Article
Immunology
A. Galan-Salinas, G. Corral-Ruiz, M. J. Perez-Vega, L. Fabila-Castillo, R. Silva-Garcia, B. Marquina-Castillo, J. C. Leon-Contreras, J. Barrios-Payan, A. Francisco-Cruz, M. Montecillo-Aguado, S. Huerta-Yepez, J. Calderon-Amador, L. Flores-Romo, R. Hernandez-Pando, L. E. Sanchez-Torres
Summary: The study demonstrated that the administration of anti-inflammatory peptide MLIF increased survival and provided neuroprotection in murine cerebral malaria by reducing neuroinflammation, inhibiting cell adhesion, and maintaining blood-brain barrier integrity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biology
Nigel A. Morrison, Mark R. Forwood
Summary: In this study, the effects of different cytokines on the expression of chemokines in human CD14(+) cells in culture were investigated. It was found that M-CSF treatment promoted MCP1 expression, while GM-CSF suppressed MCP1 expression. Furthermore, addition of MCP1 significantly increased osteoclast formation and overcame the suppression caused by GM-CSF.
Article
Multidisciplinary Sciences
Ken Yoshida, Haruyasu Ito, Daisaburo Kurosaka, Ryo Ikeda, Kentaro Noda, Mitsuru Saito, Daitaro Kurosaka
Summary: PAD4 contributes to the production of citrullinated proteins as autoantigens in RA. This study showed that autocitrullinated PAD4 can recruit monocytes and induce inflammation in mouse joints. Higher levels of citrullinated PAD4 were found in the synovial fluid of RA patients compared to osteoarthritis patients.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Wenya He, Xiaozhe Li, Marco Morsch, Muhammad Ismail, Yanjie Liu, Fawad Ur Rehman, Dongya Zhang, Yibin Wang, Meng Zheng, Roger Chung, Yan Zou, Bingyang Shi
Summary: In this study, the researchers discovered that the Mcl-1-specific inhibitor A12 synergizes with ABT to induce potent cell apoptosis in GBM. They also developed a biomimetic nanomedicine that can effectively deliver ABT and A12 to the brain, exhibiting good biocompatibility and efficient blood-brain barrier penetration. This nanomedicine effectively suppressed tumor growth and prolonged the survival time of mice with GBM xenografts without inducing adverse effects.
Review
Immunology
Zhuqing Jin, En Zheng, Candice Sareli, Pappachan E. Kolattukudy, Jianli Niu
Summary: Inflammatory response is a protective mechanism of the host, but can also lead to immunopathology and tissue damage. Recent studies on the MCPIP family of chemical molecules, particularly the role of MCPIP-1 in the NF kappa B signaling pathway, have revealed important biological functions in resolving inflammation. Understanding the roles of the MCPIP family members can provide new insights into the treatment of infections and other inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Pharmacology & Pharmacy
Sorabh Sharma, Craig E. Brown
Summary: This review discusses the relationship between microvascular dysfunction caused by type 1 diabetes and cognitive impairment, aiming to synthesize the current knowledge in this field.
PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Immunology
Jian Huang, Jiuyang Ding, Xiaohan Wang, Cihang Gu, Yitong He, Yanning Li, Haoliang Fan, Qiqian Xie, Xiaolan Qi, Zhuo Wang, Pingming Qiu
Summary: This study found that METH exposure leads to the transmission of alpha-synuclein (alpha-syn) from neurons to astrocytes, resulting in astrocyte activation and disruption of the blood-brain barrier (BBB) by downregulating the expression of nuclear receptor-related protein 1 (Nurr1). The findings suggest that targeting alpha-syn and Nurr1 could be promising interventions to reduce BBB injury and neurotoxicity in METH abusers.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Review
Pharmacology & Pharmacy
Stefan Trapp, Daniel Brierley
Summary: This review examines the similarities and differences between physiological systems regulated by gut-derived and neuronally produced GLP-1, discussing whether peripheral and central sources of GLP-1 are separate, linked, or redundant systems, as well as the heterogeneity or homogeneity of the brain GLP-1 system, and the implications for using GLP-1 receptor agonists as anti-obesity drugs.
BRITISH JOURNAL OF PHARMACOLOGY
(2022)
Article
Immunology
Huiling Hu, Xue Yang, Yuqing He, Chaohui Duan, Nannan Sun
Summary: Psychological stress plays an important role in the development of psychiatric disorders. This study found that psychological stress can trigger the recruitment and migration of bone marrow-derived monocytes to the hippocampus, which contributes to the regulation of depressive-like behaviors.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Pharmacology & Pharmacy
Sho Sato, Kota Matsumiya, Kimio Tohyama, Yohei Kosugi
Summary: A translational CNS steady-state drug disposition model was developed to successfully predict the brain-to-plasma unbound concentration ratio and cerebrospinal fluid-to-plasma unbound concentration ratio across rats, monkeys, and humans, improving CNS drug discovery workflow.
Article
Biochemistry & Molecular Biology
Frederik Desmarais, Vincent Herve, Karl F. Bergeron, Gaetan Ravaut, Morgane Perrotte, Guillaume Fyfe-Desmarais, Eric Rassart, Charles Ramassamy, Catherine Mounier
Summary: The study revealed that ApoD can quickly and efficiently exit the CNS and reach the liver and kidneys/urine, organs associated with lipid and toxin recycling and excretion. Therefore, overexpression of ApoD in the brain during neurodegenerative episodes may help eliminate neurotoxic ApoD ligands.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Christina B. Schroeter, Christopher Nelke, Marcus Schewe, Lucas Spohler, Alexander M. Herrmann, Thomas Muentefering, Niklas Huntemann, Maria Kuzikov, Philip Gribbon, Sarah Albrecht, Stefanie Bock, Petra Hundehege, Lea Christine Neelsen, Thomas Baukrowitz, Guiscard Seebohm, Bernhard Wuensch, Stefan Bittner, Tobias Ruck, Thomas Budde, Sven G. Meuth
Summary: This study identifies and validates three new activators of TREK1 channel, namely E1, B3, and A2. These compounds reduce levels of adhesion molecules on human brain and muscle endothelial cells without affecting cell viability. Among them, A2 has the strongest effect on adhesion molecules but lacks TREK1 activation in neuronal cells. This study provides new activators that might be employed to pharmacologically modulate TREK1 activity.
BIOLOGICAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Xiangliang Zeng, Guohua He, Xirong Yang, Guoyao Xu, Yidan Tang, Hanwen Li, Bing Yu, Zhen Wang, Wei Xu, Kangping Song
Summary: Zebularine preserves BBB integrity, reduces inflammation, and improves neurological deficits in ischemic stroke. It mitigates endothelial hyper-permeability by activating the AMPK alpha pathway.
Article
Pharmacology & Pharmacy
Aaro J. Jalkanen, Jouni Ihalainen, Marko Lehtonen, Markus M. Forsberg, Jarkko Rautio, Kristiina M. Huttunen, Mikko Gynther
Summary: The study found significant species differences in the intra-brain distribution of compounds utilizing L-type amino acid transporter 1 between mice and rats, with more pronounced effects in rats. These results underscore the importance of cross-species characterization of prodrug pharmacokinetics and pharmacodynamics in preclinical studies.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Jingjing Wei, Di Wu, Yu Shao, Beibei Guo, Jingjing Jiang, Jian Chen, Jinping Zhang, Fenghua Meng, Zhiyuan Zhong
Summary: The use of ApoE peptide-mediated nanodelivery system enables targeted delivery of GrB and CpG ODN to malignant glioma cells, enhancing the immunotherapy response and leading to delayed tumor progression and prolonged survival time in mice.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Multidisciplinary Sciences
Ying Jiang, Aihua Sun, Yang Zhao, Wantao Ying, Huichuan Sun, Xinrong Yang, Baocai Xing, Wei Sun, Liangliang Ren, Bo Hu, Chaoying Li, Li Zhang, Guangrong Qin, Menghuan Zhang, Ning Chen, Manli Zhang, Yin Huang, Jinan Zhou, Yan Zhao, Mingwei Liu, Xiaodong Zhu, Yang Qiu, Yanjun Sun, Cheng Huang, Meng Yan, Mingchao Wang, Wei Liu, Fang Tian, Huali Xu, Jian Zhou, Zhenyu Wu, Tieliu Shi, Weimin Zhu, Jun Qin, Lu Xie, Jia Fan, Xiaohong Qian, Fuchu He, Yunping Zhu, Yi Wang, Dong Yang, Wanlin Liu, Qiongming Liu, Xiaoming Yang, Bei Zhen, Zhenyu Wu, Jia Fan, Huichuan Sun, Juying Qian, Tao Hong, Lin Shen, Baocai Xing, Pengyuan Yang, Huali Shen, Lijuan Zhang, Shujun Cheng, Jianqiang Cai, Xiaohang Zhao, Yulin Sun, Ting Xiao, Yousheng Mao, Xiangmei Chen, Di Wu, Lin Chen, Jun Dong, Haiteng Deng, Minjia Tan, Zhixing Wu, Qingchuan Zhao, Zhongyang Shen, Xinguo Chen, Youhe Gao, Wei Sun, Tong Wang, Siqi Liu, Liang Lin, Jin Zi, Xiaomin Lou, Rong Zeng, Yi Wu, Sanjun Cai, Bo Jiang, Anqing Chen, Zijian Li, Fuquan Yang, Xiulan Chen, Yuna Sun, Quanli Wang, Yi Zhang, Guangshun Wang, Zhuchu Chen, Weisong Qin, Zesong Li
Article
Cell Biology
Wenbin Zhong, Mengyang Xu, Chanjuan Li, Biying Zhu, Xiuye Cao, Dan Li, Huanzhao Chen, Chunxiu Hu, Rong Li, Chengwei Luo, Guoping Pan, Wenqiang Zhang, Chaofeng Lai, Tong Wang, Xin Du, Hong Chen, Guowang Xu, Vesa M. Olkkonen, Pingsheng Lei, Jun Xu, Daoguang Yan
Article
Immunology
Raj Putatunda, Yonggang Zhang, Fang Li, Philip Regis Fagan, Huaqing Zhao, Servio H. Ramirez, Domenico Pratico, Mary F. Barbe, Wenhui Hu
BRAIN BEHAVIOR AND IMMUNITY
(2019)
Article
Critical Care Medicine
Lee Anne Cannella, Allison M. Andrews, Fionya Tran, Roshanak Razmpour, Hannah McGary, Ceryce Collie, Tarik Tsegaye, Marquis Maynard, Marc J. Kaufman, Scott M. Rawls, Servio H. Ramirez
JOURNAL OF NEUROTRAUMA
(2020)
Article
Biochemistry & Molecular Biology
Alana N. Vagnozzi, Jian-Guo Li, Jin Chiu, Roshanak Razmpour, Rebecca Warfield, Servio H. Ramirez, Domenico Pratico
Summary: VPS35 plays a crucial role in tau metabolism and neuropathology, with its overexpression reducing pathological tau in neuronal cells while genetic silencing leads to accumulation. The availability of active cathepsin D mediates the effect of VPS35 on pathological tau accumulation, making it a potential therapeutic target for human tauopathies.
MOLECULAR PSYCHIATRY
(2021)
Article
Behavioral Sciences
Lee Anne Cannella, Allison M. Andrews, Roshanak Razmpour, Hannah McGary, Cali B. Corbett, Jana Kahn, Servio H. Ramirez
BEHAVIOURAL BRAIN RESEARCH
(2020)
Article
Medicine, Research & Experimental
Killian S. Hanlon, Jonah C. Meltzer, Tetyana Buzhdygan, Ming J. Cheng, Miguel Sena-Esteves, Rachel E. Bennett, Timothy P. Sullivan, Roshanak Razmpour, Yi Gong, Carrie Ng, Josette Nammour, Daniela Maiz, Simon Dujardin, Servio H. Ramirez, Eloise Hudry, Casey A. Maguire
MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT
(2019)
Review
Biology
Shaohua Lu, Tong Wang, Gong Zhang, Qing-Yu He
SCIENCE CHINA-LIFE SCIENCES
(2020)
Article
Microbiology
Victoria Lutgen, Srinivas D. Narasipura, Hannah J. Barbian, Maureen Richards, Jennillee Wallace, Roshanak Razmpour, Tetyana Buzhdygan, Servio H. Ramirez, Lisa Prevedel, Eliseo A. Eugenin, Lena Al-Harthi
Article
Biochemical Research Methods
Ziqi Yan, Wanling Zhang, Pengcheng Xu, Wenting Zheng, Xinyi Lin, Jian Zhou, Jianwu Chen, Qing-Yu He, Jingxiang Zhong, Jiahui Guo, Biao Cheng, Tong Wang
Summary: Through phosphoproteome analysis, we found aberrant phospho-signaling changes in keloid fibroblasts, including disrupted calcium homeostasis and induced platelet aggregation. Additionally, some phosphoproteins were identified to predict activation of upstream regulators relevant to keloid. Importantly, phosphorylated FLNA was confirmed as a key phosphoprotein associated with keloid phenotype.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Infectious Diseases
Yongsong Yue, Yijia Li, Yizhi Cui, Nidan Wang, Yunda Huang, Wei Cao, Yang Han, Ting Zhu, Wei Lyu, Jing Xie, Xiaojing Song, Yanling Li, Tong Wang, Tuofu Zhu, Taisheng Li
Summary: Baseline total HIV-1 DNA and CD4+ T cell count are two independent predictors of total HIV-1 DNA after treatment. The derived model based on these two baseline factors provides a useful prognostic tool in predicting HIV-1 DNA reservoir control during cART.
BMC INFECTIOUS DISEASES
(2021)
Article
Cell Biology
Jiahui Guo, Caihong Wu, Xinyi Lin, Jian Zhou, Jiayi Zhang, Wenting Zheng, Tong Wang, Yizhi Cui
Summary: The study established a simplified SEC method and compared different resins for EV isolation. By increasing column bed volumes and optimizing operations, the resolution and purity of EVs were improved. A dichotomic SEC method requiring only two bulk elutions was developed for efficient EV and protein separation from complex samples.
JOURNAL OF EXTRACELLULAR VESICLES
(2021)
Article
Oncology
Weiqiang Gan, Xi Chen, Zeqian Wu, Xiang Zhu, Jing Liu, Tong Wang, Zhiliang Gao
Summary: HBV-miR-3, encoded by hepatitis B virus (HBV), is positively correlated with viral markers HBV DNA, pgRNA, and particularly HBsAg in chronic hepatitis B (CHB) patients. Following nucleoside analogues (NA) treatment, sequential therapy with Peg-IFN has a positive impact on the decrease of HBsAg, pgRNA, and HBV-miR-3.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Letter
Infectious Diseases
Bianchuan Cao, Mei Liu, Rui Zhu, Tianru Yuan, A'shamu E'er, Shaofang Song, Tong Wang, Li Zhong
SEXUALLY TRANSMITTED INFECTIONS
(2023)
Article
Biochemistry & Molecular Biology
Zimei Chen, Ke Yang, Jiayi Zhang, Shufan Ren, Hui Chen, Jiahui Guo, Yizhi Cui, Tong Wang, Min Wang
Summary: In this study, the proteome of HIV-1 associated colorectal cancer (HA-CRC) and paired remote tissues (HA-RT) were analyzed, revealing differential protein expression. It was found that HA-CRC exhibited crosstalk between antiviral response and cancerous pathways. Moreover, it was demonstrated that HIV-1 reservoir cells could activate the interferon pathway in macrophages through the horizontal transfer of cell-associated HIV-1 RNA carried by extracellular vesicles.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)