期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 245, 期 1-2, 页码 48-55出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2012.02.004
关键词
Thrombin; Blood-brain barrier; hCMEC/D3; Endothelial cells
资金
- National Institutes of Health [AI 072434-01A2, R01 NS063011]
In this study, we utilized the human brain endothelial cell line, hCMEC/D3, to determine the effects of the coagulation factor, thrombin, on the human blood-brain barrier (BBB). We show that thrombin increased the mRNA and cell surface levels of ICAM-1 and VCAM-1 in hCMEC/D3 cells. Thrombin similarly upregulated several chemokines implicated in human neurological conditions. Additionally, the paracellular permeability of the human BBB in vitro was also increased following thrombin treatment. Overall, this study demonstrates that thrombin can effectively induce an inflamed phenotype in an in vitro human BBB. (C) 2012 Elsevier B.V. All rights reserved.
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