Review
Optics
Renata Goncalves Rando, Daniela Vieira Buchaim, Paula Cristina Cola, Rogerio Leone Buchaim
Summary: Alveolar bone repair is a vital and intricate process for restoring functions such as mastication, occlusion, and implant osseointegration. Various methods including biomaterial grafting, platelet-rich fibrin (PRF), and low-level laser therapy (LLLT) have been investigated to optimize this process. This review analyzed the use of LLLT as an auxiliary tool in alveolar bone repair, and found that it promotes repair by enhancing ATP production, activating growth factors, reducing inflammation, and inducing angiogenesis. The Gallium Aluminum Arsenide-GaAlAs laser with a wavelength of 830 nm was found to be the most effective. Overall, PBM with LLLT has beneficial effects on alveolar bone repair, accelerating the formation of new bone matrix and preserving or increasing the height and/or thickness of the alveolar bone ridge.
Review
Medicine, General & Internal
Jia-You Wang, Zou-Qin Huang, Hai-Ping Deng, Ling Zhao, Hong-Yong Deng, Jian-Ping Liu, Xue-Yong Shen, Ke Cheng
Summary: This systematic review and meta-analysis aims to evaluate the effects and safety of low level light therapy (LLLT)/photobiomodulation for diabetic peripheral neuropathy (DPN). Randomised controlled trials will be included, and the synthesized results will be used to assess pain change and other secondary outcomes, as well as explore the influence of possible clinical and methodological characteristics.
Review
Surgery
Graeme E. Glass
Summary: Light energy is now being utilized in therapy through photobiomodulation (PBM), a phenomenon that is becoming increasingly commercialized. The lack of regulatory standards makes it challenging to determine the efficacy and safety of PBM, necessitating further research for validation.
JOURNAL OF PLASTIC RECONSTRUCTIVE AND AESTHETIC SURGERY
(2021)
Article
Oncology
Ori Finfter, Batia Avni, Sigal Grisariu, Yaron Haviv, Chen Nadler, Ori Rimon, Yehuda Zadik
Summary: Photobiomodulation therapy (PBMt) appears to be a promising treatment for refractory oral cGVHD lesions, providing rapid pain relief with relatively long-lasting effects. In this study, most patients reported a significant reduction in pain levels after treatment, with no adverse effects reported.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Health Care Sciences & Services
Mohammad Khursheed Alam, Kiran Kumar Ganji, Ahmed Ali Alfawzan, Srinivas Munisekhar Manay, Kumar Chandan Srivastava, Prabhat Kumar Chaudhari, Hala A. Hosni, Haytham Jamil Alswairki, Reem Ahmed Alansari
Summary: This study evaluates the role of low-level laser emission/photobiomodulation in quantitative measurements of root resorption. The results show that certain treatment interventions lead to significantly higher levels of root resorption, indicating the need for further investigation into specific causes.
Article
Oncology
Douglas Magno Guimaraes, Tamara Melo Nunes Ota, Diego Assuncao Calixto Da Silva, Fabio De Lucas Da Silva Almeida, Tatiana Dias Schalch, Alessandro Melo Deana, Jose Miguel Alves Junior, Kristianne Porta Santos Fernandes
Summary: This study compared the efficacy of LLLT and LEDT for prevention and treatment of oral mucositis, finding that LEDT has similar effects to LLLT in reducing symptoms of oral mucositis. Therefore, LEDT could be considered as an alternative option for preventing and treating oral mucositis.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Surgery
Graeme Ewan Glass
Summary: LLLT has shown clinical efficacy in skin rejuvenation, acne vulgaris, alopecia, and body contouring, but challenges remain in regulating and standardizing this therapy. The existing body of clinical evidence supports the effectiveness of low-energy red/near-infrared light, but methodological flaws and industry funding require improvement in evidence quality. The use of light-emitting diode sources and their comparative physiological effects to laser-based systems need further investigation in high-quality, independent clinical trials.
AESTHETIC SURGERY JOURNAL
(2021)
Review
Engineering, Biomedical
Alexandra Melo Pingarilho Carneiro, Antonia Patricia Oliveira Barros, Roberta Pimentel de Oliveira, Brennda Lucy Freitas de Paula, Aryvelto Miranda Silva, Cristiane de Melo Alencar, Cecy Martins Silva
Summary: The authors conducted a systematic review to evaluate the effectiveness of low-level laser therapy (LLLT) in preventing tooth sensitivity after tooth whitening. The analyzed studies indicated that LLLT shows promise in preventing tooth sensitivity, but more high-quality clinical trials are needed to reach a definitive conclusion.
LASERS IN MEDICAL SCIENCE
(2022)
Review
Ophthalmology
Maria Markoulli, Nivaasheni Chandramohan, Eric B. Papas
Summary: Dry eye disease is a common complaint in clinical practice, with evaporative dry eye often caused by meibomian gland dysfunction. Treatments for this dysfunction include warm compress therapy, eyelid hygiene, and artificial tears. Low-level light therapy, or photobiomodulation, is a new in-office treatment that may promote tissue repair and pain relief.
CLINICAL AND EXPERIMENTAL OPTOMETRY
(2021)
Review
Engineering, Biomedical
Taina Caroline dos Santos Malavazzi, Kristianne Porta Santos Fernandes, Talita Christine Camilo Lopez, Maria Fernanda Setubal Destro Rodrigues, Anna Carolina Ratto Tempestini Horliana, Sandra Kalil Bussadori, Raquel Agnelli Mesquita-Ferrari
Summary: Systemic photobiomodulation (PBM) involving intravascular laser irradiation of blood (ILIB) or non-invasive vascular photobiomodulation (VPBM) using low-level laser (LLL) has various positive effects on inflammation, tissue repair, atherosclerosis, and arterial hypertension. The literature review evaluated the use of VPBM with LLL in animal models and found positive effects on arterial pressure, blood circulation, blood composition, hematological markers, and tissue repair. However, there is a lack of standardization in the dosimetric parameters, calling for further research in this area.
LASERS IN MEDICAL SCIENCE
(2023)
Article
Oncology
Joel B. Epstein, Judith E. Raber-Durlacher, Geena L. Epstein, Mette D. Hazenberg, Dimitrios Tzachanis, Ricardo T. Spielberger
Summary: This study provides long-term follow-up of patients with chronic symptomatic oral chronic graft-versus-host-disease (cGVHD) managed with photobiomodulation therapy (PBM therapy. The results show that PBM therapy is effective in controlling oral sensitivity and mucosal changes in cGVHD, with treatment frequency individualized for optimal control of symptoms and signs.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Engineering, Biomedical
Evdoxia Mathioudaki, Michail Rallis, Konstantinos Politopoulos, Eleni Alexandratou
Summary: This study investigates the effectiveness of low power red light in accelerating wound healing in an in vitro keratinocyte scratch assay model and sheds light on the role of light irradiation parameters and wound closure mechanisms. The results show that low level laser light can enhance cell proliferation and migration, potentially stimulating wound healing.
ANNALS OF BIOMEDICAL ENGINEERING
(2023)
Review
Biology
Thais P. Prado, Flavia Cristina Zanchetta, Beatriz Barbieri, Caroline Aparecido, Maria Helena Melo Lima, Eliana P. Araujo
Summary: Photobiomodulation is a healing technique that uses light irradiation. This review investigates the effect of blue light on the healing process. The analysis of 22 articles shows that low energy density (<20 J/cm(2)) stimulates cell types and proteins involved in healing, while high energy density (20.6-50 J/cm(2)) significantly reduces cell proliferation, migration, and metabolism. The variety of device parameters makes it difficult to determine the optimal technical specifications, suggesting the need for further studies.
Article
Rehabilitation
Marcelo F. De Oliveira, Douglas S. Johnson, Timothy Demchak, Shaiane S. Tomazoni, Ernesto C. Leal-Junior
Summary: Pain is a common reason for seeking medical help and for missing work or school. Over the years, doctors have increasingly prescribed opioids for pain management, but this can lead to side effects and dependence. Photobiomodulation therapy, using low-intensity LASER and LED, has been proposed as a safe and side-effect-free alternative for pain and inflammation. Studies have shown that it can reduce pain in various musculoskeletal conditions.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Chemistry, Physical
Shuang-Qiao Sun, Jing-Jing Shen, Yu-Fei Wang, Yu-Tong Jiang, Lin-Fu Chen, Hua Xin, Jiang-Nan Wang, Xiao-Bo Shi, Xiao-Zhao Zhu, Qi Sun, Liang-Sheng Liao, Qian Chen, Man-Keung Fung, Shuit-Tong Lee
Summary: The use of red OLED as a PBMT for hair growth has shown promising results and is considered a non-invasive therapeutic option for hair loss.
Article
Oncology
Natalia Rangel Palmier, Adriana Franco Paes Leme, Tatiane De Rossi, Guilherme Pimentel Telles, Karina Morais-Faria, Luiz Paulo Kowalski, Gustavo Nader Marta, Thais Bianca Brandao, Praveen R. Arany, Cesar Augusto Migliorati, Alan Roger Santos-Silva, Ana Carolina Prado-Ribeiro
Summary: The study evaluated the abundance of salivary A1AT and MIF in patients with oral mucositis and found a significant correlation with the severity of oral mucositis. The results suggest the potential use of salivary MIF and A1AT levels as prognostic markers for effective therapeutic interventions.
SUPPORTIVE CARE IN CANCER
(2021)
Article
Biochemistry & Molecular Biology
Andrea Amaroli, Praveen Arany, Claudio Pasquale, Stefano Benedicenti, Alessandro Bosco, Silvia Ravera
Summary: The therapeutic potential of photobiomodulation therapy in various medical fields has been discussed, with a focus on the enzymatic mechanisms involved. The study aimed to improve photobiomodulation devices and delivery methods by comparing different hand-pieces for treatment. Results showed that the novel flat-top hand-piece prototype provided a more uniform distribution of power density compared to standard hand-pieces, leading to enhanced ATP synthesis in treated areas and potentially improving clinical outcomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
Felipe Martins Silveira, Tuany Rafaeli Schmidt, Bruna Neumann, Clevia Rosset, Virgilio Gonzales Zanella, Gerson Schulz Maahs, Marco Antonio Trevizani Martins, Praveen Arany, Vivian Petersen Wagner, Marcio Ajudarte Lopes, Alan Roger Santos-Silva, Manoela Domingues Martins
Summary: This study evaluated the impact of photobiomodulation therapy (PBMT) in an oral squamous cell carcinoma (OSCC) patient-derived xenograft (OSCC-PDX) model. The results showed that PBMT did not affect tumor behavior. This is an important clinical outcome for assessing the safety of PBMT in cancer patients.
Article
Biochemical Research Methods
Nicholas C. Young, Vinicius Maximiano, Praveen R. Arany
Summary: This study investigated the effects of different wavelengths on odontoblast differentiation and found that certain wavelengths can increase alkaline phosphatase (ALP) activity. However, using equivalent photon fluence dosing significantly improved the results. These findings suggest that considering wavelength-specific photon energy transfer is important for enhancing the effectiveness and safety of PBM treatments.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Dentistry, Oral Surgery & Medicine
Jaewon Kim, Yu-Chun Lin, Michael Danielak, Minh Van, Du-Hyeong Lee, Hyeongil Kim, Praveen R. Arany
Summary: Progress in additive 3D printing is transforming biomaterial manufacturing in the field of clinical dentistry and prosthodontics. Using digital techniques and CAD software, surgical guides for crown lengthening can be produced with comparable effectiveness to conventional methods. However, further research is needed to address concerns regarding proximal bone reduction.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2022)
Article
Optics
Rodrigo Crespo Mosca, Sofia Nascimento Santos, Gesse Eduardo Calvo Nogueira, Daisa Lima Pereira, Francielli Campos Costa, Jonathas Xavier Pereira, Carlos Alberto Zeituni, Praveen Ravindra Arany
Summary: The use of photobiomodulation (PBM) therapy in radiation brachytherapy has shown promising results in reducing localized skin damage and improving healing. This study conducted on athymic mice demonstrated that both red and near-infrared PBM treatments significantly reduced incidence and severity of skin radionecrosis and improved functional parameters. This is the first report on the successful use of PBM therapy in brachytherapy.
Article
Biochemistry & Molecular Biology
Gagana Karkada, G. Arun Maiya, Praveen Arany, K. G. Mohandas Rao, Shalini Adiga, Shobha U. Kamath
Summary: This study aimed to establish the dose-response relationship of photobiomodulation therapy on the healing dynamics of diabetic neuropathic ulcers. The findings suggest that photobiomodulation therapy with dosages of 4, 6, and 8 J cm(-2) showed better wound healing properties with optimized levels of matrix metalloproteinases-1 and 8.
PHOTOCHEMISTRY AND PHOTOBIOLOGY
(2023)
Article
Biology
Marina Cecilia Gimenez, Michelle Luxwolda, Eila G. Van Stipriaan, Pauline P. Bollen, Rieks L. Hoekman, Marthe A. Koopmans, Praveen R. Arany, Michael R. Krames, Anne C. Berends, Roelof A. Hut, Marijke C. M. Gordijn
Summary: In Western societies, people's indoor lifestyle and limited exposure to sunlight can have negative effects on their health and well-being. This study investigated the benefits of near-infrared light exposure in improving well-being and health, especially in winter when sunlight is less available. The results highlight the potential of incorporating near-infrared light technology into daily life for a healthier society.
Article
Endocrinology & Metabolism
Gagana Karkada, G. Arun Maiya, Praveen Arany, K. G. Mohandas Rao, Shalini Adiga, Shobha U. Kamath
Summary: Photobiomodulation therapy is effective in treating diabetic neuropathic ulcers and improves oxidative stress. There is a strong dose-response relationship in the wound healing dynamics of the experimental groups treated with 4, 6, and 8 J/cm(2) dosages.
JOURNAL OF DIABETES AND METABOLIC DISORDERS
(2022)
Article
Biochemical Research Methods
Robert Bowen, Praveen. R. R. Arany
Summary: There is growing recognition of the persistent symptoms such as chronic fatigue and brain fog following COVID-19 infection. This study explored the effectiveness of photobiomodulation (PBM) therapy using two devices: a transcranial helmet and a whole-body light bed. Significantly improved cognitive performance was observed after PBM therapy, as supported by EEG analysis. This study highlights the potential benefits of PBM therapy in treating post-COVID-19 brain fog.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Dermatology
Sunayana Begum Syed, Ismayil Ahmet, Khalid Chakir, Christopher H. Morrell, Praveen R. Arany, Edward G. Lakatta
Summary: Photobiomodulation (PBM) therapy has shown promising effects in mitigating age-associated cardiovascular changes, improving cardiac function and neuromuscular coordination, and increasing longevity. However, further studies and clinical trials are needed for mechanistic understanding and effective translation to human applications.
LASERS IN SURGERY AND MEDICINE
(2023)
Review
Oncology
Margherita Gobbo, Praveen R. Arany, Elisabetta Merigo, Rene-Jean Bensadoun, Alan Roger Santos-Silva, Luiz Alcino Gueiros, Giulia Ottaviani
Summary: The role of photobiomodulation (PBM) in head and neck cancer (HNC) treatment was investigated. PBM showed beneficial effects in improving quality of life (QoL), nutritional status, reducing pain and functional impairment. It may also reduce interruptions in radiotherapy (RT) and improve cancer treatment outcomes. However, it does not directly impact cancer survival/recurrences. PBM should be included in supportive cancer care for HNC patients due to its efficacy, safety, feasibility, and tolerability.
SUPPORTIVE CARE IN CANCER
(2023)
Article
Engineering, Biomedical
Natalia Pieretti Bueno, Cecilia Cardoso Kfouri, Isabella Nunes Copete, Fabiola Singaretti de Oliveira, Praveen Arany, Marcia Martins Marques, Emanuela Prado Ferraz
Summary: Diabetes negatively affects the osteogenic potential of bone marrow mesenchymal stem cells, leading to increased adipocyte differentiation. Photobiomodulation therapy can improve this condition by promoting osteoblast differentiation and potentially optimizing bone regeneration in diabetic patients.
LASERS IN MEDICAL SCIENCE
(2022)
Article
Cell & Tissue Engineering
Saeed Ur Rahman, Sasikumar Ponnusamy, Malvika Nagrath, Praveen R. Arany
Summary: The study demonstrates the efficacy of a modular combinatorial scaffold system in promoting MSC adhesion and proliferation for dentin regeneration. The scaffold system selectively induces differentiation into either dentin or bone, offering a promising approach for preserving tooth pulp vitality.
JOURNAL OF TISSUE ENGINEERING
(2022)
Article
Surgery
Praveen R. Arany
Summary: The review discusses the central role of the TGF-beta pathway in various physiological processes and the challenges faced in developing targeted therapeutics. The use of photobiomodulation (PBM) treatments for selectively activating endogenous latent TGF-beta 1 offers a novel therapeutic approach with growing evidence for its potential roles in cancer immunotherapy and stem cell biology.
PHOTOBIOMODULATION PHOTOMEDICINE AND LASER SURGERY
(2022)
