Article
Biochemistry & Molecular Biology
Hiroyuki Inoue, Hidetaka Kuroda, Wataru Ofusa, Sadao Oyama, Maki Kimura, Tatsuya Ichinohe, Yoshiyuki Shibukawa
Summary: The ionotropic P2X receptor P2X(7) is believed to play a role in regulating and generating nociceptive pain in neuropathological diseases. Detailed examination of its functional properties in trigeminal ganglion (TG) neurons revealed that P2X(7) may interact with other P2X receptors and pannexin-1 (PANX1) channels to influence pain sensing pathways through autocrine or paracrine signaling. The complex formed by P2X(7)-PANX1-P2X receptor/channel may be involved in long-lasting neuronal activity driven by extracellular high-concentration ATP following tissue damage in the orofacial area.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Francesca Bonomini, Gaia Favero, Stefania Castrezzati, Elisa Borsani
Summary: Orofacial pain is a complex biomedical challenge without a satisfactory solution. This review evaluates the involvement of neurotrophins in orofacial nociception and their potential role as targets for pain modulation. Further studies are needed to clarify their application in clinical practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Food Science & Technology
Arief Waskitho, Yumiko Yamamoto, Swarnalakshmi Raman, Fumiya Kano, Huijiao Yan, Resmi Raju, Shaista Afroz, Tsuyoshi Morita, Daisuke Ikutame, Kazuo Okura, Masamitsu Oshima, Akihito Yamamoto, Otto Baba, Yoshizo Matsuka
Summary: BoNT/A reduces neurotransmitter release to alleviate neuropathic pain and may exert therapeutic effects through axonal and hematogenous transport.
Article
Neurosciences
K. C. Elina, Jaisan Islam, Soochong Kim, Hyong Kyu Kim, Young Seok Park
Summary: Inhibiting TG through optogenetics can reduce neuronal activity and pain behavior in TN rats, indicating its potential as a management approach for trigeminal neuralgia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Pharmacology & Pharmacy
Minjee Kwon, Il Young Jung, Myeounghoon Cha, Bae Hwan Lee
Summary: Pulpitis causes changes in the peripheral nervous system, leading to hyperalgesia. Experimental pulpitis activates Nav1.7 expression peripherally and affects TG neuronal activity. Inhibition of the Nav1.7 channel can modulate nociceptive signal processing in the TG following pulp inflammation.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Clinical Neurology
Elina Kc, Jaisan Islam, Young Seok Park
Summary: This article discusses the challenging management of trigeminal neuralgia and the lack of modulation approaches targeting the trigeminal ganglion. By exploring the role of the trigeminal ganglion and associated molecules and neuropeptides in TN, it is possible to improve the management of this intractable pain.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Biochemistry & Molecular Biology
Jean Kwon, Young In Choi, Hang Joon Jo, Sang Hoon Lee, Han Kyu Lee, Heesoo Kim, Jee Youn Moon, Sung Jun Jung
Summary: The study confirms that PGE1 can induce pain in mice and enhances the excitability of trigeminal ganglion neurons through HCN channel facilitation. The research also identifies the target mechanism of PGE1 in nociceptive neurons, suggesting its potential as a therapeutic target for pain management under inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Rui Guo, Yiyin Chen, Lu Liu, Jing Wen, Hong Yang, Yafen Zhu, Meiya Gao, Hengyan Liang, Wenli Lai, Hu Long
Summary: NGF plays an important role in regulating orofacial pain by positively regulating CCL19 expression in the trigeminal ganglia of rats, while CCL19 increases sensitivity to experimental tooth movement orofacial pain.
FRONTIERS IN NEUROLOGY
(2021)
Article
Anesthesiology
Xinyan Gao, Shu Han, Qian Huang, Shao-Qiu He, Neil C. Ford, Qin Zheng, Zhiyong Chen, Shaoyong Yu, Xinzhong Dong, Yun Guan
Summary: The mechanisms of visceral pain sensitization and referred somatic hypersensitivity are unclear. Through experiments, it was found that TNBS-induced colitis may lead to mechanical hypersensitivity, simultaneously stimulating the intestines and body surface, causing increased sensitivity in L6 and L4 DRG neurons to inputs.
Article
Multidisciplinary Sciences
Tarek Ibrahim, Ping Wu, Li-Ju Wang, Chang Fang-Mei, Josue Murillo, Jaclyn Merlo, Sergey S. Shein, Alexei V. Tumanov, Zhao Lai, Korri Weldon, Yidong Chen, Shivani Ruparel
Summary: Mechanisms of sex-dependent orofacial pain are poorly understood, particularly in relation to the regulation of trigeminal sensory neurons in diseased states. Using RNA sequencing, this study found significant differences in gene expression between male and female mice, as well as between naive and tongue-tumor bearing conditions. These findings suggest a potential role for immune cell markers in female tongue-innervating sensory neurons and identified differentially expressed genes associated with transcription factors in males and enzymes, cytokines, and chemokines in females.
SCIENTIFIC REPORTS
(2023)
Article
Neurosciences
Yuhui Luo, Abbie Suttle, Qiaojuan Zhang, Peng Wang, Yong Chen
Summary: Orofacial pain, affecting millions of Americans, is influenced by transient receptor potential (TRP) ion channels. The orofacial sensory system differs from the spinal sensory system in pain processing and sensitivities. TRPs in trigeminally-mediated pain have not been extensively documented compared to spinally-mediated pain.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Cell Biology
Yalda Moayedi, Shan Xu, Sophie K. Obayashi, Benjamin U. Hoffman, Gregory J. Gerling, Ellen A. Lumpkin
Summary: Mechanosensory neurons innervating the tongue play a crucial role in feeding, speech, and social grooming. By using in vivo calcium imaging of mouse trigeminal ganglion neurons, different functional groups of these neurons can be identified. These neurons respond to thermal and mechanical stimuli and are tuned to detect moving stimuli across the tongue. The findings provide insights into the contributions of functionally distinct mechanosensory neurons in oral behaviors crucial for mammalian survival.
Article
Immunology
Lijia Mai, Shilin Jia, Qing Liu, Yanhao Chu, Jinyue Liu, Shengyan Yang, Fang Huang, Wenguo Fan
Summary: The study revealed that the sympathetic nervous system (SNS) plays a role in orofacial inflammatory pain by modulating trigeminal ganglion (TG) macrophage phenotypes. Targeting sympathetic activation may be useful in treating such painful conditions in the orofacial region.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Neurosciences
Lin-Xia Zhao, Ming Jiang, Xue-Qiang Bai, De-Li Cao, Xiao-Bo Wu, Jing Zhang, Jian-Shuang Guo, Tong-Tong Chen, Juan Wang, Hao Wu, Yong-Jing Gao, Zhi-Jun Zhang
Summary: TLR8 expression is increased in trigeminal neuropathic pain, and targeting TLR8 signaling may be effective in reducing pain and neuroinflammation.
NEUROSCIENCE BULLETIN
(2021)
Article
Medicine, General & Internal
Vittorio Schweiger, Riccardo Nocini, Daniele De Santis, Pasquale Procacci, Giovanni Zanette, Erica Secchettin, Giovanna Del Balzo, Andrea Fior, Alvise Martini, Marta Nizzero, Katia Donadello, Gabriele Finco, Leonardo Gottin, Enrico Polati
Summary: This study aimed to evaluate the demographic and clinical characteristics of patients with Persistent Idiopathic Facial Pain (PIFP). The presence of previous minor oro-surgery procedures in the painful area was found to be common among PIFP patients, but its role in the pathophysiology of PIFP remains unknown.
JOURNAL OF CLINICAL MEDICINE
(2022)