期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 261, 期 1-2, 页码 60-66出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.05.001
关键词
Parkinson's disease; MPTP; Dopaminergic degeneration; Cell polarity; Inflammation; Microglial motility
资金
- Spanish Ministry of Science [SAF2010-21274, SAF2007-062262, FIS PI10-02827, RYC-2010-06729]
- Fundacion Seneca [FS/15329/PI/10]
- CIBERNED (Centro de Investigacion Biomedica en Red sabre Enfermedades Neurodegenerativas)
Patients with Parkinson's disease show persistent microglial activation in the areas of the brain where the degeneration of dopaminergic neurons takes place. The reason for maintaining this activated state is still unknown, but it is thought that this persistent microglial activation may contribute to the degeneration of dopaminergic neurons. In this study, we report the microanatomical details of microglia and the relationship between microglia and neurons in the substantia nigra pars compacta of Parkinsonian monkeys years after insult with MPTP. We observed that microglial cells appear polarized toward dopaminergic neurons in MPTP-treated macaques compared to untreated animals and present clear phagocytic characteristics, such as engulfing gliaptic contacts, an increase in Golgi apparatus protein machinery and ball-and-chain phagocytic buds. These results demonstrate that activated microglia maintain phagocytic characteristics years after neurotoxin insult, and phagocytosis may be a key contributor to the neurodegenerative process. (C) 2013 Elsevier B.V. All rights reserved.
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