Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis
出版年份 2014 全文链接
标题
Partial suppression of M1 microglia by Janus kinase 2 inhibitor does not protect against neurodegeneration in animal models of amyotrophic lateral sclerosis
作者
关键词
Amyotrophic lateral sclerosis, SOD1-G93A transgenic mice, R723, Janus kinase 2, JAK2 inhibitor, Neuroinflammation, Interferon gamma, M1/M2 microglia
出版物
Journal of Neuroinflammation
Volume 11, Issue 1, Pages -
出版商
Springer Nature
发表日期
2014-10-18
DOI
10.1186/s12974-014-0179-2
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- A1.72 Baricitinib, an oral janus kinase inhibitor, in the treatment of rheumatoid arthritis: safety and efficacy in an open-label, long-term extension study1
- (2014) Peter Taylor et al. ANNALS OF THE RHEUMATIC DISEASES
- A Phase 2 Study of Tofacitinib, an Oral Janus Kinase Inhibitor, in Patients With Crohn’s Disease
- (2014) William J. Sandborn et al. Clinical Gastroenterology and Hepatology
- A randomized phase 2a efficacy and safety trial of the topical Janus kinase inhibitor tofacitinib in the treatment of chronic plaque psoriasis
- (2013) W.C. Ports et al. BRITISH JOURNAL OF DERMATOLOGY
- Therapeutic Efficacy of Suppressing the JAK/STAT Pathway in Multiple Models of Experimental Autoimmune Encephalomyelitis
- (2013) Y. Liu et al. JOURNAL OF IMMUNOLOGY
- Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
- (2013) Weihua Zhao et al. Journal of Neuroimmune Pharmacology
- BAFF Controls Neural Cell Survival through BAFF Receptor
- (2013) Satoru Tada et al. PLoS One
- IL-4 and IL-13 employ discrete signaling pathways for target gene expression in alternatively activated monocytes/macrophages
- (2012) Ashish Bhattacharjee et al. FREE RADICAL BIOLOGY AND MEDICINE
- Biology and significance of the JAK/STAT signalling pathways
- (2012) Hiu Kiu et al. GROWTH FACTORS
- Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
- (2012) Oleg Butovsky et al. JOURNAL OF CLINICAL INVESTIGATION
- The many faces of Janus kinase
- (2011) Matthew M. Seavey et al. BIOCHEMICAL PHARMACOLOGY
- R723, a selective JAK2 inhibitor, effectively treats JAK2V617F-induced murine myeloproliferative neoplasm
- (2011) K. Shide et al. BLOOD
- BCR-ABL1—Negative Myeloproliferative Neoplasms: A Review of Molecular Biology, Diagnosis, and Treatment
- (2011) Erik Vakil et al. Clinical Lymphoma Myeloma & Leukemia
- The potential role of JAK2/STAT3 pathway on the anti-apoptotic effect of recombinant human erythropoietin (rhEPO) after experimental traumatic brain injury of rats
- (2011) Jinbing Zhao et al. CYTOKINE
- Deleterious effects of lymphocytes at the early stage of neurodegeneration in an animal model of amyotrophic lateral sclerosis
- (2011) Satoru Tada et al. Journal of Neuroinflammation
- A highly selective, orally active inhibitor of Janus kinase 2, CEP-33779, ablates disease in two mouse models of rheumatoid arthritis
- (2011) Kristine L Stump et al. ARTHRITIS RESEARCH & THERAPY
- Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice
- (2010) David R. Beers et al. BRAIN BEHAVIOR AND IMMUNITY
- IFNγ triggers a LIGHT-dependent selective death of motoneurons contributing to the non-cell-autonomous effects of mutant SOD1
- (2010) J Aebischer et al. CELL DEATH AND DIFFERENTIATION
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