Article
Environmental Sciences
Woo-Ju Song, Jeongtae Kim, Taekyun Shin, Myeong-Seon Jeong, Kil-Nam Kim, Jang-Hyuk Yun, Myung-Bok Wie
Summary: The study showed that esculetin and fucoidan can attenuate the neurotoxic effects of ZnO NPs in rats, possibly through modulating reactive astrocytes and proinflammatory cytokines in the brain.
Article
Dentistry, Oral Surgery & Medicine
Omer Alperen Kirmiziguel, Arife Sabanci, Faruk Disli, Sedat Yildiz, Michael R. Milward, Kubra Aral
Summary: This study aimed to evaluate MFN1 and MFN2 in gingival crevicular fluid (GCF) of patients with periodontal disease. The results showed that the levels of MFN1 were significantly higher in patients with periodontitis and gingivitis compared to healthy controls, while the concentrations of MFN1, MFN2, calcium, caspase-1, and TNF-α significantly decreased in the periodontal disease groups. There was a positive correlation among all evaluated markers.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Neurosciences
Changsheng Li, Sufang Liu, Xihua Lu, Feng Tao
Summary: The study demonstrates that TNF alpha can enhance calcium influx and increase neuronal activity by activating TNF alpha receptors in the spinal dorsal horn. The interaction between TNF alpha receptors and calcium-permeable AMPA receptors is involved in this process.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Andy Ruiz, Yadira Palacios, Irene Garcia, Leslie Chavez-Galan
Summary: Tumor necrosis factor (TNF) is a key cytokine regulating inflammatory responses and plays a crucial role in granuloma formation during mycobacterial infections. The interactions between soluble and transmembrane TNF with their receptors influence effector mechanisms, providing insights into potential therapeutic strategies against mycobacterial infections. Understanding the structural and activation pathways of TNF and its receptors can offer valuable knowledge for developing more efficient therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Claudia A. Valente, Francisco J. Meda, Mafalda Carvalho, Ana M. Sebastiao
Summary: Organotypic slice cultures are valuable tools for modeling brain disorders and assessing the neuroprotective and therapeutic potential of drugs. Hippocampal and rhinal cortex-hippocampus slices are suitable for studying the mechanisms and progression of epileptogenesis.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Review
Immunology
Maha Sellami, Nicola Luigi Bragazzi, Baha Aboghaba, Mohamed A. Elrayess
Summary: This review summarizes the effects of acute and chronic exercise on immunoglobulins and cytokines in the elderly. Acute endurance exercise increases salivary SIgA, while acute muscle strengthening exercise raises levels of IL-6, IL-8, and TNF-alpha. Chronic exercise, both short-term and long-term, leads to improvements in immune function.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Elzbieta Lazar-Poloczek, Ewa Romuk, Wojciech Jachec, Wiktoria Stanek, Bartosz Stanek, Monika Szoltysik, Tomasz Techmanski, Maja Hasterok, Celina Wojciechowska
Summary: This study aimed to compare the levels of adipokines, TNF-alpha, and soluble receptors in heart failure patients with different BMI. The study found that obese patients had the lowest NT-proBNP concentrations and higher leptin levels. TNF-alpha concentrations were positively correlated with sTNFr1 in all groups. Higher levels of sTNFr1 were associated with higher sTNFr2 and CRP levels. Obese patients may respond better to anti-TNF therapy.
Review
Oncology
Wei-Cheng Tseng, Hou-Chuan Lai, Yi-Hsuan Huang, Shun-Ming Chan, Zhi-Fu Wu
Summary: Cancer is a leading cause of death worldwide, and surgical resection is the main treatment for solid tumors. However, surgery-induced stress responses can lead to immunosuppression and cancer regrowth and spread. The tumor microenvironment, particularly the presence of tumor necrosis factor alpha (TNF-alpha), plays a crucial role in cancer progression and immune surveillance. Anesthetic agents and perioperative management have varying effects on inflammation, immune responses, and cancer-promoting signaling pathways, which may affect long-term cancer outcomes.
Review
Medicine, Research & Experimental
Farid Ghorbaninezhad, Patrizia Leone, Hajar Alemohammad, Basira Najafzadeh, Niloufar Nourbakhsh, Marcella Prete, Eleonora Malerba, Hossein Saeedi, Neda Tabrizi, Vito Racanelli, Behzad Baradaran
Summary: This study reviews the dual role of tumor necrosis factor-alpha (TNF-alpha) in systemic lupus erythematosus (SLE), as well as the efficacy and safety of anti-TNF-alpha therapies in SLE.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Yi-Wen Duan, Shao-Xia Chen, Qiao-Yun Li, Ying Zang
Summary: This review focuses on the neuroimmune mechanism of neuropathic pain. TNF-alpha plays a crucial role in inducing and modulating neuropathic pain by facilitating peripheral and central sensitization. It controls cell survival and death through an inflammatory response and programmed cell death mechanisms. Overproduction of TNF-alpha in certain brain structures has an important role in pain-associated emotional disorders and memory deficits. The review also highlights the research prospects of the TNF-alpha-necroptosis pathway in pain modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Hematology
Tiantian Chu, Shuhong Hu, Jiaqian Qi, Xueqian Li, Xiang Zhang, Yaqiong Tang, Meng Yang, Yang Xu, Chang-Geng Ruan, Yue Han, De-Pei Wu
Summary: This study investigated the effects of TNF alpha on megakaryocyte and platelet generation and found that TNF alpha had differential effects on their production at different concentrations.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Neurosciences
Nevin Varghese, Nicolas E. Amelinez-Robles, Barclay Morrison III
Summary: In this study, the effects of blast-induced traumatic brain injury (bTBI) on the hippocampal network of rat organotypic hippocampal slice cultures (OHSCs) were investigated. The results showed reduced connectivity and clustering coefficients in the hippocampal network following bTBI, along with decreased expression of alpha 1 and alpha 5 GABAA receptor subunits. Treatment with the histone deacetylase inhibitor suberanilohydroxamic acid (SAHA) restored the alpha 1 subunit and attenuated deficits in network measures. These findings suggest that GABAA receptors may play a role in neuronal network changes and could be targeted for therapeutic intervention in bTBI-induced neurological symptoms.
EXPERIMENTAL NEUROLOGY
(2023)
Article
Chemistry, Multidisciplinary
Sarah Belperain, Zi Yae Kang, Andrew Dunphy, Brandon Priebe, Norman H. L. Chiu, Zhenquan Jia
Summary: CNDs, as a novel form of nanoparticles, have shown potential anti-inflammatory properties in reducing TNF-alpha induced endothelial cell inflammation. This finding may open up a new direction for the treatment of cardiovascular diseases.
Editorial Material
Hematology
Federico Simonetta
Summary: The study demonstrates that dual blockade of TNF-α and IL-6R provides a significant advantage over single-cytokine blockade in protecting mice from lethal graft-versus-host disease.
Article
Neurosciences
Hans-Georg Konig, Orla Watters, Sinead Kinsella, Mohammed Ameen, Beau J. Fenner, Jochen H. M. Prehn
Article
Biochemical Research Methods
J. J. O'Connor, K. M. O'Boyle, J. P. Lowry
JOURNAL OF NEUROSCIENCE METHODS
(2018)
Article
Neurosciences
Sinead M. Lanigan, John J. O'Connor
Article
Neurosciences
Sinead Lanigan, Alan E. Corcoran, Audrey Wall, Gatambwa Mukandala, John J. O'Connor
Article
Multidisciplinary Sciences
Hans-Georg Konig, Robert Schwamborn, Silke Andresen, Sinead Kinsella, Orla Watters, Beau Fenner, Jochen H. M. Prehn
SCIENTIFIC REPORTS
(2017)
Article
Anatomy & Morphology
Luke M. Alvey, James F. X. Jones, Cathal Tobin-O'Brien, Mark Pickering
JOURNAL OF ANATOMY
(2019)
Review
Neurosciences
Sinead M. Lanigan, John J. O'Connor
Article
Gastroenterology & Hepatology
Keira Turner, Mark Pickering, P. Ronan O'Connell, James F. X. Jones
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Engineering, Biomedical
Owen Humphreys, Mark Pickering, Eoin D. O'Cearbhaill, Thomas C. Flanagan
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Neurosciences
Amy Courtney, Jeremy Liegey, Niamh Burke, Amy R. Hassett, Madeleine Lowery, Mark Pickering
Summary: Neuroscience lacks diverse model organisms, but Ctenophores show neurobiological and experimental features that make them a promising candidate for expanding our understanding of neural function. The researchers investigated the structure and organization of the nerve net in Pleurobrachia pileus and found that certain morphological features remain unchanged during growth, suggesting their importance for the functionality of the nervous system. They also identified different geometric properties in different regions of the body, indicating potential functional differences. This study provides the most comprehensive structural description of a ctenophore nerve net to date.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Niamh Moreton, Martina Puzio, John J. O'Connor
Summary: This study investigated the effects of the ROS scavenger MnTMPyP on synaptic transmission in hypoxia and OGD models, revealing a modulatory effect specific to the CA1 region of the hippocampus and a protective role in cell viability post hypoxia and OGD.
BRAIN RESEARCH BULLETIN
(2022)
Article
Biochemistry & Molecular Biology
Martina Puzio, Niamh Moreton, Mairead Sullivan, Caitriona Scaife, Jeffrey C. Glennon, John J. O'Connor
Summary: Metabolic stress and ROS production contribute to neuronal damage and synaptic plasticity in acute ischemic stroke. MnTMPyP has a neuroprotective effect in hippocampal slices and regulates synaptic transmission during hypoxia and OGD. This study investigates the molecular changes and mechanisms involved in the effect of MnTMPyP, revealing impairments in vesicular trafficking and cell differentiation signaling. These findings provide insights into the role of MnTMPyP in synaptic transmission and plasticity during ischemia.
Meeting Abstract
Anatomy & Morphology
[Anonymous]
JOURNAL OF ANATOMY
(2023)
Article
Engineering, Electrical & Electronic
George O. T. Merces, Conor Kennedy, Blanca Lenoci, Emmanuel G. Reynaud, Niamh Burke, Mark Pickering
Summary: The study presents a low-cost microscope designed for conventional tissue culture incubators, allowing for various imaging experiments. The open-source design aims to facilitate adaptation by the community and individual researchers, with an easy-to-use graphic user interface for experimental design.
Meeting Abstract
Medicine, General & Internal
N. Burke, G. O. T. Merces, A. Courtney, M. Pickering
IRISH JOURNAL OF MEDICAL SCIENCE
(2019)