期刊
JOURNAL OF NEUROIMMUNOLOGY
卷 199, 期 1-2, 页码 83-93出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jneuroim.2008.05.013
关键词
EAE; multiple sclerosis; T cells; microglia; axons
资金
- National Multiple Sclerosis Society (USA) [CA 1029-A-2, TR 3760-A-3]
- Nancy Davis Center without walls
We measured inflammatory and neural markers of disease from 7 days to one year after induction of experimental autoimmune encephalomyelitis (EAE) by immunization with myelin oligodendrocyte glycoprotein (MOG) peptide. Axon loss began before behavioral signs when T cell infiltration and microglial activation were very subtle. Remyelination was only detectable ultrastructurally. Axon numbers in the dorsal column plateau around day 30 p.i. while behavioral measures (EAE scores, rotarod, grip strength) partially recover. These results provide a starting point for testing potential neuroprotective treatments I or multiple sclerosis (MS). (C) 2008 Elsevier B.V. All rights reserved.
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