Article
Psychiatry
Haiting Xu, Yanyan Wei, Lina Zheng, Hua Zhang, Tangren Luo, Hongjuan Li, Jinbao Ma, Jingxu Chen
Summary: Inflammation and oxidative stress are major hypothetical causes of schizophrenia. This study found that UCB has a protective effect on the acute stage of schizophrenia, likely by affecting proinflammatory processes. The combination of MLR, MPV, PLR, and UCB could be used to predict the acute stage of schizophrenia.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Biochemistry & Molecular Biology
Anthony Fernandez-Castaneda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Michael R. O'Dea, Selena Dutton, Kiarash Shamardani, Kamsi Nwangwu, Rebecca Mancusi, Belgin Yalcin, Kathryn R. Taylor, Lehi Acosta-Alvarez, Karen Malacon, Michael B. Keough, Lijun Ni, Pamelyn J. Woo, Daniel Contreras-Esquivel, Angus Martin Shaw Toland, Jeff R. Gehlhausen, Jon Klein, Takehiro Takahashi, Julio Silva, Benjamin Israelow, Carolina Lucas, Tianyang Mao, Mario A. Pena-Hernandez, Alexandra Tabachnikova, Robert J. Homer, Laura Tabacof, Jenna Tosto-Mancuso, Erica Breyman, Amy Kontorovich, Dayna McCarthy, Martha Quezado, Hannes Vogel, Marco M. Hefti, Daniel P. Perl, Shane Liddelow, Rebecca Folkerth, David Putrino, Avindra Nath, Akiko Iwasaki, Michelle Monje
Summary: COVID survivors may experience lingering neurological symptoms similar to cognitive impairment related to cancer therapy. Research has found that respiratory SARS-CoV-2 infection can cause white-matter-selective microglial reactivity and affect neurogenesis and CCL11 levels.
Article
Biochemistry & Molecular Biology
Sho Yamazaki, Keisuke Yamaguchi, Akimasa Someya, Isao Nagaoka, Masakazu Hayashida
Summary: Dexmedetomidine may alleviate delirium by exhibiting anti-inflammatory action on microglial cells. The study found that Dexmedetomidine suppressed the production of inflammatory cytokines and inhibited the activation of related signaling pathways in both stimulated and unstimulated microglial cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Evin Magner, Pamela Sandoval-Sanchez, Ashley C. Kramer, Ryan Thummel, Peter F. Hitchcock, Scott M. Taylor
Summary: The study reveals that disruption of miR-18a plays a critical role in injury-induced photoreceptor regeneration in zebrafish, affecting proliferation, inflammation response, and cell migration.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ronak Mousaviyan, Nahid Davoodian, Faezeh Alizadeh, Maryam Ghasemi-Kasman, Seyed Abdollah Mousavi, Fatemeh Shaerzadeh, Haniyeh Kazemi
Summary: The study reveals that maternal exposure to LPS increases the density of neuroinflammatory mediators in the PFC of adult offspring, along with elevated mRNA levels, while the number of neurons remains unchanged. However, prenatal zinc supplementation can alleviate the alterations induced by LPS.
BIOLOGICAL TRACE ELEMENT RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hyun Jung Kwon, Kyu Ri Hahn, Sung Min Nam, Yeo Sung Yoon, Seung Myung Moon, In Koo Hwang, Dae Won Kim
Summary: Purpurin has potent anti-oxidant and anti-inflammatory effects in brain damage. This study shows that purpurin can ameliorate the aging phenotypes induced by D-galactose and improve memory impairment in mice.
NEUROCHEMISTRY INTERNATIONAL
(2023)
Article
Immunology
Anina S. von Arx, Kara Dawson, Han-Yu Lin, Daniele Mattei, Tina Notter, Urs Meyer, Sina M. Schalbetter
Summary: The prefrontal cortex (PFC) in the brain plays an important role in cognitive processes and matures throughout adolescence to early adulthood. Recent research using a mouse model shows that microglia, a type of brain cell, contribute to the maturation of the PFC in males. This study aimed to investigate whether microglia have a similar role in the maturation of the female PFC. The findings demonstrate that transient depletion of microglia during a specific window of adolescence disrupts cognitive functions and synaptic structures in the female PFC.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Multidisciplinary Sciences
Judith Leyh, Karsten Winter, Madlen Reinicke, Uta Ceglarek, Ingo Bechmann, Julia Landmann
Summary: Obesity caused by excessive dietary fat intake is a risk factor for cognitive decline and neurodegenerative diseases. Long-term high-fat diet (HFD) led to general health issues in mice, but did not affect sensory and motor reflexes, emotional state, memory, or learning. The microglial response in the hypothalamus was increased by HFD and reversible upon dietary changes.
Article
Psychiatry
Kitty Reemst, Laura Kracht, Janssen M. Kotah, Reza Rahimian, Astrid A. S. van Irsen, Gonzalo Congrains Sotomayor, Laura N. Verboon, Nieske Brouwer, Sophie Simard, Gustavo Turecki, Naguib Mechawar, Susanne M. Kooistra, Bart J. L. Eggen, Aniko Korosi
Summary: Early-life stress has persistent effects on microglial function and may contribute to the development of psychiatric disorders.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Qiburi Qiburi, Tsogzolmaa Ganbold, Aoqier Aoqier, Dezhi Yang, Zhiyu Su, Mingming Bao, Meng He, Saren Gaowa, Temuqile Temuqile, Huricha Baigude
Summary: Ethnomedicine Eerdun Wurile (EW) can significantly promote poststroke neuro-recovery through modulation of microglia polarization. Alantolactone (Ala) and dehydrodiisoeugenol (Deh) were identified as the active anti-inflammatory components of EW. They downregulated the expression of pro-inflammatory genes and upregulated the expression of anti-inflammatory genes in microglia. Furthermore, they enhanced the proliferation of N2a cells and promoted neurite outgrowth through the upregulation of specific genes. The mechanism of action involves the downregulation of NF-kappa B p65 expression and inhibition of its nuclear translocation.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES
(2022)
Article
Cell Biology
Katarzyna Chamera, Katarzyna Curzytek, Kinga Kaminska, Ewa Trojan, Agnieszka Basta-Kaim
Summary: Maternal immune activation through systemic administration of lipopolysaccharide (LPS) in rats provides insights into the basis of behavioural schizophrenia-like disturbances and biochemical changes in the offspring's brains. Antipsychotic drugs, such as quetiapine, may have anti-inflammatory effects by inhibiting microglial activation. Quetiapine may have a beneficial impact on deficits in sensorimotor gating in offspring prenatally exposed to LPS. Further research is needed to fully understand the involvement of quetiapine and other antipsychotics in neuron-microglia communication and inflammation processes.
Article
Plant Sciences
Yu-En Lin, Hsiang-Lan Wang, Kuan-Hung Lu, Yun-Ju Huang, Suraphan Panyod, Wei-Ting Liu, Shu-Hui Yang, Mei-Hsing Chen, Yun-Shen Lu, Lee-Yan Sheen
Summary: Armillaria mellea (Vahl) P. Kumm. (AM) is a potential antidepressant with anti-inflammatory effects, as demonstrated in rodent models of forced-swimming test (FST) and unpredictable chronic mild stress (UCMS). The water extract of AM showed acute and chronic antidepressant-like effects by reducing immobility time in FST and preventing stress-induced abnormal behaviors in UCMS models. Additionally, AM attenuated stress-induced increases in inflammatory markers, suggesting its potential as a dietary therapy or adjuvant for depression treatment.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)