期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 237, 期 1-2, 页码 4-12出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2011.06.007
关键词
Progesterone; Traumatic brain injury; Neuroprotection; Glial cells; Microglia
资金
- U.S. Army Institute of Surgical Research
- U.S. Army Medical Research Acquisition Activity (USAMRAA)
- National Institute of Neurological Disorders and Stroke-ProTECT III (Progesterone for the Treatment of Traumatic Brain Injury)
- SCDR Cancer Research Fund
- Virginia Commonwealth University Reanimation Engineering Shock Center (VCURES)
TBI is a complex disease process caused by a cascade of systemic events. Attention is now turning to drugs that act on multiple pathways to enhance survival and functional outcomes. Progesterone has been found to be beneficial in several animal species, different models of brain injury, and in two preliminary human clinical trials. It holds promise as a treatment for TBI. Progesterone's multiple mechanisms of action may work synergistically to prevent the death of neurons and glia, leading to reduced morbidity and mortality. This review highlights the importance of glial cells as mediators of progesterone's actions on the CNS and describes progesterone's pleiotrophic effects on immune enhancement and neuroprotection in TBI. (C) 2011 Elsevier B.V. All rights reserved.
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