期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 234, 期 1-2, 页码 103-108出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2011.03.006
关键词
HSV-1; CXCL10; Chemokine production; Mouse chimera; T cell chemotaxis
资金
- NIH [R01 A1067309]
- Research to Prevent Blindness
- [P20 RR017703]
The chemokine CXCL10 is crucial for the control of viral replication through the regulation of mobilization of antigen-specific T cells to sites of infection. CXCL10 is highly expressed both at sites of inflammation as well as constitutively within lymphoid organs by both bone marrow (BM)-derived and non-BM-derived cells. However, the relative immunologic importance of CXCL10 expressed by these divergent sources relative to HSV-1 infection is unknown. Using mouse chimeras reconstituted with either wild type or CXCL10 deficient mouse BM, we show BM-derived, radiation-sensitive cells from wild type mice were solely responsible for resistance to HSV-1 in the trigeminal ganglia and brain stem. The resistance was not reflected by a deficiency in the recruitment of effector cells to sites of inflammation or expression of chemokines or IFN-gamma and likely results from additional, yet-to-be-determined factors emanating from wild type. BM-derived cells. (C) 2011 Elsevier B.V. All rights reserved.
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