Article
Biochemistry & Molecular Biology
Zhenlong Xu, Lin Mei, Yanmei Shi, Mengyao Yun, Yidan Luan, Zhiqiang Miao, Zhimin Liu, Xiu-Min Li, Mingli Jiao
Summary: A novel photodynamic antibacterial therapeutic platform based on a polymeric photosensitizer has been proposed for the efficient healing of bacteriainfected wounds, showing excellent biocompatibility.
Review
Chemistry, Inorganic & Nuclear
Zhiheng Li, Zhenwu Zhou, Yarui Wang, Jie Wang, Liming Zhou, Hong-Bo Cheng, Juyoung Yoon
Summary: Due to deficiencies in specific accumulation at tumors and undesired activation in normal tissues, many photodynamic therapy (PDT) agents show off-target phototoxicity. To address this issue, activatable photodynamic nano-photosensitizers (nanoPSs) that generate reactive oxygen species (ROS) in response to tumor-associated or external stimuli have been developed. These nanoPSs are in an off-state during delivery and are only activated in targeted lesions, enhancing the accuracy and minimizing side effects. This review discusses the design, work principle, and therapeutic performance of PDT using activatable nanoPSs, categorized by different stimuli and composite materials.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Yi Zhang, Xiangqian Zhang, Huocheng Yang, Le Yu, Yunjie Xu, Amit Sharma, Peng Yin, Xiangyang Li, Jong Seung Kim, Yao Sun
Summary: The article discusses the advantages and potential of photodynamic therapy and sonodynamic therapy in the treatment of deep-seated tumors, as well as imaging-guided precise SDT and recent clinical trials. It also summarizes the strategies for designing sonosensitizers based on tumor environment and structure modifications, as well as the approach of SDT combination therapy.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Organic
Chengming Li, Yinchan Wang, Sisi Wu, Weihua Zhuang, Zhenmei Huang, Linsen Zhou, Yinggang Li, Mao Chen, Jingsong You
Summary: The synthesis of isoquinoline-fused porphyrins 3 and 4 with remarkable NIR-absorbing capacity and their efficient singlet oxygen generation capabilities make them promising candidates for photodynamic therapy, showing excellent tumoricidal behavior and biocompatibility in the phototherapeutic window.
Article
Chemistry, Multidisciplinary
Zhaoyou Chu, Hao Chen, Peisan Wang, Wanni Wang, Juan Yang, Jianan Sun, Benjin Chen, Tian Tian, Zhengbao Zha, Hua Wang, Haisheng Qian
Summary: In this study, a combined therapy using a fluoroquinolone antibiotic drug and photosensitizer was developed. The drug was incorporated into a thermally sensitive amphiphilic polymer with upconversion nanoparticles, enabling controlled release and enhanced photosensitizer effects. Both in vitro and in vivo experiments demonstrated the effectiveness of this approach in inhibiting cell migration and metastasis, inducing cancer cell apoptosis, and achieving enhanced therapeutic efficacy.
Review
Biotechnology & Applied Microbiology
Biljana S. Maluckov
Summary: Microorganisms play a crucial role in geological transformations, facilitating the mobility of metals and formation of new minerals for practical applications in metal recovery, including the formation of nanogold and nanogold compounds.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Review
Nanoscience & Nanotechnology
Aurelie Bessiere, Jean-Olivier Durand, Camille Nous
Summary: PerL materials, in the form of nanoparticles, have shown great potential as bio-nanoprobes for in vivo small animal imaging and photodynamic therapy in deep-seated tissues. The physical association and targeting ability of PerL materials and photosensitizers, as well as the versatility in excitation protocols, play important roles in their successful application.
Article
Chemistry, Multidisciplinary
Chang Liu, Chendong Ji, Zongyang Fan, Ruihao Ma, Meizhen Yin
Summary: A series of thionated perylenediimides with modulating phototheranostic modalities have been synthesized using a one-pot method for multiple anti-cancer applications. The degree of thionation in the perylenediimides affects their photodynamic and photothermal properties, making them potential agents for different cancer treatments.
CHEMICAL COMMUNICATIONS
(2021)
Article
Chemistry, Inorganic & Nuclear
Ziyong Li, Xiao-Gang Yang, Haining Zhang, Ji-Rui Zhang, Xu-Ke Tian, Jian-Huan Qin, Lu-Fang Ma, Dongpeng Yan
Summary: A new type of thermally activated delayed fluorescence material, BCzSFB, with broad absorption range and small singlet-triplet energy gap, has been designed and synthesized. BCzSFB nanoparticles dispersed in aqueous media exhibit long lifetime of NIR TADF. The material shows high singlet oxygen quantum yield and selective photodynamic killing of Gram-positive bacteria.
INORGANIC CHEMISTRY FRONTIERS
(2022)
Review
Biochemistry & Molecular Biology
K. I. Dhanalekshmi, K. Sangeetha, P. Magesan, Jijo Johnson, Xiang Zhang, K. Jayamoorthy
Summary: Photodynamic therapy (PDT) is being increasingly utilized as an effective treatment modality for cancer. However, the organic photosensitizers employed for PDT have some limitations. Therefore, there is growing interest in the use of non-toxic inorganic photosensitizers such as noble metal nanoparticles.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Chemistry, Multidisciplinary
Shi-yin Wang, Guo Chen, Ji-feng Chen, Jin Wang, Shao-hui Deng, Du Cheng
Summary: This study synthesized a GSH-scavenging copolymer to deliver a photosensitizer, enhancing the therapeutic effect of photodynamic therapy. The copolymer depleted the concentration of intracellular glutathione (GSH) in tumor cells, preventing the consumption of reactive oxygen species (ROS) generated by the photosensitizer, thus synergistically enhancing the therapeutic effect. In vitro and in vivo experiments confirmed the antitumor effect of the copolymer.
Article
Chemistry, Multidisciplinary
Hang Zhang, Jia-Hui Wu, Hao-Zong Xue, Ruijing Zhang, Zi-Shu Yang, Song Gao, Jun-Long Zhang
Summary: This study reports a molecular-level strategy to modulate tumor hypoxia and angiogenesis by reinforcing the synergistic action between a hydrogen peroxide scavenger and a photosensitizer, thereby enhancing the efficacy of photodynamic therapy. The proof-of-principle experiments demonstrate that this strategy can improve the outcomes of photodynamic therapy and prolong the survival of patients.
Article
Chemistry, Analytical
Dong Joon Lee, Vinayak Juvekar, Hyo Won Lee, Eun Seo Kim, Choong-Kyun Noh, Sung Jae Shin, Hwan Myung Kim
Summary: In this study, a two-photon photosensitizer ACC-B was designed for real-time cancer therapy, which triggered highly selective cancer ablation through photodynamic therapy and enabled real-time imaging differentiation between normal and cancer tissues using fluorescence microscopy images.
ANALYTICAL CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Kunal Gogde, Shatabdi Paul, Anil Kumar Pujari, Ashok Kumar Yadav, Jayeeta Bhaumik
Summary: Photodynamic therapy (PDT), an advanced and promising treatment, can inhibit dental pathogens by activating photosensitizers through specific wavelength light. This study synthesized and characterized three chromone-porphyrins and established a correlation between their photophysical properties and theoretical calculations. The chromone-porphyrins were encapsulated in starch nanoparticles to develop soluble nano-starch sensitizers with excellent singlet oxygen generation ability under green light exposure. These nano-starch sensitizers showed great potential for prospective PDT to treat enterococci dental pathogens.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Review
Engineering, Biomedical
Debalina Bhattacharya, Mainak Mukhopadhyay, Kumar Shivam, Satyajit Tripathy, Ranjan Patra, Arindam Pramanik
Summary: Photodynamic therapy (PDT) is a potential cancer treatment method that minimizes tissue damage. Nanoparticles-based photosensitizers are being developed to overcome multidrug resistance in cancer cells.
BIOMEDICAL MATERIALS
(2023)
