期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 259, 期 1-2, 页码 66-74出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2013.03.007
关键词
Multiple sclerosis; Cell adhesion molecules; Chemokine receptors; Trafficking; Chemokines; Migration
资金
- Canadian Institutes of Health Research
- Alberta Innovates-Health Solutions (AIHS)
- Canada Foundation for Innovation
- Multiple Sclerosis Society of Canada
- Alberta EndMS RRTC
- AIHS
- TMF by CIHR Vanier
- HBI Fong
- MS Society of Canada
- Alberta Innovates [201001321, 200901464] Funding Source: researchfish
CRYAB, a small heat shock protein, was previously shown to decrease neuroinflammation in experimental allergic encephalomyelitis (EAE). We investigated whether the expression of cell adhesion molecules and chemokine receptors on peripheral and spinal cord T cells, that could possibly affect their migration to the central nervous system, was altered following EAE CRYAB treatment. Less LFA-1 + lymphocytes and lower levels of iTAC, MCP-5 and MIG were observed in spinal cords of CRYAB-injected EAE animals. In addition, fewer blood T cells expressed CCR6, CXCR4 and CCR7 and in vivo-derived CRYAB EAE CD4+ lymphocytes were less migratory towards a MIP-3alpha gradient in vitro. (c) 2013 Elsevier B.V. All rights reserved.
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