Article
Medicine, Research & Experimental
Zhao-Lan Hu, Cong Luo, Plinio Reinaldo Hurtado, Hui Li, Shuang Wang, Bo Hu, Jun-Mei Xu, Yang Liu, Shi-Qing Feng, Ernesto Hurtado-Perez, Kang Chen, Xin-Fu Zhou, Chang-Qi Li, Ru-Ping Dai
Summary: The study found that proBDNF from immune cells promotes the immunopathogenesis of multiple sclerosis (MS). Monoclonal Ab-proB may be a promising therapeutic agent for treating MS.
Article
Clinical Neurology
Manuel Comabella, Mar Tintore, Augusto Sao Aviles, Pere Carbonell-Mirabent, Sunny Malhotra, Alex Rovira, Nicolas Fissolo, Jan D. Luenemann, Xavier Montalban
Summary: This study evaluated the impact of viral infections on multiple sclerosis (MS) disease progression and found that antibody responses against viruses at disease onset are associated with long-term disease outcomes. The results suggest that immune responses against human cytomegalovirus (HCMV) at early stages have protective effects on long-term disability and inflammation disease outcomes, and immune responses against Epstein-Barr virus (EBV) may influence long-term disease prognosis.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Neurosciences
Mette D. Diechmann, Evan Campbell, Elaine Coulter, Lorna Paul, Ulrik Dalgas, Lars G. Hvid
Summary: This study systematically reviewed the effects of acute and chronic exercise on neurotrophic factors in individuals with multiple sclerosis, finding that exercise can improve chronic levels of neurotrophic factors, especially brain-derived neurotrophic factor (BDNF).
Article
Biochemistry & Molecular Biology
Jessica Lamberty Faverzani, Gilian Guerreiro, Tatiane Grazieli Hammerschmidt, Franciele Fatima Lopes, Daniella de Moura Coelho, Angela Sitta, Caroline Paula Mescka, Marion Deon, Moacir Wajner, Carmen Regla Vargas
Summary: This study evaluated the levels of neurodegenerative markers in the plasma of PKU patients at early and late diagnosis and during treatment, and found the effectiveness of the treatment and a compensatory response.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2023)
Article
Clinical Neurology
Emilio Portaccio, Angelo Bellinvia, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Mattia Fonderico, Giovanni Bosco Zimatore, Nunzia Alessandra Losignore, Sandro Sorbi, Maria Pia Amato
Summary: The study suggests a potential protective effect of BDNF Val66Met polymorphism against cognitive impairment in MS patients, possibly due to the detrimental effect of increased BDNF concentration in a neuroinflammatory environment. Higher EDSS score is associated with a progressive disease course, with a marginal association with the presence of the BDNF Val66Met polymorphism.
FRONTIERS IN NEUROLOGY
(2021)
Article
Immunology
Simon Faissner, Neele Heitmann, Carlos Plaza-Sirvent, Paulina Trendelenburg, Ulas Ceylan, Jeremias Motte, Clara Bessen, Doris Urlaub, Carsten Watzl, Oliver Overheu, Anke Reinacher-Schick, Kerstin Hellwig, Stephanie Pfaender, Ingo Schmitz, Ralf Gold
Summary: This study investigated the immune cell alterations and immune response in patients receiving early ofatumumab treatment and compared them to healthy controls following SARS-CoV-2 vaccination. The results showed that ofatumumab treatment led to depletion of B cells and changes in certain T cell subpopulations. The humoral immune response to SARS-CoV-2 was impaired, while the cellular immune response was preserved.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Ophthalmology
Adnan Khan, Yi Li, Georgios Ponirakis, Naveed Akhtar, Hoda Gad, Pooja George, Faiza M. Ibrahim, Ioannis N. Petropoulos, Beatriz G. Canibano, Dirk Deleu, Ashfaq Shuaib, Saadat Kamran, Rayaz A. Malik
Summary: This study compared corneal immune cell density and near-nerve distance in different subtypes of patients with multiple sclerosis using corneal confocal microscopy (CCM). The results showed increased immature immune cell density and near-nerve distance in MS patients, suggesting CCM may serve as an imaging biomarker for assessing neuroimmune alterations in MS.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Immunology
Stephanie N. Blandford, Neva J. Fudge, Chris P. Corkum, Craig S. Moore
Summary: Extracellular vesicles (EVs) secreted from cells have emerged as potential biomarkers for neurological conditions, including multiple sclerosis (MS). This study found that immune cell-derived EVs were significantly increased in the plasma of untreated RRMS patients, despite limited changes in circulating immune cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Clinical Neurology
Livnat Brill, Catarina Raposo, Ariel Rechtman, Omri Zveik, Netta Levin, Esther Oiknine-Djian, Dana G. Wolf, Adi Vaknin-Dembinsky
Summary: This study aimed to evaluate the humoral and cellular response to SARS-CoV-2 mRNA vaccine in multiple sclerosis patients treated with B-cell depletion, particularly those who had a weak response to initial vaccination. The study found that the antibody titers did not increase in patients who had a weak or no response after the initial vaccination following the third vaccine dose. However, in healthy controls and MS patients treated with B-cell depletion, cellular response significantly increased after the third dose of the vaccine.
ANNALS OF NEUROLOGY
(2022)
Review
Immunology
Donghui Shen, Kang Liu, Hongyan Wang, Haifeng Wang
Summary: Autophagy plays a significant role in both protective and detrimental effects in multiple sclerosis (MS). Targeting autophagy may be a potential therapeutic approach, but further studies are needed to determine its mechanisms.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Stephanie N. Blandford, Neva J. Fudge, Craig S. Moore
Summary: In this study, elevated levels of CXCL10 were detected in the cerebrospinal fluid (CSF) of multiple sclerosis (MS) cases, and these levels were associated with increased T cell numbers but not with peripheral CXCR3 expression. These findings support the importance of CXCL10 in MS and suggest the presence of alternative mechanisms of CXCL10 beyond solely influencing immune cell trafficking.
Article
Biochemistry & Molecular Biology
Valentina Mazziotti, Francesco Crescenzo, Agnese Tamanti, Caterina Dapor, Stefano Ziccardi, Maddalena Guandalini, Annalisa Colombi, Valentina Camera, Angela Peloso, Francesco Pezzini, Ermanna Turano, Damiano Marastoni, Massimiliano Calabrese
Summary: The impact of disease-modifying therapies (DMTs) on the immune response to COVID-19 vaccines in multiple sclerosis patients needs further investigation. This study examined the effects of the BNT162b2 mRNA vaccine on antibody production, inflammatory mediators, and immune cell profile in patients treated with different DMTs. The results showed that patients treated with ocrelizumab had a weaker humoral immune response compared to other treatment groups, but a strengthened cellular immune response was observed in ocrelizumab-treated patients who did not seroconvert.
Article
Biochemistry & Molecular Biology
Maya Golan, Avivit Krivitsky, Karin Mausner-Fainberg, Moshe Benhamou, Ifat Vigiser, Keren Regev, Hadar Kolb, Arnon Karni
Summary: The study found an increased expression of ephrins on immune cells of patients with RR-MS, especially on T cell subpopulations. This overexpression of ephrins has an inhibitory effect on the differentiation capacity of oligodendrocyte precursor cells (OPCs).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michael Seiberl, Julia Feige, Patrick Hilpold, Wolfgang Hitzl, Lukas Machegger, Arabella Buchmann, Michael Khalil, Eugen Trinka, Andrea Harrer, Peter Wipfler, Tobias Moser
Summary: This study investigated the impact of cladribine on serum neurofilament light chain (sNfL) and its potential as a predictor of long-term treatment response. The results showed that cladribine significantly reduced sNfL levels, but baseline and 12-month sNfL assessments failed to predict clinical and radiological treatment response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Danila Di Majo, Francesco Cacciabaudo, Giulia Accardi, Giuditta Gambino, Giuseppe Giglia, Giuseppe Ferraro, Giuseppina Candore, Pierangelo Sardo
Summary: Ketogenic Diet is a dietary therapy often used in the treatment of inflammatory neurological disorders. This research focuses on investigating the cognitive impairments and neuroprotection in multiple sclerosis (MS) by analyzing the alteration of biomarkers. The proposed ketogenic diet combined with a modified Mediterranean diet could potentially improve neuroinflammation in MS.
Article
Immunology
Jelena Brasanac, Caren Ramien, Stefanie Gamradt, Aline Taenzer, Laura Glau, Kristin Ritter, Kostas Patas, Agorastos Agorastos, Klaus Wiedemann, Cuneyt Demiralay, Felix Fischer, Christian Otte, Judith Bellmann-Strobl, Manuel A. Friese, Eva Tolosa, Friedemann Paul, Christoph Heesen, Martin Weygandt, Stefan M. Gold
Summary: This study identified CD4(+)CCR7(low)T(CM) cell frequencies as a robust correlate of depression in MS, associated with core symptoms and severity of depression. The findings suggest immune pathways linked to affective symptoms of autoimmune disorders like MS, providing potential relevance for understanding inflammatory subtypes of depression.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Biochemistry & Molecular Biology
Luca Sforzini, Courtney Worrell, Melisa Kose, Ian M. Anderson, Bruno Aouizerate, Volker Arolt, Michael Bauer, Bernhard T. Baune, Pierre Blier, Anthony J. Cleare, Philip J. Cowen, Timothy G. Dinan, Andrea Fagiolini, I. Nicol Ferrier, Ulrich Hegerl, Andrew D. Krystal, Marion Leboyer, R. Hamish McAllister-Williams, Roger S. McIntyre, Andreas Meyer-Lindenberg, Andrew H. Miller, Charles B. Nemeroff, Claus Normann, David Nutt, Stefano Pallanti, Luca Pani, Brenda W. J. H. Penninx, Alan F. Schatzberg, Richard C. Shelton, Lakshmi N. Yatham, Allan H. Young, Roland Zahn, Georgios Aislaitner, Florence Butlen-Ducuing, Christine Fletcher, Marion Haberkamp, Thomas Laughren, Fanni-Laura Mantyla, Koen Schruers, Andrew Thomson, Gara Arteaga-Henriquez, Francesco Benedetti, Lucinda Cash-Gibson, Woo Ri Chae, Heidi De Smedt, Stefan M. Gold, Witte J. G. Hoogendijk, Valeria Jordan Mondragon, Eduard Maron, Jadwiga Martynowicz, Elisa Melloni, Christian Otte, Gabriela Perez-Fuentes, Sara Poletti, Mark E. Schmidt, Edwin van de Ketterij, Katherine Woo, Yanina Flossbach, J. Antoni Ramos-Quiroga, Adam J. Savitz, Carmine M. Pariante
Summary: The document discusses the criteria for treatment-resistant depression (TRD) and partially responsive depression (PRD) as subtypes of major depressive disorder (MDD) which are not clearly defined, using a Delphi-method-based consensus approach. It reviews literature and gathers international experts to evaluate controversies and provide recommendations on designing clinical trials and guiding research. It aims to support the design of a protocol for platform trials of new medications for TRD/PRD as part of the EUropean Patient-cEntric clinicAl tRial pLatforms, Innovative Medicines Initiative (EU-PEARL, IMI) MDD project.
MOLECULAR PSYCHIATRY
(2022)
Letter
Biochemistry & Molecular Biology
Jelena Brasanac, Stefanie Gamradt, Christian Otte, Yuri Milaneschi, Anna S. Monzel, Martin Picard, Stefan M. Gold
MOLECULAR PSYCHIATRY
(2022)
Review
Clinical Neurology
Melanie Filser, Axel Buchner, Gereon Rudolf Fink, Stefan M. Gold, Iris-Katharina Penner
Summary: Patients with multiple sclerosis (MS) are at increased risk of experiencing mental health problems, including depression and anxiety. However, there is limited knowledge about the assessment and association of these affective symptoms in MS. Further research is needed to improve diagnosis and care.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Arzu Ceylan Has Silemek, Guido Nolte, Jana Poettgen, Andreas K. Engel, Christoph Heesen, Stefan M. Gold, Jan-Patrick Stellmann
Summary: This study aimed to explore the longitudinal reorganization of brain networks in multiple sclerosis (MS) patients over a period of 2 years, and analyze its association with cognition. The results showed a decline in hub connectivity and global connectivity at a structural level in MS patients, while the hub connectivity in the default-mode network was preserved. In addition, the network models based on functional MRI and magnetoencephalography were similar to diffusion tensor imaging, but had weaker associations with cognition in MS patients.
JOURNAL OF NEUROSCIENCE RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Ke Chen, Torsten Wuestenberg, Victoria Stiglbauer, Linda El-Ahmad, Annika Rosenthal, Patricia Pelz, Stefan M. Gold, Andreas Heinz, Miriam Sebold
Summary: Social exclusion contributes to alcohol consumption and can lead to the exclusion of people with alcohol dependence (AD), while AD can also cause social exclusion. Previous research has found that patients with AD exhibit altered neural responses to experimental social exclusion. Our study aimed to investigate the behavioral response and inflammatory effects of social exclusion in male patients with a history of AD. We analyzed ball tossing behavior and the cytokine interleukin (IL)-1b levels in saliva before and after a Cyberball game among AD patients and healthy controls. The results revealed a distinct dynamic behavioral response to social exclusion in male patients with a history of AD.
Article
Clinical Neurology
Woo Ri Chae, Jens Baumert, Julia Nuebel, Jelena Brasanac, Stefan M. Gold, Ulfert Hapke, Christian Otte
Summary: Inflammation and metabolic dysregulations are likely to underlie atypical depressive symptoms such as appetite and sleep alterations. This study aimed to replicate associations between individual depressive symptoms and immunometabolic markers, extend previous findings with additional markers, and evaluate their relative contribution to depressive symptoms. The results indicated that appetite alterations and insomnia were the most important symptoms associated with metabolic markers.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Penelope Tilsley, Isanbert Arun Strohmeyer, Inga Heinrich, Friederike Rosenthal, Stefan Patra, Karl Heinz Schulz, Sina C. Rosenkranz, Caren Ramien, Jana Poettgen, Christoph Heesen, Arzu Ceylan Has, Stefan M. Gold, Jan-Patrick Stellmann
Summary: The aim of this study was to explore the interaction between fitness, brain networks, and disability in progressive MS. The results showed that exercise increased functional connectivity in highly connected brain regions, but no structural changes were observed. The correlation between fitness and functional outcomes was influenced by connectivity, especially in more disrupted brain networks.
JOURNAL OF NEUROLOGY
(2023)
Review
Clinical Neurology
Charlotte Schubert, Lea Steinberg, Julia Peper, Caren Ramien, Kerstin Hellwig, Sascha Koepke, Alessandra Solari, Andrea Giordano, Stefan M. Gold, Tim Friede, Christoph Heesen, Anne Christin Rahn
Summary: The influence of pregnancy on the course of multiple sclerosis has long been controversial. Recent research shows that women with MS have a significantly increased relapse rate in the first 6 months postpartum, but a decreased relapse rate at 10-12 months postpartum. Disease-modifying therapies and exclusive breastfeeding play important roles in influencing postpartum relapse risk.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Review
Psychiatry
Ole Kohler-Forsberg, Victoria Stiglbauer, Jelena Brasanac, Woo Ri Chae, Frederike Wagener, Kim Zimbalski, Oskar H. Jefsen, Shuyan Liu, Malik R. Seals, Stefanie Gamradt, Christoph U. Correll, Stefan M. Gold, Christian Otte
Summary: This umbrella systematic review and meta-analysis aimed to evaluate the efficacy and safety of antidepressant use in populations with medical diseases and comorbid depression. The results showed that antidepressants are effective and safe in treating and preventing depression in patients with comorbid medical disease.
Article
Clinical Neurology
Julia Peper, Sascha Kopke, Alessandra Solari, Andrea Giordano, Stefan M. Gold, Kerstin Hellwig, Lea Steinberg, Anke Steckelberg, Christoph Heesen, Anne Christin Rahn
Summary: This study aimed to assess the measurement properties of two patient-reported outcome measures on motherhood choice in MS and explore the information and support needs of women with MS concerning motherhood. The results suggested that both questionnaires were suitable and acceptable measures for assessing knowledge and worries about motherhood/pregnancy in MS. The findings emphasized the importance of providing evidence-based information on motherhood in MS to increase knowledge, reduce worries, and support women with MS in making informed decisions.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Medical Informatics
Stefan M. Gold, Tim Friede, Bjoern Meyer, Rona Moss-Morris, Joanna Hudson, Susanna Asseyer, Judith Bellmann-Strobl, Andreas Leisdon, Leonie Issels, Kristin Ritter, David Schymainski, Hayley Pomeroy, Sharon G. Lynch, Julia S. Cozart, Joan Thelen, Cristina A. F. Roman, Margaret Cadden, Erin Guty, Stephanie Lau, Jana Poettgen, Caren Ramien, Susan Seddiq-Zai, Anna-Maria Kloidt, Johannes Wieditz, Iris-Katharina Penner, Friedemann Paul, Nancy L. Sicotte, Jared M. Bruce, Peter A. Arnett, Christoph Heesen
Summary: Depression is more common in patients with neurological and inflammatory disorders. This study evaluated the safety and efficacy of an internet-based cognitive behavioural therapy program specific to multiple sclerosis in reducing depressive symptoms. The results showed that the program significantly reduced depressive symptoms, providing a new treatment option for patients with multiple sclerosis.
LANCET DIGITAL HEALTH
(2023)
Article
Clinical Neurology
Nicole Krause, Karin Riemann-Lorenz, Anne Christin Rahn, Jana Poettgen, Sascha Koepke, Bjoern Meyer, Frithjof Thale, Herbert Temmes, Markus van de Loo, Stefan M. Gold, Christoph Heesen
Summary: This study aimed to develop and investigate a new digital health application that provides evidence-based lifestyle information for multiple sclerosis (MS) patients and engages them in behavior change techniques. The results showed that the application was perceived as understandable, trustworthy, and relevant, and it was found to be helpful in supporting patients in adapting to their diagnosis and making lifestyle changes.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Clinical Neurology
Lil Meyer-Arndt, Joseph Kuchling, Jelena Brasanac, Andrea Hermann, Susanna Asseyer, Judith Bellmann-Strobl, Friedemann Paul, Stefan M. Gold, Martin Weygandt
Summary: This study reveals that depression in multiple sclerosis patients is characterized by impaired neurobehavioral emotion regulation, and the relationship between neural emotion regulation and depression is influenced by lesion load.
BRAIN COMMUNICATIONS
(2022)
Article
Clinical Neurology
Jelena Brasanac, Stefan Hetzer, Susanna Asseyer, Joseph Kuchling, Judith Bellmann-Strobl, Kristin Ritter, Stefanie Gamradt, Michael Scheel, John-Dylan Haynes, Alexander U. Brandt, Friedemann Paul, Stefan M. Gold, Martin Weygandt
Summary: Researchers have found a link between central stress processing and T-cell stress hormone sensitivity in multiple sclerosis patients, which is related to disease severity. This suggests that altered CNS-immune system crosstalk in multiple sclerosis has clinical significance.
BRAIN COMMUNICATIONS
(2022)