期刊
JOURNAL OF NEUROENDOCRINOLOGY
卷 22, 期 5, 页码 343-354出版社
WILEY-BLACKWELL
DOI: 10.1111/j.1365-2826.2010.01961.x
关键词
supraoptic nucleus; oxytocin; dehydration
资金
- New Zealand Lottery [223744]
Moderate dehydration impairs concentration and co-ordination, whereas severe dehydration can cause seizures, brain damage or death. To slow the progression of dehydration until body fluids can be replenished by drinking, the increased body fluid osmolality associated with dehydration increases vasopressin (antidiuretic hormone) secretion from the posterior pituitary gland. Increased vasopressin secretion reduces water loss in the urine by promoting water reabsorption in the collecting ducts of the kidney. Vasopressin secretion is largely determined by action potential discharge in vasopressin neurones, and depends on both the rate and pattern of discharge. Vasopressin neurone activity depends on intrinsic and extrinsic mechanisms. We review recent advances in our understanding of the physiological regulation of vasopressin neurone activity patterning and the mechanisms by which this is altered to cope with the increased secretory demands of dehydration.
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