Article
Geriatrics & Gerontology
Richard Agren, Amar Awad, Patric Blomstedt, Anders Fytagoridis
Summary: Comparison of cerebellar lobule volumes between ET patients and HCs using automated segmentation revealed smaller volumes in ET patients, opposing the hypothesis of localized atrophy in cerebellar motor areas in ET. However, the possibility of cerebellar pathophysiology in ET was not ruled out. Further prospective investigations using alternative neuroimaging modalities may help elucidate the pathophysiology of ET and guide diagnostic and therapeutic approaches.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Neurosciences
Feng-Yi Su, Jyun-Ru Chen, Chun-Ming Chen, Yen-Chih Huang, Shin-Lei Peng
Summary: This study identified patterns of gray matter volume changes with age in a young population, highlighting the influence of field strength on results and the importance of considering this factor when comparing brain differences across studies.
Review
Clinical Neurology
Xiang Huang, Junyu Lin, Huifang Shang, Jing Yang
Summary: In this study, a meta-analysis was conducted to investigate gray matter changes in patients with idiopathic dystonia. The results showed consistent widespread gray matter abnormalities in various brain regions. These abnormalities were shared among different subtypes of idiopathic dystonia and were not limited to the corticostriatal circuits.
JOURNAL OF NEUROLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Wang, Song Wang, Jiaji Lin, Dong Zhang, Haoxuan Lu, Yongqin Xiong, Linlin Deng, Dekang Zhang, Xiangbing Bian, Jiayou Zhou, Longsheng Pan, Xin Lou
Summary: This study explored the clinical value of gray matter volume (GMV) to assess the treatment of tremor-dominant Parkinson's disease (TDPD) using magnetic resonance imaging-guided focused ultrasound (MRgFUS) thalamotomy. Results showed that tremors were significantly relieved after MRgFUS thalamotomy, and changes in GMV were significantly correlated with tremor scores. Furthermore, specific basal ganglia and related nuclei as well as cerebellum subregions showed long-term structural alterations related to MRgFUS thalamotomy. These findings contribute to a better understanding of the effectiveness of MRgFUS thalamotomy and the role of GMV in tremor control in TDPD.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaoyu Wang, Song Wang, Jiaji Lin, Dong Zhang, Haoxuan Lu, Yongqin Xiong, Linlin Deng, Dekang Zhang, Xiangbing Bian, Jiayou Zhou, Longsheng Pan, Xin Lou
Summary: Gray matter volume (GMV) can be used as a clinical marker to assess the effectiveness of magnetic resonance imaging-guided focused ultrasound (MRgFUS) thalamotomy in treating tremor-dominant Parkinson's disease (TDPD). The study found that there were significant changes in GMV after MRgFUS thalamotomy, which were closely related to tremor improvement. This discovery helps to better understand the remote effects of MRgFUS thalamotomy and the role of GMV in tremor control.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Article
Psychiatry
Stuart B. Murray, Christina J. Duval, Ane A. Balkchyan, Ryan P. Cabeen, Jason M. Nagata, Arthur W. Toga, Steven J. Siegel, Kay Jann
Summary: Early-onset binge eating disorder (BED) may be characterized by diffuse morphological abnormalities in gray matter density, suggesting alterations in cortical architecture which may reflect decreased synaptic pruning and arborization, or decreased myelinated fibers and therefore inter-regional afferents.
PSYCHIATRY RESEARCH
(2022)
Article
Psychology, Clinical
Stuart B. Murray, Joel P. Diaz-Fong, Christina J. Duval, Ane A. Balkchyan, Jason M. Nagata, Darrin J. Lee, Kyle T. Ganson, Arthur W. Toga, Steven J. Siegel, Kay Jann
Summary: This study found regional sex differences in terms of gray matter morphometry in early-onset binge eating disorder (BED), with girls showing higher gray matter density.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
Sally C. Chester, Tatsuyoshi Ogawa, Maki Terao, Ryusuke Nakai, Nobuhito Abe, Stephane A. De Brito
Summary: This study investigated the neuroanatomical correlates of psychopathic traits in a Japanese sample using structural magnetic resonance imaging data. The results showed associations between psychopathic traits and gray matter volume as well as gyrification in specific brain regions. The associations varied based on sex and different levels of psychopathy factors.
Article
Neurosciences
Jiayan Liu, Yahui Lei, Yuyao Diao, Yamei Lu, Xingbo Teng, Qingting Chen, Lian Liu, Jingxiang Zhong
Summary: This study investigates the morphological alterations in gray matter volume (GMV) in form-deprivation myopia (FDM) rats using voxel-based morphometry (VBM) method. The results show that compared to the normal controls, the FDM group exhibits significantly decreased GMVs in the left primary visual cortex, left secondary visual cortex, right subiculum, right cornu ammonis, right entorhinal cortex, and bilateral molecular layer of the cerebellum, while significantly increased GMVs were found in the right dentate gyrus, parasubiculum, and olfactory bulb.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Clinical Neurology
Dayao Lv, Cheng Zhou, Jiali Pu, Jinyu Lu, Gaohua Zhao, Luyan Gu, Xiaojun Guan, Tao Guo, Xiaojun Xu, Minming Zhang, Jun Tian, Xinzhen Yin, Baorong Zhang, Guohua Zhao, Yaping Yan
Summary: This study found that both the LC and the cerebellum might be involved in the pathophysiology of ET. Evaluation of the LC using NM-MRI could be an effective tool for further exploring the pathophysiology of ET.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Ji Hye Shin, Min Ji Song, Ji Hyun Kim
Summary: This study examined the effect of valproate (VPA) on brain volume in patients with idiopathic generalized epilepsy. The results showed that patients taking VPA had significant gray matter volume reduction in various brain regions compared to the control group. This finding suggests that the use of VPA may lead to brain volume reductions in certain regions.
Article
Clinical Neurology
Alessia Sarica, Andrea Quattrone, Marianna Crasa, Rita Nistico, Maria Grazia Vaccaro, Maria Giovanna Bianco, Vera Gramigna, Marida De Maria, Basilio Vescio, Federico Rocca, Aldo Quattrone
Summary: The study found that essential tremor (ET) and resting tremor (rET) are different tremor syndromes with mild cerebellar gray matter involvement in both. In rET patients, the left Crus II may play a crucial role in modulating brainstem excitability.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Huai-Bin Liang, Liao Dong, Yangyang Cui, Jing Wu, Wei Tang, Xiaoxia Du, Jian-Ren Liu
Summary: This study found significant structural changes and changes in functional connectivity (FC) patterns in the posterior cerebellar lobe of patients with somatic symptom disorder (SSD). These findings provide new insights into the psychological and neural substrates of SSD and may serve as a potential treatment target.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Psychiatry
Carolin Spindler, Louisa Mallien, Sebastian Trautmann, Nina Alexander, Markus Muehlhan
Summary: White matter (WM) alterations are significant in patients with alcohol use disorder (AUD), and these changes may contribute to motor, cognitive, affective, and perceptual impairments. However, further research is needed to understand the variations of WM alterations over the course of the disorder and their reversibility with prolonged abstinence.
TRANSLATIONAL PSYCHIATRY
(2022)
Article
Neurosciences
C'iana P. Cooper, Andrea T. Shafer, Nicole M. Armstrong, Sharyn L. Rossi, Jennifer Young, Christa Herold, Hong Gu, Yihong Yang, Elliot A. Stein, Susan M. Resnick, Peter R. Rapp
Summary: The study used rhesus monkeys as a model to investigate the effects of cognitive aging on gray matter volume through structural imaging and voxel-based morphometry, revealing age-related differences in volume changes in specific brain regions and their relationships with task performance. The results demonstrate age-dependent correlations between volume changes in different brain regions and task performance, indicating that the aged primate brain retains the ability for structural reorganization.
Review
Pharmacology & Pharmacy
S. Sajith Kumar, Bhavani Shankara Bagepally, Akhil Sasidharan
Summary: The cost-effectiveness of rituximab in the treatment of rheumatoid arthritis (RA) compared to other disease-modifying anti-rheumatic drugs (DMARDs) is inconsistent. This study aimed to provide synthesised cost-effectiveness evidence of rituximab in RA treatment and found that it is cost-effective compared to other DMARDs, but not as a third-line therapy after the failure of biologics.
CLINICAL DRUG INVESTIGATION
(2023)
Article
Cardiac & Cardiovascular Systems
S. Sajith Kumar, Akhil Sasidharan, Bhavani Shankara Bagepally
Summary: The study explores the link between air pollution-attributed cardiovascular disease (APACVD) burden and its contributing factors in India. It reveals an inverse relationship between the APACVD burden and human development index (HDI), but a positive correlation with economic development indicators such as new motor vehicle registration and functional factories. Economically developed states seem to contribute a higher share of the APACVD burden.
HEART LUNG AND CIRCULATION
(2023)
Article
Biochemistry & Molecular Biology
Dhiraj Srivastava, Ravi P. Yadav, Sneha Singh, Kimberly Boyd, Nikolai O. Artemyev
Summary: PDE6 is important for visual signal transduction and relies on the chaperone complex of HSP90 and AIPL1 for maturation. Disruption of PDE6 maturation leads to severe retina degeneration.
Article
Health Care Sciences & Services
Madhumitha Haridoss, Sajith Kumar, Meenakumari Natarajan, Akhil Sasidharan, Kavitha Rajsekar, Nikhil Kumar Oswal, Bhavani Shankara Bagepally
Summary: This study compared the cost-effectiveness of laparoscopic cholecystectomy with conservative management in patients with uncomplicated symptomatic gallstones or cholecystitis in India. The results showed that laparoscopic cholecystectomy is more cost-effective than conservative management, and early laparoscopic cholecystectomy is more cost-effective than delayed laparoscopic cholecystectomy.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Review
Genetics & Heredity
Madhumitha Haridoss, Lavanya Ayyasamy, Bhavani Shankara Bagepally
Summary: Telomere shortening, a marker of cellular aging, has been found to be associated with the severity and hospitalization of COVID-19. However, the results from this systematic review and meta-analysis do not provide clear evidence of an association between shorter telomere length and severe COVID-19 disease.
Article
Cell Biology
Roon Banerjee, Aishwarya Raj, Chandrakanta Potdar, Pramod Kumar Pal, Ravi Yadav, Nitish Kamble, Vikram Holla, Indrani Datta
Summary: In this study, we investigated the cell-intrinsic effect of the LRRK2-I1371V mutant variant on astrocyte biology. Our findings reveal that the mutation in the LRRK2-I1371V allele significantly impairs astrocytic function in terms of Nrf2-mediated antioxidant machinery, ATP generation, and glutamate metabolism, despite comparable astrocyte yields.
Article
Neurosciences
Franziska Knolle, Shyam S. Arumugham, Roger A. Barker, Michael W. L. Chee, Azucena Justicia, Nitish Kamble, Jimmy Lee, Siwei Liu, Abhishek Lenka, Simon J. G. Lewis, Graham K. Murray, Pramod Kumar Pal, Jitender Saini, Jennifer Szeto, Ravi Yadav, Juan H. Zhou, Kathrin Koch
Summary: Psychotic symptoms are common in schizophrenia and Parkinson's disease (PD) patients. Altered grey matter structure in various brain areas and networks may contribute to their pathogenesis. This study investigated the similarities in psychotic symptoms between schizophrenia and PD, and found significant grey matter reduction in both PD and early schizophrenia. Classification algorithms based on grey matter values within specific networks showed good accuracy in differentiating early psychosis cases and fair performance in distinguishing PD patients with and without psychotic symptoms. Results suggest some common underlying mechanisms and potential biomarkers for identifying these conditions.
NPJ PARKINSONS DISEASE
(2023)
Letter
Clinical Neurology
Vikram V. Holla, Prashant Phulpagar, Jitender Saini, Nitish Kamble, Pramod Kumar Pal, Ravi Yadav, Babylakshmi Muthusamy, Manjunath Netravathi
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Debayan Dutta, Kulanthaivelu Karthik, Vikram V. Holla, Nitish Kamble, Ravi Yadav, Pramod Kumar Pal, Rohan R. Mahale
Summary: This study measured the olfactory bulb volume (OBV) and olfactory sulcus depth (OSD) using MRI in patients with Parkinson's disease (PD) and compared them with patients with progressive supranuclear palsy (PSP), multiple system atrophy (MSA), vascular parkinsonism (VP), and controls. The results showed that PD patients had significantly lower OBV compared to the other groups. However, there was no significant difference in OSD. The findings suggest that OBV estimation by MRI can aid in the diagnosis of PD.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Review
Environmental Sciences
Ankit Viramgami, Ankit Sheth, Bhavani Shankara Bagepally, Rakesh Balachandar
Summary: This study investigated the impact of biomass fuel smoke exposure on pulmonary dysfunction through systematic review and meta-analysis. The findings suggest that biomass fuel smoke exposure is detrimental to pulmonary function and increases the risk of chronic pulmonary ailments, regardless of smoking.
AIR QUALITY ATMOSPHERE AND HEALTH
(2023)
Review
Health Care Sciences & Services
Sajith Kumar, Bhavani Shankara Bagepally
Summary: This study systematically reviewed the cost-utility evidence of TNF-a-i treatment for rheumatoid arthritis (RA) and found that TNF-a-i is not cost-effective compared to other disease-modifying anti-rheumatic drugs (DMARDs) and conventional synthetic DMARDs for RA treatment. However, the results cannot be generalized due to high heterogeneity and low confidence in GRADE quality assessment.
EXPERT REVIEW OF PHARMACOECONOMICS & OUTCOMES RESEARCH
(2023)
Article
Clinical Neurology
Ragasudha Botta, Keshav J. Kumar, Bindu Kutty, Anita Mahadevan, Pramod Kumar Pal, Ravi Yadav
Summary: This study aimed to validate the NIMHANS Neuropsychological Battery for Elderly (NNB-E) in diagnosing subtle cognitive deficits in Parkinson's Disease (PD) patients and evaluate cognitive impairment compared to healthy controls. The results showed that NNB-E had good internal consistency and construct validity, and it was able to detect mild cognitive impairment in PD patients with high accuracy. The study also revealed that PD patients had poor cognitive performance, particularly in executive and attention domains.
ANNALS OF INDIAN ACADEMY OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sandeep Gurram, Vikram V. Holla, Praveen Sharma, Nitish Kamble, Jitender Saini, Manjunath Netravathi, Ravi Yadav, Pramod Kumar Pal
Summary: This study reviewed the clinical, radiological features, and outcome of 25 CJD patients with movement disorders. The most common movement disorders observed were myoclonus, ataxia, and parkinsonism, while chorea was the least common. MRI showed basal ganglia abnormality and cortical ribboning in the majority of cases. EEG abnormalities were seen in 21 patients, with triphasic waves and periodic sharp waves being the most common. Abnormal 14-3-3 assay was found in 2 out of 4 patients. Atypical presentations, such as ataxic, CBS-like, and choreiform, were also noted.
TREMOR AND OTHER HYPERKINETIC MOVEMENTS
(2023)
Article
Immunology
Tina Damodar, Bhagteshwar Singh, Namratha Prabhu, Srilatha Marate, Vykuntaraju K. Gowda, A. V. Lalitha, Fulton Sebastian Dsouza, Sushma Veeranna Sajjan, Mallesh Kariyappa, Uddhava V. Kinhal, P. V. Prathyusha, Anita Desai, Kandavel Thennarasu, Tom Solomon, Vasanthapuram Ravi, Ravi Yadav
Summary: We systematically investigated 376 children with acute encephalitis syndrome (AES) in southern India and found that scrub typhus is an emerging common treatable cause of AES in this region. Diagnosing scrub typhus using IgM and PCR testing of blood and cerebrospinal fluid (CSF) showed that 16 cases were confirmed to be associated with AES, 55 cases were probable, and 16 cases were possible. Testing for IgM in CSF had a high sensitivity (93%) and specificity (82%) compared to PCR. These findings highlight the importance of routine testing for scrub typhus in diagnostic algorithms and suggest the potential promise of IgM screening of CSF for diagnosing AES caused by scrub typhus.
EMERGING INFECTIOUS DISEASES
(2023)
Proceedings Paper
Computer Science, Hardware & Architecture
Abin Ghosh, Nishita Anand, Pavan Kaushik, Vaishali Bagrodia, Pramod Kumar Pal, Ravi Yadav
Summary: Parkinson's Disease (PD) is a challenge for automated monitoring due to its heterogeneous symptoms and progression. The current method involves physical records made by the patient or care giver about the response to medication, which adds burden to medical experts. Our aim is to use a combination of Non-Contact sleep monitoring system and wearable inertial measurement units to create a 24-hour monitoring system that can provide reliable data for better disease management with minimal intrusion.
2023 15TH INTERNATIONAL CONFERENCE ON COMMUNICATION SYSTEMS & NETWORKS, COMSNETS
(2023)