Article
Immunology
Xiaoran Ma, Shuang Wang, Chenglin Li, Xihui Jia, Tiantian Wang, Zhe Leng, Ran Lu, Xiaowen Kong, Jinyu Zhang, Ling Li
Summary: Baicalein (BAI), a natural flavonoid, has been found to alleviate clinical symptoms, demyelination, and inflammatory response in EAE mice. It inhibits M1 microglia/macrophage activation, decreases the expression of proinflammatory cytokines, and targets STAT1 to inhibit polarization. These findings suggest the potential use of BAI in the treatment of MS.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Payam Bayat, Maral Farshchi, Mozhdeh Yousefian, Mahmoud Mahmoudi, Rezvan Yazdian-Robati
Summary: Research indicates that flavonoids can effectively alleviate the severity of multiple sclerosis and experimental autoimmune encephalomyelitis, showing potential therapeutic effects and paving the way for improving MS therapeutic strategies.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Chemistry, Multidisciplinary
Niloufar Rahiman, Marzieh Mohammadi, Seyedeh Hoda Alavizadeh, Leila Arabi, Ali Badiee, Mahmoud Reza Jaafari
Summary: Multiple Sclerosis is an autoimmune disease that can be effectively managed through the use of nanoparticles, which support early detection and therapeutic treatment.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Immunology
Gabriel Siracusano, Annamaria Finardi, Claudia Pastori, Vittorio Martinelli, Roberto Furlan, Lucia Lopalco
Summary: Recent studies suggest that immunological tolerance may hinder the development of Env-specific autoreactive broadly neutralizing antibodies. While Env immunization in a systemic lupus erythematosus model showed success in producing antibodies that neutralize HIV-1 strains, similar attempts in a multiple sclerosis model failed to elicit neutralizing antibodies.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Niloufar Rahiman, Parvin Zamani, Ali Badiee, Leila Arabi, Seyedeh Hoda Alavizadeh, Mahmoud Reza Jaafari
Summary: Liposomes as novel pharmaceutical vehicles show great promise in the management of multiple sclerosis by supporting effective detection, prognosis, and therapy. They can target immune cells with various surface modifications, encapsulate anti-inflammatory or MS-related therapeutics, and play a role in gene delivery or as diagnostic agents, ultimately providing a high-throughput medication approach for overcoming challenges faced by MS patients.
EXPERT OPINION ON DRUG DELIVERY
(2021)
Article
Multidisciplinary Sciences
Anna S. Thomann, Courtney A. McQuade, Katarina Pinjusic, Anna Kolz, Rosa Schmitz, Daisuke Kitamura, Hartmut Wekerle, Anneli Peters Ab
Summary: In multiple sclerosis, pathogenic T cell responses play a major role in autoimmune inflammation, but B cells may also contribute to the pathogenesis through antigen presentation and the production of proinflammatory cytokines. This study developed a new model to study the roles of pathogenic B cells in the development of multiple sclerosis, providing insights into the disease's pathogenic processes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Ranjithkumar Rajendran, Vinothkumar Rajendran, Mario Giraldo-Velasquez, Fevronia-Foivi Megalofonou, Fynn Gurski, Christine Stadelmann, Srikanth Karnati, Martin Berghoff
Summary: MS is a chronic inflammatory and degenerative disease of the central nervous system commonly affecting the cerebellum. FGFs and FGFRs are involved in demyelinating pathologies such as MS. Recent research shows that cell-specific deletion of FGFR1 has anti-inflammatory and neuroprotective effects in the cerebellum.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Marianno Franzini, Luigi Valdenassi, Sergio Pandolfi, Umberto Tirelli, Giovanni Ricevuti, Salvatore Chirumbolo
Summary: Ozone has a positive effect in treating bacterial infections, especially those caused by multi-drug resistant bacteria. Ozone improves the bacteria clearance ability of macrophages by activating Nrf2, and plays a complex role in modulating immunity.
Article
Immunology
Bao Ying Chen, Jessica R. Salas, Alyssa O. Trias, Arely Perez Rodriguez, Jonathan E. Tsang, Miriam Guemes, Thuc M. Le, Zoran Galic, H. Michael Shepard, Lawrence Steinman, David A. Nathanson, Johannes Czernin, Owen N. Witte, Caius G. Radu, Kenneth A. Schultz, Peter M. Clark
Summary: Research on multiple sclerosis and autoimmune diseases has found that targeting deoxycytidine kinase (dCK) can limit the progression of symptoms, and dCK activity is essential for activation-induced proliferation in specific lymphocytes.
Review
Biochemistry & Molecular Biology
Insha Zahoor, Bin Rui, Junaid Khan, Indrani Datta, Shailendra Giri
Summary: Multiple sclerosis is an inflammatory demyelinating disease of the nervous system that primarily affects young adults, with alterations in the metabolome contributing to the disease progression. Metabolomics studies offer insights into disease pathophysiology, therapeutic strategies, and identification of unique markers indicative of treatment responses. The research suggests that metabolic profiling of MS patient samples may uncover biomarkers that improve early therapeutic interventions and evaluation of treatment responses.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Immunology
Valentina Pegoretti, Jan Bauer, Roman Fischer, Iskra Paro, Wanda Douwenga, Roland E. Kontermann, Klaus Pfizenmaier, Evelien Houben, Bieke Broux, Niels Hellings, Wia Baron, Jon D. Laman, Ulrich L. M. Eisel
Summary: TNF signaling plays a crucial role in cellular homeostasis, and its activation of TNFR1 and TNFR2 can determine cell death or survival. It regulates important biological functions such as inflammation, neuronal activity, and tissue regeneration. Modulating TNF-TNFRs signaling can potentially be used for the treatment of neurodegenerative diseases, but conflicting findings have been reported. This study investigates the therapeutic effects of sequential modulation of TNFR1 and TNFR2 signaling in an experimental mouse model of autoimmune encephalomyelitis (EAE).
JOURNAL OF NEUROINFLAMMATION
(2023)
Article
Clinical Neurology
Marjan Gharagozloo, Matthew D. Smith, Elias S. Sotirchos, Jing Jin, Keya Meyers, Michelle Taylor, Thomas Garton, Riley Bannon, Hannah-Noelle Lord, Ted M. Dawson, Valina L. Dawson, Seulki Lee, Peter A. Calabresi
Summary: GLP-1R agonist NLY01 shows therapeutic potential in EAE mouse model by delaying disease onset, reducing severity, inhibiting immune cell activation, decreasing cell trafficking to CNS, and suppressing chemokine production associated with leukocyte recruitment to inflammation sites. Additionally, NLY01 may block the expression of genes associated with neurotoxic astrocytes, preventing RGC loss in the progressive stage of EAE and decreasing clinical score in a model of relapsing-remitting EAE.
Review
Biochemistry & Molecular Biology
Michal K. Zarobkiewicz, Izabela Morawska, Adam Michalski, Jacek Rolinski, Agnieszka Bojarska-Junak
Summary: NKT cells, especially iNKT cells, may play a key role in autoimmune diseases. Researchers summarized the results of NKT-oriented studies in major neurological autoimmune diseases such as multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Immunology
Eleni Stamoula, Spyridon Siafis, Ioannis Dardalas, Alexandra Ainatzoglou, Alkis Matsas, Theodoros Athanasiadis, Chrysanthi Sardeli, Konstantinos Stamoulas, Georgios Papazisis
Summary: Antidepressants have been found effective in treating depression comorbid to MS, alleviating various MS symptoms, and reducing stress-related relapses. Through promoting neural and glial cell viability and differentiation, reducing proinflammatory cytokines, and exerting neuroprotective activity by eliminating axonal loss, they target multiple aspects of MS pathophysiology in both in vitro and in vivo models.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Chemistry, Applied
Lingrong Wen, Yueming Jiang, Xuesong Zhou, Huimin Bi, Bao Yang
Summary: Soybean peptides are functional foods with health benefits, with their structure playing a key role in determining these benefits. By identifying peptide structure and evaluating immunomodulatory activity, soybean peptides were found to facilitate macrophage proliferation.
Article
Immunology
Achilleas Floudas, Sean P. Saunders, Tara Moran, Christian Schwartz, Emily Hams, Denise C. Fitzgerald, James A. Johnston, Graham S. Ogg, Andrew N. McKenzie, Patrick T. Walsh, Padraic G. Fallon
JOURNAL OF IMMUNOLOGY
(2017)
Article
Neurosciences
Yvonne Dombrowski, Thomas O'Hagan, Marie Dittmer, Rosana Penalva, Sonia R. Mayoral, Peter Bankhead, Samara Fleville, George Eleftheriadis, Chao Zhao, Michelle Naughton, Rachel Hassan, Jill Moffat, John Falconer, Amanda Boyd, Peter Hamilton, Ingrid V. Allen, Adrien Kissenpfennig, Paul N. Moynagh, Emma Evergren, Bernard Perbal, Anna C. Williams, Rebecca J. Ingram, Jonah R. Chan, Robin J. M. Franklin, Denise C. Fitzgerald
NATURE NEUROSCIENCE
(2017)
Article
Multidisciplinary Sciences
Elodie Martin, Mohamed El-Behi, Bertrand Fontaine, Cecile Delarasse
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2017)
Article
Neurosciences
Marie Dittmer, Andrew Young, Thomas O'Hagan, George Eleftheriadis, Peter Bankhead, Yvonne Dombrowski, Reinhold J. Medina, Denise C. Fitzgerald
Article
Clinical Neurology
Ryan J. Bevan, Rhian Evans, Lauren Griffiths, Lewis M. Watkins, Mark I. Rees, Roberta Magliozzi, Ingrid Allen, Gavin McDonnell, Rachel Kee, Michelle Naughton, Denise C. Fitzgerald, Richard Reynolds, James W. Neal, Owain W. Howell
ANNALS OF NEUROLOGY
(2018)
Article
Biochemistry & Molecular Biology
Nira de la Vega Gallardo, Marie Dittmer, Yvonne Dombrowski, Denise C. Fitzgerald
NEUROCHEMISTRY INTERNATIONAL
(2019)
Review
Immunology
Frances L. Evans, Marie Dittmer, Alerie G. de la Fuente Denise, Denise C. Fitzgerald
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Christopher E. McMurran, Alerie Guzman de la Fuente, Rosana Penalva, Ofra Ben Menachem-Zidon, Yvonne Dombrowski, John Falconer, Ginez A. Gonzalez, Chao Zhao, Fynn N. Krause, Adam M. H. Young, Julian L. Griffin, Clare A. Jones, Claire Hollins, Markus M. Heimesaat, Denise C. Fitzgerald, Robin J. M. Franklin
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Microbiology
Jean-Philippe Barnier, Daniel Euphrasie, Olivier Join-Lambert, Mathilde Audry, Sophia Schonherr-Hellec, Taliah Schmitt, Sandrine Bourdoulous, Mathieu Coureuil, Xavier Nassif, Mohamed El Behi
Summary: Neisseria meningitidis is a major cause of bacterial meningitis and fatal sepsis, as it can adhere to human endothelial cells and colonize microvessels using type IV pili (TFP). TFP dynamics, facilitated by PilT ATPase, play a crucial role in promoting sustained bacteremia and lethality in a humanized mouse model, highlighting the significance of pilus retraction in the pathogenesis and outcome of meningococcal sepsis.
Article
Immunology
Jelka Pohar, Richard O'Connor, Benoit Manfroi, Mohamed El-Behi, Luc Jouneau, Pierre Boudinot, Mario Bunse, Wolfgang Uckert, Marine Luka, Mickael Menager, Roland Liblau, Stephen M. Anderton, Simon Fillatreau
Summary: Research has found that in the autoimmune disease EAE, antigen receptor-engineered Tregs used in cell therapy undergo changes in both local lymph nodes and the central nervous system. IL-10 and CTLA-4 are non-redundantly required for the protective function of these Tregs against EAE, as confirmed by genetic approaches. These molecules play important roles in suppressing CD4(+) T-cell activation and disease control, and also affect the accumulation of engineered Tregs in the recipients. Although the transferred Tregs persist and have a protective effect, autoreactive T cells eventually accumulate in the spleen.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Cell Biology
Eva-Maria Cox, Mohamed El-Behi, Stefanie Ries, Johannes F. Vogt, Vivien Kohlhaas, Thomas Michna, Benoit Manfroi, Mona Al-Maarri, Florian Wanke, Boaz Tirosh, Corinne Pondarre, Harry Lezeau, Nir Yogev, Romy Mittenzwei, Marc Descatoire, Sandra Weller, Jean-Claude Weill, Claude-Agnes Reynaud, Pierre Boudinot, Luc Jouneau, Stefan Tenzer, Ute Distler, Anne Rensing-Ehl, Christoph Koenig, Julian Staniek, Marta Rizzi, Aude Magerus, Frederic Rieux-Laucat, F. Thomas Wunderlich, Nadine Hoevelmeyer, Simon Fillatreau
Summary: This study reveals that AKT is involved in the formation of marginal zone (MZ) B cells in both mice and humans. By manipulating AKT signaling in B cells and its impact on FoxO transcription factors, the AKT-FoxO axis is identified as a switch for MZ B cell formation in mice. This developmental pathway is conserved in humans, where AKT-dependent splenic IgD+CD27+ B cells are proposed as the equivalent of MZ B cells.
Article
Ophthalmology
Gemma McIlwaine, Lajos Csincsik, Rachel Coey, Luping Wang, Denise Fitzgerald, Jill Moffat, Adam M. Dubis, Gavin McDonnell, Stella Hughes, Tunde Peto, Imre Lengyel
Summary: This study examined outer retinal changes in patients with multiple sclerosis (MS). Results showed thinning of the inner retina and thickening of the outer retina in patients with a history of optic neuritis. No changes were observed in patients without optic neuritis. Furthermore, cone density was found to be decreased in all MS cases.
OPHTHALMOLOGY SCIENCE
(2023)
Meeting Abstract
Clinical Neurology
C. Sanson, C. Bachelin, L. Guillot Noel, M. El Behi, P. Buissonniere, J. Fransson, V. Damotte, V. Guillemot, H. Abdi, I. Cournu Rebeix, B. Fontaine, V. Zujovic
MULTIPLE SCLEROSIS JOURNAL
(2018)
Meeting Abstract
Clinical Neurology
C. Sanson, M. El Behi, C. Bachelin, L. Guillot-Noel, J. Fransson, B. Stankoff, E. Maillart, N. Sarrazin, V. Guillemot, H. Abdi, I. Cournu-Rebeix, B. Fontaine, V. Zujovic
MULTIPLE SCLEROSIS JOURNAL
(2017)
Article
Clinical Neurology
Mohamed El Behi, Charles Sanson, Corinne Bachelin, Lena Guillot-Noel, Jennifer Fransson, Bruno Stankoff, Elisabeth Maillart, Nadege Sarrazin, Vincent Guillemot, Herve Abdi, Isabelle Cournu-Rebeix, Bertrand Fontaine, Violetta Zujovic