期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 243, 期 1-2, 页码 1-11出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.11.008
关键词
Multiple sclerosis; CD4(+)CD28(-) T-cells; Activation; NK cells markers; Adhesion molecules; Cytotoxic markers
资金
- Fondo de Investigacion Sanitaria (FIS)
- Ministerio de Ciencia e Innovacion [02/0671, 05/1592, CP 03/00042]
- Consejeria de Salud de la Junta de Andalucia [PI 03/0010]
Multiple sclerosis (MS) is a chronic debilitating disease, in which T-cells are considered to play a pivotal role. CD28 is the quintessential costimulatory molecule on T-cells and its expression declines progressively with repeated stimulations, leading to the generation of CD28(-) T-cells. Our aim was to examine whether CD4(+)CD28(-) T-cells were enriched in MS patients, and characterize the phenotype of this subset in MS patients and healthy controls (HC). All these changes could provide these CD4(+)CD28(-) T-cell characteristics that might be involved in the pathogenesis of MS, turning this T-cell subset into a potential target for future therapeutic strategies. (C) 2011 Elsevier B.V. All rights reserved.
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