期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 226, 期 1-2, 页码 194-197出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.07.003
关键词
Multiple sclerosis; Glypican-5; Glypican-6; Genetics; Immune-mediated disease
资金
- University of Oslo
- Research Council of Norway [166005N5]
- South and Eastern Norway Regional Health Authority
- Ulleval University Hospital Scientific Advisory Council (VIRUUS)
- Norwegian Foundation for Health and Rehabilitation [2004/2/0125]
- Odd Fellow MS society
- Norwegian MS society, Norway
- DFG
- German Ministry of Education and Research (BMBF) through the National Genome Research Network (NGFN)
Multiple sclerosis (MS) is an inflammatory, demyelinating disease affecting the central nervous system. MS-associated variants have been reported at both HLA and non-HLA loci, the latter including chromosome 13q31-32 and the Glypican-5 and Glypican-6 genes. In order to further explore the 13q31-32 region in MS, we genotyped 33 SNPs in 1355 Norwegian MS patients and 1446 Norwegian controls. An intronic SNP in the Glypican-5 gene (rs9523787) showed association with MS (P-corr = 0.006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene. (C) 2010 Elsevier B.V. All rights reserved.
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