Article
Immunology
Paola Antonello, Diego U. Pizzagalli, Mathilde Foglierini, Serena Melgrati, Egle Radice, Sylvia Thelen, Marcus Thelen
Summary: Chemotaxis is an essential process in tumors metastasis, and in this study, ACKR3 was found to control the migration of lymphoma cells in response to CXCL12. The interaction between LTB4 and CXCL12 enhances the migration of lymphoma cells, providing a novel mechanism for cell-to-cell-induced migration.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yaru Yang, Jiayan Li, Wangrui Lei, Haiying Wang, Yunfeng Ni, Yanqing Liu, Huanle Yan, Yifan Tian, Zheng Wang, Zhi Yang, Shulin Yang, Yang Yang, Qiang Wang
Summary: Cancer is a complex disease caused by genetic mutations and/or epigenetic changes, and it poses the biggest challenge worldwide. Cytokines, particularly chemokines, play a significant role in various human cancers by affecting homeostasis, immune function, and facilitating cancer development stages such as invasion, metastasis, and angiogenesis. Specifically, chemokines such as CXCL12 and its receptors CXCR4 and CXCR7 exert extensive influence on tumor cell behavior, including proliferation, survival, angiogenesis, metastasis, and tumor microenvironment, making them crucial players in the initiation and progression of cancers such as leukemia, breast cancer, lung cancer, prostate cancer, and multiple myeloma. This review aims to summarize the recent research progress and future challenges related to the CXCL12-CXCR4/CXCR7 signaling axis in cancer, emphasizing the potential of utilizing CXCL12-CXCR4/CXCR7 as a biomarker or therapeutic target for cancer treatment and providing valuable insights for the development of targeted cancer therapies.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Cell Biology
Peng Liu, Hongke Sun, Xin Zhou, Qiaozhu Wang, Feng Gao, Yuping Fu, Tong Li, Yixin Wang, Yingqi Li, Boyuan Fan, Xiaoli Li, Tiannan Jiang, Xinghua Qin, Qiangsun Zheng
Summary: This study identified three hub genes involved in atrial fibrillation (AF), with the CXCL12/CXCR4 axis standing out as a potent target for AF prevention. In vivo investigation showed that inhibiting CXCR4 reduced AF inducibility and duration by decreasing atrial inflammation and structural remodeling. Mechanistically, this effect was achieved by reducing immune cell recruitment and suppressing signaling pathways in the atria. These findings suggest that CXCL12/CXCR4 axis may be a potential therapeutic target for AF.
CELL DEATH & DISEASE
(2021)
Article
Multidisciplinary Sciences
Shi-sen Wang, Zi-jun Xu, Ye Jin, Ji-chun Ma, Pei-hui Xia, Xiangmei Wen, Zhen-wei Mao, Jiang Lin, Jun Qian
Summary: The study found that CXCL12 expression is significantly reduced in AML, and low CXCL12 expression is correlated with worse prognosis, predicting decreased overall survival and event-free survival rates.
Article
Cell Biology
Crescenzo D'Alterio, Alessandro Giardino, Giosue Scognamiglio, Giovanni Butturini, Luigi Portella, Giuseppe Guardascione, Isabella Frigerio, Marco Montella, Stefano Gobbo, Guido Martignoni, Vincenzo Napolitano, Ferdinando De Vita, Fabiana Tatangelo, Renato Franco, Stefania Scala
Summary: CXCR4-CXCL12 evaluation in PDAC identifies prognostic categories and could guide therapeutic approaches.
Article
Hematology
Julian Leberzammer, Stijn M. Agten, Xavier Blanchet, Rundan Duan, Hans Ippel, Remco T. A. Megens, Christian Schulz, Maria Aslani, Johan Duchene, Yvonne Doring, Natalie J. Jooss, Pengyu Zhang, Richard Brandl, Konstantin Stark, Wolfgang Siess, Kerstin Jurk, Johan W. M. Heemskerk, Tilman M. Hackeng, Kevin H. Mayo, Christian Weber, Philipp von Hundelshausen
Summary: The study explored the molecular mechanisms of CXCL12 in arterial thrombosis, revealing that inhibition of CXCR4 can attenuate platelet aggregation and limit arterial thrombosis. Mechanistically, CXCL12 activates Btk leading to platelet aggregation, while the interaction between CXCL12 and CCL5 can inhibit this process. A novel peptide was found to inhibit CXCL12-induced platelet aggregation without prolonging bleeding time.
Article
Cell Biology
Liam A. Ridge, Dania Kewbank, Dagmar Schuetz, Ralf Stumm, Peter J. Scambler, Sarah Ivins
Summary: The study shows that CXCL12 signaling through its receptor CXCR4 plays distinct roles in different stages of SLV development, guiding cellular distribution and regulating cell proliferation. The atypical chemokine receptor CXCR7 may have a role in regulating ligand bioavailability during SLV morphogenesis.
Article
Pharmacology & Pharmacy
Mahdieh Mehrpouri
Summary: CXCL12/CXCR4 and CXCL12/CXCR7 axes play a key role in hematopoiesis and their aberrant expression may lead to the development of leukemia. Various therapeutic interventions have been developed to target these axes in leukemic cells, showing promising results in pre-clinical and clinical studies.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Microbiology
Kathryn Wright, Kumudika de Silva, Karren M. Plain, Auriol C. Purdie, Tamika A. Blair, Lain G. Duggin, Warwick J. Britton, Stefan H. Oehlers
Summary: Mycobacterial infections cause significant disease burden and pathogenic mycobacteria induce host miR-206 expression to suppress protective neutrophil recruitment, promoting permissive granuloma microenvironments in the host.
Article
Chemistry, Medicinal
Daniel J. Sprague, Anthony E. Getschman, Tyler G. Fenske, Brian F. Volkman, Brian C. Smith
Summary: The CXCL12-CXCR4 signaling axis plays a critical role in development, immune function, and various diseases, including cancer and inflammatory diseases. A study has identified trisubstituted 1,3,5-triazines as competent ligands for the sY12-binding pocket of CXCL12, improving drug efficiency and offering new possibilities for therapeutic development and structural studies.
ACS MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Multidisciplinary Sciences
Jose Mario Gonzalez-Meljem, Sarah Ivins, Cynthia Lilian Andoniadou, Paul Le Tissier, Peter Scambler, Juan Pedro Martinez-Barbera
Summary: The role of the chemokine SDF-1 and its receptor CXCR4 in pituitary gland development was investigated. The expression patterns of CXCR4, SDF-1, and CXCR7 were characterized, and it was found that SDF-1 is expressed in progenitor-rich regions of the pituitary gland. Conditional deletion of CXCR4 in embryonic pituitary progenitors did not lead to observable defects, suggesting that CXCR4 expression in HESX1+ cells and their descendants is not essential for normal pituitary development in mice.
Article
Fisheries
Beibei Zhao, Jing Diao, Le Li, Hidehiro Kondo, Lei Li, Ikuo Hirono
Summary: This study identified and characterized the CXCR2 gene in Japanese flounder, showing that the expression levels of JfCXCR1 and JfCXCR2 increase significantly in response to bacterial infections, with JfCXCR1 potentially activated by bacterial infections and JfCXCR2 activated by both bacterial and viral infections to mediate the immune response. These findings contribute to understanding the functions of CXCR1 and CXCR2 in the fish immune system.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Martine J. Smit, Geraldine Schlecht-Louf, Maria Neves, Jelle van den Bor, Petronila Penela, Marco Siderius, Francoise Bachelerie, Federico Mayor
Summary: The elevated expression of chemokine receptors CXCR4 and ACKR3 and their ligand CXCL12 in tumors and the tumor microenvironment has led to complex research on their contribution to cancer pathogenesis. Discussions include their impact on signaling networks, crosstalk with RTKs and other TME factors, as well as the infiltration of immune cells supporting tumor progression. Targeting the CXCL12/CXCR4/ACKR3 axis along with RTKs and immune cells modulation shows promising therapeutic potential in multitargeted cancer therapies.
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 61, 2021
(2021)
Article
Pharmacology & Pharmacy
Riccardo Capecchi, Cristina Croia, Ilaria Puxeddu, Federico Pratesi, Andrea Cacciato, Daniela Campani, Ugo Boggi, Luca Morelli, Antonio Tavoni, Paola Migliorini
Summary: The study revealed significantly higher levels of serum SDF-1/CXCL12 in IgG4-RD patients compared to normal controls, suggesting a potential role of this chemokine in the pathogenesis of IgG4-RD. Additionally, the IgG4-RD AIP subgroup showed higher serum levels of SDF-1/CXCL12 compared to the SSj group.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Isabel Hamshaw, Marco M. D. Cominetti, Wing-Yee Lai, Mark Searcey, Anja Mueller
Summary: Cancer metastasis is a major cause of cancer-related death. The CXCR4 receptor and its ligand CXCL12 play important roles in promoting metastasis, making them attractive therapeutic targets. In this study, a novel CXCR4 antagonist was developed and used for CXCR4-based imaging. The results showed that these antagonists were non-toxic and effectively inhibited cancer cell migration and calcium release.
BIOCHEMICAL PHARMACOLOGY
(2023)