期刊
JOURNAL OF NEUROGENETICS
卷 28, 期 3-4, 页码 181-189出版社
TAYLOR & FRANCIS LTD
DOI: 10.3109/01677063.2014.898639
关键词
brain tumor; cancer stem cells; Drosophila; neural stem cells; neuroblasts
资金
- Swiss National Science Foundation (SNSF) [SNSF-NFP63]
Neuroblasts, the neural stem cells in Drosophila, generate the complex neural structure of the central nervous system. Significant progress has been made in understanding the mechanisms regulating the self-renewal, proliferation, and differentiation in Drosophila neuroblast lineages. Deregulation of these mechanisms can lead to severe developmental defects and the formation of malignant brain tumors. Here, the authors review the molecular genetics of Drosophila neuroblasts and discuss some recent advances in stem cell and cancer biology using this model system.
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