Review
Neurosciences
Alessia Furgiuele, Marco Cosentino, Marco Ferrari, Franca Marino
Summary: Multiple sclerosis is a common chronic autoimmune disease of the central nervous system. Cannabinoids, particularly cannabidiol, may have anti-inflammatory and immunosuppressive effects, but further clinical evidence and research are needed to confirm their efficacy in treating MS.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Review
Immunology
Qiugang Zhu, Ke Rui, Shengjun Wang, Jie Tian
Summary: Recent research has shown that B cells, traditionally seen as effectors of the immune system, can also act as regulatory B cells (Bregs) with immunosuppressive functions. Bregs exert their effects through various mechanisms such as secretion of anti-inflammatory cytokines and direct cell contact. Maintaining a balance between Bregs and effector B cells is crucial for immune tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francesco Piacente, Marta Bottero, Andrea Benzi, Tiziana Vigo, Antonio Uccelli, Santina Bruzzone, Giovanni Ferrara
Summary: Myeloid cells, including parenchymal microglia, perivascular and meningeal macrophages, and dendritic cells (DCs), have a crucial role in the central nervous system (CNS). DCs play a critical role in orchestrating the immune response and act as sentinels under steady-state conditions. The exact function of DCs in CNS disease is still debated, but their neuroprotective nature and therapeutic potential for neurological conditions are emphasized.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jarne Belien, An Goris, Patrick Matthys
Summary: This review highlights the important role of natural killer (NK) cells in the immunopathology of multiple sclerosis (MS). Through studies using animal models, genetics, as well as ex vivo and in vitro research on MS patients, evidence has been found for the contribution of NK cells to the pathogenesis of MS. The discovery of NK cell heterogeneity using modern hypothesis-free technologies such as single-cell transcriptomics has further blurred the boundaries between adaptive and innate immunity. Understanding the heterogeneity of NK cells and the mechanistic link between innate and adaptive immune cell functions may lead to the use of NK cells as prognostic tools and therapeutic targets for MS and other currently incurable autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Malik R. Seals, Monica M. Moran, Jonathan D. Leavenworth, Jianmei W. Leavenworth
Summary: This article provides an updated review on the role of B cells and antibody response in multiple sclerosis and its murine model, experimental autoimmune encephalomyelitis (EAE). It focuses on the regulation of antibody-producing B cells and discusses the potential role of IgE antibody in microglia and macrophage activation, autoimmunity, and the development of MS/EAE.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Krista D. DiSano, Francesca Gilli, Andrew R. Pachner
Summary: Multiple Sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system, with B cells emerging as central players in the immune pathogenesis of the disease. Memory B cells (Bmem) are considered key B cell phenotypes in MS due to their antigen-experience, increased lifespan, and rapid response to stimulation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sabine Tacke, Rittika Chunder, Verena Schropp, Eduard Urich, Stefanie Kuerten
Summary: This study investigated the effects of a novel class of anti-CD20 monoclonal antibodies on B cells in an animal model of multiple sclerosis. The results showed that these antibodies can modulate the immune response and pathology of the central nervous system driven by B cells, with type II antibodies potentially being more effective in depleting tissue-infiltrating B cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Jorge Mena, Iraide Alloza, Raquel Tulloch Navarro, Ane Aldekoa, Javier Diez Garcia, Ane Villanueva Etxebarria, Cecilia Lindskog, Alfredo Antiguedad, Sabas Boyero, Maria del Mar Mendibe-Bilbao, Amaya Alvarez de Arcaya, Jose Luis Sanchez Menoyo, Luciana Midaglia, Noelia Villarrubia, Sunny Malhotra, Xavier Montalban, Luisa Maria Villar, Manuel Comabella, Koen Vandenbroeck
Summary: Intronic single-nucleotide polymorphisms (SNPs) in the ANKRD55 gene are associated with the risk for multiple sclerosis (MS) and rheumatoid arthritis. This study shows that the expression of ANKRD55 in monocyte-derived dendritic cells (moDCs) is influenced by differentiation and different stimuli. The study also suggests that the differentiation of monocytes into moDCs may be influenced by MS risk SNPs.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Gaurav Kumar, Robert C. Axtell
Summary: B cells have emerged as important immune cells in multiple sclerosis (MS) and can be targeted for therapy. Depleting B cells with anti-CD20 antibodies is effective, but blocking B-cell Activating Factor (BAFF) and A Proliferation-Inducing Ligand (APRIL) with atacicept paradoxically increases disease activity in MS patients. The reasons for this failure are not well understood. Clinical outcomes with these therapies illustrate that B cells have both inflammatory and anti-inflammatory functions in MS. This review summarizes the importance of B cells in MS, discusses different B cell subsets and their functions, and explores how therapies modulate B cell functions in MS patients. The potential anti-inflammatory functions of BAFF and APRIL in MS disease are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Hossein Zeinali, Tourandokht Baluchnejadmojarad, Mehrdad Roghani
Summary: Diosgenin was found to improve the clinical signs of EAE by reducing neuroinflammation, demyelination, and axonal degeneration, but did not have significant effects on neuroprotective factors in this study. Diosgenin could potentially be a promising candidate for new MS treatment strategies that focus on enhancing myelination in addition to its anti-inflammatory effects.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Review
Immunology
Ayumi Yoshizaki, Takemichi Fukasawa, Satoshi Ebata, Asako Yoshizaki-Ogawa, Shinichi Sato
Summary: This article outlines the role of B cells in the development of systemic sclerosis (SSc), including their involvement in autoimmune abnormalities, pro-inflammatory actions, and inhibitory functions. Studies have found B-cell depletion therapy to be effective for SSc.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Negar Sadeghi Hassanabadi, Bieke Broux, Sonja Marinovic, Dagmar Gotthardt
Summary: Multiple sclerosis (MS) is a debilitating autoimmune disease with millions of patients worldwide. Recent studies have shown that innate lymphoid cells (ILCs), in addition to T cells, play a role in the disease pathology. However, the exact role of ILCs in MS is still controversial.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Richard A. Miller, Jason John Luke, Shenshen Hu, Suresh Mahabhashyam, William B. Jones, Thomas Marron, Jaime R. Merchan, Brett G. M. Hughes, Stephen B. Willingham
Summary: This study evaluated the effects of Mupadolimab on immune cells and found that it activates B cells and stimulates the production of antigen specific antibodies. These results support further investigation of Mupadolimab as an immunotherapy for cancer and its potential use as a vaccine adjuvant.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Immunology
Guo-Guo Chu, Jing Wang, Zhi-Bin Ding, Jin-Zhu Yin, Li-Juan Song, Qing Wang, Jian-Jun Huang, Bao-Guo Xiao, Cun-Gen Ma
Summary: The study demonstrated that Hydroxyfasudil could alleviate the symptoms and pathological damage of experimental autoimmune encephalomyelitis (EAE), regulate the balance of peripheral T cells, inhibit inflammatory signaling cascades, promote anti-inflammatory factors in the central nervous system, and protect the blood-brain barrier. These findings suggest that Hydroxyfasudil may be a promising treatment for multiple sclerosis (MS).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Ruoyu Li, Hui Li, Xiaoyan Yang, Huiru Hu, Peidong Liu, Hongbo Liu
Summary: This review summarizes the interaction and protective mechanisms between dendritic cells (DCs) and regulatory T cells (Tregs) in multiple sclerosis (MS), explores their potential value in the treatment of MS, and proposes new therapeutic directions.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Morad K. Nakhleh, Haitham Amal, Raneen Jeries, Yoav Y. Broza, Manal Aboud, Alaa Gharra, Hodaya Ivgi, Salam Khatib, Shifaa Badarneh, Lior Har-Shai, Lea Glass-Marmor, Izabella Lejbkowicz, Ariel Miller, Samih Badarny, Raz Winer, John Finberg, Sylvia Cohen-Kaminsky, Frederic Perros, David Montani, Barbara Girerd, Giles Garcia, Gerald Simonneau, Farid Nakhoul, Shira Baram, Raed Salim, Marwan Hakim, Maayan Gruber, Ohad Ronen, Tal Marshak, Ilana Doweck, Ofer Nativ, Zaher Bahouth, Da-you Shi, Wei Zhang, Qing-ling Hua, Yue-yin Pan, Li Tao, Hu Liu, Amir Karban, Eduard Koifman, Tova Rainis, Roberts Skapars, Armands Sivins, Guntis Ancans, Inta Liepniece-Karele, Ilze Kikuste, Ieva Lasina, Ivars Tolmanis, Douglas Johnson, Stuart Z. Millstone, Jennifer Fulton, John W. Wells, Larry H. Wilf, Marc Humbert, Marcis Leja, Nir Peled, Hossam Haick
Article
Immunology
Shimrat Mamrut, Nili Avidan, Frederique Truffault, Elsebeth Staun-Ram, Tarek Sharshar, Bruno Eymard, Melinee Frenkian, Jiri Pitha, Marc de Baets, Laurent Servais, Sonia Berrih-Aknin, Ariel Miller
JOURNAL OF AUTOIMMUNITY
(2017)
Article
Clinical Neurology
Maria Pia Amato, Tobias Derfuss, Bernard Hemmer, Roland Liblau, Xavier Montalban, Per Soelberg Sorensen, David H. Miller
MULTIPLE SCLEROSIS JOURNAL
(2018)
Article
Clinical Neurology
Maria Pia Amato, Tobias Derfuss, Bernard Hemmer, Roland Liblau, Xavier Montalban, Per Soelberg Sorensen, David H. Miller
MULTIPLE SCLEROSIS JOURNAL
(2018)
Article
Clinical Neurology
Shiri Blumenfeld-Kan, Elsebeth Staun-Rani, Ariel Miller
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2019)
Article
Immunology
Eiman Najjar, Elsebeth Staun-Ram, Anat Volkowich, Ariel Miller
JOURNAL OF NEUROIMMUNOLOGY
(2020)
Article
Clinical Neurology
Efrat Neter, Lea Glass-Marmor, Anat Wolkowitz, Idit Lavi, Ariel Miller
Summary: This study revealed that adherence and persistence to disease-modifying therapies among persons with multiple sclerosis were mainly influenced by medication beliefs. Clinical and demographic characteristics were mostly found to not be predictive of adherence and persistence in this study.
Article
Multidisciplinary Sciences
Daniel Golan, Smadar Sagiv, Lea Glass-Marmor, Ariel Miller
Summary: Many sclerosis patients show high adherence to recording PROs in an e-diary on smartphones, and changes in e-diary-derived PROs over time can predict clinical MS relapses at the group level, indicating their potential for use in clinical research and improving MS care in real-world settings.
Article
Medicine, General & Internal
Efrat Neter, Lea Glass-Marmor, Loren Haiien, Ariel Miller
Summary: The study found a significant level of agreement between MS patients and physicians on the assessment of medication effectiveness, indicating that effective communication between physicians and patients may contribute to improved medication adherence.
PATIENT PREFERENCE AND ADHERENCE
(2021)
Article
Clinical Neurology
Daniel Golan, Smadar Sagiv, Lea Glass-Marmor, Ariel Miller
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2020)
Article
Clinical Neurology
S. Blumenfeld Kan, E. Staun-Ram, D. Golan, A. Miller
MULTIPLE SCLEROSIS JOURNAL-EXPERIMENTAL TRANSLATIONAL AND CLINICAL
(2019)
Article
Clinical Neurology
Elsebeth Staun-Ram, Eiman Najjar, Anat Volkowich, Ariel Miller
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2018)
Article
Biochemistry & Molecular Biology
Yoav Y. Broza, Lior Har-Shai, Raneen Jeries, John C. Cancilla, Lea Glass-Marmor, Izabella Lejbkowicz, Jose S. Torrecilla, Xuelin Yao, Xinliang Feng, Akimitsu Narita, Klaus Muellen, Ariel Miller, Hossam Haick
ACS CHEMICAL NEUROSCIENCE
(2017)
Article
Immunology
Elsebeth Staun-Ram, Ariel Miller
CLINICAL IMMUNOLOGY
(2017)
Article
Clinical Neurology
Kathryn C. Fitzgerald, Kassandra L. Munger, Hans-Peter Hartung, Mark S. Freedman, Xavier Montalban, Gilles Edan, Eva-Maria Wicklein, Ernst-Wilhelm Radue, Ludwig Kappos, Christoph Pohl, Alberto Ascherio
ANNALS OF NEUROLOGY
(2017)
