Article
Virology
Matteo Nazzareno Barbaglia, James Michael Harris, Artem Smirnov, Michela Emma Burlone, Cristina Rigamonti, Mario Pirisi, Rosalba Minisini, Andrea Magri
Summary: 17β-estradiol induces an interferon-mediated antiviral state in hepatocytes, pre-activating immune response signaling to control and suppress viral spread.
Article
Biochemistry & Molecular Biology
Udochi F. Azubuike, Claire L. Newton, Iman van den Bout
Summary: The study investigates the role of Kisspeptin in breast cancer and finds that it promotes migration of triple-negative breast cancer cells but has no effect on non-metastatic breast cancer cells. Additionally, there are differences in the response of the two cell lines to Kisspeptin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
William C. Krause, Ruben Rodriguez, Bruno Gegenhuber, Navneet Matharu, Andreas N. Rodriguez, Adriana M. Padilla-Roger, Kenichi Toma, Candice B. Herber, Stephanie M. Correa, Xin Duan, Nadav Ahituv, Jessica Tollkuhn, Holly A. Ingraham
Summary: Depletion of estrogen leads to inactivity, fat accumulation, and diabetes in rodents and humans. Research has found that estrogen-sensitive neurons in the brain play a role in rebalancing energy allocation in female mice, with implications for metabolism and physical activity. Melanocortin-4 receptor signaling extends beyond regulation of food intake, impacting physical activity levels and offering potential targets for intervention in obesity.
Review
Cardiac & Cardiovascular Systems
Marius Wits, Clarissa Becher, Frances de Man, Gonzalo Sanchez-Duffhues, Marie-Jose Goumans
Summary: This review explores the gender bias in pulmonary arterial hypertension (PAH) and investigates the gender differences in the TGF beta signaling family through mechanistic and translational evidence. Sex hormones and sex chromosome-related genetic processes can influence the function of the TGF beta signaling family.
CARDIOVASCULAR RESEARCH
(2023)
Article
Neurosciences
Daiki Watanabe, Ryo Ikegami, Yutaka Kano
Summary: This study investigated the mechanisms underlying faster force recovery from eccentric contractions in female mice compared to male mice. Superior mitochondrial responses and the contribution of estrogen were found to play a significant role in the faster recovery of force in females. These findings highlight the importance of mitochondrial function and estrogen in sex differences in force recovery.
JOURNAL OF PHYSIOLOGY-LONDON
(2021)
Article
Biochemistry & Molecular Biology
Kristina Holubova, Marketa Chvojkova, Barbora Hrcka Krausova, Vojtech Vyklicky, Eva Kudova, Hana Chodounska, Ladislav Vyklicky, Karel Vales
Summary: Different neuroactive steroids show varied antipsychotic effects in an animal model of schizophrenia, with positive and negative NMDAR modulators demonstrating different outcomes. Furthermore, rats exposed to higher stress levels performed worse in cognitive tests, suggesting that enhancement of NMDAR function can result in nonspecific behavioral responses.
Article
Plant Sciences
Susanna Pollastri, Nur Afiqah Sukiran, Bryony C. I. C. Jacobs, Marc R. Knight
Summary: After experiencing heat stress, plants retain a cellular memory known as thermomemory, which helps them better cope with subsequent heat events. This memory is maintained through heat shock proteins synthesized after the initial stress, but resetting is crucial for growth. Recent studies suggest that autophagy plays a key role in resetting thermomemory. Additionally, Arabidopsis responds to heat by increasing chloroplast calcium concentration, although the purpose of this signal is still not fully understood.
JOURNAL OF PLANT PHYSIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Ewa Szczurowska, Eszter Szanti-Pinter, Nikolai Chetverikov, Alena Randakova, Eva Kudova, Jan Jakubik
Summary: Muscarinic acetylcholine receptors in the central nervous system have various functions, such as cognition, memory, or reward. They are potential targets for diseases like Alzheimer's, schizophrenia, addiction, epilepsy, or depression. These receptors are modulated by neurosteroids and steroid hormones, and this review focuses on their modulation in the context of CNS diseases and proposes the use of neuroactive steroids in drug development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Shane O'Grady, Maria P. Morgan
Summary: The Ca2+ signalling network is crucial for normal cellular activities and is frequently altered in breast cancer, driving tumorigenesis. Understanding these pathways may offer clinical benefit in terms of prognosis and treatment, providing potential therapeutic targets.
SEMINARS IN CANCER BIOLOGY
(2021)
Article
Oncology
Anette H. Skjervold, Marit Valla, Anna M. Bofin
Summary: In this study, we examined the associations between levels of ER expression and tumour characteristics and prognosis in three large cohorts of BC patients. The results showed that ER Low Positive tumours were mainly found in Luminal B (HER2+) subtype and grade 3 tumours. The risk of death from BC was lower in ER Low Positive and ER ≥ 10% compared to ER-negative cases. Patients diagnosed in 1995 or later with ER Low Positive BCs had smaller, lower-grade tumours with lower proliferation status and similar prognosis compared to those with ER ≥ 10% tumours.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Review
Biochemistry & Molecular Biology
Jan Elias, Cicely K. K. Macnamara
Summary: The p53 gene has been the focus of intense research for over 40 years, with recent advances in mathematical biology leading to new insights into its oscillatory dynamics in response to DNA damage. Mathematical models have provided valuable tools for understanding the complex mechanisms involved in p53 response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Chen Dong, Ben-ping Zhang, Yan-Qin Ying, Ling Hou, Wei Wu, Hong Wei, Xiao-ping Luo
Summary: The study found that estradiol can promote the differentiation of hepatoblasts into cholangiocytes and the development of intrahepatic bile ducts, while the antiestrogen drug tamoxifen inhibits this process. Additionally, estradiol was found to upregulate the expression of Notch signaling pathway-associated proteins and genes both in vitro and in vivo.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Sirui Li, Xianlong Li, Feng He, Rui Jiao, Song Zhang, Zhihua Li
Summary: This study investigated the beneficial effect of amarogentin in the management of osteoporosis using in vivo and in vitro methods. The results demonstrated that amarogentin can increase bone density, reduce inflammatory cytokine levels, and regulate biochemical markers and signaling pathways, thereby promoting osteoblast differentiation.
ARCHIVES OF MEDICAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Basappa Basappa, Baburajeev Chumadathil Pookunoth, Mamatha Shinduvalli Kempasiddegowda, Rangappa Knchugarakoppal Subbegowda, Peter E. Lobie, Vijay Pandey
Summary: This study reports on the activity of adamantanyl-tethered-biphenyl amines (ATBAs) as modulating ligands for the estrogen receptor alpha (ERα). One compound, AMTA, demonstrated better binding affinity and inhibitory effect compared to tamoxifen. Treatment with AMTA significantly decreased cell viability and transcriptional activity of ERα in ER+ mammary carcinoma cells. In silico molecular docking analysis suggests that AMTA compounds interact with the ligand-binding domain of ERα, providing a basis for developing a newer class of ERα partial agonists.
Review
Biochemistry & Molecular Biology
Mustapha Irnaten, Colm J. O'Brien
Summary: Glaucoma is a common cause of treatable visual impairment, affecting millions of people worldwide. In this study, we investigated the role of calcium signaling in glaucomatous lamina cribrosa (LC) cells and found evidence of oxidative stress, mitochondrial dysfunction, and an abnormal rise in cytosolic calcium. This abnormal calcium signaling was dependent on calcium entry channels and released from internal stores in the endoplasmic reticulum and mitochondria. Further research in this area may help identify potential therapeutic targets for optic neuropathy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Geriatrics & Gerontology
Amy Christensen, Christian J. Pike
FRONTIERS IN AGING NEUROSCIENCE
(2015)
Article
Geriatrics & Gerontology
Mafalda Cacciottolo, Amy Christensen, Alexandra Moser, Jiahui Liu, Christian J. Pike, Conor Smith, Mary Jo LaDu, Patrick M. Sullivan, Todd E. Morgan, Egor Dolzhenko, Andreas Charidimou, Lars-Olof Wahlund, Maria Kristofferson Wiberg, Sara Shams, Gloria Chia-Yi Chiang, Caleb E. Finch
NEUROBIOLOGY OF AGING
(2016)
Article
Neurosciences
Amy Christensen, Christian J. Pike
NEUROSCIENCE LETTERS
(2018)
Article
Endocrinology & Metabolism
Amy Christensen, Paul Micevych
Review
Endocrinology & Metabolism
A. Christensen, G. E. Bentley, R. Cabrera, H. H. Ortega, N. Perfito, T. J. Wu, P. Micevych
HORMONE AND METABOLIC RESEARCH
(2012)
Article
Behavioral Sciences
Kevin Sinchak, Phoebe Dewing, Laura Ponce, Liliana Gomez, Amy Christensen, Max Berger, Paul Micevych
HORMONES AND BEHAVIOR
(2013)
Article
Neurosciences
Amy Christensen, Phoebe Dewing, Pavel Micevych
JOURNAL OF NEUROSCIENCE RESEARCH
(2015)
Article
Geriatrics & Gerontology
V. Alexandra Moser, Amy Christensen, Jiahui Liu, Amanda Zhou, Shunya Yagi, Christopher R. Beam, Liisa Galea, Christian J. Pike
NEUROBIOLOGY OF AGING
(2019)
Article
Endocrinology & Metabolism
Amy Christensen, Paul Micevych
NEUROENDOCRINOLOGY
(2013)
Article
Multidisciplinary Sciences
Amy Christensen, Christian J. Pike
Article
Multidisciplinary Sciences
Kelvin Yen, Junxiang Wan, Hemal H. Mehta, Brendan Miller, Amy Christensen, Morgan E. Levine, Matthew P. Salomon, Sebastian Brandhorst, Jialin Xiao, Su-Jeong Kim, Gerardo Navarrete, Daniel Campo, G. Jean Harry, Valter Longo, Christian J. Pike, Wendy J. Mack, Howard N. Hodis, Eileen M. Crimmins, Pinches Cohen
SCIENTIFIC REPORTS
(2018)
Article
Biochemistry & Molecular Biology
Amy Christensen, Christian J. Pike
Article
Geriatrics & Gerontology
Amy Christensen, Jiahui Liu, Christian J. Pike
FRONTIERS IN AGING NEUROSCIENCE
(2020)
Review
Endocrinology & Metabolism
Ana C. Valencia-Olvera, Juan Maldonado Weng, Amy Christensen, Mary Jo LaDu, Christian J. Pike
Summary: Alzheimer's disease (AD) exhibits sexual dimorphisms which are influenced by estrogens and apolipoprotein E (APOE) genotype, impacting women's vulnerability to the disease. APOE modulates the outcomes of menopause, estrogen-based hormone therapy, as well as dementia risk in the brain. Additionally, estrogen and APOE genotype affect menopause-associated bone loss, dyslipidemia, and cardiovascular disease risk. The potential interaction between APOE and estrogen responsiveness may link these relationships. This review emphasizes the importance of considering age as a key AD risk factor in a sex-specific manner for the development of personalized therapeutic approaches.
JOURNAL OF NEUROENDOCRINOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Amy Christensen, Christian J. J. Pike
Summary: A Western diet high in sugars and saturated fats can lead to metabolic and inflammatory impairments associated with age-related disorders. The APOE genotype, specifically APOE4, increases the risk for Alzheimer's disease and type 2 diabetes. In this study, female mice with APOE3 or APOE4 were given a control or Western diet for 13 weeks. APOE4 mice on the control diet had worse metabolic profiles, poorer cognitive performance, and higher expression of inflammatory genes compared to APOE3 mice. The Western diet had minimal effects on both genotypes, suggesting protective factors of female sex and young adult age.