Article
Immunology
Dongni Huang, Yuxin Ran, Zheng Liu, Jie He, Nanlin Yin, Hongbo Qi
Summary: Preterm labor is a multifactorial syndrome that involves the abnormal expression of IL-27 and its receptors. This study demonstrated that the IL-27/IFN-γ/ERK axis mediates the inflammatory effect in preterm labor, and WSX-1 knockdown can delay birth. The findings suggest a potential therapeutic target in inhibiting the pro-inflammatory effect in preterm labor.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Rahim Ullah, Qing Yin, Aidan H. Snell, Lixin Wan
Summary: The RAF-MEK-ERK signaling cascade is a well-characterized MAPK pathway that plays a critical role in cell proliferation and survival. Genetic alterations in this pathway are highly prevalent in human cancers and can lead to uncontrolled cell growth and tumor formation. The crosstalk between the RAF-MEK-ERK axis and other signaling pathways further enhances its proliferative potential in human cancers.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Yue Li, Lin Zhang, Yan Li, Baoyan Shi, Yujuan Zhang
Summary: Limonin inhibits the growth and proliferation of colorectal cancer cells by downregulating the expression of factors involved in the ERK/MEK signaling pathway.
JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
(2022)
Article
Plant Sciences
Guowei Gong, Yuzhong Zheng, Xiangpeng Kong, Zhen Wen
Summary: Ononin, a bioactive compound found in functional foods or plants, has been shown to exhibit anticancer properties in both in vitro and in vivo studies. In this study, ononin was also found to inhibit endothelial cell angiogenesis and suppress tumor cell proliferation. The potential role of ononin as a candidate for prevention and treatment of angiogenesis-related diseases was highlighted in this research.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Biochemistry & Molecular Biology
Yuh-Fung Chen, Kuo-Jen Wu, Lian-Ru Siao, Huei-Yann Tsai
Summary: Cerebrovascular disease is a leading cause of disability and death worldwide. Trilinolein (TriL), a natural compound, has protective effects and can potentially prevent cerebral ischemia and cerebrovascular diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Prachi Umbarkar, Sultan Tousif, Anand P. Singh, Joshua C. Anderson, Qinkun Zhang, Michelle D. Tallquist, James Woodgett, Hind Lal
Summary: This study reveals the important role of cardiac fibroblast-GSK-3 alpha in myocardial fibrosis and heart failure, and identifies the molecular mechanism underlying this role through fibroblast kinome mapping. The results suggest that GSK-3 alpha plays a critical role in fibroblast transformation and fibrotic remodeling, independently of the canonical TGF-beta 1-SMAD3 pathway.
CIRCULATION RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Zeyang Li, Minghui Zhao, Xiaoqian Zhang, Yiran Lu, Yang Yang, Yalong Xie, Zhimiao Zou, Liang Zhou, Runshi Shang, Limin Zhang, Fengchao Jiang, Dunfeng Du, Ping Zhou
Summary: The MyD88 inhibitor TJ-M2010-5 has shown neuroprotective and anti-neuroinflammatory effects on cerebral ischemia-reperfusion injury (CIRI) in the central nervous system. It inhibits inflammatory cytokines, microglia activation, and peripheral myeloid cell infiltration, while downregulating the MyD88/NF-kappa B and ERK pathway. TJ-M2010-5 also demonstrates good blood-brain barrier permeability and no neurotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kyuhee Park, Yoonkyoung Shin, Gyeongbeen Lee, Hwantae Park, Yongmun Choi
Summary: The small molecule dabrafenib has been identified to promote Schwann cell differentiation by inhibiting ERK phosphorylation and enhancing ErbB2 and Akt phosphorylation. However, MEK and ERK inhibitors have no effect on key transcription factor expression, while pharmacological inhibition of PI3K interferes with dabrafenib-induced differentiation. This suggests that the ErbB2-PI3K-Akt axis is essential for Schwann cell differentiation induced by dabrafenib in vitro.
Article
Biochemistry & Molecular Biology
Zining Yu, Guangjun Su, Limei Zhang, Gaigai Liu, Yonggang Zhou, Shicai Fang, Qian Zhang, Tianyun Wang, Cheng Huang, Zhihua Huang, Liangdong Li
Summary: The study found that ICT can inhibit microglial activation and M1 polarization, promote M2 polarization, and alleviate inflammatory response and achieve neuroprotection by regulating the GPER-ERK-NF-kappa B signaling pathway.
MOLECULAR MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Xiao-Di Fan, Ming-Jiang Yao, Bin Yang, Xiao Han, Ye-Hao Zhang, Guang-Rui Wang, Peng Li, Li Xu, Jian-Xun Liu
Summary: The Chinese herbal preparation SaiLuoTong (SLT) capsule has shown outstanding therapeutic effects on stroke and its sequelae, possibly related to its Nrf2-dependent protection of brain microvascular endothelial cells (BMECs). The study confirmed SLT's anti-brain ischemia effect in rats and its direct protective effect on BMECs through in vitro experiments, highlighting the obligatory role of the Nrf2 pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Jingya Lyu, Kensaku Fukunaga, Hitomi Imachi, Seisuke Sato, Toshihiro Kobayashi, Takanobu Saheki, Tomohiro Ibata, Takafumi Yoshimura, Hisakazu Iwama, Koji Murao
Summary: The study demonstrated that oxidized low-density lipoprotein (OxLDL) downregulates ABCA1 expression through the MEK/ERK/LXR pathway, leading to lipid accumulation in INS-1 cells, potentially resulting in impaired insulin synthesis and glucose-stimulated insulin secretion (GSIS).
Article
Biochemistry & Molecular Biology
Wei Liu, Lei Wang, Jiajia Zhang, Kun Cheng, Wenming Zheng, Zhenling Ma
Summary: Ovarian cancer has a lower incidence rate compared to other gynecological tumor types, but it has the second-highest death rate. CCL2, a multifunctional factor associated with cancer progression, was found to promote proliferation and metastasis of ovarian cancer cells when overexpressed. Knocking down CCL2 inhibited ovarian cancer cell proliferation, migration, and invasion. The study showed that MAP3K19 is the key target through which CCL2 regulates ovarian cancer progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Wenxun Liu, Qingshan Ye, Wenhua Xi, Yan Li, Xiaohong Zhou, Yun Wang, Zhenhai Ye, Kerong Hai
Summary: Heparin treatment significantly improves neurological deficits and cerebral edema in rats with CPR-induced cerebral ischemia-reperfusion injury. Heparin also reduces neuronal apoptosis and promotes neurite outgrowth in vitro. Furthermore, heparin attenuates neuronal apoptosis and neuroinflammation, potentially through regulating the ERK/CREB-mediated PTN/syndecan-3 pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Oncology
Thomas Yul Avery, Natalie Koehler, Robert Zeiser, Tilman Brummer, Dietrich Alexander Ruess
Summary: Hyperactivation of the RAS-RAF-MEK-ERK cascade plays a significant role in the oncogenesis of various tumors. It mediates the crosstalk between tumor, tumor microenvironment, and the immune system, leading to immune escape mechanisms and establishment of a tumor-supporting environment. Pharmacological interruption of this pathway disrupts tumor cells and modifies the tumor microenvironment, as well as anti-tumor immunomodulation. MEK inhibition has shown promise in modulating immune responses. However, the durable efficacy, therapy resistance, and toxicity still pose challenges for the clinical application of therapeutic agents targeting RAS-RAF-MEK-ERK hyperactivation.
FRONTIERS IN ONCOLOGY
(2022)
Article
Fisheries
Linlin Zhang, Lu Chen, Meng Qi, Fuchang Yu, Xiaotong Ni, Haozheng Hong, Haotian Xu, Shiwen Xu
Summary: Glyphosate exposure induces autophagy in hepatic L8824 cells by activating nitric oxide (NO), regulating energy metabolism, and activating the RAS/RAF/MEK/ERK signaling pathway. This study provides insight into the mechanism of glyphosate toxicity and its effects on cellular processes.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Simon Bentsen, Anette Sams, Philip Hasbak, Lars Edvinsson, Andreas Kjaer, Rasmus S. Ripa
Summary: The study found that the CGRP analogue, SAX, has a cardioprotective effect in a rat model of myocardial infarction, improving myocardial perfusion recovery after chronic occlusion of the coronary artery.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Editorial Material
Pharmacology & Pharmacy
Lars Edvinsson, Amynah Pradhan
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Mimmi Rehnstrom, Hilda Ahnstedt, Diana N. Krause, Marie Louise Edvinsson, Kristian Agmund Haanes, Lars Edvinsson
Summary: The effects of sex hormones on post-stroke vascular responses are not fully understood. This study found that loss of ovarian function affects vascular contractile responses after cerebral ischemia, suggesting that sex hormones do not directly influence these alterations.
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2022)
Article
Clinical Neurology
Jacob C. A. Edvinsson, Aida Maddahi, Isabella M. Christiansen, Philip Reducha, Karin Warfvinge, Majid Sheykhzade, Lars Edvinsson, Kristian A. Haanes
Summary: This study reveals the presence of a subgroup of C-fibres that store 5-HT and shows high expression of 5-HT1B/1D receptors. The study suggests that the 5-HT1F receptor is a relatively unlikely target in the rat trigeminal system. Furthermore, Lasmiditan works as a partial agonist on 5-HT1B/1D receptors in clinically relevant dose regiments.
JOURNAL OF HEADACHE AND PAIN
(2022)
Article
Clinical Neurology
Isabella Mai Christiansen, Jacob C. A. Edvinsson, Philip Reducha, Lars Edvinsson, Kristian Agmund Haanes
Summary: The present study demonstrates that ACEA alone does not exhibit antimigraine potential due to its dual agonistic properties, resulting in activation of both CB1 and TRPV1.
JOURNAL OF HEADACHE AND PAIN
(2022)
Review
Physiology
Jacob C. A. Edvinsson, Kristian A. Haanes, Lars Edvinsson
Summary: This review focuses on the trigeminovascular system (TGV) and discusses the signaling between fibers, as well as the potential role of neuropeptides and their receptors in migraine pathophysiology.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Neurosciences
Maryam Mostajeran, Lars Edvinsson, Hilda Ahnstedt, Kajsa Arkelius, Saema Ansar
Summary: This study aimed to evaluate spontaneous recovery and molecular mechanisms involved in the recovery phase two weeks after stroke in female rats. The results showed that there were differences in the expression of specific proteins in different brain regions of female rats after stroke, which may be important for future therapeutic strategies.
Review
Medicine, General & Internal
Lars Edvinsson
Summary: Migraine is a common neurovascular disorder, affecting over 15% of the global population. Women are three times more likely to suffer from migraine compared to men. The underlying mechanisms of migraine are still largely unknown, but molecules such as CGRP play a crucial role in its pathophysiology.
JOURNAL OF INTERNAL MEDICINE
(2022)
Editorial Material
Clinical Neurology
Lars Edvinsson, Jacob C. A. Edvinsson, Kristian A. Haanes
Summary: The paper presents an analysis of mRNA expression in human and mouse trigeminal ganglia at single-nucleus resolution. It suggests new targets for pain therapies, but the findings should be interpreted in the context of available protein data and warrant functional verification.
NATURE REVIEWS NEUROLOGY
(2022)
Article
Physiology
Andre Erdling, Sara Ellinor Johansson, Aneta Radziwon-Balicka, Saema Ansar, Lars Edvinsson
Summary: Ischemia causes upregulation of vasoconstrictive receptor systems in the cerebral vasculature. Focal ischemic stroke increases vascular sensitivity to UDP-beta-S, while subarachnoid hemorrhage does not.
PHYSIOLOGICAL REPORTS
(2022)
Article
Clinical Neurology
Philip V. Reducha, Jesper P. Boemers, Lars Edvinsson, Kristian A. Haanes
Summary: This study aimed to investigate the behavioral changes similar to migraine caused by CFA application on the skull in rats, and the potential mitigating effects of the CGRP specific antibody fremanezumab after CFA application. The results showed that surgical application of CFA to the dura caused periorbital allodynia and increased CGRP positive fibers in the trigeminal ganglion. However, fremanezumab did not alleviate periorbital allodynia, although it reduced the amount of CGRP positive fibers.
FRONTIERS IN NEUROLOGY
(2023)
Editorial Material
Medicine, General & Internal
Kristian A. Haanes, Lars Edvinsson
Article
Clinical Neurology
Aida Maddahi, Karin Warfvinge, Anja Holm, Jacob C. A. Edvinsson, Philip Victor Reducha, Spyridoula Kazantzi, Kristian A. Haanes, Lars Edvinsson
Summary: This study investigated the distribution of progesterone in the trigeminovascular system and its role in modulating sensory neurotransmission. The results suggest that progesterone may modulate sensory neurotransmission and vascular responses in a complex manner, with effects varying by sex, tissue type, and the nature of the stimulus. Further research is needed to fully understand the underlying mechanisms and physiological implications of these findings.
JOURNAL OF HEADACHE AND PAIN
(2023)
Article
Multidisciplinary Sciences
Lena Erlandsson, Lena Ohlsson, Zahra Masoumi, Mimmi Rehnstrom, Tina Cronqvist, Lars Edvinsson, Stefan R. Hansson
Summary: Preeclampsia (PE) is a pregnancy syndrome characterized by hypertension and organ damage. This study found that placenta-derived extracellular vesicles (STBEVs) in PE patients have negative effects on vascular contractility and cause structural damage to blood vessels. These effects can be reduced by blocking vesicle uptake. This discovery provides a new therapeutic strategy for preventing cardiovascular risks caused by PE.
SCIENTIFIC REPORTS
(2023)
Article
Pharmacology & Pharmacy
Anette Sams, Kristian Agmund Haanes, Anja Holm, Spyridoula Kazantzi, Lars Friis Mikkelsen, Lars Edvinsson, Susan Brain, Majid Sheykhzade
Summary: This study characterized the vasomotor responses of isolated coronary, cerebral, and mesenteric arteries in Gottingen Minipigs (GM), and compared the responses to those obtained from parallel studies using other artery types. The results showed that different arterial sources had different responses to selected agonists of endothelial, sympathetic, parasympathetic, and sensory pathways. The study also demonstrated the robust nature of the vasomotor responses after 24 hours of cold storage of vascular tissue.
VASCULAR PHARMACOLOGY
(2023)