefan Blaschke, Helene Luise Walter, Anne Ladwig, Gereon Rudolf Fink, Maria Adele Rueger, Michael Schroeter
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Immunology
Sabine Ulrike Vay, Lea Jessica Flitsch, Monika Rabenstein, Helena Moniere, Igor Jakovcevski, Pavle Andjus, Dunja Bijelic, Stefan Blaschke, Helene Luise Walter, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
JOURNAL OF NEUROINFLAMMATION
(2020)
Article
Clinical Neurology
Carolin Eckardt, Sabine Ulrike Vay, Clemens Warnke, Pia Flossdorf, Melanie Weinert
Summary: Dysphagia is a common but underestimated symptom in patients with multiple sclerosis. There is a lack of class 1 evidence for the diagnosis and treatment options of dysphagia.
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
(2021)
Article
Geriatrics & Gerontology
Johannes Boltze, Jaroslaw A. Aronowski, Jerome Badaut, Marion S. Buckwalter, Mateo Caleo, Michael Chopp, Kunjan R. Dave, Nadine Didwischus, Rick M. Dijkhuizen, Thorsten R. Doeppner, Jens P. Dreier, Karim Fouad, Mathias Gelderblom, Karen Gertz, Dominika Golubczyk, Barbara A. Gregson, Edith Hamel, Daniel F. Hanley, Wolfgang Haertig, Friedhelm C. Hummel, Maulana Ikhsan, Miroslaw Janowski, Jukka Jolkkonen, Saravanan S. Karuppagounder, Richard F. Keep, Inga K. Koerte, Zaal Kokaia, Peiying Li, Fudong Liu, Ignacio Lizasoain, Peter Ludewig, Gerlinde A. S. Metz, Axel Montagne, Andre Obenaus, Alex Palumbo, Monica Pearl, Miguel Perez-Pinzon, Anna M. Planas, Nikolaus Plesnila, Ami P. Raval, Maria A. Rueger, Lauren H. Sansing, Farida Sohrabji, Charlotte J. Stagg, R. Anne Stetler, Ann M. Stowe, Dandan Sun, Akihiko Taguchi, Mickael Tanter, Sabine U. Vay, Raghu Vemuganti, Denis Vivien, Piotr Walczak, Jian Wang, Ye Xiong, Marietta Zille
Summary: The past decade has witnessed significant advancements in both diagnosis and treatment of cerebrovascular diseases, with the introduction of thrombectomy in ischemic stroke and the identification of new therapeutic targets based on deeper understanding of pathomechanisms. Additionally, translational aspects are increasingly recognized in basic science studies, enhancing their predictive value for clinical application.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sabine Ulrike Vay, Jan-Michael Werner, Christoph Kabbasch, Matthias Schmidt, Alexander Drzezga, Gereon R. Fink, Norbert Galldiks, Clemens Warnke
Summary: This case highlights the value of somatostatin receptor ligand PET/CT in patients with suspected optic neuritis, when the diagnostic workup does not support an immune-mediated pathogenesis.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Neurosciences
Sabine Ulrike Vay, Daniel Navin Olschewski, Helena Petereit, Felix Lange, Nilufar Nazarzadeh, Elena Gross, Monika Rabenstein, Stefan Johannes Blaschke, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger
Summary: The glycoprotein osteopontin is considered a crucial regulator in CNS disorders like ischemic stroke, influencing cell growth, adhesion, and survival. Research suggests that osteopontin can impact the activation state and survival of astrocytes, making it a promising target for experimental therapies aimed at modulating neuroregeneration and repair.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)
Article
Multidisciplinary Sciences
Anna Katharina Schlusche, Sabine Ulrike Vay, Niklas Kleinenkuhnen, Steffi Sandke, Rafael Campos-Martin, Marta Florio, Wieland Huttner, Achim Tresch, Jochen Roeper, Maria Adele Rueger, Igor Jakovcevski, Malte Stockebrand, Dirk Isbrandt
Summary: The development of the cerebral cortex relies on the controlled division of neural stem and progenitor cells, with ion channels playing a crucial role in shaping the intrinsic properties of precursor cells and neurons. Dysfunction in HCN channels can impair proliferation and cause microcephaly in rodents, highlighting the importance of ion channels in cortical development in mammals.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Clinical Neurology
Stefan J. Blaschke, Lukas Hensel, Anuka Minassian, Susan Vlachakis, Caroline Tscherpel, Sabine U. Vay, Monika Rabenstein, Michael Schroeter, Gereon R. Fink, Mathias Hoehn, Christian Grefkes, Maria A. Rueger
Summary: The study showed that network parameters computed for both mouse models of stroke and humans follow a similar pattern in the postacute stroke phase. Parameters indicating the global communication structure's facilitation, such as small worldness and characteristic path length, were similarly changed in humans and mice in the first days after stroke. Additionally, small worldness correlated with concurrent motor impairment in humans and a negative correlation between initial small worldness and motor recovery was observed in mice during the subacute phase.
Article
Neurosciences
Jella-Andrea Abraham, Stefan Blaschke, Samar Tarazi, Georg Dreissen, Sabine U. Vay, Michael Schroeter, Gereon R. Fink, Rudolf Merkel, Maria A. Rueger, Bernd Hoffmann
Summary: The study suggests that neural stem cells are affected by pulsatile strain, influencing their quiescence and cytoskeletal organization. In addition, stem cells and their young progeny exhibit characteristic and distinct mechanoresponsiveness compared to other cell types in mammalian organisms.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Ines Klein, Janne Boenert, Felix Lange, Britt Christensen, Meike K. Wassermann, Martin H. J. Wiesen, Daniel Navin Olschewski, Monika Rabenstein, Carsten Mueller, Helmar C. Lehmann, Gereon Rudolf Fink, Michael Schroeter, Maria Adele Rueger, Sabine Ulrike Vay
Summary: Glia cells play a critical role in mediating the side effects of paclitaxel, influencing their (neuro-) inflammatory and (neuro-) regenerative properties and their interaction with other glia cells.
FRONTIERS IN PHARMACOLOGY
(2022)
Meeting Abstract
Neurosciences
D. N. Olschewski, F. Lange, C. Kulka, N. Nazarzadeh, S. Blaschke, J. -A. Abraham, R. Merkel, B. Hoffmann, M. Schroeter, G. R. Fink, M. A. Rueger, S. U. Vay
Article
Neurosciences
Stefan J. Blaschke, Seda Demir, Anna Koenig, Jella-Andrea Abraham, Sabine U. Vay, Monika Rabenstein, Daniel N. Olschewski, Christina Hoffmann, Marco Hoffmann, Nils Hersch, Rudolf Merkel, Bernd Hoffmann, Michael Schroeter, Gereon R. Fink, Maria A. Rueger
FRONTIERS IN CELLULAR NEUROSCIENCE
(2020)