期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 254, 期 1-2, 页码 76-82出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2012.09.010
关键词
Cerebrospinal fluid; Immunoglobulin; Neuromyelitis optica; Mouse
资金
- Soenderborg Hospital Research Fund
- Vejle Hospital Research Fund
- Danish Foundation for Neurological Research
- Ole Jacobsen Commemoration Fund
- Danish Council for Independent Research
- Scleroseforeningen
- University of Southern Denmark
The specificity and potential pathogenicity of autoantibodies vary between neurological diseases. It is often unclear whether their detection in cerebrospinal fluid (CSF) is a consequence or a cause of pathology. The goal was to test whether administration of brain-specific antibodies into CSF would be sufficient for pathology. Purified immunoglobulin G from a neuromyelitis optica patient was injected intrathecally with complement to naive mice. Histopathological analysis at 7 days revealed damage to the ependyma, disruption of the CSF parenchymal barrier and pathologic lesions, distant from the site of injection. In the absence of complement there was no pathology. Autoantibody and complement in CSF are thus sufficient to initiate a pathologic cascade. (C) 2012 Elsevier B.V. All rights reserved.
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