Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors
出版年份 2014 全文链接
标题
Target Engagement Analysis and Link to Pharmacodynamic Endpoint for a Novel Class of CNS-penetrant and Efficacious p38α MAPK Inhibitors
作者
关键词
Mitogen-activated protein kinase, Drug discovery, Neurodegeneration, Signal transduction, Cytokine, Microglia
出版物
Journal of Neuroimmune Pharmacology
Volume 9, Issue 4, Pages 454-460
出版商
Springer Nature
发表日期
2014-04-30
DOI
10.1007/s11481-014-9543-3
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Microglial dysfunction in brain aging and Alzheimer's disease
- (2014) Kira Irving Mosher et al. BIOCHEMICAL PHARMACOLOGY
- Reactive Gliosis and the Multicellular Response to CNS Damage and Disease
- (2014) Joshua E. Burda et al. NEURON
- The p38 MAPK Regulates Microglial Responsiveness to Diffuse Traumatic Brain Injury
- (2013) A. D. Bachstetter et al. JOURNAL OF NEUROSCIENCE
- Deficiency in p38β MAPK Fails to Inhibit Cytokine Production or Protect Neurons against Inflammatory Insult in In Vitro and In Vivo Mouse Models
- (2013) Bin Xing et al. PLoS One
- Development of Novel In Vivo Chemical Probes to Address CNS Protein Kinase Involvement in Synaptic Dysfunction
- (2013) D. Martin Watterson et al. PLoS One
- Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase
- (2013) Gerardo A. Morfini et al. PLoS One
- Casein Kinase I Mutations in Familial Migraine and Advanced Sleep Phase
- (2013) K. C. Brennan et al. Science Translational Medicine
- Brain-Derived Neurotrophic Factor-Dependent Synaptic Plasticity Is Suppressed by Interleukin-1 via p38 Mitogen-Activated Protein Kinase
- (2012) L. Tong et al. JOURNAL OF NEUROSCIENCE
- A call for transparent reporting to optimize the predictive value of preclinical research
- (2012) Story C. Landis et al. NATURE
- Non-specific in vivo inhibition of CK1 by the pyridinyl imidazole p38 inhibitors SB 203580 and SB 202190
- (2011) Naval P. Shanware et al. BMB Reports
- Inhibition of Wnt/β-Catenin Signaling by p38 MAP Kinase Inhibitors Is Explained by Cross-Reactivity with Casein Kinase Iδ/ɛ
- (2011) Folkert Verkaar et al. CHEMISTRY & BIOLOGY
- Microglial p38α MAPK is a key regulator of proinflammatory cytokine up-regulation induced by toll-like receptor (TLR) ligands or beta-amyloid (Aβ)
- (2011) Adam D Bachstetter et al. Journal of Neuroinflammation
- Microglial p38α MAPK is critical for LPS-induced neuron degeneration, through a mechanism involving TNFα
- (2011) Bin Xing et al. Molecular Neurodegeneration
- Accelerating drug discovery for Alzheimer's disease: best practices for preclinical animal studies
- (2011) Diana W Shineman et al. Alzheimers Research & Therapy
- Microglial Physiology: Unique Stimuli, Specialized Responses
- (2009) Richard M. Ransohoff et al. Annual Review of Immunology
- Chemokines and Chemokine Receptors: Standing at the Crossroads of Immunobiology and Neurobiology
- (2009) Richard M. Ransohoff IMMUNITY
- Targeting protein kinases in central nervous system disorders
- (2009) Laura K. Chico et al. NATURE REVIEWS DRUG DISCOVERY
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