期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 229, 期 1-2, 页码 238-242出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2010.08.009
关键词
Multiple sclerosis; Epstein-Barr virus; Cellular immunity; Cytotoxicity
资金
- EMD Serono
- Pfizer, Inc.
- National Multiple Sclerosis Society [PP1470]
- Clayton Foundation for Research
- NIH [UL1 RR024148]
We investigated T cell immunity to Epstein-Barr virus (EBV) in multiple sclerosis (MS) and assessed cross-reactivity of the anti-EBV cellular response with brain antigens. We measured the proliferation, cytotoxicity, and number of interferon-gamma secreting cells following stimulation with autologous EBV-infected lymphoblastoid cell lines (LCL) in MS patients and matched controls. There were no statistically significant differences for any of the measured responses, but there was a trend towards decreased proliferative responses in MS patients. There was no measured cross-reactivity between LCL and brain antigens. We conclude that the cellular immune response against EBV-infected cells is neither increased nor decreased in MS. (C) 2010 Elsevier B.V. All rights reserved.
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