期刊
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY
卷 12, 期 3, 页码 459-465出版社
ELSEVIER
DOI: 10.1016/j.pdpdt.2015.05.002
关键词
Biomedical; Optical properties; Absorption coefficient; Scattering coefficient; Anisotropy factor
类别
资金
- Institute of Biomedical and Genetic Engineering, Pakistan
- IT and Telecom Endowment Fund, PIEAS, Pakistan
A Summary Increase in local temperature during light exposure of biological tissues plays an important role in determining the fate of most therapeutic modalities. Variations in the optical properties (absorption coefficient, scattering coefficient, anisotropy factor, optical depth etc.) of two cancer cell lines Rhobdomyosarcoma and Cervical carcinoma due to gradual increase in temperature were determine quantitatively with a double integrating sphere system. It was observed that all three coefficients showed decreasing tendency as the temperature increases for both the cell lines except for scattering coefficient of HeLa which remain constant within error limit. Anisotropy factor for both cell lines increased indicating temperature dependent subcellular density variations. Temperature dependent optical properties information may lead to precise dosimetry and could help clinicians for predicting the therapeutic modality outcome. (C) 2015 Elsevier B.V. All rights reserved.
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