期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 229, 期 1-2, 页码 123-128出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.07.021
关键词
Leucine-rich repeat kinase 2; B-1 cells; B-2 cells; Parkinson's disease; PARK8; Downregulation
资金
- Kitasato University [18-1]
- Graduate School of Medical Sciences, Kitasato University
LRRK2, the causal molecule of familial Parkinson's disease, is expressed strongly by one of the B cell subsets, B-2 cells, but not by the other subset. B-1 cells, in the mouse peritoneal cavity, spleen, and peripheral blood. Bone marrow pre-B cells or T cells exhibited little LRRK2 expression. LRRK2 expression was dramatically downregulated upon activation of B-2 cells with various types of stimulation. These results suggest that LRRK2, whose true function has not yet been clarified, may play some important role(s) in the development and function of B cells, particularly the maintenance of B-2 cells in a resting status. (C) 2010 Elsevier B.V. All rights reserved.
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