Article
Clinical Neurology
Andrea Quattrone, Maria G. Bianco, Angelo Antonini, David E. Vaillancourt, Klaus Seppi, Roberto Ceravolo, Antonio P. Strafella, Gioacchino Tedeschi, Alessandro Tessitore, Roberto Cilia, Maurizio Morelli, Salvatore Nigro, Basilio Vescio, Pier Paolo Arcuri, Rosa De Micco, Mario Cirillo, Luca Weis, Eleonora Fiorenzato, Roberta Biundo, Roxana G. Burciu, Florian Krismer, Nikolaus R. McFarland, Christoph Mueller, Elke R. Gizewski, Mirco Cosottini, Eleonora Del Prete, Sonia Mazzucchi, Aldo Quattrone
Summary: This study developed an automated Magnetic Resonance Parkinsonism Index 2.0 (MRPI 2.0) algorithm to differentiate progressive supranuclear palsy-parkinsonism (PSP-P) from Parkinson's disease (PD) and validated its diagnostic performance in two large independent cohorts. The automated MRPI 2.0 showed excellent performance in distinguishing PSP-P from PD and control subjects in both cohorts, suggesting its generalizability. The use of the automated MRPI 2.0 algorithm could standardize measures in patients with PSP-P across centers and have a positive impact on multicenter studies and clinical trials.
MOVEMENT DISORDERS
(2022)
Article
Computer Science, Artificial Intelligence
Xinchun Cui, Yubang Xu, Yue Lou, Qinghua Sheng, Miao Cai, Liying Zhuang, Gang Sheng, Jiahu Yang, Jinxing Liu, Yue Feng, Xiaoli Liu
Summary: In this study, a FResnet18 model is proposed to classify MRI images of PD and HC by fusing image texture features with deep features. The results show that the model can successfully differentiate between PD and HC with high accuracy, and it outperforms existing approaches.
INTERNATIONAL JOURNAL OF INTELLIGENT SYSTEMS
(2022)
Article
Clinical Neurology
Malco Rossi, Santiago Perez-Lloret, Marcelo Merello
Summary: The study found that in a clinical setting, the time needed to reach a final clinical diagnosis for patients presenting with parkinsonism and/or tremor was 2.75 years. Patients with a positive response to levodopa challenge (LDC) benefited from shorter delays until the final clinical diagnosis (FCD).
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Geriatrics & Gerontology
Shuangfang Li, Lei Yue, Shuzhen Chen, Zhuang Wu, Jingxing Zhang, Ronghua Hong, Ludi Xie, Kangwen Peng, Chenghong Wang, Ao Lin, Lingjing Jin, Qiang Guan
Summary: Recent studies have found that decreased uptake of I-131-metaiodobenzylguanidine (MIBG) in the major salivary glands may be a diagnostic feature of Parkinson's disease (PD). This study aimed to assess the diagnostic value of major salivary gland MIBG scintigraphy in PD and explore the usefulness of combining myocardial and salivary gland MIBG scintigraphy in differentiating PD from non-PD. The results showed that the combination of left parotid and left submandibular gland early images had good diagnostic performance, and the combination of major salivary gland and myocardial scintigraphy had high diagnostic accuracy in both the early and delayed periods.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Neurosciences
Julia M. Lappin, Shane Darke
Summary: Methamphetamine users, typically young adults, are at elevated risk for neurological harms such as stroke and Parkinson's disease which may develop prematurely. Evidence suggests a link between methamphetamine use and increased risk for haemorrhagic stroke and early onset of Parkinson's disease. However, direct evidence of dopaminergic neuron degeneration in methamphetamine users has not been demonstrated.
EXPERIMENTAL NEUROLOGY
(2021)
Review
Clinical Neurology
Sule Tinaz
Summary: Accurate and timely diagnosis of atypical parkinsonian syndromes (APS) remains a challenge. However, recent advances in MRI technology have introduced promising imaging modalities to aid in the diagnosis of APS.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Yasuko Toyoshima, Hitoshi Takahashi, Shinnichi Katada, Naoyuki Kojima, Mari Tada, Takashi Tani, Ryoko Koike, Takanori Nozawa, Izumi Aida, Takashi Nakajima, Osamu Onodera, Akiyoshi Kakita
Summary: Parkinson's disease is a common neurodegenerative disorder characterized by the loss of pigmented neurons, deficiencies in dopaminergic signaling, and the presence of Lewy bodies in the nervous system. Parkinsonism, a clinical feature of movement disorders, is shared by other neurodegenerative diseases like progressive supranuclear palsy, corticobasal degeneration, and multiple system atrophy. Distinguishing PD from other parkinsonism-related neurological disorders can be challenging, and parkinsonism can also be caused by drug intoxication or cerebrovascular disease.
Article
Clinical Neurology
W. R. Wayne Martin, Michael Miles, Qiaonan Zhong, Johanna Hartlein, Brad A. Racette, Scott A. Norris, Mwiza Ushe, Baijayanta Maiti, Susan Criswell, Albert A. Davis, Paul T. Kotzbauer, Nigel J. Cairns, Richard J. Perrin, Joel S. Perlmutter
Summary: A significant response to dopaminergic therapy is common but not universal in Parkinson's disease (PD). Lack of response does not necessarily exclude PD. In other neurodegenerative disorders associated with parkinsonism, a prominent therapeutic response may also be present, but less frequently than in PD.
MOVEMENT DISORDERS
(2021)
Article
Clinical Neurology
Ji-tian Guan, Xin Zheng, Lingfeng Lai, Shuyi Sun, Yiqun Geng, Xiaolei Zhang, Teng Zhou, Huan-ze Wu, Jia-qing Chen, Zhong-xian Yang, Xiao-hong Zheng, Jia-xu Wang, Wei Chen, You-qiao Zhang
Summary: This study investigated the alteration of metabolites in patients with Parkinson's disease (PD) and non-motor symptoms using 1H-MRS. The results suggest that Cr, NAA/Cr, and mI/Cr may serve as potential biomarkers for the progression of PD. Furthermore, MRS of the thalamus may be a sensitive region for the detection of cognitive decline in PD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Javier Riancho, Manuel Delgado-Alvarado
Summary: This study observed 15 patients with asymmetric arm swing and provided a new clinical clue to evaluate the risk of subjacent parkinsonism.
NEUROLOGICAL SCIENCES
(2023)
Review
Medicine, General & Internal
Kenneth R. Dalton, Charles J. Kidd, Nawaz Hack
Summary: Patients with Parkinson's disease admitted to the hospital require a multidisciplinary care team to reduce critical care admissions, morbidity, and mortality. Early recognition of toxic exposures or medication-induced symptoms can greatly improve patient outcomes. This review provides valuable guidance in assessing new or exacerbating Parkinson's disease symptoms.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Clinical Neurology
Young Hee Sung, Suk Yun Kang
Summary: The present study investigated the characteristics of pain in Parkinson's disease (PD) and other parkinsonian disorders. The results suggest that pain can be a pre-motor symptom in PD, multiple system atrophy (MSA), and vascular parkinsonism (VP), but not in progressive supranuclear palsy (PSP). The study also found that the location of pain differed among the different disorders.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Silja Kannenberg, Julian Caspers, Lars Dinkelbach, Alexia-S. Moldovan, Stefano Ferrea, Martin Suedmeyer, Markus Butz, Alfons Schnitzler, Christian J. Hartmann
Summary: The relative change of MTPR is a potentially useful tool to support the differential diagnosis of PSP from IPD, but further evaluation is needed.
JOURNAL OF NEUROLOGY
(2021)
Article
Clinical Neurology
Marco Percetti, Giulia Franco, Edoardo Monfrini, Leonardo Caporali, Raffaella Minardi, Chiara La Morgia, Maria Lucia Valentino, Rocco Liguori, Ilaria Palmieri, Donatella Ottaviani, Maria Vizziello, Dario Ronchi, Federica Di Berardino, Antoniangela Cocco, Bertil Macao, Maria Falkenberg, Giacomo Pietro Comi, Alberto Albanese, Bruno Giometto, Enza Maria Valente, Valerio Carelli, Alessio Di Fonzo
Summary: This study identified potentially pathogenic variants in the TWNK gene in a cohort of Italian PD patients and found that some TWNK-adPEO patients also exhibited parkinsonism. Further studies are needed to confirm these findings.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
James Saravanamuttu, Natasha Radhu, Kaviraja Udupa, Julianne Baarbe, Carolyn Gunraj, Robert Chen
Summary: The study revealed that SICF is increased and the facilitatory effect of SICI on SICF is absent in Parkinson's disease patients, but can be restored with dopaminergic medication. This suggests that impaired interaction between M1 circuits is a pathophysiological feature of PD.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Tomas Vikner, Anders Eklund, Nina Karalija, Jan Malm, Katrine Riklund, Ulman Lindenberger, Lars Backman, Lars Nyberg, Anders Wahlin
Summary: Microvascular damage in the hippocampus is emerging as a key factor contributing to cognitive decline and dementia in aging. Abnormal hemodynamic forces related to pulsatile flow may indicate compromised neurovascular unit integrity. Individuals with steep systolic onset and high amplitude may exhibit poorer memory, lower brain perfusion, and weaker microvascular oscillations in the hippocampus and parahippocampal gyrus.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Neurosciences
Kristin Nordin, Lars Nyberg, Micael Andersson, Nina Karalija, Katrine Riklund, Lars Backman, Alireza Salami
Summary: The study found that in older individuals, the resting-state networks in the hippocampus maintained axis-dependent connectivity, and networks related to episodic memory were influenced by the dopamine system, with shared connections in regions including the medial frontal, posterior parietal, and striatal areas.
Article
Geriatrics & Gerontology
Nina Karalija, Goran Papenberg, Anders Wahlin, Jarkko Johansson, Micael Andersson, Jan Axelsson, Katrine Riklund, Ulman Lindenberger, Lars Nyberg, Lars Backman
Summary: This study found that women have higher levels of dopamine D2 receptor availability and better memory performance, while sex is not a significant moderator of the reported links to D2DR levels.
NEUROBIOLOGY OF AGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Susanna Jakobson Mo, Jan Axelsson, Lars J. Stiernman, Anne Larsson, Sara Af Bjerken, David Backstrom, Therese Gabrielsson Kellgren, Andrea Varrone, Katrine Riklund
Summary: This study investigated the potential impact of polymorphism in the SLC6A3 gene on dopamine transporter (DAT) imaging. The results showed no significant effect of genotype on imaging, instead age had a significant effect on DAT levels.
NUCLEAR MEDICINE COMMUNICATIONS
(2022)
Article
Neurosciences
Kristin Nordin, Tetiana Gorbach, Robin Pedersen, Vania Panes Lundmark, Jarkko Johansson, Micael Andersson, Charlotte McNulty, Katrine Riklund, Anders Wahlin, Goran Papenberg, Gregoria Kalpouzos, Lars Backman, Alireza Salami
Summary: The concomitant exploration of structural, functional, and neurochemical brain mechanisms underlying age-related cognitive decline is essential for promoting healthy aging. The DyNAMiC project is a multimodal longitudinal study that aims to examine changes in brain connectome and dopamine receptors in relation to cognitive decline across the adult lifespan. Initial analyses have revealed age-related variations in D1DR and D2DR, as well as performance across multiple cognitive domains. This study, being the largest D1DR study worldwide, will provide valuable insights into the brain mechanisms underlying age-related cognitive decline.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Surgery
Josefin Jonsson, Oskar Hemmingsson, Rebecca Strengbom, Jan Axelsson, Katrine Riklund, Hanna Nystrom
Summary: This study investigated the role of preoperative positron emission tomography/computed tomography in the surgical decision-making and prognosis of patients with colorectal liver metastases. The results showed that the findings of positron emission tomography/computed tomography changed the surgical management in a portion of patients, but had no impact on postoperative survival.
SCANDINAVIAN JOURNAL OF SURGERY
(2022)
Article
Clinical Neurology
Erica Irene Uneus, Christer Wilhelmsson, David Backstrom, Intissar Anan, Jonas Wixner, Bjorn Pilebro, Katrine Riklund, Mattias Ogren, Margareta Ogreen, Jan Axelsson, Ole B. Suhr, Torbjorn Sundstrom
Summary: This study found that amyloid deposition within the brain is common in long-term survivors of ATTRv amyloidosis, especially in the cerebellum. A cerebellar amyloid uptake profile seems to be related to TFNE symptoms.
FRONTIERS IN NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Luis Marti-Bonmati, Dow-Mu Koh, Katrine Riklund, Maciej Bobowicz, Yiannis Roussakis, Joan C. Vilanova, Jurgen J. Futterer, Jordi Rimola, Pedro Mallol, Gloria Ribas, Ana Miguel, Manolis Tsiknakis, Karim Lekadir, Gianna Tsakou
Summary: To achieve clinical impact in daily oncological practice, emerging AI-based cancer imaging research needs to have clearly defined medical focus, AI methods, and outcomes to be estimated. AI-supported cancer imaging should predict major relevant clinical endpoints, aiming to extract associations and draw inferences in a fair, robust, and trustworthy way. Ensuring clinical impact in AI solutions requires careful consideration of key aspects, including target population selection, sample size definition, standards and common data elements utilization, balanced dataset splitting, appropriate validation methodology, adequate ground truth, and careful selection of clinical endpoints.
INSIGHTS INTO IMAGING
(2022)
Article
Clinical Neurology
Tomas Vikner, Nina Karalija, Anders Eklund, Jan Malm, Anders Lundquist, Nikodemus Gallewicz, Magnus Dahlin, Ulman Lindenberger, Katrine Riklund, Lars Backman, Lars Nyberg, Anders Wahlin
Summary: In healthy older adults, indicators of small vessel disease (SVD) are related in a lead-lag fashion, in which the expression of white matter lesions (WML) and enlarged perivascular spaces (PVS) precedes increases in cerebral arterial pulsatility index (PI).
ANNALS OF NEUROLOGY
(2022)
Article
Clinical Neurology
Nina Karalija, Jarkko Johansson, Goran Papenberg, Anders Wahlin, Alireza Salami, Ylva Kohncke, Andreas M. Brandmaier, Micael Andersson, Jan Axelsson, Katrine Riklund, Martin Lovden, Ulman Lindenberger, Lars Backman, Lars Nyberg
Summary: This study provides the first longitudinal evidence of individual and region-specific differences in DRD2 decline in older age, and supports the hypothesis that cerebrovascular factors are linked to age-related dopaminergic decline.
Article
Multidisciplinary Sciences
Lars Nyberg, Nina Karalija, Goran Papenberg, Alireza Salami, Micael Andersson, Robin Pedersen, Tomas Vikner, Douglas D. D. Garrett, Katrine Riklund, Anders Wahlin, Martin Lovden, Ulman Lindenberger, Lars Backman
Summary: This study found that cognitive functions are well-preserved for some older individuals, but the underlying brain mechanisms remain disputed. The prefrontal cortex and general brain maintenance play important roles in explaining heterogeneity in cognitive trajectories in aging.
SCIENTIFIC REPORTS
(2022)
Article
Psychiatry
Bryn Farnsworth von Cederwald, Jarkko Johansson, Katrine Riklund, Nina Karalija, Carl-Johan Boraxbekk
Summary: Age-related dopamine reductions have been suggested to contribute to maladaptive working memory function in older ages. Increasing physical activity can improve working memory through plasticity of the striatal dopamine system, but its efficacy may vary due to individual differences. This study found that physical activity intervention improved striatal dopamine D2-like receptor availability and working memory performance in individuals with no or mild white-matter lesions, but had no effect in individuals with moderate-to-severe lesions. The findings highlight the importance of considering cerebrovascular health in interventions targeting neurocognitive outcomes.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Susanna Jakobson Mo, Jan Axelsson, Lars Stiernman, Katrine Riklund
Summary: This study aimed to test whether the radiotracer [F-18]FE-PE2I can be used to assess both cerebral blood flow and dopamine transporter (DAT) availability. The results showed a strong linear correlation and good consistency between [F-18]FE-PE2I and cerebral perfusion measured with [O-15]H2O PET. This finding suggests that [F-18]FE-PE2I may be a valuable tool for the differential diagnosis of parkinsonian syndromes.
Article
Clinical Neurology
David Backstrom, Gabriel Granasen, Susanna Jakobson Mo, Katrine Riklund, Miles Trupp, Henrik Zetterberg, Kaj Blennow, Lars Forsgren, Magdalena Eriksson Domellof
Summary: In a population-based cohort of patients with new-onset Parkinson disease, approximately half develop dementia within 10 years. Measurement of CSF biomarkers together with baseline cognitive function, olfaction, and motor disease severity has high accuracy for predicting who will develop dementia.
BRAIN COMMUNICATIONS
(2022)
Article
Oncology
Kristina Sandgren, Erik Nilsson, Angsana Keeratijarut Lindberg, Sara Strandberg, Lennart Blomqvist, Anders Bergh, Bengt Friedrich, Jan Axelsson, Margareta Ogren, Mattias Ogren, Anders Widmark, Camilla Thellenberg Karlsson, Karin Soderkvist, Katrine Riklund, Joakim Jonsson, Tufve Nyholm
Summary: This study developed a registration procedure between histopathology and in-vivo MRI of the prostate with high accuracy and low uncertainty. The contour-correcting registration was beneficial, particularly in patients with extraprostatic surgical margins.
PHYSICS & IMAGING IN RADIATION ONCOLOGY
(2021)