Article
Environmental Sciences
Yanfeng Sun, Yanjian Wan, Ying Jiang, Huaiji Wang
Summary: The study found that exposure to Acetaminophen (AAP) was common in young children in central and south China, with AAP concentrations positively correlated with oxidative stress biomarkers 8-hydroxy-guanosine (8-OHG) and 8-hydroxy-2'-deoxyguanosine (8-OHdG). This suggests a potential association between AAP exposure and DNA and RNA damage.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Chemistry, Analytical
Raluca-Ioana Stefan-van Staden, Oana-Raluca Musat
Summary: This article proposes two stochastic microsensors based on single-walled and multi-walled carbon nanotubes modified with alpha-cyclodextrin for the assay of 8-hydroxy-2'-deoxyguanosine in whole blood. The microsensor based on single-walled carbon nanotubes showed a wider linear concentration range, while the microsensor based on multi-walled carbon nanotubes showed the highest sensitivity.
MICROCHEMICAL JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Ben Schottker, Emil L. Larsen, Allan Weimann, Trine Henriksen, Hermann Brenner, Henrik E. Poulsen
Summary: The study found an association between urinary oxidized guanine/guanosine (OxGuo) levels and incident type 2 diabetes (T2D) among older adults. However, there were differences in the results obtained from different testing methods.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Chemistry, Applied
Meijuan Liao, Ruyi Zhang, Yi Zhou, Duoxia Xu, Yahong Han, Fuguo Liu, Jiaqi Su, Shuai Chen
Summary: The aim of this study was to develop particle-filled microgels based on zein and rc-carrageenan for efficient delivery of CoQ10. The optimized formulation showed an average particle diameter of 807.4 nm and a zeta-potential of -28.4 mV. It effectively reduced the chemical degradation of CoQ10 and controlled its release during simulated gastrointestinal digestion, leading to improved oral bioavailability.
FOOD HYDROCOLLOIDS
(2023)
Article
Chemistry, Analytical
Jianhui Xu, Jiaxin Zhang, Ruijin Zeng, Ling Li, Meijin Li, Dianping Tang
Summary: This work presents an ultrasensitive photoelectrochemical aptasensor for the detection of 8-hydroxy-2'-deoxyguanosine (8-OHdG). The sensor utilizes target-triggered hemin/G-quadruplex photocurrent polarity switching on ultrathin ZnIn2S4 nanosheets, and demonstrates a broad detection range, low detection limit, and good sensitivity, stability, and selectivity in complex biological matrices.
SENSORS AND ACTUATORS B-CHEMICAL
(2022)
Article
Biochemistry & Molecular Biology
Jelena Mirnic, Milanko Djuric, Ivana Gusic, Tanja Veljovic, Sasa Cakic, Jasmina Katanic, Karolina Vukoje, Bojana Ramic, Snezana Brkic
Summary: This study aimed to evaluate the influence of nonsurgical periodontal treatment on salivary 8-hydroxy-deoxyguanosine (8-OHdG) levels and glycemic control in patients suffering from both type 2 diabetes mellitus (DM2) and periodontitis. The results showed that nonsurgical periodontal treatment significantly reduced salivary 8-OHdG levels and resulted in modest improvement in glycemic control for DM2 patients.
Article
Biochemistry & Molecular Biology
Javier Frontinan-Rubio, Yoana Rabanal-Ruiz, Mario Duran-Prado, Francisco Javier Alcain
Summary: The study demonstrates that CoQ10 is the most effective ubiquinone in preventing NADPH oxidase activity and reducing reactive oxygen species generation induced by Aβ(25-35), ultimately protecting endothelial brain cells from apoptosis and necrosis. This specific cytoprotective effect of CoQ10 with a side chain of 10 isoprenoid units is attributed to its ability to significantly reduce the entry of Aβ(25-35) into mitochondria.
Article
Cardiac & Cardiovascular Systems
Albert E. Raizner, Miguel A. Quinones
Summary: Coenzyme Q(10) is a naturally occurring compound in animals and humans, playing a fundamental role in cellular energy production. Deficiency of CoQ(10) may be related to symptoms like statin-associated muscle symptoms (SAMS) and features observed in heart failure (HF) patients. While conflicting results have been seen in clinical trials of CoQ(10) in SAMS, meta-analyses support its use. Additional research is needed to explore the potential benefits of exogenous CoQ(10) in patients with HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Trine Baur Opstad, Jan Alexander, Jan Aaseth, Anders Larsson, Ingebjorg Seljeflot, Urban Alehagen
Summary: This study aimed to investigate the influence of a SeQ(10) intervention on SIRT1 concentration and its potential interactions with microRNAs. The results showed that the SeQ(10) intervention increased SIRT1 concentration, which was associated with reduced cardiovascular mortality, partly mediated via miR-130a-3p.
Article
Chemistry, Analytical
Raluca-Ioana Stefan-van Staden, Liliana-Roxana Balahura, Hassan Y. Aboul-Enein
Summary: Three stochastic sensors based on different modifications of reduced graphene oxide were reported for detecting two biomarkers in whole blood and urine samples. Among them, the sensor based on reduced graphene oxide decorated with TiO(2)and gold nanoparticles showed the highest sensitivity for the electroanalysis of 8-nitroguanine and 8-hydroxy-2`-deoxyguanosine.
ANALYTICAL LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Zuzana Sumbalova, Jarmila Kucharska, Zuzana Rausova, Anna Gvozdjakova, Maria Szantova, Branislav Kura, Viliam Mojto, Jan Slezak
Summary: This study investigated the effects of hydrogen-rich water on coenzyme Q10 content and platelet mitochondrial bioenergetics in patients with non-alcoholic fatty liver disease (NAFLD). The results showed that drinking hydrogen-rich water can increase coenzyme Q10 concentration, reduce oxidative stress levels, and improve mitochondrial function, suggesting a potential therapeutic effect on NAFLD patients' recovery.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Electrochemistry
Maria G. Trachioti, Jan Hrbac, Mamas Prodromidis
Summary: The development of an advanced sensor for the biomarker 8-OHdG on a low-cost graphite screen-printed electrode was reported in this study, which showed resistance to interference by dopamine, ascorbic acid, and uric acid. A simple treatment method based on uricase was optimized to eliminate interference caused by uric acid, and the sensor was successfully applied to the determination of 8-OHdG in synthetic urine samples with a recovery rate of 95%.
ELECTROCHIMICA ACTA
(2021)
Article
Cell Biology
Ali Sani, Ibrahim Lawal Abdullahi, Muhammad Idrees Khan, ChengXi Cao
Summary: This study investigated the oxidative stress levels and DNA damage in coal vendors in Nigeria. The results showed that prolonged exposure to coal dusts could lead to higher levels of oxidative stress and DNA damage in coal vendors.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Jin Li, Deli Zhang, Kennedy S. Ramos, Lucienne Baks, Marit Wiersma, Eva A. H. Lanters, Ad J. J. C. Bogers, Natasja M. S. de Groot, Bianca J. J. M. Brundel
Summary: The study revealed a gradual increase in 8-OHdG levels during the progression of arrhythmia in patients with AF. Patients with AF recurrence after PVI treatment showed significantly elevated 8-OHdG levels. Furthermore, patients with POAF after cardiac surgery had significantly higher 8-OHdG levels compared to those without POAF.
Article
Biochemistry & Molecular Biology
Viktoria Premusz, Dominika Lendvai-Emmert, Alexandra Makai, Krisztina Amrein, Shalini Chauhan, Jozsef Bodis, Kalman Andras Kovacs, Akos Varnagy
Summary: This study aimed to investigate the impact of oxidative stress induced by habitual physical activity on outcome measures in IVF patients. The results showed that physical activity was positively related to the number of matured oocytes, embryo quality, and ss-hCG levels. Additionally, a positive correlation was found between 8-OHdG and ss-hCG levels, and there were significant differences in 8-OHdG levels in biochemical pregnancies.