期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 234, 期 1-2, 页码 155-160出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2011.03.009
关键词
Th17; Immunological memory; Neuromyelitis optica; Multiple sclerosis; Glucocorticoids
资金
- Sun Yat-Sen University [2007027]
- Technology Project of Guangzhou City [2060402]
Object: To investigate the clinical relevance of memory Th17 cells in patients with neuromyelitis optica (NMO) or multiple sclerosis (MS). Patients and methods: The proportion of peripheral memory Th17 cells was determined by flow cytometry. Sera IL-17A and IL-23 levels were detected by ELISA kits. Results: Memory Th17 proportion and IL-17A level were much higher in patients with NMO or MS and were related to clinical features. After high-dose intravenous methylprednisolone (IVMP) therapy, memory Th17 proportion and IL-17A and IL-23 levels were decreased. Conclusions: Memory Th17 is related to the development and relapse of NMO and MS, and IVMP can inhibit memory Th17. (C) 2011 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据