Article
Pharmacology & Pharmacy
Shang Xian Bo, Wang Yan Jie, Cai De Chao, Ma Sai, Wang Zhe, Zhu Ya Kun, Guo Hui Hui, Wang Chen, Ma Xiao, Hu Zhong Yao, Yu Hao Ran, Zhang Ji Sen, Cheng Wen Dan
Summary: The study demonstrated that compound 22o effectively inhibited the inflammatory response and catabolism of chondrocytes, reducing articular cartilage injury in a rat OA model induced by ACLT. The compound showed potential as a disease-modifying OA drug.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Cell Biology
Tana S. Pottorf, Travis M. Rotterman, William M. McCallum, Zoe A. Haley-Johnson, Francisco J. Alvarez
Summary: Peripheral nerve injuries trigger immune reactions in the spinal cord which are mainly governed by microglia activation. The mechanisms of microglial activation and response vary depending on the location, type, severity, and proximity of the injury, as well as the age and species of the organism. Recent advancements in neuro-immune research techniques have provided insights into the mechanisms of microglial activation and their function in injured motoneurons and sensory afferents. This review provides a comparative analysis of the dorsal and ventral horns regarding microglial activation mechanisms and their functionality in neuroprotection, degeneration, regeneration, synaptic plasticity, and spinal circuit reorganization following peripheral nerve injury, aiming to address unsettled controversies on the diversity of spinal microglial-neuronal interactions.
Article
Biochemistry & Molecular Biology
Shaimaa Maher, Lauren A. Smith, Celine A. El-Khoury, Haitham Kalil, Khalid Sossey-Alaoui, Mekki Bayachou
Summary: Nitric oxide (NO) is a small molecule that has a significant impact on various biological activities. It has been linked to cancer-related processes and has the potential to be used as an anti-cancer agent. In this study, NO-releasing materials were developed using modified sodium alginate hydrogel, which showed compatibility with cell growth. The release of NO from the hydrogel exhibited distinct kinetic features.
Article
Biochemistry & Molecular Biology
Stanislav Rodkin, Valentina Dzreyan, Mikhail Bibov, Alexey Ermakov, Tatyana Derezina, Evgeniya Kirichenko
Summary: Peripheral-nerve injury can cause disability, and there is currently a lack of clinically effective neuroprotectors. This study investigated the role of NO-dependent expression of p53 in the death of neurons and glial cells following axotomy. The results showed that axotomy led to redistribution of p53 in neurons, and the application of a NO donor increased p53 levels in nuclei and cytoplasm of neurons, as well as karyoplasm of glial cells. In contrast, inhibition of iNOS had a neuroprotective effect. These findings suggest that the NO-dependent expression of p53 may play a signaling mechanism in neural and glial cell death after axotomy.
Article
Biotechnology & Applied Microbiology
Agnieszka Zablocka, Dominika Jakubczyk, Katarzyna Leszczynska, Katarzyna Pacyga-Prus, Jozefa Macala, Sabina Gorska
Summary: This study investigated the ability of Bifidobacterium species to induce iNOS-dependent NO synthesis in macrophages. The results showed that Bifidobacterium can regulate the expression of iNOS and produce NO by activating MAPK kinases. TLR2 and TLR4 receptors are involved in Bifidobacterium-induced macrophage activation and NO production. The study suggests that Bifidobacterium has a protective mechanism in the intestine, and its efficacy is strain-dependent.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Biochemistry & Molecular Biology
Tetsuya Tachibana, Maki Takahashi, Sakirul Khan, Ryosuke Makino, Mark A. Cline
Summary: This study aimed to investigate the effects of virus component analogues on NO production in chicks and found that poly I:C and R848 significantly increased plasma NO concentrations and induced an increase in iNOS mRNA expression. The study also found that these virus analogues decreased mRNA expressions of endothelial NOS and neural NOS in several organs, suggesting that iNOS might be responsible for the increased plasma NO levels. These findings suggest that viral infections facilitate NO production by inducing iNOS and are associated with corticosterone release in birds.
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY A-MOLECULAR & INTEGRATIVE PHYSIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Chang-Ho Kang, Jin-Seong Kim, Hyemin Kim, Hye Min Park, Nam-Soo Paek
Summary: The study found that heat-killed lactic acid bacteria have immunomodulatory functions and antioxidant activity, making them suitable for use as probiotics. Heat treatment of strains can prolong the shelf-life of probiotic foods and significantly inhibit the expression of nitric oxide synthase and cyclooxygenase-2.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2021)
Article
Neurosciences
Alyssa L. Wiseman, Clark A. Briggs, Ariel Peritt, Nicolas Kapecki, Daniel A. Peterson, Seong S. Shim, Grace E. Stutzmann
Summary: This study investigated the stabilizing effect of lithium on calcium signaling abnormalities in hippocampal neurons and its subsequent effects on AD neuropathology and synaptic plasticity. The results showed that lithium treatment reduced aberrant calcium signaling and restored nNOS and p-tau levels, as well as enhanced short-term synaptic plasticity in 3xTg-AD mice. Lithium could be an effective treatment or co-therapeutic for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
David Perez-Boyero, Carlos Hernandez-Perez, Jorge Valero, Valeria Lorena Cabedo, Jose Ramon Alonso, David Diaz, Eduardo Weruaga
Summary: The main olfactory bulb (MOB) is a neural structure that processes olfactory information. Nitric oxide (NO), produced mainly by neuronal nitric oxide synthase (nNOS), plays a crucial role in the plasticity and functioning of the MOB. The absence of nNOS expression in nNOS-KO mice leads to a reduced olfactory capacity, while an increase in the expression of endothelial nitric oxide synthase (eNOS) is observed. However, the level of NO generated in the MOB does not appear to change significantly. These findings suggest that nNOS is essential for the proper functioning of the olfactory system.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Amir Asgari, Paul Jurasz
Summary: Megakaryocytes are important members of the hematopoietic system, responsible for regulating vascular homeostasis through platelets. The process of megakaryopoiesis generates mature megakaryocytes which release proplatelets into blood vessels. Nitric oxide (NO) plays a modulatory role in hematopoiesis and hemostasis. This review summarizes the effect of NO and its signaling on megakaryopoiesis and thrombopoiesis under physiological and pathophysiological conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Deepali Singh, Archana Yadav, Chetna Singh
Summary: The study revealed that iNOS and CYP2E1 in rat PMNs contribute to oxidative stress induced by MB+PQ through differential regulatory mechanisms, with iNOS being regulated by inflammatory mediators and CYP2E1 expression triggered via the MEK-ERK1/2-PKC pathway.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Corina Daniela Ene, Ilinca Nicolae
Summary: This study explores the relationship between NOS2-associated inflammation profiles and SLE phenotypes. The variations in biomarkers are strongly associated with the decrease in eGFR and increase in albuminuria.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Medicine, Research & Experimental
George J. Dugbartey
Summary: Kidney transplantation is the preferred treatment for patients with kidney failure. However, ischemia-reperfusion injury (IRI) poses a significant challenge to the long-term success of this intervention. Nitric oxide (NO) has emerged as a potential candidate for mitigating IRI and preventing graft rejection in kidney transplantation. This review provides an overview of the sources and protective effects of endogenous and exogenous NO in kidney transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Fabio Arias, Francisco Franco-Montalban, Miguel Romero, Juan Duarte, M. Dora Carrion, M. Encarnacion Camacho
Summary: This paper describes the design, synthesis, and biological evaluation of selective inhibitors of inducible nitric oxide synthase (iNOS). The most potent and selective compound showed inhibitory activity against iNOS without undesirable cardiovascular effects. In silico analysis predicted good drug-likeness properties for promising compounds, which also exhibited adequate cell viability. Docking studies revealed a unique binding mode for one compound and explained its selectivity towards iNOS.
BIOORGANIC CHEMISTRY
(2022)
Article
Neurosciences
Camille Quilgars, Jean-Rene Cazalets, Sandrine S. Bertrand
Summary: The study investigated the impact of metabotropic glutamate receptor (mGluR) activation on activity-dependent synaptic plasticity (ADSP) and the intrinsic membrane properties of lumbar motoneurons (MNs). Results showed subtype-specific and developmentally regulated modulation of ADSP and synaptic transmission at VLF-MN synapses, and a downregulation of mGluR gene expression with age in the ventral part of the lumbar spinal cord. Additionally, mGluR agonists induced distinct effects on motor burst amplitudes and locomotor rhythms, depending on the developmental stage of the animals.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Andre Luis Bombeiro, Bruno Henrique de Melo Lima, Amanda Pires Bonfanti, Alexandre Leite Rodrigues de Oliveira
MOLECULAR IMMUNOLOGY
(2020)
Article
Neurosciences
Andre Luis Bombeiro, Bruna Toledo Nunes Pereira, Amanda Pires Bonfanti, Alexandre Leite Rodrigues de Oliveira
BRAIN RESEARCH BULLETIN
(2020)
Article
Neurosciences
Willians Fernando Vieira, Kaue Franco Malange, Silviane Fernandes de Magalhaes, Gilson Goncalves dos Santos, Alexandre Leite Rodrigues de Oliveira, Maria Alice Cruz-Hofling, Carlos Amilcar Parada
NEUROSCIENCE LETTERS
(2020)
Article
Biochemistry & Molecular Biology
Daniela Fernanda Dezotti Silva, Lucas de Oliveira Fujii, Gabriela Bortolanca Chiarotto, Camila Andrea de Oliveira, Thiago Antonio Moretti de Andrade, Alexandre Leite Rodrigues de Oliveira, Marcelo Augusto Marretto Esquisatto, Fernanda Aparecida Sampaio Mendonca, Glaucia Maria Tech dos Santos, Andrea Aparecida de Aro
Summary: The study demonstrated that microcurrent therapy can promote fibroblast migration and modulate the expression of specific genes, with increased Ctgf expression and decreased Tnc and Fmod expression. The therapy did not have an impact on cell viability.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Clinical Neurology
Tauana Bernardes Leoni, Carelis Gonzalez-Salazar, Thiago Junqueira R. Rezende, Ana Luisa C. Hernandez, Alexandre Hilario B. Mattos, Antonio Rodrigues Coimbra Neto, Felipe Franco da Graca, Joao Pedro Nunes Goncalves, Alberto R. M. Martinez, Lucas Taniguti, Joao Paulo Kitajima, Fernando Kok, Fabio Rogerio, Andre Macedo Serafim da Silva, Alexandre Leite Rodrigues de Oliveira, Edmar Zanoteli, Anamarli Nucci, Marcondes C. Franca Jr
Summary: This study provides a detailed description of unique hIBM patients from three Brazilian families, showing a slowly progressive limb-girdle syndrome. Neuroimaging and muscle pathology results indicate the association with the ANXA11 gene, expanding the spectrum of diseases related to ANXA11.
ANNALS OF NEUROLOGY
(2021)
Article
Neurosciences
Tarika Goncalves do Carmo Oliveira, Ana Claudia Moreira dos Santos, Alex Dias Assis, Raphael Teixeira Borges, Jessica Regina da Costa Silva, Carlos Ueira-Vieira, Gustavo Ferreira Simoes, Renata Graciele Zanon
Summary: The combination of BthTL glue and TNF mimetic peptide promoted axonal regrowth and remyelination, leading to better regeneration outcomes. The Tube + Glue + Pep group exhibited intense inflammatory infiltrate, higher expression of NGFRp75 receptor, increased myelin thickness and fiber diameter, as well as more type III collagen deposition.
BRAIN RESEARCH BULLETIN
(2021)
Article
Neurosciences
Alex Dias Assis, Gabriela Bortolanca Chiarotto, Gustavo Ferreira Simoes, Alexandre Leite Rodrigues Oliveira
Summary: Treatment with pregabalin (PGB) can protect peripheral nerves in MDX mice, improve motor coordination, and potentially be translated to clinical applications in the future.
MOLECULAR AND CELLULAR NEUROSCIENCE
(2021)
Article
Cell & Tissue Engineering
Diego Noe Rodriguez-Sanchez, Giovana Boff Araujo Pinto, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues de Oliveira, Ana Livia Carvalho Bovolato, Marcio de Carvalho, Jorge Vicente Lopes da Silva, Janaina de Andrea Dernowsek, Marjorie Golim, Benedito Barraviera, Rui Seabra Ferreira, Elenice Deffune, Mathues Bertanha, Rogerio Martins Amorim
Summary: The study demonstrated that the combination of 3D-printed PLC-NGCs with AdMSCs derived from adipose tissue exerted neuroregenerative effects on rats with sciatic nerve injury, improving motor function and nerve conduction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Neurosciences
Matheus Perez, Luciana Politti Cartarozzi, Gabriela Bortolanca Chiarotto, Francisco Silveira Guimaraes, Alexandre Leite Rodrigues de Oliveira
Summary: The study showed that CBD has neuroprotective effects after neonatal nerve crush in rats, reducing astroglial reaction and requiring involvement of CB1 and CB2 receptors for effectiveness.
Article
Cell Biology
Lais Rosa Viana, Gabriela de Matuoka e Chiocchetti, Lucas Oroy, Willians Fernando Vieira, Estela Natacha Brandt Busanello, Ana Carolina Marques, Carla de Moraes Salgado, Alexandre Leite Rodrigues de Oliveira, Andre Schwambach Vieira, Paula Saenz Suarez, Lizandra Maia de Sousa, Bianca Gazieri Castelucci, Anibal Eugenio Vercesi, Silvio Roberto Consonni, Maria Cristina Cintra Gomes-Marcondes
Summary: A leucine-rich diet may prevent muscle atrophy in cancer cachexia patients, improve muscle strength and behavior performance, and decrease some protein degradation markers.
Article
Cell Biology
Bruno Henrique de Melo Lima, Andre Luis Bombeiro, Luciana Politti Cartarozzi, Alexandre Leite Rodrigues De Oliveira
Summary: The expression of MHC-I and other related molecules following peripheral nerve injury is associated with the recovery of neurons, glial cells, sensorimotor function, gait, and nociceptive threshold in mice. Different strains of mice exhibit varying recovery capacities.
Article
Polymer Science
Paula Regina Gelinski Kempe, Mateus Vidigal de Castro, Victor Campos Khuriyeh, Benedito Barraviera, Rui Seabra Ferreira Jr, Alexandre Leite Rodrigues de Oliveira
Summary: Spinal cord injury leads to severe loss of motor and sensory function. Our study aimed to test the combined treatment of surgical repair with fibrin biopolymer and pharmacological treatment with dimethyl fumarate. Results showed that this combination can protect neurons and promote motor neuron regeneration.
Article
Cell & Tissue Engineering
Mateus Vidigal de Castro, Monize Valeria Ramos da Silva, Gabriela Bortolanca Chiarotto, Maria Helena Andrade Santana, Angela Cristina Malheiros Luzo, Sergiy Kyrylenko, Alexandre Leite Rodrigues de Oliveira
STEM CELLS INTERNATIONAL
(2020)
Article
Multidisciplinary Sciences
Viviane Theodoro, Lucas de Oliveira Fujii, Leticia Dudri Lucke, Fernanda Oriani Bortolazzo, Daniela Fernanda Dezotti Silva, Giane Daniela Carneiro, Maria Esmeria Corezola Amaral, Camila Andrea de Oliveira, Thiago Antonio Moretti de Andrade, Andre Luis Bombeiro, Cristina Pontes Vicente, Fernando Russo Costa Bomfim, Alexandre Leite Rodrigues de Oliveira, Vanderlei Salvador Bagnato, Marcelo Augusto Marretto Esquisatto, Fernanda Aparecida Sampaio Mendonca, Glaucia Maria Tech dos Santos, Andrea Aparecida de Aro
Article
Toxicology
Paula R. G. Kempe, Gabriela Bortolanca Chiarotto, Benedito Barraviera, Rui Seabra Ferreira, Alexandre L. R. de Oliveira
JOURNAL OF VENOMOUS ANIMALS AND TOXINS INCLUDING TROPICAL DISEASES
(2020)