Article
Clinical Neurology
Lize C. C. Jiskoot, Esther van den Berg, Sascha A. A. M. Laenen, Jackie M. M. Poos, Lucia A. A. Giannini, Djaina D. D. Satoer, Judy van Hemmen, Yolande A. L. Pijnenburg, Jet M. J. Vonk, Harro Seelaar
Summary: Research suggests that qualitative measures of semantic fluency can provide valuable insights into the progression of different genetic mutations associated with Frontotemporal Dementia (FTD). Specifically, GRN mutation carriers show a decrease in clustering and an increase in cluster size, which is associated with decline in executive function. On the other hand, MAPT mutation carriers display an increase in lexical frequency and a decline in age of acquisition, which is associated with decline in semantic processing. These qualitative measures have the potential to serve as sensitive cognitive biomarkers for the diagnosis and monitoring of FTD.
JOURNAL OF NEUROLOGY
(2023)
Article
Linguistics
Mohamad El Haj, Dimitrios Kapogiannis, Claire Boutoleau-Bretonniere
Summary: This study assessed linguistic processing in patients with behavioral variant frontotemporal dementia (bvFTD) using pupillometry. The results showed that patients with bvFTD had smaller pupil size during verbal fluency tasks and counting compared to control participants. However, larger pupil size was observed during verbal fluency tasks compared to counting in both groups. Moreover, patients with bvFTD performed poorer in verbal fluency tasks compared to control participants.
JOURNAL OF NEUROLINGUISTICS
(2024)
Article
Psychology, Multidisciplinary
Aino M. Saranpaa, Sasa L. Kivisaari, Riitta Salmelin, Sabine Krumm
Summary: The semantic fluency task is a valuable tool for diagnosing Alzheimer's disease, and this study investigates its use in differentiating between healthy individuals, patients with mild cognitive impairment, and patients with early Alzheimer's dementia. By using word2vec and t-SNE visualization, a multidimensional semantic space is created to effectively analyze semantic categories. The frequency of returning to sub-categories provides additional information for diagnosing early Alzheimer's disease. This research highlights the potential of word2vec and t-SNE as tools for studying the semantic space.
FRONTIERS IN PSYCHOLOGY
(2022)
Article
Clinical Neurology
Alfonso Delgado-Alvarez, Maria Nieves Cabrera-Martin, Vanesa Pytel, Cristina Delgado-Alonso, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: The study found that there are different underlying cognitive processes involved in verbal and design fluency in AD and bvFTD. Memory and executive functioning associated with fronto-temporo-parietal regions were key in AD, while attention and executive functions correlated with the frontal cortex played a more significant role in bvFTD during fluency tasks.
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY
(2022)
Article
Geriatrics & Gerontology
Alfonso Delgado-Alvarez, Maria Nieves Cabrera-Martin, Maria Valles-Salgado, Cristina Delgado-Alonso, Maria Jose Gil, Maria Diez-Cirarda, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study investigated the visuospatial task performance and neural mechanisms in patients with bvFTD and AD. The results showed that patients with AD performed the worst in visuospatial tasks in mild dementia, while patients with bvFTD showed higher correlations between attention and executive functioning and visuospatial performance. The visuospatial deficits in patients with bvFTD were associated with bilateral frontal regions.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Multidisciplinary
Maria Nieves Cabrera-Martin, Pedro Nespral, Maria Valles-Salgado, Pablo Bascunana, Cristina Delgado-Alonso, Alfonso Delgado-Alvarez, Lucia Fernandez-Romero, Juan Ignacio Lopez-Carbonero, Maria Diez-Cirarda, Maria Jose Gil-Moreno, Jorge Matias-Guiu, Jordi A. Matias-Guiu
Summary: This study investigated the metabolic correlates associated with the performance of ACE-III in Alzheimer's disease (AD) and frontotemporal dementia (FTD). The results showed distinct neural correlates for ACE-III in bvFTD and AD, with lower scores associated with more advanced stages in both disorders. ACE-III exhibited high discrimination between bvFTD vs. HC and AD vs. HC. It was also sensitive to detect hypometabolism in brain regions associated with bvFTD and AD.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychology, Multidisciplinary
Giulia Fusi, Maura Crepaldi, Laura Colautti, Massimiliano Palmiero, Alessandro Antonietti, Luca Rozzini, Maria Luisa Rusconi
Summary: Studies have shown that patients with frontotemporal dementia (FTD) exhibit changes in their divergent thinking abilities, depending on the specific anatomical and functional changes associated with the disease. Some patients can generate multiple ideas due to unimpaired access to memory stores, while others are unable to produce original ideas due to brain damage.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Psychology, Multidisciplinary
Marco Hirnstein, Josephine Stuebs, Angelica Moe, Markus Hausmann
Summary: Women have a slight advantage in verbal abilities, particularly in phonemic fluency and recall. The gender difference in semantic fluency and recognition appears to be category-dependent. Published articles report stronger female advantages, and first authors believe their own gender performs better.
PERSPECTIVES ON PSYCHOLOGICAL SCIENCE
(2023)
Review
Neurosciences
Consuelo Sepulveda-Silva, Teresa Julio-Ramos, Eduardo Fuentes-Lopez, David Toloza-Ramirez, Rodrigo A. Santibanezd, David A. Copland, Carolina Mendez-Orellana
Summary: This study compared the performance of semantic and phonological fluency tasks in healthy volunteers, volunteers with probable AD, and patients with AD diagnosis. The results showed that all three groups performed better on semantic fluency compared to phonological fluency. With the progression to AD diagnosis, a significant difference in performance on both tasks was observed among the groups, and age explained a portion of this difference.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Psychology, Multidisciplinary
Eun Jin Paek
Summary: The study investigated the relationship between emotion and memory in individuals with amnestic Alzheimer's disease (AD), finding that AD participants produced words with higher emotional valence during action fluency tasks, and that the emotional valence of words was negatively correlated with verbal memory and learning skills. This suggests that those with poorer memory skills tended to retrieve words with higher emotional valence, indicating preserved emotional enhancement of memory effects in AD individuals.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Geriatrics & Gerontology
Zhongyun Chen, Jinghong Ma, Li Liu, Shuying Liu, Jing Zhang, Min Chu, Zhen Wang, Piu Chan, Liyong Wu
Summary: This study investigates the roles of striatal subdivisions in the pathogenesis of frontotemporal dementia with parkinsonism (FTDP) in a patient with prion protein gene (PRNP) mutation. The findings suggest that the alteration of frontal striatal loops may be involved in cognitive impairment in FTDP, while the development of parkinsonism in FTDP may primarily be due to the involvement of the presynaptic nigrostriatal loops in PRNP V180I mutation.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Camillo Marra, Chiara Piccininni, Giovanna Masone Iacobucci, Alessia Caprara, Guido Gainotti, Emanuele Maria Costantini, Antonio Callea, Annalena Venneri, Davide Quaranta
Summary: The assessment of semantic memory is crucial in predicting the progression of individuals with MCI to AD. The study revealed that MCI patients with lower SPD were more likely to progress to dementia, and SPD was the only measure with significant predictive effect at the five-year follow-up.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Kristina Horne, Rebekah M. Ahmed, Olivier Piguet, Muireann Irish
Summary: This study demonstrates the link between motivational changes and behavioral rigidity in frontotemporal dementia (FTD). The researchers found that FTD patients with severe behavioral rigidity also had a lack of motivation and decreased hedonic tone. By identifying candidate mechanisms of behavioral rigidity, these findings can inform targeted interventions to manage inflexible patterns of thought and behavior in daily life.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Bradley T. Peet, Salvatore Spina, Nidhi Mundada, Renaud La Joie
Summary: Frontotemporal dementia encompasses degeneration of the frontal and temporal lobes and has historically been challenging to diagnose. Neuroimaging research has identified biomarkers to help narrow the diagnosis and improve accuracy. Patterns of neurodegeneration correlate with neuropathological substrates, aiding clinicians in determining etiology and prognosis.
Article
Psychiatry
Kaley Angers, Julie A. Suhr, Melissa T. Buelow
Summary: This study aimed to investigate the relationship between schizotypy and language ability, measured by semantic fluency. It found a non-linear relation between schizotypy and semantic infrequency and productivity, indicating atypical semantic activation and processing in individuals with schizotypal traits. Valuable content-based information is missed when only analyzing semantic fluency data via the traditional method in the schizophrenia spectrum population.
JOURNAL OF PSYCHIATRIC RESEARCH
(2021)
Article
Neurosciences
Alexandre Bejanin, Renaud La Joie, Brigitte Landeau, Serge Belliard, Vincent de La Sayette, Francis Eustache, Beatrice Desgranges, Gael Chetelat
Article
Oncology
Marie Lange, Natacha Heutte, Sabine Noal, Olivier Rigal, Jean-Emmanuel Kurtz, Christelle Levy, Djelila Allouache, Chantal Rieux, Johan Lefel, Benedicte Clarisse, Alexandra Leconte, Corinne Veyret, Philippe Barthelemy, Nadine Longato, Laure Tron, Helene Castel, Francis Eustache, Benedicte Giffard, Florence Joly
Article
Neuroimaging
Joy Perrier, Armelle Viard, Christelle Levy, Nastassja Morel, Djelila Allouache, Sabine Noal, Florence Joly, Francis Eustache, Benedicte Giffard
BRAIN IMAGING AND BEHAVIOR
(2020)
Article
Clinical Neurology
Shailendra Segobin, Alice Laniepce, Ludivine Ritz, Coralie Lannuzel, Celine Boudehent, Nicolas Cabe, Laurent Urso, Francois Vabret, Francis Eustache, Helene Beaunieux, Anne-Lise Pitel
Article
Neurosciences
Marie Caillaud, Alexandre Bejanin, Mickael Laisney, Pierre Gagnepain, Malo Gaubert, Armelle Viard, Patrice Clochon, Vincent de La Sayette, Philippe Allain, Francis Eustache, Beatrice Desgranges
HUMAN BRAIN MAPPING
(2020)
Article
Clinical Neurology
Marie Caillaud, Mickael Laisney, Alexandre Bejanin, Clarisse Scherer-Gagou, Dominique Bonneau, Harmony Duclos, Francis Eustache, Christophe Verny, Beatrice Desgranges, Philippe Allain
Article
Clinical Neurology
R. Schneckenburger, M. Hainselin, F. Viader, F. Eustache, P. Quinette
REVUE NEUROLOGIQUE
(2020)
Article
Multidisciplinary Sciences
Alison Mary, Jacques Dayan, Giovanni Leone, Charlotte Postel, Florence Fraisse, Carine Malle, Thomas Vallee, Carine Klein-Peschanski, Fausto Viader, Vincent de la Sayette, Denis Peschanski, Francis Eustache, Pierre Gagnepain
Article
Psychology, Biological
Pierre Gagnepain, Thomas Vallee, Serge Heiden, Matthieu Decorde, Jean-Luc Gauvain, Antoine Laurent, Carine Klein-Peschanski, Fausto Viader, Denis Peschanski, Francis Eustache
NATURE HUMAN BEHAVIOUR
(2020)
Article
Neurosciences
Renaud Coppalle, Caroline Mauger, Sophie Quernet, Axel Dewald, Odile Letortu, Beatrice Desgranges, Mathilde Groussard, Herve Platel
JOURNAL OF ALZHEIMERS DISEASE
(2020)
Article
Neurosciences
Alexandrine Morand, Shailendra Segobin, Gregory Lecouvey, Julie Gonneaud, Francis Eustache, Geraldine Rauchs, Beatrice Desgranges
Summary: This study found that older participants had lower gray matter volumes in several brain areas, but these did not correlate with TBPM performance. On the other hand, a decline in white matter integrity was correlated with TBPM performance, indicating a disconnection process that occurs in aging and contributes to cognitive decline.
Article
Clinical Neurology
Maxime Bertoux, Harmony Duclos, Marie Caillaud, Shailendra Segobin, Catherine Merck, Vincent de La Sayette, Serge Belliard, Beatrice Desgranges, Francis Eustache, Mickael Laisney
Article
Psychology, Multidisciplinary
Herve Platel, Marie-Loup Eustache, Renaud Coppalle, Armelle Viard, Francis Eustache, Mathilde Groussard, Beatrice Desgranges
Summary: Studies have shown that Alzheimer's Disease patients with severe dementia can maintain consistent, albeit impoverished, representations of themselves and a preserved sense of identity even at advanced stages of the illness. Participation in reminiscence workshops with familiar songs as prompts can enrich autobiographical memories and support self-representation for these patients. However, while autobiographical memories of AD patients can reach levels comparable to matched controls with repeated participation, this increase in memories does not necessarily lead to enriched sense of identity.
FRONTIERS IN PSYCHOLOGY
(2021)