Review
Clinical Neurology
Melissa J. Armstrong
Summary: Dementia with Lewy bodies (DLB) is a specific presentation of a pathological alpha-synucleinopathy, with recent advances including updated diagnostic criteria and recognition of prodromal states. Research shows common co-occurrence of Alzheimer's disease pathology in individuals with DLB, impacting biomarker use and progression. Identifying biomarkers and effective therapies remain key areas of focus for future research in DLB.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2021)
Review
Cell Biology
Augoustos Tsamourgelis, Peter Swann, Leonidas Chouliaras, John T. O'Brien
Summary: Dementia with Lewy Bodies (DLB) is the second most common neurodegenerative dementia. Proteomics has revealed protein dysregulation in the brain and peripheral tissues in DLB, which shares common features with other dementias but also has unique protein signatures. Identifying novel protein targets and diagnostic biomarkers could lead to new therapeutics and improved clinical trials for DLB.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Kurt A. Jellinger
Summary: PDD and DLB are two major neurocognitive disorders in the spectrum of Lewy body diseases with overlapping clinical and neuropathological features. DLB has higher Braak LB scores and neuritic Braak stages, as well as more severe neuropathological features like Thal A beta phases and neuritic Braak stages. Worse prognosis in DLB is linked to increased Braak neuritic stages and more severe cerebral amyloid angiopathy.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Neurosciences
David J. Koss, Daniel Erskine, Andrew Porter, Pawel Palmoski, Hariharan Menon, Olivia G. J. Todd, Marta Leite, Johannes Attems, Tiago F. Outeiro
Summary: Through a multidisciplinary approach, this study confirms the presence of nuclear alpha-synuclein in the brains of patients with dementia with Lewy bodies, which may undergo pathogenic modifications and contribute to the disease phenotype.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2022)
Review
Clinical Neurology
Zina Hijazi, Nawaf Yassi, John T. O'Brien, Rosie Watson
Summary: This review examines cerebrovascular lesions in Lewy body dementia (LBD), finding that white matter changes and cerebral microbleeds are common pathological features. Compared to Parkinson's disease without dementia and age-matched controls, LBD patients have increased severity of white matter changes, which is not supported by neuropathological examination. The prevalence of cerebral microbleeds in LBD varies greatly, but is similar to Alzheimer's disease. Larger studies are needed to assess the impact of cerebrovascular lesions on clinical symptoms, disease progression, and outcomes.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Tatyana Dmitrievna Fedorova, Karoline Knudsen, Jacob Horsager, Allan K. Hansen, Niels Okkels, Hanne Gottrup, Kim Vang, Per Borghammer
Summary: The study compared the striatal dopaminergic dysfunction asymmetry between patients with dementia with Lewy bodies (DLB) and Parkinson's disease (PD). It found that DLB patients had more symmetric striatal degeneration compared to PD patients, which supports the hypothesis that DLB patients may conform to the body-first subtype while PD patients may conform to the brain-first subtype.
JOURNAL OF PARKINSONS DISEASE
(2023)
Article
Geriatrics & Gerontology
Victor Calil, Andrea Silveira de Souza, Felipe Kenji Sudo, Gustavo Santiago-Bravo, Naima Assuncao, Claudia Drummond, Fernanda Rodrigues, Rejane Soares, Natalia Oliveira, Alina Teldeschi, Gabriel Bernardes, Gabriel Lima, Camila Lima, Marco Antonio Lima, Paulo Mattos
Summary: This study compared anosognosia for memory between individuals with DLB and dementia due to AD, finding that individuals with DLB had worse awareness of memory deficits. While there were no significant differences in age, education, sex, or disease duration between DLB and AD groups, DLB patients had a higher index of anosognosia compared to AD patients.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Review
Clinical Neurology
Shannon Y. Chiu, Kathryn A. Wyman-Chick, Tanis J. Ferman, Ece Bayram, Samantha K. Holden, Parichita Choudhury, Melissa J. Armstrong
Summary: This review summarizes the current knowledge on sex differences in dementia with Lewy bodies (DLB) in terms of epidemiology, clinical features, neuropathology, biomarkers, disease progression, and caregiving. The prevalence of DLB in men is higher in many studies, but this finding is inconsistent. Women with DLB may experience more visual hallucinations, while men may have a higher frequency of REM sleep behavior disorder and parkinsonism. Women tend to be older, have greater cognitive impairment, and meet DLB criteria later than men. The impact of sex on DLB progression and the lack of research on sex differences in biomarkers and treatment are mixed. Women provide the majority of caregiving in DLB, but the effects of this on the caregiving experience are uncertain. Understanding sex differences will aid in developing sex-specific strategies in DLB.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Jing Xu, Jia Li, Ya-juan Sun, Wei Quan, Li Liu, Qing-hui Zhang, Yi-dan Qin, Xiao-chen Pei, Hang Su, Jia-jun Chen
Summary: In this study, mRNA expression profiles were analyzed to identify potential biomarkers and mechanisms distinguishing between Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB). Seven hub genes were found to be significantly associated with PDD, suggesting their involvement in the heterogeneous pathogenesis of PDD and DLB. Additionally, several signaling pathways related to different diseases were identified.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Kyoungwon Baik, Hye Ryun Kim, Mincheol Park, Younggun Lee, Han Kyu Na, Young H. H. Sohn, Joon-Kyung Seong, Phil Hyu Lee
Summary: This study investigated the effect of amyloid accumulation on cognitive dysfunction in patients with Parkinson's disease and dementia with Lewy bodies. The results showed that while the burden of amyloid was higher in the dementia with Lewy bodies group, amyloid accumulation was negatively associated with memory and language functions only in the Parkinson's disease group.
MOVEMENT DISORDERS
(2023)
Article
Clinical Neurology
Alice Tisserand, Benjamin Cretin, Mary Mondino, Anne Botzung, Lea Sanna, Catherine Demuynck, Pierre Anthony, Candice Muller, Olivier Bousiges, Nathalie Philippi, Frederic Blanc
Summary: This study aimed to investigate the association between photophobia and dementia with Lewy bodies (DLB). The study found that photophobia was more frequent in DLB patients and was associated with decreased gray matter in the right precentral cortex and the eyelid motor region. This finding is important for understanding the pathological mechanism of DLB.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
David J. Koss, Odeta Bondarevaite, Sara Adams, Marta Leite, Flaviano Giorgini, Johannes Attems, Tiago F. Outeiro
Summary: The study found that the reduction of RAB39B in DLB cases is associated with an increase in aSyn and Aβ, potentially leading to aggregation of LBs and synaptic impairment. While total RAB39B levels remained unchanged, the decrease in cytoplasmic pool suggests impaired function. RAB39B may be considered as a future therapeutic target for DLB.
Article
Behavioral Sciences
Stefania Pezzoli, Raquel Sanchez-Valle, Aleix Solanes, Matthew J. Kempton, Oliver Bandmann, Jae Il Shin, Annachiara Cagnin, Jennifer G. Goldman, Doug Merkitch, Michael J. Firbank, John-Paul Taylor, Javier Pagonabarraga, Jaime Kulisevsky, Frederic Blanc, Norma Verdolini, Annalena Venneri, Joaquim Radua
Summary: The study found that visual hallucinations in patients with Parkinson's disease and dementia with Lewy bodies are associated with reductions in grey matter volume in certain brain regions, as well as lower verbal immediate memory performance in Parkinson's disease patients.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Neurosciences
Tamara Shiner, Anat Mirelman, Yevgenia Rosenblum, Gitit Kave, Mali Gana Weisz, Anat Bar-Shira, Orly Goldstein, Avner Thaler, Tanya Gurevich, Avi Orr-Urtreger, Nir Giladi, Noa Bregman
Summary: The study found high frequencies of GBA mutations and the APOE epsilon 4 allele among AJ patients with DLB, with distinct effects on the clinical disease phenotype separately and in combination. GBA mutation carriers had earlier onset age, poorer cognition, and more severe parkinsonism compared to non-carriers. There were significant interactions between the two genetic factors, with patients carrying both mutations showing more severe cognitive and motor dysfunction.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Clinical Neurology
Rotem Iris Orad, Tamara Shiner
Summary: Dementia with Lewy bodies presents a diagnostic challenge due to clinical overlap with other neurodegenerative conditions, such as Parkinson's disease dementia and Alzheimer's disease. Neuroimaging plays a central role in improving diagnostic accuracy and management of this disorder.
JOURNAL OF NEUROLOGY
(2022)
Review
Anesthesiology
Valerie Graff, Luca Gabutti, Giorgio Treglia, Mariarosa Pascale, Luciano Anselmi, Stefano Cafarotti, Davide La Regina, Francesco Mongelli, Andrea Saporito
Summary: In this systematic review, the peri-operative costs of local or regional anesthesia versus general anesthesia in the ambulatory setting were assessed. The findings indicated that local or regional anesthesia is associated with lower average total hospital costs than general anesthesia when performed in the ambulatory setting.
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesco Dondi, Domenico Albano, Pietro Bellini, Elisabetta Cerudelli, Giorgio Treglia, Francesco Bertagna
Summary: The objective of this study was to investigate the prognostic role of baseline 18F-FDG PET/CT in stage I-II NSCLC. A total of 296 patients were included, and clinicopathological features and PET/CT semiquantitative parameters were extracted. The results showed a correlation between PET/CT semiquantitative parameters and histology, stage, size, grading, and presence of nodal metastasis. Kaplan-Meier analyses revealed most of the semiquantitative parameters as predictive for progression-free, overall survival, and disease-specific survival. SUVmax, SUVmean, SUVlbm, SUVbsa, and S-L were identified as independent prognosticators for overall survival and disease-specific survival.
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Roberto C. Delgado Bolton, Adriana K. Calapaqui Teran, Giorgio Treglia, Francesco Giammarile
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Francesco Dondi, Roberto Gatta, Domenico Albano, Pietro Bellini, Luca Camoni, Giorgio Treglia, Francesco Bertagna
Summary: The aim of this study was to compare two different PET/CT scanners for predicting the histological classification of NSCLC using RaF and ML. 227 patients were included and RaF were extracted. kNN and LR models showed the best performances for all scanners, with kNN outperforming the others. The choice of PET/CT scanner had an impact on RaF performances, with scanner 2 showing lower AUC values. In conclusion, this study identified promising RaF and ML models for predicting the histological subtype of NSCLC, while considering the influence of the scanner type.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Antonio Corsello, Marina Macchi, Veronica D'Oria, Chiara Pigazzi, Ilaria Alberti, Giorgio Treglia, Valentina De Cosmi, Alessandra Mazzocchi, Carlo Agostoni, Gregorio Paolo Milani
Summary: Due to the lipophilic nature of vitamin D, overweight and obese patients have an increased risk of inadequate circulating 25-hydroxy-vitamin D concentrations. Although supplementation strategies of vitamin D for pediatric subjects with excessive body weight have been proposed, the efficacy remains controversial. This systematic review and meta-analysis found that vitamin D supplementation slightly increases 25-hydroxy-vitamin D levels in overweight and obese children and adolescents, but its effects on metabolic and cardiovascular outcomes remain controversial.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Francesco Fiz, Gianluca Bottoni, Michela Massollo, Pierpaolo Trimboli, Ugo Catrambone, Lorenzo Bacigalupo, Sergio Righi, Giorgio Treglia, Alessio Imperiale, Arnoldo Piccardo
Summary: Primary hyperparathyroidism is a difficult-to-diagnose condition that can remain asymptomatic for many years, causing long-term consequences such as osteoporosis and renal impairment. First-line diagnostic methods like ultrasound and parathyroid scintigraphy have unsatisfactory detection rates. Second-line imaging methods like [18F]F-Choline PET/CT and 4D-CT have shown higher detection rates and sensitivity, but are less commonly used. Both PET and 4D-CT have specific advantages, limitations, and applications. This review extensively describes the pros and cons of these two techniques and explores the potential role of combined examination in diagnosing parathyroid tissue hyperfunction.
QUARTERLY JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Editorial Material
Medicine, General & Internal
Salvatore Annunziata, Giorgio Treglia
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Luca Urso, Angelo Castello, Giorgio Treglia, Stefano Panareo, Alberto Nieri, Ilaria Rambaldi, Matteo Caracciolo, Naima Ortolan, Licia Uccelli, Corrado Cittanti, Massimo Castellani, Mirco Bartolomei
Summary: This study aims to explore the prognostic and predictive role of volumetric parameters on [Ga-68]Ga-DOTATOC PET/CT in NET patients treated with PRRT. The results suggest the importance of evaluating the burden of disease on PRRT in NET patients.
Review
Cardiac & Cardiovascular Systems
Gregorio Tersalvi, Vittorio Beltrani, Martin R. Gruebler, Alessandra Molteni, Yvonne Cristoforetti, Giovanni Pedrazzini, Giorgio Treglia, Luigi Biasco
Summary: Imaging modalities, such as PET, are increasingly used to evaluate the underlying pathophysiology of heart failure. PET imaging of the heart provides information on various aspects that contribute to the development and progression of heart failure, including metabolism, perfusion, inflammation, fibrosis, and sympathetic nervous system activity.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Review
Endocrinology & Metabolism
Francesco Dondi, Roberto Gatta, Giorgio Treglia, Arnoldo Piccardo, Domenico Albano, Luca Camoni, Elisa Gatta, Maria Cavadini, Carlo Cappelli, Francesco Bertagna
Summary: Growing evidences show the role of radiomics and machine learning in the assessment of thyroid diseases. This systematic review analyzes the diagnostic performances of these technologies in this setting. Seventeen studies were included, demonstrating the promising role of radiomics and machine learning in the evaluation of thyroid diseases. However, further validation in multicentric studies is needed to translate these approaches into clinical practice.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Medicine, General & Internal
Marco Cuzzocrea, Gaetano Paone, Giorgio Treglia
Summary: We present a case of a patient with hepatocellular carcinoma (HCC) who underwent [F-18]fluorocholine PET/CT for staging and discovered a coexisting small cell lung cancer (SCLC). The PET/CT scan showed increased radiopharmaceutical uptake in both the liver lesion and a suspicious lung lesion, leading to histological assessment and different treatments for the two tumors. This case highlights the importance of [F-18]fluorocholine PET/CT in detecting coexisting tumors and guiding personalized treatment strategies.
Article
Radiology, Nuclear Medicine & Medical Imaging
Edel Noriega-Alvarez, Ana M. Garcia Vicente, Maria P. Talavera Rubio, Giorgio Treglia, Mariano Amo-Salas, Angel M. Soriano Castrejon, Victor M. Poblete Garcia
Summary: In patients with cutaneous malignant melanoma, sentinel lymph node biopsy (SLNB) can predict prognosis. The study found that patients with lymph node metastases had lower survival rates, and SLNB, lymphovascular invasion, and age were independent risk factors for overall survival and progression-free survival.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Clinical Neurology
Lisa Taruffi, Lorenzo Muccioli, Micaela Mitolo, Lorenzo Ferri, Carlo Descovich, Stefania Mazzoni, Roberto Michelucci, Raffaele Lodi, Rocco Liguori, Pietro Cortelli, Caterina Tonon, Francesca Bisulli
Summary: This study retrospectively observed the neurological manifestations of long COVID. The results showed that most patients had mild COVID-19 symptoms during the acute phase, and the neurological symptoms persisted afterwards. The most common neurological symptoms include fatigue, cognitive disorders, and olfactory dysfunction. These findings suggest the need for further research on therapeutic strategies.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Review
Endocrinology & Metabolism
Pierpaolo Trimboli, Caterina Mian, Arnoldo Piccardo, Giorgio Treglia
Summary: This systematic review summarizes the more robust evidence about the performance of tools useful for diagnosis of medullary thyroid carcinoma (MTC) such as calcitonin (Ctn) and other circulating markers, ultrasound (US), fine-needle aspiration (FNA), and other imaging procedures. The findings suggest that Ctn is the most reliable diagnostic marker for MTC, while CEA doubling time is more reliable in identifying MTC cases with poorer prognosis. Ultrasound sensitivity in MTC is suboptimal, and cytology can detect MTC in just over half of cases. PET/CT is useful for detecting recurrent MTC. Future guidelines should consider these evidence-based data for thyroid nodule management and MTC diagnosis.
Review
Oncology
Fabio Turco, Silke Gillessen, Giorgio Treglia, Karim Fizazi, Matthew R. Smith, Bertrand Tombal, Richard Cathomas, Consuelo Buttigliero, Massimo Di Maio, Marcello Tucci, Ursula M. Vogl
Summary: In this study, the safety profile of darolutamide in prostate cancer patients was reviewed and analyzed. The results showed that darolutamide had a similar toxicity profile to placebo, except for a significant difference in bone fractures.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)