Effects of rapamycin and curcumin on inflammation and oxidative stress in vitro and in vivo — in search of potential anti-epileptogenic strategies for temporal lobe epilepsy

Molecular neurobiology of mTOR

(2017) Katarzyna Switon et al.   NEUROSCIENCE

Systematic review and meta-analysis of differentially expressed miRNAs in experimental and human temporal lobe epilepsy

(2017) A. Korotkov et al.   Scientific Reports

mTOR and MAPK: from localized translation control to epilepsy

(2016) Helena F. Pernice et al.   BMC NEUROSCIENCE

Modulation of neuronal excitability by immune mediators in epilepsy

(2016) Valentina Iori et al.   CURRENT OPINION IN PHARMACOLOGY

Effects of rapamycin and curcumin treatment on the development of epilepsy after electrically induced status epilepticus in rats

(2016) Cato M. Drion et al.   EPILEPSIA

Comparative study of the neurotoxicological effects of tramadol and tapentadol in SH-SY5Y cells

(2016) Juliana Faria et al.   TOXICOLOGY

Blood-brain barrier leakage after status epilepticus in rapamycin-treated rats II: Potential mechanisms

(2015) Erwin A. van Vliet et al.   EPILEPSIA

Status epilepticus, blood–brain barrier disruption, inflammation, and epileptogenesis

(2015) Jan A. Gorter et al.   EPILEPSY & BEHAVIOR

Microglial HO-1 induction by curcumin provides antioxidant, antineuroinflammatory, and glioprotective effects

(2015) Esther Parada et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Curcumin attenuates inflammatory response and cognitive deficits in experimental model of chronic epilepsy

(2015) Harpreet Kaur et al.   NEUROCHEMISTRY INTERNATIONAL

Curcumin inhibits Aβ-induced microglial inflammatory responses in vitro: Involvement of ERK1/2 and p38 signaling pathways

(2015) Xiaolei Shi et al.   NEUROSCIENCE LETTERS

Role of mTOR inhibitors in epilepsy treatment

(2015) Krzysztof Sadowski et al.   Pharmacological Reports

Curcumin supplementation improves mitochondrial and behavioral deficits in experimental model of chronic epilepsy

(2014) Harpreet Kaur et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Interleukin-6 Secretion by Astrocytes Is Dynamically Regulated by PI3K-mTOR-Calcium Signaling

(2014) Simone Codeluppi et al.   PLoS One

Regulation of ERK1/2 mitogen-activated protein kinase by NMDA-receptor-induced seizure activity in cortical slices

(2013) Yoko Yamagata et al.   BRAIN RESEARCH

Upregulation of glutamate transporter GLT-1 by mTOR-Akt-NF-кB cascade in astrocytic oxygen-glucose deprivation

(2013) Yi-Fei Ji et al.   GLIA

Hippocampal subregion-specific microRNA expression during epileptogenesis in experimental temporal lobe epilepsy

(2013) Jan A. Gorter et al.   NEUROBIOLOGY OF DISEASE

Rapamycin Reverses Status Epilepticus-Induced Memory Deficits and Dendritic Damage

(2013) Amy L. Brewster et al.   PLoS One

The Targets of Curcumin

(2012) Hongyu Zhou et al.   CURRENT DRUG TARGETS

Finding a better drug for epilepsy: The mTOR pathway as an antiepileptogenic target

(2012) Aristea S. Galanopoulou et al.   EPILEPSIA

Inhibition of mammalian target of rapamycin reduces epileptogenesis and blood-brain barrier leakage but not microglia activation

(2012) Erwin A. van Vliet et al.   EPILEPSIA

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

(2012) Antonio CP de Oliveira et al.   Journal of Neuroinflammation

Preparation of Curcumin-Loaded Liposomes and Evaluation of Their Skin Permeation and Pharmacodynamics

(2012) Yan Chen et al.   MOLECULES

Time-Dependent Modulation of Mitogen Activated Protein Kinases and AKT in Rat Hippocampus and Cortex in the Pilocarpine Model of Epilepsy

(2012) Mark William Lopes et al.   NEUROCHEMICAL RESEARCH

Post-treatment with rapamycin does not prevent epileptogenesis in the amygdala stimulation model of temporal lobe epilepsy

(2012) Anna Sliwa et al.   NEUROSCIENCE LETTERS

Mapping the Spatio-Temporal Pattern of the Mammalian Target of Rapamycin (mTOR) Activation in Temporal Lobe Epilepsy

(2012) Long-Ze Sha et al.   PLoS One

Rapamycin protects against middle cerebral artery occlusion induced focal cerebral ischemia in rats

(2011) Anjali Chauhan et al.   BEHAVIOURAL BRAIN RESEARCH

Combination Therapy Targeting Akt and Mammalian Target of Rapamycin Improves Functional Outcome after Controlled Cortical Impact in Mice

(2011) Juyeon Park et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Therapeutic role of mammalian target of rapamycin (mTOR) inhibition in preventing epileptogenesis

(2011) Sharon S. McDaniel et al.   NEUROSCIENCE LETTERS

Mechanisms of Cell Protection by Heme Oxygenase-1

(2010) Raffaella Gozzelino et al.   Annual Review of Pharmacology and Toxicology

Pharmacological inhibition of the mammalian target of rapamycin pathway suppresses acquired epilepsy

(2010) Xiaoxing Huang et al.   NEUROBIOLOGY OF DISEASE

Curcumin Disrupts the Mammalian Target of Rapamycin-Raptor Complex

(2009) C. S. Beevers et al.   CANCER RESEARCH

Definition of drug resistant epilepsy: Consensus proposal by the ad hoc Task Force of the ILAE Commission on Therapeutic Strategies

(2009) Patrick Kwan et al.   EPILEPSIA

The descriptive epidemiology of epilepsy—A review

(2009) Poonam Nina Banerjee et al.   EPILEPSY RESEARCH

Contributions of peripheral inflammation to seizure susceptibility: Cytokines and brain excitability

(2009) Kiarash Riazi et al.   EPILEPSY RESEARCH

Amelioration of experimental autoimmune encephalomyelitis by curcumin treatment through inhibition of IL-17 production

(2009) Lin Xie et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Inhibition of the Mammalian Target of Rapamycin Signaling Pathway Suppresses Dentate Granule Cell Axon Sprouting in a Rodent Model of Temporal Lobe Epilepsy

(2009) P. S. Buckmaster et al.   JOURNAL OF NEUROSCIENCE

The Mammalian Target of Rapamycin Signaling Pathway Mediates Epileptogenesis in a Model of Temporal Lobe Epilepsy

(2009) L.-H. Zeng et al.   JOURNAL OF NEUROSCIENCE

The Rheb-mTOR Pathway Is Upregulated in Reactive Astrocytes of the Injured Spinal Cord

(2009) S. Codeluppi et al.   JOURNAL OF NEUROSCIENCE

Amplification efficiency: linking baseline and bias in the analysis of quantitative PCR data

(2009) J. M. Ruijter et al.   NUCLEIC ACIDS RESEARCH

Intractable epilepsy: management and therapeutic alternatives

(2008) Stephan U Schuele et al.   LANCET NEUROLOGY

Role of mTOR in physiology and pathology of the nervous system

(2007) Lukasz Swiech et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS