Article
Neurosciences
Hyeon-Man Baek
Summary: The pathology of Parkinson's disease involves dopaminergic neuron death in the substantia nigra, gradually affecting basal ganglia pathways due to decreased dopamine transport. Diffusion MRI has been used to diagnose PD by evaluating white matter connectivity in certain brain areas. This study employed Lead-DBS to automatically segment subcortical structures in human connectome project data, reducing reliance on manual segmentation for improved consistency. The Lead-connectome pipeline was applied to investigate differences in diffusion measures between 3T and 7T data acquisition protocols, revealing significant variations in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity values in different regions.
Article
Statistics & Probability
Zhengwu Zhang, Yuexuan Wu, Di Xiong, Joseph G. Ibrahim, Anuj Srivastava, Hongtu Zhu
Summary: Magnetic resonance imaging has become a common tool for visualizing changes in subcortical structures of the brain. However, quantifying these structures still faces challenges. This study develops a simple and efficient framework for analyzing the longitudinal elastic shape of subcortical structures, providing tools for quantifying shape changes over time.
JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION
(2023)
Article
Clinical Neurology
Astrid Suchy-Dicey, Yi Su, Dedra S. Buchwald, Spero M. Manson, Eric M. Reiman
Summary: This study suggests that diabetes is an important risk factor for cortical atrophy and memory loss in American Indians. Future research should focus on this underserved population and explore opportunities for primary prevention.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Arenn F. F. Carlos, Nirubol Tosakulwong, Stephen D. D. Weigand, Matthew L. L. Senjem, Christopher G. G. Schwarz, David S. S. Knopman, Bradley F. F. Boeve, Ronald C. C. Petersen, Aivi T. T. Nguyen, R. Ross Reichard, Dennis W. W. Dickson, Clifford R. R. Jack Jr, Val Lowe, Jennifer L. L. Whitwell, Keith A. A. Josephs
Summary: This study investigated the impact of age and TDP-43 pathology on the volume-uptake mismatch in older Alzheimer's disease patients. The results showed that TDP-43 pathology was associated with reduced medial temporal volumes but not with F-18-flortaucipir uptake. The effect size of TDP-43 pathology remained consistent across the age spectrum, but in older age, the mean volumes moved towards those of TDP-43-positive cases, reflecting the increasing frequency of TDP-43 pathology with age.
ALZHEIMERS & DEMENTIA
(2022)
Article
Multidisciplinary Sciences
Francesca Del Signore, Germain Arribarat, Leonardo Della Salda, Giovanni Mogicato, Alexandra Deviers, Benjamin Cartiaux, Massimo Vignoli, Patrice Peran, Francesco de Pasquale
Summary: This study assessed the segmentation variability of Beagle dog brain MRI and the effect of formalin fixation. The segmentation was found to be reproducible, and formalin fixation improved brain structure visualization and segmentation.
Article
Neurosciences
Wen Gu, Ronghua He, Hang Su, Zhuanqin Ren, Lei Zhang, Huijie Yuan, Ming Zhang, Shaohui Ma
Summary: Our study found that patients with ESRD have subcortical structural atrophy, which is related to impaired cognitive performance and sleep disturbances. These findings may help to further understand the underlying neural mechanisms of brain changes in patients with ESRD.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Geriatrics & Gerontology
Chen Liu, Nanyan Zhu, Haoran Sun, Junhao Zhang, Xinyang Feng, Sabrina Gjerswold-Selleck, Dipika Sikka, Xuemin Zhu, Xueqing Liu, Tal Nuriel, Hong-Jian Wei, Cheng-Chia Wu, J. Thomas Vaughan, Andrew F. Laine, Frank A. Provenzano, Scott A. Small, Jia Guo
Summary: This article proposes a method for generating contrast-equivalent information from non-contrast MRI scans using a deep learning model, and validates its effectiveness using data from mice and humans. The results of the study show that the model can approximate Gadolinium-based contrast agents and provide high-resolution quantitative analysis of brain activity. Furthermore, the study demonstrates the potential application of the model in identifying functional abnormalities in the aging brain and in patients with Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ji Young Lee, Se Won Oh, Mi Sun Chung, Ji Eun Park, Yeonsil Moon, Hong Jun Jeon, Won-Jin Moon
Summary: The study compared two clinically available MR volumetry software, NeuroQuant (NQ) and Inbrain (IB), and found significant volume differences in most brain regions between them, with good to excellent inter-method reliability overall except for the pallidum. The effect size of volume differences varied across brain regions, with the largest in the pallidum and the smallest in the cerebellum.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Clinical Neurology
Julien Lagarde, Pauline Olivieri, Matteo Tonietto, Cecile Tissot, Isabelle Rivals, Philippe Gervais, Fabien Caille, Martin Moussion, Michel Bottlaender, Marie Sarazin
Summary: Based on the study findings, tau tracer binding in specific brain regions is strongly associated with cognitive decline in patients with Alzheimer's disease (AD). In contrast, initial amyloid load, regional cortical atrophy or CSF biomarkers do not show significant relationship with cognitive decline.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Medicine, General & Internal
David Strelnikov, Amirreza Alijanpourotaghsara, Marton Piroska, Laszlo Szalontai, Bianka Forgo, Zsofia Jokkel, Aliz Persely, Anita Hernyes, Lajos Rudolf Kozak, Adam Szabo, Pal Maurovich-Horvat, David Laszlo Tarnoki, Adam Domonkos Tarnoki
Summary: This study examined the heritability of subcortical and general brain volumes in twins and found that most of the subcortical volumes are strongly heritable. The thalamus volume was more influenced by common environmental factors. The study highlights the importance of identifying relevant genes associated with variations in subcortical structure volume and related diseases.
MEDICINA-LITHUANIA
(2022)
Article
Clinical Neurology
Rebecca L. Winfree, Mabel Seto, Logan Dumitrescu, Vilas Menon, Philip De Jager, Yanling Wang, Julie Schneider, David A. Bennett, Angela L. Jefferson, Timothy J. Hohman
Summary: This study investigated the correlation between region-specific TREM2 mRNA expression and neuropathology measures in a large sample size. The results showed that TREM2 expression was related to Alzheimer's disease pathology, cerebrovascular pathology, microglial activation, and cognitive decline, but the associations varied across different brain regions. These findings suggest that TREM2's pathological associations are dependent on the brain region.
ACTA NEUROPATHOLOGICA
(2023)
Article
Clinical Neurology
Jose Bernal, Stefanie Schreiber, Inga Menze, Anna Ostendorf, Malte Pfister, Jonas Geisendoerfer, Aditya Nemali, Anne Maass, Renat Yakupov, Oliver Peters, Lukas Preis, Luisa Schneider, Ana Lucia Herrera, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Bjoern H. Schott, Ayda Rostamzadeh, Wenzel Glanz, Katharina Buerger, Daniel Janowitz, Michael Ewers, Robert Perneczky, Boris-Stephan Rauchmann, Stefan Teipel, Ingo Kilimann, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Laura Dobisch, Peter Dechent, Klaus Scheffler, Stefan Hetzer, Steffen Wolfsgruber, Luca Kleineidam, Matthias Schmid, Moritz Berger, Frank Jessen, Miranka Wirth, Emrah Duezel, Gabriel Ziegler
Summary: Hypertension and A-beta positivity are associated with larger volumes of white matter hyperintensities (WMH), which in turn negatively impact cognition. Both hypertension and A-beta positivity are related to worse cognitive performance, and the relationship is partially mediated by WMH in specific brain regions.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Geriatrics & Gerontology
Chun-Yu Chen, Yung-Shuan Lin, Wei-Ju Lee, Yi-Chu Liao, Yu-Shan Kuo, Albert C. Yang, Jong-Ling Fuh
Summary: The study found that different variants of the SORL1 gene are associated with the volume of the right putamen and pallidum, which may affect cognitive function and clinical progression in patients with late-onset Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Engineering, Biomedical
Amar Shukla, Rajeev Tiwari, Shamik Tiwari
Summary: Alzheimer's disease is a neurological condition that leads to cognitive deterioration in the brain. This paper utilizes the fusion of PET and MRI modalities and machine learning methods to analyze different subcortical structures, identifying the most critical regions in AD detection.
BIOMEDICAL SIGNAL PROCESSING AND CONTROL
(2024)
Article
Neurosciences
Stefan J. Teipel, Martin Dyrba, Tommaso Ballarini, Frederic Brosseron, Davide Bruno, Katharina Buerger, Nicoleta-Carmen Cosma, Peter Dechent, Laura Dobisch, Emrah Duezel, Michael Ewers, Klaus Fliessbach, John D. Haynes, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Nunzio Pomara, Lukas Preis, Josef Priller, Alfredo Ramirez, Nina Roy, Klaus Scheffler, Anja Schneider, Bjoern H. Schott, Annika Spottke, Eike J. Spruth, Michael Wagner, Jens Wiltfang, Frank Jessen, Michael T. Heneka
Summary: This study investigated the association between cholinergic basal forebrain volume and functional connectivity with neuroinflammation measures in individuals within the AD spectrum. The findings suggest that the cholinergic basal forebrain may be involved in the neuroinflammation response to A beta(42) and phospho-tau pathology.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Jingwen Zhu, Anqi Qiu
Summary: This study constructed a multimodal brain atlas for a Chinese aging population, including T1, HARDI, and rs-fMRI atlases. Using spectral clustering, 20 brain functional networks were generated, and joint independent component analysis was used to explore coherent markers for aging and gender.
Article
Neurosciences
Jingwen Zhu, Anqi Qiu
Summary: This study used multi-modal MRI data to investigate the functional connectivity of the brain in adolescents and found that the IVFC of the triple and cerebellar networks plays a crucial role in cognitive, emotional, and psychopathological development during adolescence.
Article
Computer Science, Artificial Intelligence
Chaoqiang Liu, Fei Huang, Anqi Qiu
Summary: This study develops a Monte Carlo Ensemble Neural Network (MCENN) which takes advantage of 2D-slice CNN fast computation and ensemble approaches to improve CNN performance in the diagnosis of Alzheimer's Disease. The MCENN model incorporates one neural network learner and uses Monte Carlo sampling to generate possible classification decisions, overcoming the lack of 3D brain anatomical information in 2D-slice CNNs. The MCENN achieves high accuracy in AD classification and is insensitive to image resolution, making it suitable for clinical use. Rating: 8/10.
Article
Psychiatry
Jian Huang, Ai Peng Tan, Evelyn Law, Keith M. Godfrey, Anqi Qiu, Lourdes Mary Daniel, Marielle Fortier, Kok Hian Tan, Jerry Kok Yen Chan, David Cameron-Smith, Yap Seng Chong, Shiao-Yng Chan, Johan G. Eriksson, Michael J. Meaney, Jonathan Huang
Summary: This study found that higher levels of certain nutrient-related biomarkers in maternal preconception blood were associated with an increased risk of behavioral problems in infants. The study also found that an increase in preconception thiamine levels was associated with higher CBCL scores and a lower right subthalamic nucleus ODI.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Clinical Neurology
Kanta Horie, Yan R. Li, Nicolas Barthelemy, Brian Gordon, Jason Hassenstab, Tammie L. S. M. Benzinger, Anne C. Fagan, John M. Morris, Celeste Karch, Chengjie Xiong, Ricardo Allegri, Patricio Chrem Mendez, Takeshi Ikeuchi, Kensaku Kasuga, James Noble, Martin Farlow, Jasmeer Chhatwal, Gregory R. Day, Peter R. Schofield, Colin Masters, Johannes Levin, Mathias Jucker, Jae-Hong Lee, Jee Hoon Roh, Chihiro Sato, Pallavi Sachdev, Akihiko Koyama, Larisa J. Reyderman, Randall Bateman, Eric McDade
Summary: Identifying cerebrospinal fluid measures of the microtubule binding region of tau (MTBR-tau) species that reflect tau aggregation could provide fluid biomarkers that track Alzheimer's disease related neurofibrillary tau pathological changes.
ANNALS OF NEUROLOGY
(2023)
Article
Neurosciences
Anqi Qiu, Chaoqiang Liu
Summary: This study aimed to explore the possible pathways from genetic and environmental risks to structural brain organization and psychopathology in adolescents. The findings showed that lower socioeconomic status was associated with lower structural connectivity in certain brain networks and more severe psychosis and internalizing problems in youth. Prematurity and birth weight were related to early-developed sensorimotor and subcortical networks. Increased parental psychopathology, decreased socioeconomic status, and school engagement were associated with elevated family conflict, psychosis, and externalizing behaviors in youth. Increased maternal substance use predicted increased developmental adversity, internalizing problems, and psychosis. However, polygenic risks for psychiatric disorders had moderate effects on brain structural connectivity and psychopathology in youth.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Sungyang Jo, Hyunna Lee, Hyung-Ji Kim, Chong Hyun Suh, Sang Joon Kim, Yoojin Lee, Jee Hoon Roh, Jae-Hong Lee
Summary: The aim of this study was to predict amyloid-beta positivity using conventional T1-weighted images, radiomics, and diffusion-tensor images obtained from MRI. A machine learning algorithm was developed using demographic and MRI features, and it was found that T1 volume was the best predictor of amyloid PET positivity. Radiomics and diffusion-tensor images did not provide additional benefits in predicting amyloid-beta positivity.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Allergy
Jee Hoon Roh, Kyunhyung Henry Kim
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Neurosciences
Jingwen Zhu, Daniel Margulies, Anqi Qiu
Summary: It has been found that fluctuations in fMRI data can reflect meaningful patterns of brain activity in the white matter. This study used resting-state fMRI from adolescents to investigate the formation of large-scale white matter functional gradients. The results showed gray-matter-like unimodal-to-transmodal and sensorimotor-to-visual gradients with specific cognitive associations, as well as a unique superficial-to-deep gradient with nonspecific cognitive associations. The formation of these functional gradients is likely influenced by both functional and structural mechanisms during adolescence.
Article
Biochemistry & Molecular Biology
Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric McDade, Nicolas R. Barthelemy, Celeste M. Karch, Chengjie Xiong, Carlos Cruchaga, Richard J. Perrin, Aliza P. Wingo, Thomas S. Wingo, Jasmeer P. Chhatwal, Gregory S. Day, James M. Noble, Sarah B. Berman, Ralph Martins, Neill R. Graff-Radford, Peter R. Schofield, Takeshi Ikeuchi, Hiroshi Mori, Johannes Levin, Martin Farlow, James J. Lah, Christian Haass, Mathias Jucker, John C. Morris, Tammie L. S. Benzinger, Blaine R. Roberts, Randall J. Bateman, Anne M. Fagan, Nicholas T. Seyfried, Allan Levey
Summary: Alzheimer's disease pathology, characterized by aggregation of Aβ peptide into plaques and tau protein into neurofibrillary tangles, develops years before cognitive symptoms. By analyzing cerebrospinal fluid proteomics in individuals with autosomal dominant AD, researchers identified protein changes associated with Aβ plaques and their temporal evolution over six decades. These proteomic measurements were able to differentiate mutation carriers from noncarriers before symptom onset better than traditional Aβ and tau measures. Understanding the multifaceted landscape of AD pathology and its progression is crucial for developing precise therapeutic interventions and biomarkers.
Correction
Neurosciences
Anqi Qiu, Chaoqiang Liu
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Chenye Shen, Chaoqiang Liu, Anqi Qiu
Summary: Metabolic syndrome (MetS) is associated with stroke and neurodegenerative diseases, and this study explored the associations of brain morphology with MetS and brain aging due to MetS. The research found that increased cortical surface area, decreased thickness, and reduced volumes in certain brain areas were associated with MetS components. Obesity had the strongest impact on brain morphology. Participants with more severe MetS had older brain age, and patients with stroke, dementia, Parkinson's, and multiple sclerosis showed greater brain age than the metabolic aging group. The obesity-related brain morphology can be used for risk assessment of stroke and neurodegenerative diseases.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Computer Science, Artificial Intelligence
Jing Xia, Nanguang Chen, Anqi Qiu
Summary: This study proposes a multi-level and joint attention network for learning high-order representations of brain functional connectivities to predict different cognitive tasks. The experiments demonstrate the effectiveness of attention modules and identify specific and shared brain functional connectivities and regions. The joint attention module significantly improves the prediction of cognitive functions. The network outperforms existing machine learning techniques on the ABCD dataset.
MEDICAL IMAGE ANALYSIS
(2023)
Article
Neurosciences
Eun-Joo Kim, Duk L. Na, Hee-Jin Kim, Kyung Won Park, Jae-Hong Lee, Jee Hoon Roh, Jay C. Kwon, Soo Jin Yoon, Na-Yeon Jung, Jee Hyang Jeong, Jae-Won Jang, Hee-Jin Kim, Kee Hyung Park, Seong Hye Choi, SangYun Kim, Young Ho Park, Byeong C. Kim, Young Chul Youn, Chang-Seok Ki, Seung Hyun Kim, Sang Won Seo, Young-Eun Kim
Summary: This study found that the known pathogenic variants of the three main FTD genes are rare in Korean FTD patients. The results indicate a difference in genetic background between Korean FTD patients and those in Western countries.
JOURNAL OF ALZHEIMERS DISEASE REPORTS
(2022)
Review
Clinical Neurology
Giuseppina Pilloni, Leigh E. Charvet, Marom Bikson, Nikhil Palekar, Min-Jeong Kim
Summary: Transcranial direct current stimulation (tDCS) is a safe and noninvasive method for stimulating the brain, showing potential therapeutic effects for Alzheimer's disease and mild cognitive impairment. However, more clinical trials are needed to determine its effectiveness and mechanisms for clinical applications.
JOURNAL OF CLINICAL NEUROLOGY
(2022)
