Article
Microbiology
Geovana Calvo-Anguiano, Jose de Jesus Lugo-Trampe, Gustavo Ponce-Garcia, Angel Lugo-Trampe, Laura Elia Martinez-Garza, Marisol Ibarra-Ramirez, Luis Daniel Campos-Acevedo, Sandra Caballero-Sosa, Alan Esteban Juache-Villagrana, Ildefonso Fernandez-Salas, Adriana Elizabeth Flores-Suarez, Iram Pablo Rodriguez-Sanchez, Karina del Carmen Trujillo-Murillo
Summary: In serum samples from 253 suspected arbovirus infection patients in the southern border region of Mexico, a high percentage tested positive for CHIKV, with the first identification of Leptospira Kmetyi in Mexico. Etiological agents for fever were determined in 94% of the analyzed samples.
Review
Virology
Leonardo F. Ormundo, Carolina T. Barreto, Lilian R. Tsuruta
Summary: Antibody-based passive immunotherapy is effective in treating and preventing infectious diseases. Selecting neutralizing monoclonal antibodies (mAbs) and developing highly effective mAbs have become important strategies in combating emerging arbovirus infections.
Article
Public, Environmental & Occupational Health
Agnes Bjornstrom, Anne-Lie Blomstrom, Manish Chandra Singh, Jenny C. Hesson
Summary: The study revealed that horses in Sweden have become infected with SINV and developed neutralising antibodies, raising important questions for future studies regarding potential connections between infection and disease development.
Article
Immunology
Benjamin C. Pierson, Anthony P. Cardile, Arthur C. Okwesili, Isaac L. Downs, Ronald B. Reisler, Ellen F. Boudreau, Mark G. Kortepeter, Craig D. Koca, Manmohan Ranadive, Patricia L. Petitt, Niranjan Kanesa-thasan, Robert G. Rivard, Dani L. Liggett, Jeannine M. Haller, Sarah L. Norris, Bret K. Purcell, Phillip R. Pittman, David L. Saunders, Maryam Keshtkar Jahromi
Summary: The study showed that an inactivated EEEV vaccine is safe and immunogenic in at-risk laboratory personnel. Prolonging the primary vaccination series with a dose at month 6 significantly improved vaccine immunogenicity.
Article
Veterinary Sciences
Daniela Luethy
Summary: The ongoing recognition and emergence of alphavirus and flavivirus diseases pose a growing concern in veterinary and public health. With the constantly changing global environment, mosquito-borne diseases will continue to evolve and spread. Developing easily accessible vaccines for prevention and researching effective antiviral treatments are crucial in controlling the outbreaks of these diseases.
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE
(2023)
Article
Chemistry, Medicinal
Sirle Saul, Pei-Tzu Huang, Shirit Einav, Christopher R. M. Asquith
Summary: This study identified three potent compounds against dengue virus and Venezuelan equine encephalitis virus, all of which showed nearly no toxicity, providing promising prospects for the development of clinical compounds against these emerging viral threats.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Immunology
Rebeca Froes Rocha, Juliana L. Del Sarto, Giovanni F. Gomes, Mariana P. Goncalves, Milene A. Rachid, Juliana H. C. Smetana, Daniele G. Souza, Mauro Martins Teixeira, Rafael Elias Marques
Summary: The research found that type I and type II interferons have different roles in St. Louis encephalitis virus infection, with type I interferon being essential for controlling viral replication while type II interferon is not associated with protection in this model.
Article
Virology
Lana Langendries, Sofie Jacobs, Rana Abdelnabi, Sam Verwimp, Suzanne Kaptein, Pieter Baatsen, Lieve Van Mellaert, Leen Delang
Summary: In recent decades, there has been a significant increase in the epidemics of alphavirus and flavivirus infections worldwide. The impact of host microbiota on arbovirus infections is not well understood. This study demonstrates that certain components of bacterial cell walls can reduce the infectivity of arboviruses by directly interacting with the virus particles.
JOURNAL OF VIROLOGY
(2022)
Article
Virology
Lucia Moreira Marrero, German Botto Nunez, Sandra Frabasile, Adriana Delfraro
Summary: This study reports the genomic detection and identification of Rio Negro virus (RNV) and eastern equine encephalitis virus (EEEV) in oral swabs from bats captured in Northern Uruguay. The findings suggest that bats can be infected by these arboviruses and may play a role in their natural cycle.
Article
Microbiology
Rubing Chen, Jessica A. Plante, Kenneth S. Plante, Ruimei Yun, Divya Shinde, Jianying Liu, Sherry Haller, Suchetana Mukhopadhyay, Scott C. Weaver
Summary: This study examined whether Asian lineage CHIKV strains are likely to acquire Aedes albopictus-adaptive E2 substitutions and found that these mutations significantly decreased infectivity for A. albopictus in the Asian lineage backbone. Additionally, species-specific factors in mosquitoes were identified to play a role in vector infection efficiency, leading to different effects between Aedes albopictus and Aedes aegypti. The divergence between Asian lineage and IOL CHIKVs has led them onto different adaptive landscapes, affecting their potential to expand their vector host range.
Review
Immunology
Robyn S. Klein
Summary: The article provides a review of mosquito-borne viruses causing neurologic infections in Africa, discussing their neuropathogenesis and host neuroimmunological responses. It also explores the potential of neuroimmune responses in the development of new diagnostics and therapeutics, highlighting current knowledge gaps that need to be addressed in arbovirus research.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Parasitology
Luis M. Romero-Vega, Marta Piche-Ovares, Claudio Soto-Garita, Daniel Felipe Barantes Murillo, Luis Guillermo Chaverri, Alejandro Alfaro-Alarcon, Eugenia Corrales-Aguilar, Adriana Troyo
Summary: This study describes and analyzes the community structure of mosquito vectors in Costa Rica. The results show that there are significant differences in mosquito populations in coastal areas of Costa Rica during different seasons. However, year-long continuous sampling is needed to better understand the local dynamics.
PARASITES & VECTORS
(2023)
Article
Immunology
Masayuki Ohira, Kentaro Yoshii, Yasuhiro Aso, Hideto Nakajima, Toru Yamashita, Ikuko Takahashi-Iwata, Norihisa Maeda, Katsuro Shindo, Toshihiko Suenaga, Tohru Matsuura, Kazuma Sugie, Tadanori Hamano, Akira Arai, Rikiya Furutani, Yasuhiro Suzuki, Chikako Kaneko, Yasuhiro Kobayashi, Eduardo Campos-Alberto, Lisa R. Harper, Juanita Edwards, Cody Bender, Andreas Pilz, Shuhei Ito, Frederick J. Angulo, Wilhelm Erber, Harish Madhava, Jennifer Moisi, Luis Jodar, Hidehiro Mizusawa, Masaki Takao
Summary: Tick-borne encephalitis (TBE) cases have been identified in Japan, including outside of Hokkaido, suggesting that TBEV infection may be undiagnosed in the country. This study retrospectively tested serum and cerebrospinal fluid (CSF) samples from hospitalized patients and confirmed three TBE cases. Limited clinical awareness and lack of TBE diagnostic tests contribute to the underdiagnosis of TBE in Japan.
EMERGING MICROBES & INFECTIONS
(2023)
Article
Virology
Lukasz Kedzierski, Abigail Er Qi Tan, Isabelle Jia Hui Foo, Sandra E. Nicholson, John K. Fazakerley
Summary: SOCS5 plays a crucial role in regulating anti-viral immunity in the brain, influencing the critical balance between immunopathology and virus persistence, thus affecting the pathogenesis and clinical outcomes of neurotropic virus infections.
Article
Immunology
Shirlene Telmos Silva de Lima, William Marciel de Souza, John Washington Cavalcante, Darlan da Silva Candido, Marcilio Jorge Fumagalli, Jean-Paul Carrera, Leda Maria Simoes Mello, Fernanda Montenegro de Carvalho Araujo, Izabel Leticia Cavalcante Ramalho, Francisca Kalline de Almeida Barreto, Deborah Nunes de Melo Braga, Adriana Rocha Simiao, Mayara Jane Miranda da Silva, Rhaquel de Morais Alves Barbosa Oliveira, Clayton Pereira Silva Lima, Camila de Sousa Lins, Rafael Ribeiro Barata, Marcelo Nunes Pereira Melo, Michel Platini Caldas de Souza, Luciano Monteiro Franco, Fabio Rocha Fernandes Tavora, Daniele Rocha Queiroz Lemos, Carlos Henrique Morais de Alencar, Ronaldo de Jesus, Vagner de Souza Fonseca, Leonardo Hermes Dutra, Andre Luiz de Abreu, Emerson Luiz Lima Araujo, Andre Ricardo Ribas Freitas, Joao Lidio da Silva Goncalves Vianez Junior, Oliver G. Pybus, Luiz Tadeu Moraes Figueiredo, Nuno Rodrigues Faria, Marcio Roberto Teixeira Nunes, Luciano Pamplona de Goes Cavalcanti, Fabio Miyajima
Summary: The investigation of fatal Chikungunya virus cases in Ceara state, Brazil, revealed co-infections with Dengue and Zika viruses, neurological symptoms as a major presentation in fatal cases, and no unique virus genomic mutation associated with fatal outcomes.
CLINICAL INFECTIOUS DISEASES
(2021)
Meeting Abstract
Oncology
Troy E. Messick, Samantha S. Soldan, Julianna Deakyne, Paul M. Lieberman
JOURNAL OF CLINICAL ONCOLOGY
(2017)
Article
Neurosciences
Evan C. Rosenberg, Jocelyn J. Lippman-Bell, Marcus Handy, Samantha S. Soldan, Sanjay Rakhade, Cristina Hilario-Gomez, Kaitlyn Folweiler, Leah Jacobs, Frances E. Jensen
NEUROBIOLOGY OF DISEASE
(2018)
Article
Immunology
Ryan H. Moy, Beth Gold, Jerome M. Molleston, Veronica Schad, Kilangsungla Yanger, Mary-Virginia Salzano, Yoshimasa Yagi, Katherine A. Fitzgerald, Ben Z. Stanger, Samantha S. Soldan, Sara Cherry
Article
Virology
Bradley S. Hollidge, Natalia B. Nedelsky, Mary-Virginia Salzano, Jonathan W. Fraser, Francisco Gonzalez-Scarano, Samantha S. Soldan
JOURNAL OF VIROLOGY
(2012)
Article
Virology
Heike Hofmann, Xingxing Li, Xiaoai Zhang, Wei Liu, Annika Kuehl, Franziska Kaup, Samantha S. Soldan, Francisco Gonzalez-Scarano, Friedemann Weber, Yuxian He, Stefan Poehlmann
JOURNAL OF VIROLOGY
(2013)
Article
Biochemistry & Molecular Biology
P. P. Banerjee, L. Pang, S. S. Soldan, S. M. Miah, A. Eisenberg, S. Maru, A. Waldman, E. A. Smith, Y. Rosenberg-Hasson, D. Hirschberg, A. Smith, D. V. Ablashi, K. S. Campbell, J. S. Orange
MOLECULAR IMMUNOLOGY
(2019)
Article
Cell Biology
Troy E. Messick, Garry R. Smith, Samantha S. Soldan, Mark E. McDonnell, Julianna S. Deakyne, Kimberly A. Malecka, Lois Tolvinski, A. Pieter J. van den Heuvel, Bai-Wei Gu, Joel A. Cassel, Donna H. Tran, Benjamin R. Wassermann, Yan Zhang, Venkata Velvadapu, Edward R. Zartler, Pierre Busson, Allen B. Reitz, Paul M. Lieberman
SCIENCE TRANSLATIONAL MEDICINE
(2019)
Article
Microbiology
R. Jason Lamontagne, Samantha S. Soldan, Chenhe Su, Andreas Wiedmer, Kyoung Jae Won, Fang Lu, Aaron R. Goldman, Jayamanna Wickramasinghe, Hsin-Yao Tang, David W. Speicher, Louise Showe, Andrew V. Kossenkov, Paul M. Lieberman
Summary: EBV immortalizes resting B-lymphocytes through orchestrated reprogramming of chromatin structure, transcription, and metabolism. The virus alters accessible chromatin, leading to complex transcriptional responses and changes in nucleotide metabolism. Purine metabolism, particularly the role of adenosine deaminase, emerges as a major therapeutic target in EBV-driven lymphoid cancers. This study highlights the importance of purine metabolism and ADA in EBV-induced immortalization process.
Article
Oncology
Samantha S. Soldan, Emma M. Anderson, Drew M. Frase, Yue Zhang, Lisa B. Caruso, Yin Wang, Julianna S. Deakyne, Benjamin E. Gewurz, Italo Tempera, Paul M. Lieberman, Troy E. Messick
Summary: The study demonstrated that the EBNA1 inhibitor VK-1727 selectively inhibited cell growth in EBV-positive gastric carcinoma and reduced tumor growth in animal models, but not in EBV-negative gastric carcinoma. Short-term treatment tended to activate viral genes, while long-term treatment resulted in significant decrease in viral gene expression.
Article
Virology
Fang Lu, Kayla A. Martin, Samantha S. Soldan, Andrew Kossenkov, Priyankara Wickramasinghe, Olga Vladimirova, Alessandra De Leo, Cindy Lin, Yulia Nefedova, Paul M. Lieberman
Summary: Aberrant viral genomes and lytic gene expression are found in rare B cells derived from multiple myeloma tumors, suggesting a potential role of Epstein-Barr virus (EBV) in the etiology of multiple myeloma. Further studies are needed to fully understand the mechanisms of EBV oncogenesis in this context.
JOURNAL OF VIROLOGY
(2021)
Article
Microbiology
Samantha S. Soldan, Chenhe Su, R. Jason Lamontagne, Nicholas Grams, Fang Lu, Yue Zhang, James D. Gesualdi, Drew M. Frase, Lois E. Tolvinski, Kayla Martin, Troy E. Messick, Jonathan T. Fingerut, Ekaterina Koltsova, Andrew Kossenkov, Paul M. Lieberman
Summary: The study demonstrates that epigenetic changes in EBV+ B-cells lead to a neuroinvasive phenotype, and blocking the upregulated protein SPP1/Osteopontin can reduce the ability of these cells to penetrate the central nervous system.
Article
Microbiology
Chenhe Su, Fang Lu, Samantha S. Soldan, R. Jason Lamontagne, Hsin-Yao Tang, Giorgia Napoletani, Paul J. Farrell, Italo Tempera, Andrew V. Kossenkov, Paul M. Lieberman
Summary: The study reveals a new transcriptional mechanism by which EBV encoded EBNA2 down-regulates HLA class II gene expression, impacting T-cell recognition of infected cells. EBNA2 competes with CIITA binding, leading to CIITA transcriptional down-regulation and subsequent HLA-II gene expression attenuation. This indirect regulation is proposed to be due to enhancer competition at neighboring chromosome domains.
Review
Microbiology
Samantha S. Soldan, Paul M. Lieberman
Summary: EBV plays a significant role in the development of multiple sclerosis (MS) through the reprogramming of infected B lymphocytes and the chronic presentation of viral antigens. Understanding how EBV contributes to MS may also provide insights into the relationship between EBV and cancer.
NATURE REVIEWS MICROBIOLOGY
(2023)
Article
Hematology
Zhiwei Ang, Luca Paruzzo, Katharina E. Hayer, Carolin Schmidt, Manuel Torres Diz, Feng Xu, Urvi Zankharia, Yunlin Zhang, Samantha Soldan, Sisi Zheng, Catherine D. Falkenstein, Joseph P. Loftus, Scarlett Y. Yang, Mukta Asnani, Patricia King Sainos, Vinodh Pillai, Emeline Chong, Marilyn M. Li, Sarah K. Tasian, Yoseph Barash, Paul M. Lieberman, Marco Ruella, Stephen J. Schuster, Andrei Thomas-Tikhonenko
Summary: Skipping of coding exons in CD19 and CD22 genes compromises immunotherapy response in B-cell malignancies. This study demonstrates that CD20 gene (MS4A1) also produces multiple mRNA isoforms with distinct untranslated regions. Modulating CD20 isoforms enhances CD20 expression and antibody-mediated cytotoxicity, potentially overcoming immunotherapy resistance.
Review
Microbiology
Samantha S. Soldan, Paul M. Lieberman
Summary: This review article examines the evidence for EBV as a causal agent of MS and discusses how various risk factors can affect EBV infection and immune control. The article focuses on the reprogramming of latently infected B lymphocytes by EBV and the chronic presentation of viral antigens as a potential mechanism for MS development. The potential for therapies targeting EBV to treat MS is also discussed.
NATURE REVIEWS MICROBIOLOGY
(2023)