Article
Pharmacology & Pharmacy
Denglu Long, Meng Liu, Haiyang Li, Jinhuan Song, Xiaohua Jiang, Guang Wang, Xuesong Yang
Summary: The study identified that the suppression of neurogenesis induced by dysbacteriosis-derived LPS could be significantly reversed through fecal microbiota transplantation. This suggests that gut dysbacteriosis impairs embryonic neurogenesis. The NF-kappa B/IL-6 pathway may be one of the main factors triggering the downstream signaling cascade.
PHARMACOLOGICAL RESEARCH
(2021)
Editorial Material
Immunology
Travis E. Faust, Dorothy P. Schafer
Summary: The study reveals that the pro-inflammatory cytokine IL-6 specifically increases synaptogenesis in immature excitatory neurons through downstream neuronal STAT3-dependent transcriptional regulation of Rgs4.
Article
Biochemistry & Molecular Biology
Yue Peng, Qingchen Yang, Shuya Gao, Zekun Liu, Weixian Kong, Xiaohong Bian, Zhe Li, Junmei Ye
Summary: This study reveals the crucial role of Interleukin-6 (IL-6) in sepsis-induced cardiac injury and its function as an antioxidant molecule via activating the Nrf2 signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Jihye Yoo, Jiyoung Park, Darong Kim, Yeonjoo Huh, Hea-Young Park Choo, Hyun Ae Woo
Summary: By synthesizing 12 novel compounds and evaluating their biological activities, it was found that 4 compounds exhibited strong inhibitory activities on IL-1 beta and IL-6 mRNA expression. Further in vivo activity evaluation indicated that 2 compounds significantly decreased mRNA levels of IL-1 beta, IL-6, and TNF-alpha.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dentistry, Oral Surgery & Medicine
Helmut Schweikl, Sarah Weissenberger, Marialucia Gallorini, Carola Bolay, Claudia Waha, Karl - Anton Hiller, Wolfgang Buchalla
Summary: This study analyzed the formation of pro-inflammatory cytokines in dental pulp cells and pulp fibroblasts when stimulated by immunogenic components. The findings showed that the resin monomer 2-hydroxyethyl methacrylate (HEMA) disturbs the redox homeostasis and impairs the protective immune response in these cells.
Article
Immunology
Zijun Bai, Tiantian Gao, Rui Zhang, Youyuan Lu, Jinlong Tian, Tao Wang, Keke Zhao, Hanqing Wang
Summary: This study suggests that Saikosaponin C (SSc), a traditional Chinese medicine compound, has potential therapeutic effects on depressive symptoms by reducing inflammatory cytokines levels, enhancing synaptic plasticity, and alleviating chronic social defeat stress-induced depression-like behavior in mice. The mechanism of action may involve the inhibition of DNMT1 protein expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
John Benjamin W. Duncan, Swarna Basu, Pavithra Vivekanand
Summary: Interleukin-6 (IL-6) is a cytokine that regulates host immune responses. Excessive IL-6 can lead to chronic inflammatory diseases. Researchers have found that gold nanoparticles synthesized with honey can reduce the secretion of IL-6 by LPS-activated macrophages, possibly by modulating the TLR4/NF-kappa B signaling pathway. Further studies may provide new therapeutic approaches for chronic inflammation.
Article
Clinical Neurology
Audrey C. Leasure, Lindsey R. Kuohn, Kevin N. Vanent, Matthew B. Bevers, W. Taylor Kimberly, Thorsten Steiner, Stephan A. Mayer, Charles C. Matouk, Lauren H. Sansing, Guido J. Falcone, Kevin N. Sheth
Summary: Higher admission IL-6 levels in patients with spontaneous intracerebral hemorrhage are associated with worse 90-day functional outcome, larger ICH volume, and larger perihematomal edema volume.
Article
Cell Biology
Ahmed Shamloul, Gustav Steinemann, Kerrin Roos, Celine Huajia Liem, Jonathan Bernd, Thorsten Braun, Andreas Zakrzewicz, Janine Berkholz
Summary: The methyltransferase Smyd1 plays a crucial role in regulating IL-6 expression and secretion in endothelial cells by increasing NF-kappa B activity and promoting H3K4 trimethylation within the IL-6 promoter in response to LPS stimulation.
Article
Immunology
Arani Casillas-Ramirez, Marc Mico-Carnero, Alfredo Sanchez-Gonzalez, Cristina Maroto-Serrat, Andres Trostchansky, Carmen Peralta
Summary: Brain death and steatosis are risk factors for organ dysfunction or failure in liver transplantation. This study investigated the role of interleukin 6 (IL-6) and IL-10 in liver transplantation from donors after brain death, and the molecular signaling pathways involved. The results showed that brain death decreased IL-6 levels in non-steatotic grafts and IL-10 levels in steatotic grafts. IL-6 administration protected non-steatotic grafts against damage and inflammation, while IL-10 treatment reduced injury and inflammation in steatotic grafts.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Clinical Neurology
Xiao Liu, Jingjing Huang, Yuan Jiang, Zhengyu Cao, Maoxiong Wu, Runlu Sun, Zhiteng Chen, Peng Yu, Jianyong Ma, Yangxin Chen, Yuling Zhang, Jingfeng Wang
Summary: This study investigated the inflammatory biomarker profiles of psychological treatment-naive individuals and found that levels of IL-6 and IL-8 were positively correlated with symptoms of depression, suggesting they may play a role in the pathogenesis of psychological disorders. However, these associations were not significant after multiple testing. Larger and longitudinal studies are needed to confirm these findings.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Immunology
Mingya Cao, Lina Ma, Chenyang Yan, Han Wang, Mengzhe Ran, Ying Chen, Xiao Wang, Xiaonan Liang, Lihui Chai, Xia Li
Summary: The expression of Ocilrp2 in macrophages is regulated by LPS stimulation and VSV infection. Silencing Ocilrp2 results in increased IL-6 expression, while over-expression of Ocilrp2 leads to decreased IL-6 expression. Furthermore, the binding of Ocilrp2 to Syk plays a critical role in regulating the expression of inflammatory cytokines in macrophages.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Dominik Langgartner, Raphael Winkler, Jonas Brunner-Weisser, Nicolas Rohleder, Marc N. N. Jarczok, Harald Guendel, Katja Weimer, Stefan O. O. Reber
Summary: Ex vivo culturing of isolated PBMCs from individuals vaccinated with the COVID-19 vaccine BNT162b1 showed enhanced T cell response to the RBD of the SARS-CoV-2 spike protein. The study also investigated the long-lasting effects of COVID-19 vaccination on various physiological and immunological parameters. The results showed significant increases in IL-6 secretion in vaccinated individuals compared to non-vaccinated individuals.
SCIENTIFIC REPORTS
(2023)
Review
Clinical Neurology
Molly Monsour, Davide Marco Croci, Siviero Agazzi
Summary: This literature review examines the role of IL-6 in neuroinflammation induced by TBI or PTSD, suggesting that targeting IL-6 at specific time points may be beneficial in modulating neuroinflammation and reducing its impact on cognition.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2022)
Article
Immunology
John G. Noel, Seth W. Ramser, Lori Pitstick, Holly S. Goetzman, Elizabeth L. Dale, Andrew Potter, Mike Adam, S. Steven Potter, Jason C. Gardner
Summary: This study demonstrates that the burn wound is the primary source of G-CSF and IL-6 secretion, and their secretion is independent through an IL-1/MyD88-dependent mechanism. IL-1/MyD88 signaling mediates postburn anemia by inducing G-CSF and IL-6 secretion, leading to impaired medullary erythropoiesis and limiting the access of erythroid cells to iron. Neutralizing IL-1a/b antibodies attenuate features of postburn anemia and restore deficits caused by burn injury.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Behavioral Sciences
Jennifer L. Remus, Luke T. Stewart, Robert M. Camp, Colleen M. Novak, John D. Johnson
BEHAVIORAL NEUROSCIENCE
(2015)
Article
Psychology, Biological
Robert M. Camp, John D. Johnson
PHYSIOLOGY & BEHAVIOR
(2015)
Article
Endocrinology & Metabolism
Steven A. Lowrance, Amy Ionadi, Erin McKay, Xavier Douglas, John D. Johnson
PSYCHONEUROENDOCRINOLOGY
(2016)
Editorial Material
Immunology
John D. Johnson
BRAIN BEHAVIOR AND IMMUNITY
(2018)
Article
Physiology
Z. R. Zimomra, V. M. Porterfield, R. M. Camp, J. D. Johnson
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2011)
Article
Behavioral Sciences
Robert M. Camp, Jennifer L. Remus, Sahana N. Kalburgi, Veronica M. Porterfield, John D. Johnson
BEHAVIOURAL BRAIN RESEARCH
(2012)
Article
Immunology
Veronica M. Porterfield, Kristin M. Gabella, Mark A. Simmons, John D. Johnson
BRAIN BEHAVIOR AND IMMUNITY
(2012)
Article
Immunology
Leah E. Hains, Lisa C. Loram, Frederick R. Taylor, Keith A. Strand, Julie L. Wieseler, Ruth M. Barrientos, Jennifer J. Young, Matthew G. Frank, Julia Sobesky, Thomas J. Martin, James C. Eisenach, Steven F. Maier, John D. Johnson, Monika Fleshner, Linda R. Watkins
JOURNAL OF NEUROIMMUNOLOGY
(2011)
Article
Neurosciences
V. M. Porterfield, Z. R. Zimomra, E. A. Caldwell, R. M. Camp, K. M. Gabella, J. D. Johnson
Article
Behavioral Sciences
Jay Campisi, Craig Sharkey, John D. Johnson, Alexzander Asea, Thomas Maslanik, Isaac Bernstein-Hanley, Monika Fleshner
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2012)
Editorial Material
Immunology
John D. Johnson
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Endocrinology & Metabolism
David F. Barnard, Kristin M. Gabella, Adam C. Kulp, Austin D. Parker, Patrick B. Dugan, John D. Johnson
PSYCHONEUROENDOCRINOLOGY
(2019)
Article
Behavioral Sciences
Adam C. Kulp, Brett M. Lowden, Sachi Chaudhari, Cassidy A. Ridley, James C. Krzoska, David F. Barnard, Devanshi M. Mehta, John D. Johnson
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Endocrinology & Metabolism
John D. Johnson, David F. Barnard, Adam C. Kulp, Devanshi M. Mehta
JOURNAL OF THE ENDOCRINE SOCIETY
(2019)
