期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 225, 期 1-2, 页码 52-61出版社
ELSEVIER
DOI: 10.1016/j.jneuroim.2010.04.013
关键词
EAE; RTLs; Tolerance; APCs
资金
- National Multiple Sclerosis Society [FG1749-A-1, RG3794-A-4, RG3794-B-6]
- NIH [NS47661, AI43960]
- Biomedical Laboratory R&D Service, Department of Veterans Affairs
- Artielle ImmunoTherapeutics, Inc.
Recombinant T cell ligands (RTLs) ameliorate experimental autoimmune encephalomyelitis (EAE) in an antigen-specific manner. We evaluated effects of RTL401 (I-A(s) alpha 1 beta 1 + PLP-139-151) on splenocytes from SJL/J mice with EAE to study RTL-T cell tolerance-inducing mechanisms. RTLs bound to B, macrophages and DCs, through RTL-MHC-alpha 1 beta 1 moiety. RTL binding reduced CD11b expression on splenic macrophages/DC, and RTL401-conditioned macrophages/DC, not B cells, inhibited T cell activation. Reduced ability of RU- incubated splenocytes to transfer EAE was likely mediated through macrophages/DC, since B cells were unnecessary for RTL treatment of EAE. These results demonstrate a novel pathway of T cell regulation by RTL-bound APCs. (C) 2010 Elsevier B.V. All rights reserved.
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