Article
Endocrinology & Metabolism
Rachel M. B. Bell, Elisa Villalobos, Mark Nixon, Allende Miguelez-Crespo, Lee Murphy, Angie Fawkes, Audrey Coutts, Matthew G. F. Sharp, Martha Koerner, Emma Allan, Onno C. Meijer, Rene Houtman, Alex Odermatt, Katharina R. Beck, Scott G. Denham, Patricia Lee, Natalie Z. M. Homer, Brian R. Walker, Ruth A. Morgan
Summary: Carbonyl reductase 1 regulates glucocorticoid and mineralocorticoid receptor activation in adipose tissue, influencing glucose homeostasis in lean mice.
MOLECULAR METABOLISM
(2021)
Article
Neurosciences
Seungjae Zhang, Myunghyun Cheon, Hoyong Park, Taejoon Kim, ChiHye Chung
Summary: FKBP5 is a protein that inhibits the translocation of the glucocorticoid receptor, and its expression is related to psychiatric disorders. Deletion of FKBP5 in the brain makes rodents resilient to stress-induced depression. Our study found that FKBP5 deletion in the hippocampus causes changes in synaptic transmission and insensitivity to activated glucocorticoid receptors.
Article
Biochemistry & Molecular Biology
Wladimir A. Corrales, Juan P. Silva, Claudio S. Parra, Felipe A. Olave, Felipe Aguayo, Luciano Roman-Albasini, Esteban Aliaga, Leslye Venegas-Zamora, Ana M. Avalos, Paulina S. Rojas, Vinicius Maracaja-Coutinho, Robert H. Oakley, John A. Cidlowski, Jenny L. Fiedler
Summary: The study revealed a sex-biased effect of corticosterone on hippocampal miRNA expression in rats, which may play a role in shaping the basal sex differences observed at higher levels of hippocampal functioning.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Pharmacology & Pharmacy
Cory Langreck, Eric Wauson, Dakota Nerland, Brad Lamb, Tyler Folkerts, Lori Winter, Eileen Lu, Sarah Tague, Kenneth E. McCarson, Jonathan E. Ploski, Mounira Banasr, Ronald S. Duman, Miranda M. Roland, Victor Babich, Francesca Di Sole, Vanja Duric
Summary: The study indicates that hippocampal mitogen-activated protein kinase phosphatase-1 (MKP-1) plays a crucial role in connecting brain dysfunction with systemic illness under stress. Chronic corticosterone (CORT) treatment results in behavioral emotionality and systemic pathophysiological effects, including elevated renal inflammation protein markers.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Biology
Shihui Guo, Zijin Chen, Yingying Dong, Yingdong Ni, Ruqian Zhao, Wenqiang Ma
Summary: Copper is essential for human health, but chronic stress can lead to disorders in copper metabolism. In this study, it was found that corticosterone impairs copper transport by down-regulating intestinal CTR1 expression via GR-mediated transcriptional inhibition. This study provides a theoretical basis for regulating copper homeostasis under chronic stress.
Article
Neurosciences
Pamela Toh, Lucia A. Seale, Marla J. Berry, Daniel J. Torres
Summary: Abnormal activation of the stress-response system in early life can cause long-term neurological changes. High levels of glucocorticoids can promote oxidative damage in the brain. Selenium, an essential trace element, can mitigate this damage by synthesizing antioxidant selenoproteins. This study demonstrates that early life exposure to excess glucocorticoid levels can alter selenoprotein levels in the developing brain.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Neurosciences
David E. Ehichioya, S. K. Tahajjul Taufique, Chikodi N. Anigbogu, Smith Jaja
Summary: Poor maternal sleep quality during different phases of pregnancy can impact fetal development. This study found that maternal sleep deprivation in early and late pregnancy can have adverse effects on the hypothalamic-pituitary-adrenal (HPA) axis in female offspring.
Article
Cell Biology
Emily T. Stoneham, Daniel G. McHail, Sabina Samipour-Biel, Nicole Liehr, Christina M. Lee, Jean C. Evans, Katelyn Boggs, Theodore C. Dumas
Summary: The study compared the effects of two common maternal deprivation schedules on cognitive ability in young rats, finding that daily separation impaired spatial learning, while randomly spaced separation did not affect maze performance. Additionally, some biological effects were observed, such as differences in body weight and thymus weight normalized by body weight.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Delcio E. Paula, Fabiana C. Vilela, Alexandre Giusti-Paiva
Summary: The study found that a ghrelin receptor antagonist can alleviate sickness syndrome induced by LPS, including social withdrawal, anhedonia, depressive-like behavior, and anorexia, but has no effect on LPS-induced fever.
Article
Biochemistry & Molecular Biology
Katlyn J. An, Ashley N. Hanato, Katherine W. Hui, Matthew W. Pitts, Lucia A. Seale, Jessica L. Nicholson, Pamela Toh, Jun Kyoung Kim, Marla J. Berry, Daniel J. Torres
Summary: The use of glucocorticoid medications can cause metabolic side effects such as overeating, weight gain, and insulin resistance. The hypothalamus, a regulator of feeding behavior and energy expenditure, is responsive to glucocorticoids and may play a role in metabolic defects. Selenium has been found to counter the effects of glucocorticoids and is important for hypothalamic function. This study aimed to investigate if selenium could protect hypothalamic cells from dysfunction caused by glucocorticoid exposure.
Article
Biochemistry & Molecular Biology
Xuan Zhang, Yinghui Wei, Xiaoxuan Li, Chengyu Li, Liangliang Zhang, Zhaojun Liu, Yan Cao, Weijian Li, Xiying Zhang, Jiaqing Zhang, Ming Shen, Honglin Liu
Summary: CORT inhibits Lhcgr expression in mouse ovarian granulosa cells (GCs), leading to impaired follicular development. The effect of CORT is mediated by its receptor Nr3c1 in GCs. Nr3c1 may regulate Lhcgr transcription by inhibiting the expression of Lhcgr transcription factors AP1 and Creb.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Thaddeus M. Barney, Andrew S. Vore, Sarah L. Trapp, Cristal L. Finkenberg, Dominique R. Pugliesi, Megha M. Schmalzle, Shani H. Evans, Elena Varlinskaya, Terrence Deak
Summary: Binge drinking causes rapid changes in neuroimmune gene expression and activates the hypothalamic-pituitary-adrenal axis. Inhibiting the synthesis of corticosterone can prevent the gene expression changes caused by ethanol. Ethanol can suppress the expression of IL-1 beta and TNF alpha in the hippocampus through the release of corticosterone. These findings provide potential interventions to reduce alcohol intake and alleviate ethanol-induced neuroimmune activation.
Article
Endocrinology & Metabolism
Jan Kroon, Maaike Schilperoort, Wietse In Het Panhuis, Rosa van den Berg, Lotte van Doeselaar, Cristy R. C. Verzijl, Nikki van Trigt, Isabel M. Mol, Hetty H. C. M. Sips, Jose K. van den Heuvel, Lisa L. Koorneef, Ronald J. van der Sluis, Anna Fenzl, Florian W. Kiefer, Sabine Vettorazzi, Jan P. Tuckermann, Nienke R. Biermasz, Onno C. Meijer, Patrick C. N. Rensen, Sander Kooijman
Summary: This study demonstrates that the physiological rhythm of glucocorticoids plays a crucial role in regulating BAT function, and long-term flattening of corticosterone levels can lead to adiposity.
MOLECULAR METABOLISM
(2021)
Article
Agriculture, Dairy & Animal Science
T. Bartels, J. Berk, K. Cramer, E. Kanitz, W. Otten
Summary: The study analyzed the effects of corticosterone supplementation on feather corticosterone concentrations (fCORT) in layer pullets, finding that increased corticosterone levels led to decreased body weight, shorter and lighter feathers, and a delayed molt. The results suggest that fCORT measurement can be a useful tool for evaluating long-term stress in chickens and may have implications for animal welfare research.
Article
Pharmacology & Pharmacy
Bin Zhang, Mengshi Yang, Qiongyu Yan, Xiaojian Xu, Fei Niu, Jinqian Dong, Yuan Zhuang, Shenghua Lu, Qianqian Ge, Baiyun Liu
Summary: The study found that different doses of corticosterone have dual effects on hippocampal cell survival and spatial memory in rats, with low doses improving cell survival and memory, while high doses may have the opposite effect. This suggests that endogenous glucocorticoids have neuroprotective and neurotoxic effects depending on the threshold level, and caution should be exercised with higher doses after traumatic brain injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Clinical Neurology
Marlena Wosiski-Kuhn, Miles S. Lyon, James Caress, Carol Milligan
Review
Clinical Neurology
Miles S. Lyon, Marlena Wosiski-Kuhn, Rachel Gillespie, James Caress, Carol Milligan
Article
Clinical Neurology
Sapna Pathak, James B. Caress, Marlena Wosiski-Kuhn, Carol Milligan, Delaney Williams, Michael S. Cartwright
Article
Neurosciences
Masaki Yamamoto, De-Huang Guo, Caterina M. Hernandez, Alexis M. Stranahan
JOURNAL OF NEUROSCIENCE
(2019)
Article
Clinical Neurology
Marlena Wosiski-Kuhn, Mac Robinson, Jane Strupe, Phonepasong Arounleut, Matthew Martin, James Caress, Michael Cartwright, Robert Bowser, Merit Cudkowicz, Carl Langefeld, Gregory A. Hawkins, Carol Milligan
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2019)
Article
Medicine, Research & Experimental
De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Alexis M. Stranahan
JOURNAL OF CLINICAL INVESTIGATION
(2020)
Review
Cell Biology
Mark W. Hamrick, Alexis M. Stranahan
AGEING RESEARCH REVIEWS
(2020)
Article
Clinical Neurology
Marlena Wosiski-Kuhn, James B. Caress, Michael S. Cartwright, Gregory A. Hawkins, Carol Milligan
Summary: In this longitudinal study, it was found that IL6 levels are negatively correlated with the functional status and respiratory function in ALS patients, specifically in those carrying the IL6R(358)Ala variant. This suggests that the association between IL6 and ALS is driven by genetic factors, and targeted therapeutic approaches may be more effective in this subset of patients.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION
(2021)
Article
Clinical Neurology
Carol Milligan, Nazem Atassi, Suma Babu, Richard J. Barohn, James B. Caress, Merit E. Cudkowicz, Armineuza Evora, Gregory A. Hawkins, Marlena Wosiski-Kuhn, Eric A. Macklin, Jeremy M. Shefner, Zachary Simmons, Robert P. Bowser, Shafeeq S. Ladha
Summary: The study aimed to investigate the safety, tolerability, and target engagement of tocilizumab in ALS patients. Results showed a significant decrease in CRP levels in the treatment group, with potential CSF effects associated with IL-6R genotype. However, no differences were observed between groups in terms of PBMC gene expression and clinical measures.
Article
Multidisciplinary Sciences
De-Huang Guo, Masaki Yamamoto, Caterina M. Hernandez, Hesam Khodadadi, Babak Baban, Alexis M. Stranahan
Summary: The study demonstrates that beige adipocytes are crucial for the neuroprotective effects of subcutaneous fat, opposing cognitive decline induced by obesity and potentially involving the anti-inflammatory cytokine interleukin-4 (IL4).
NATURE COMMUNICATIONS
(2021)
Article
Urology & Nephrology
Kristin M. Ates, Rachel P. Vaizer, David C. Newton, Shuai Hao, Kathleen Mahoney, Bradley A. Morganstern
Summary: Ureteropelvic junction obstruction (UPJO) is the most common cause of urinary tract obstruction in pediatric patients, and there is debate regarding the management strategies. We present a case of a 15-year-old female patient treated with ureteral stent placement, highlighting the need for caution to avoid complications during treatment.
UROLOGY CASE REPORTS
(2021)
Article
Neurosciences
Alexis M. Stranahan
Summary: The apple-shaped anatomical pattern that comes with visceral obesity increases the risk of multiple chronic diseases, including those that affect the brain. However, it is challenging to distinguish between the consequences of visceral obesity and the metabolic and cardiovascular pathologies associated with adiposity. This review summarizes the current literature on the relationship between adipose tissue distribution and cognition, particularly in preclinical models, and discusses the potential role of tissue- and cell type-specific insulin resistance.
Review
Behavioral Sciences
Anthony Tabet, Caroline Apra, Alexis M. Stranahan, Polina Anikeeva
Summary: The nervous and immune systems are closely related and influence each other. Immune cells play important roles in shaping and pruning neuronal synapses, as well as in neuro-development and disease pathology. The maintenance of the blood-brain barrier, regulated by extracellular matrix components, can be disrupted after brain insult, leading to changes in composition. These changes and immune infiltration have detrimental effects on neurophysiology and are characteristic of certain diseases.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Shuai Hao, Kristina Cossen, Adrianna L. Westbrook, Guillermo E. Umpierrez, Priyathama Vellanki
Summary: This study found that SARS-CoV-2 infection increases the risk of diabetes and diabetic ketoacidosis in both adults and children. Additionally, during the COVID-19 pandemic, there was a higher incidence of type 2 diabetes with DKA among youth compared to the prepandemic period.
ENDOCRINE PRACTICE
(2023)
Article
Cell Biology
Hui-Ping Lin, Bhupesh Singla, WonMo Ahn, Pushpankur Ghoshal, Maria Blahove, Mary Cherian-Shaw, Alex Chen, April Haller, David Y. Hui, Kunzhe Dong, Jiliang Zhou, Joseph White, Alexis M. Stranahan, Agnieszka Jasztal, Rudolf Lucas, Brian K. Stansfield, David Fulton, Stefan Chlopicki, Gabor Csanyi
Summary: The formation of lipid-laden foam cells in atherosclerosis plays a crucial role in plaque progression and late-stage complications. This study investigates the involvement of receptor-independent macropinocytosis in arterial lipid accumulation and the pathogenesis of atherosclerosis, providing insights into a potential therapeutic strategy.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
