Review
Oncology
Yuchen Zhang, Chongjie Yao, Ziyong Ju, Danli Jiao, Dan Hu, Li Qi, Shimin Liu, Xueqing Wu, Chen Zhao
Summary: Kruppel-like factors (KLFs) are DNA-binding transcriptional regulators that play essential roles in various cellular processes, including tumor development. They regulate multiple signaling pathways and mediate crosstalk among them, and their abnormal expression is closely associated with tumor cell characteristics and alterations in the tumor microenvironment. The role of each KLF in tumors varies depending on tumor type and stage of development. This review focuses on the molecular biology of KLFs, the regulation of classical signaling pathways by these factors, and their potential as molecular targets in tumor therapy.
FRONTIERS IN ONCOLOGY
(2023)
Article
Urology & Nephrology
Chelsea C. Estrada, Stephanie Cardona, Yiqing Guo, Monica P. Revelo, Vivette D. D'Agati, Siva Koganti, Jason Devaraj, John C. He, Peter S. Heeger, Sandeep K. Mallipattu
Summary: This study demonstrates that endothelial-specific knockdown of the Klf4 gene increases the susceptibility to glomerular endothelial injury and microangiopathy. The loss of Klf4 gene leads to increased pro-inflammatory and pro-thrombotic transcripts, as well as increased complement factors deposition and histologic features consistent with subacute TMA. Additionally, Klf4 gene is involved in the regulation of CD55 expression and its loss is associated with reduced expression of KLF4 and CD55 in TMA patients.
KIDNEY INTERNATIONAL
(2022)
Article
Biotechnology & Applied Microbiology
Shu Zhou, Jinjun Li, XiaoNa Zhang, Wen Xiong
Summary: This study investigated the role of miR-124 in AMP-stimulated neuroinflammation and its molecular mechanism. The findings showed that miR-124 can modulate microglia activation via targeting KLF6, accelerating M2 polarization and alleviating neurodegeneration induced by AMP.
Retraction
Cell Biology
Zaiqing Zhang, Gongzeng Luo, Chuandong Yu, Guisheng Yu, Rui Jiang, Xuefeng Shi
Summary: The study found that microRNA-493-5p inhibits proliferation and metastasis of osteosarcoma cells by targeting Kruppel-like factor 5. However, the experimental results could not be verified, leading to the retraction of the article.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Review
Oncology
Frank A. Simmen, Iad Alhallak, Rosalia C. M. Simmen
Summary: KLF9 and KLF13 are related proteins that play roles as regulators of specific target genes in various tissues and pathophysiological states, including cancer development. They have diverse functions in tumor suppression or promotion, differentiation, inflammatory pathways, oxidative stress, and tumor immune cell infiltration. The study of KLF9 and KLF13 in cancer biology is likely to provide valuable insights into oncogenesis and its prevention and treatments.
Review
Cell Biology
Ziyan Xie, Junye Chen, Chenyu Wang, Jiahao Zhang, Yanxiang Wu, Xiaowei Yan
Summary: This review summarizes the function and regulation mechanism network of KLF5 in vascular remodeling, highlighting its roles in cell proliferation, phenotype switch, extracellular matrix deposition, inflammation, and angiogenesis. The review also emphasizes the potential therapeutic applications of KLF5 in treating vascular disorders.
JOURNAL OF MOLECULAR CELL BIOLOGY
(2021)
Review
Oncology
Esther Lee, Jacky Cheung, Agnieszka B. Bialkowska
Summary: Kruppel-like factors (KLFs) are transcription factors that regulate various biological processes and participate in disease development and progression. KLF4 and KLF5, two significant members of this family, play crucial roles in embryogenesis, differentiation, and tumorigenesis. They maintain tissue homeostasis, regulate inflammation and response to injury, and have important functions in a variety of cancers. Recent studies have provided new insights into their opposing roles and mechanisms in gene expression, cellular function, and tumorigenesis. This review will focus on the roles of KLF4 and KLF5 in colorectal cancer, which can contribute to the development of targeted cancer therapy.
Article
Medicine, Research & Experimental
Liyan Fan, David R. Sweet, Domenick A. Prosdocimo, Vinesh Vinayachandran, Ernest R. Chan, Rongli Zhang, Olga Ilkayeva, Yuan Lu, Komal S. Keerthy, Chloe E. Booth, Christopher B. Newgard, Mukesh K. Jain
Summary: The skeletal muscle Kruppel-like factor 15 (KLF15) plays a critical role in coordinating pathways central to systemic lipid homeostasis, regulating lipid uptake, mitochondrial transport, and utilization. Deletion of skeletal muscle-specific KLF15 leads to elevated circulating lipids, insulin resistance/glucose intolerance, and increased lipid deposition in white adipose tissue and liver, which can be ameliorated by a diet rich in short-chain fatty acids.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cardiac & Cardiovascular Systems
David R. Sweet, Cherry Lam, Mukesh K. Jain
Summary: KLF2 and 4 play critical roles in maintaining cellular quiescence in endothelial and myeloid cells within the hemovascular system, highlighting the importance of their expression in protecting against inflammatory diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, Research & Experimental
Shih-Chiang Huang, Fang-Hsin Chen, Yu Chang, Hsiu-Fu Mei, Hsiu-Yun Huang, Wan -Yu Chen, Jong-Hwei Su Pang
Summary: This study demonstrated the protective effects of BPC 157 peptide in reducing radiation-induced liver disease (RILD) by decreasing plasma levels of AST and ALT and inhibiting liver cell degeneration.
Review
Biochemistry & Molecular Biology
Makoto Abe, Naoya Saeki, Yuki Ikeda, Shinsuke Ohba
Summary: Kruppel-like factors (KLFs), a group of zinc finger-containing transcription factors, play crucial roles in transcription regulation, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. Recent studies have shown that KLF family molecules have significant effects on skeletal cells, influencing their differentiation and function. This review provides an overview of the unique roles of each KLF in skeletal cells during normal development and skeletal pathologies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Xian Wang, Jamunarani Veeraraghavan, Chia-Chia Liu, Xixi Cao, Lanfang Qin, Jin-Ah Kim, Ying Tan, Suet Kee Loo, Yiheng Hu, Ling Lin, Sanghoon Lee, Martin J. Shea, Tamika Mitchell, Shunqiang Li, Matthew J. Ellis, Susan G. Hilsenbeck, Rachel Schiff, Xiao-Song Wang
Summary: NLK was identified as a novel actionable kinase target in endocrine-resistant breast cancer, modulating endocrine resistance through phosphorylation of ER and its coactivator SRC-3. Coadministration of VX-702 and everolimus demonstrated significant therapeutic effects in cell line- and patient-derived xenograft tumor models.
CLINICAL CANCER RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Huilun Wang, Yanhong Guo, Haocheng Lu, Yonghong Luo, Wenting Hu, Wenying Liang, Minerva T. Garcia-Barrio, Lin Chang, Anna Schwendeman, Jifeng Zhang, Y. Eugene Chen
Summary: Atherosclerosis is influenced by KLF14 expression in macrophages, which plays a role in promoting cholesterol efflux and suppressing inflammatory response. Activation of KLF14 by perhexiline can inhibit inflammation and increase cholesterol efflux in a KLF14-dependent manner without triggering hepatic lipogenesis, representing a potential new therapeutic approach for preventing or treating atherosclerosis.
CARDIOVASCULAR RESEARCH
(2022)
Article
Respiratory System
Hajime Maeda, Hongwei Yao, Hayato Go, Kelsey E. E. Huntington, Monique E. De Paepe, Phyllis A. A. Dennery
Summary: This study found that hyperoxia can induce senescence in lung epithelial cells and increase the expression of miR-34a-5p, which is partly regulated by the upregulation of the KLF4 signaling pathway. Inhibiting miR-34a-5p or KLF4 can mitigate the detrimental effects of hyperoxia on the neonatal lung.
RESPIRATORY RESEARCH
(2022)
Article
Biotechnology & Applied Microbiology
Benjamin Atwell, Cheng-Yu Chen, Matthew Christofferson, William R. Montfort, Joyce Schroeder
Summary: Targeting the retrotranslocation of EGFR may be a potent therapeutic approach for RTK-active cancer.
CANCER GENE THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Sourish Ghosh, Sriparna Mukherjee, Anirban Basu
JOURNAL OF NEUROCHEMISTRY
(2015)
Article
Immunology
Sayantika Mahanti, Arnab Majhi, Kiran Kundu, Anirban Basu, Biswadev Bishayi
JOURNAL OF NEUROIMMUNOLOGY
(2015)
Article
Immunology
Nikhil Sharma, Ruhi Verma, Kanhaiya Lal Kumawat, Anirban Basu, Sunit K. Singh
JOURNAL OF NEUROINFLAMMATION
(2015)
Article
Neurosciences
Suhas V. Vasaikar, Sourish Ghosh, Priyam Narain, Anirban Basu, James Gomes
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Article
Multidisciplinary Sciences
Sourish Ghosh, G. Vinodh Kumar, Anirban Basu, Arpan Banerjee
SCIENTIFIC REPORTS
(2015)
Article
Cell Biology
Sriparna Mukherjee, Sourish Ghosh, Arshed Nazmi, Anirban Basu
CELL BIOLOGY INTERNATIONAL
(2015)
Article
Cell Biology
Partha Pratim Manna, Sumit Kumar Hira, Anirban Basu, Santu Bandyopadhyay
CELLULAR IMMUNOLOGY
(2014)
Article
Cell Biology
Deepak Kumar Kaushik, Menaka Chanu Thounaojam, Arinjay Mitra, Anirban Basu
INFLAMMATION RESEARCH
(2014)
Article
Immunology
Arnab Majhi, Kiran Kundu, Rana Adhikary, Madhubanti Banerjee, Sayantika Mahanti, Anirban Basu, Biswadev Bishayi
JOURNAL OF INFLAMMATION-LONDON
(2014)
Article
Biochemistry & Molecular Biology
Menaka Chanu Thounaojam, Deepak Kumar Kaushik, Kiran Kundu, Anirban Basu
JOURNAL OF NEUROCHEMISTRY
(2014)
Article
Immunology
Gunjan Dhawan Manocha, Ritu Mishra, Nikhil Sharma, Kanhaiya Lal Kumawat, Anirban Basu, Sunit K. Singh
JOURNAL OF NEUROINFLAMMATION
(2014)
Article
Virology
Menaka Chanu Thounaojam, Kiran Kundu, Deepak Kumar Kaushik, Shalini Swaroop, Anita Mahadevan, Susarla Krishna Shankar, Anirban Basu
JOURNAL OF VIROLOGY
(2014)
Article
Neurosciences
Arshed Nazmi, Sriparna Mukherjee, Kiran Kundu, Kallol Dutta, Anita Mahadevan, Susarla Krishna Shankar, Anirban Basu
NEUROBIOLOGY OF DISEASE
(2014)
Article
Neurosciences
Kanhaiya Lal Kumawat, Deepak Kumar Kaushik, Praveen Goswami, Anirban Basu
Article
Multidisciplinary Sciences
Nabonita Sengupta, Sourish Ghosh, Suhas V. Vasaikar, James Gomes, Anirban Basu