期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 276, 期 1-2, 页码 24-36出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2014.07.013
关键词
Microglia; Annexin-1; Phenotype; Migration; Neuronal injury
As the immune cells of the brain, microglia are crucial for the maintenance of brain function. The aims of the present study were to determine whether and how annexin-1 is able to affect microglial phenotype and migration in the lesion microenvironment. In the current experiment, we enhanced the interaction between annexin-1 and formyl peptide receptors in microglia and analyzed the function. We found that annexin-1 could polarize microglia to a beneficial phenotype and promote microglial migration to protect neurons from ischemia-like injury, and the annexin-l-mediated neuroprotective effect was dependent on the release of glutamate and ATP from the injured neurons. (C) 2014 Elsevier B.V. All rights reserved.
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