Article
Neurosciences
Hao-Hua Wei, Xiang-Shan Yuan, Ze-Ka Chen, Pei-Pei Chen, Zhe Xiang, Wei-Min Qu, Rui-Xi Li, Guo-Min Zhou, Zhi-Li Huang
Summary: The AVP neurons in SON and PVN receive similar input patterns from multiple brain regions, with PVNAVP neurons having broader and denser inputs compared to SONAVP neurons. Additionally, differentiated input sources were found, with SONAVP neurons receiving more projections from thermoregulatory nuclei and PVNAVP neurons receiving more afferent inputs from circadian rhythm-regulating nuclei. The study provides insights into the distinct afferent framework of AVP neurons in SON and PVN, laying the foundation for further research on their diverse roles.
EXPERIMENTAL NEUROLOGY
(2021)
Article
Geriatrics & Gerontology
Yang Li, Shanchu Su, Jiaqi Yu, Minjing Peng, Shengjun Wan, Changbin Ke
Summary: The NMDG-HCl solution allowed successful patch-clamp recordings on dorsal horn neurons in middle-aged rat slices. The success rate was 34.6%, with some neurons showing GABAergic signals.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Chemistry, Analytical
Ke Li, Huiying Gong, Jinyu Qiu, Ruimin Li, Qili Zhao, Xin Zhao, Mingzhu Sun
Summary: This study proposes a method for pipette tip-cell contact in automated patch-clamp systems and designs corresponding algorithms and network models. Experimental results show that this method can improve the success rate in patch-clamp experiments.
Article
Neurosciences
Hua Shi, Yunjia Tu, Yuanai Li, Chunyan Ma, Adwoa Takyiwaa Gyabaah, Chenyi Yu, Zhijie Li, Jiayi Chen, Zhilin Li, Zhi-Li Huang, Xiaohong Cai
Summary: Caffeine, a widely used first-line drug for treating neonatal apnea, has been found to excite the neurons in the medial parabrachial nucleus (MPB) by blocking A1R receptors. This study suggests that A1Rs in MPB may be potential targets for caffeine in reducing apnea neonatorum.
Article
Biochemistry & Molecular Biology
Mehwish Abbasi, Rachael A. Augustine, Karl J. Iremonger, Colin H. Brown
Summary: Oxytocin neurons in the hypothalamic supraoptic nucleus and paraventricular nucleus secrete oxytocin to induce uterine contractions during parturition. The activation of oxytocin neurons at parturition involves a network of afferent inputs. Kisspeptin, which increases during pregnancy, only excites oxytocin neurons in late pregnancy. However, the excitation of oxytocin neurons by kisspeptin does not appear to involve the ERK1/2-p38 signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Hannah Warming, Katrin Deinhardt, Patrick Garland, John More, Diederik Bulters, Ian Galea, Mariana Vargas-Caballero
Summary: During subarachnoid haemorrhage, the release of extracellular haemoglobin (Hb) causes oxidative damage and cell death in surrounding tissues. This study shows that haptoglobin can protect surviving neurons by scavenging free Hb and preventing cellular damage and deficits in synaptic function. The findings support the potential use of haptoglobin as a therapy for subarachnoid haemorrhage.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Neurosciences
Bo Xing, Nancy R. Mack, Yu-Xiang Zhang, Erin P. McEachern, Wen-Jun Gao
Summary: Neuronal activity in the prefrontal cortex (PFC) controls dominance hierarchies, and dopamine plays a key role through D1 and D2 receptors. D1R+ neurons determine dominance while D2R+ neurons determine subordination. The synaptic strengths of D1R+ neurons and neuronal excitability of D2R+ neurons are important factors in intermale social rank determination.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
In Hae Lee, Carl Procko, Yun Lu, Shai Shaham
Summary: The study found that the nervous system of C. elegans undergoes remodeling following stress, and investigated the impact of individual neuron remodeling events under stress conditions. The results revealed the key roles of glial cells in stress-induced nervous system plasticity and demonstrated that remodeling primes animals to respond to favorable conditions.
Article
Engineering, Biomedical
Audrey Franceschi Biagioni, Giada Cellot, Elisa Pati, Neus Lozano, Belen Ballesteros, Raffaele Casani, Norberto Cysne Coimbra, Kostas Kostarelos, Laura Ballerini
Summary: Engineered small graphene oxide (s-GO) sheets have been shown to reversibly down-regulate glutamatergic synapses in the hippocampus, indicating their potential to target specific synapses in vivo. Synapses, acting as functional interfaces among neurons in the Central Nervous System (CNS), play a crucial role in synaptic plasticity, which is essential for learning and memory. Dysfunctional synaptic plasticity has been implicated in various brain diseases, such as dementia and anxiety disorders, highlighting the importance of understanding these mechanisms for potential therapeutic interventions.
Article
Neurosciences
Aniello Lombardi, Qiang Wang, Maik C. Stuettgen, Thomas Mittmann, Heiko J. Luhmann, Werner Kilb
Summary: This study investigates the role of short-term synaptic plasticity (STP) in excitatory and inhibitory synapses in the cortical layer 2/3 of mice. The results show that burst stimulation leads to short-term depression (STD) in both excitatory and inhibitory synapses, with stronger depression observed in inhibitory synapses and longer decay time.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Anatomy & Morphology
Shalini S. Kumar, Gregory T. Bouwer, Meliame K. Jackson, Michael R. Perkinson, Fiona J. McDonald, Colin H. Brown, Rachael A. Augustine
Summary: Oxytocin, synthesized in the hypothalamic supraoptic nucleus (SON) and paraventricular nucleus (PVN), plays a crucial role in triggering uterine contractions during parturition. In mice, kisspeptin neurons from the periventricular nucleus (PeN) innervate oxytocin neurons and exhibit increased activity during late pregnancy. However, eliminating kisspeptin neuron projections to oxytocin neurons does not affect the duration or timing of delivery, suggesting that they are not necessary for parturition in mice.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biochemistry & Molecular Biology
Milica Gusic, Klaus Benndorf, Christian Sattler
Summary: Our study reveals that each occupied binding site contributes to channel activation in P2X7 receptors. While the occupation of a single binding site can activate the channels, three bound ligands maximally stabilize the open state, suggesting a stepwise activation process for P2X7 receptors.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Guillermo Gonzalez-Burgos, Takeaki Miyamae, Nita Reddy, Sidney Dawkins, Chloe Chen, Avyi Hill, John Enwright, Bard Ermentrout, David A. Lewis
Summary: In primates, the DLPFC and PPC cortices play crucial roles in the working memory network, with higher frequency oscillations observed in DLPFC. The higher frequency in DLPFC may be attributed to a greater quantity of synapses in the basal dendrites, leading to stronger synaptically evoked excitation and subsequently, increased oscillation frequency and power. These findings provide insights into the mechanisms underlying regional differences in oscillation properties between brain regions.
Article
Neurosciences
Sung Jin Park, Kirk D. Haan, Yoshikazu Nakamura, Kiyoko Fukami, Thomas E. Fisher
Summary: The study revealed that the PLC delta 1 isoform plays a crucial role in the activation of Delta N-TRPV1 channels and osmosensory transduction in MNCs, with its absence leading to impaired MNC function. This research advances our understanding of the molecular mechanisms of osmoregulation in mammals.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Instruments & Instrumentation
Ian Delgadillo Bonequi, Abraham Stroschein, Lucas J. Koerner
Summary: This article describes a custom and open-source FPGA-based data acquisition system that is used for electrophysiology and closed-loop feedback experiments. The system combines FPGA acquisition and processing with high-speed analog and digital converters to enable real-time feedback. The digital approach simplifies experimental setup and repeatability by allowing for system identification and in situ tuning of filter bandwidths.
REVIEW OF SCIENTIFIC INSTRUMENTS
(2022)
Article
Orthopedics
Satoshi Tateishi, Yasuo Onishi, Hitoshi Suzuki, Makoto Takahashi, Junichiro Shiraishi, Christopher M. Larson, Soshi Uchida
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2020)
Article
Otorhinolaryngology
Hung Ba Do, Toyoaki Ohbuchi, Mitsuru Yokoyama, Takuro Kitamura, Tetsuro Wakasugi, Jun-ichi Ohkubo, Hideaki Suzuki
CLINICAL OTOLARYNGOLOGY
(2019)
Article
Orthopedics
Eisaburo Honda, Hajime Utsunomiya, Akihisa Hatakeyama, Hirotaka Nakashima, Hitoshi Suzuki, Dean K. Matsuda, Akinori Sakai, Soshi Uchida
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2020)
Article
Orthopedics
Tomoya Arashi, Yoichi Murata, Hajime Utsunomiya, Shiho Kanezaki, Hitoshi Suzuki, Akinori Sakai, Soshi Uchida
Article
Endocrinology & Metabolism
Haruki Nishimura, Makoto Kawasaki, Takanori Matsuura, Hitoshi Suzuki, Yasuhito Motojima, Kazuhiko Baba, Hideo Ohnishi, Yoshiaki Yamanaka, Teruaki Fujitani, Mitsuhiro Yoshimura, Takashi Maruyama, Hiromichi Ueno, Satomi Sonoda, Kazuaki Nishimura, Kentarou Tanaka, Kenya Sanada, Tatsushi Onaka, Yoichi Ueta, Akinori Sakai
FRONTIERS IN ENDOCRINOLOGY
(2020)
Article
Otorhinolaryngology
Thi Nga Nguyen, Ba Hung Do, Takuro Kitamura, Jun-ichi Ohkubo, Tetsuro Wakasugi, Toyoaki Ohbuchi, Hideaki Suzuki
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2020)
Article
Otorhinolaryngology
Hideaki Suzuki, Toyoaki Ohbuchi, Ba Hung Do, Thi Nga Nguyen, Tetsuro Wakasugi, Jun-ichi Ohkubo, Takuro Kitamura
ACTA OTO-LARYNGOLOGICA
(2020)
Article
Infectious Diseases
Hitoshi Suzuki, Keiji Muramatsu, Tatsuhiko Kubo, Makoto Kawasaki, Teruaki Fujitani, Manabu Tsukamoto, Soshi Uchida, Yoshihisa Fujino, Shinya Matsuda, Akinori Sakai
Summary: This study investigated factors associated with mortality among patients with necrotizing soft-tissue infection in Japan, using inpatient data from the DPC Database. Results revealed that older age, lower BMI, pre-existing cancer diagnosis, sepsis at admission, maintenance dialysis, antithrombin III use, and anti-MRSA antibiotic use were linked to higher mortality rates among NSTI patients.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Neurosciences
Kazuhiko Baba, Makoto Kawasaki, Haruki Nishimura, Hitoshi Suzuki, Takanori Matsuura, Teruaki Fujitani, Manabu Tsukamoto, Kotaro Tokuda, Yoshiaki Yamanaka, Hideo Ohnishi, Mitsuhiro Yoshimura, Takashi Maruyama, Kenya Sanada, Hiromichi Ueno, Satomi Sonoda, Kazuaki Nishimura, Kentaro Tanaka, Yoichi Ueta, Akinori Sakai
Summary: The study investigates the mechanism by which TRPV1 modulates neuropathic pain by employing the partial sciatic nerve ligation model. Results suggest that TRPV1 may modulate thermal perception via increased astrocytes in the dorsal horn of the spinal cord.
NEUROSCIENCE RESEARCH
(2021)
Article
Engineering, Biomedical
Manabu Tsukamoto, Makoto Kawasaki, Hitoshi Suzuki, Teruaki Fujitani, Soshi Uchida, Akinori Sakai
Summary: This study aimed to demonstrate the accuracy of a procedure that considers pelvic orientation using a portable navigation system for total hip arthroplasty. The results showed that the procedure significantly improved the accuracy of cup placement, with radiographic inclination and anteversion accuracies within 5 degrees of the target angle in a high percentage of cases.
Article
Neurosciences
Naofumi Ikeda, Makoto Kawasaki, Kazuhiko Baba, Haruki Nishimura, Teruaki Fujitani, Hitoshi Suzuki, Takanori Matsuura, Hideo Ohnishi, Makiko Shimizu, Kenya Sanada, Kazuaki Nishimura, Mitsuhiro Yoshimura, Takashi Maruyama, Becky L. Conway-Campbell, Tatsushi Onaka, Hitoshi Teranishi, Reiko Hanada, Yoichi Ueta, Akinori Sakai
Summary: Fibromyalgia (FM) is characterized by chronic pain and frequent comorbidity with depression. This study investigated the role of endogenous oxytocin (OXT) in an experimental FM model and found that OXT may have analgesic effects in FM, suggesting it could be a potential target for effective pain management strategies for this disorder.
Article
Medicine, Research & Experimental
Toyoaki Ohbuchi, Shohei Shimajiri, Yuki Kawamura, Yuma Koga, Toshiyuki Nakayama, Hideaki Suzuki
Summary: Actinomycosis infection, caused by anaerobic bacteria, can occur in various parts of the body. This case report highlights a rare involvement of the maxillary sinus. The patient underwent successful surgical treatment without recurrence during the 30 months of follow-up.
JOURNAL OF MEDICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Haruki Nishimura, Makoto Kawasaki, Manabu Tsukamoto, Kunitaka Menuki, Hitoshi Suzuki, Takanori Matsuura, Kazuhiko Baba, Yasuhito Motojima, Teruaki Fujitani, Hideo Ohnishi, Yoshiaki Yamanaka, Kenji Kosugi, Yasuaki Okada, Kotaro Tokuda, Takafumi Tajima, Toru Yoshioka, Nobukazu Okimoto, Yoichi Ueta, Akinori Sakai
Article
Neurosciences
Toyoaki Ohbuchi, Takeshi Saito, Toru Yokoyama, Hirofumi Hashimoto, Takashi Maruyama, Hideaki Suzuki, Yoichi Ueta
Article
Neurosciences
Teruaki Fujitani, Takanori Matsuura, Makoto Kawasaki, Hitoshi Suzuki, Haruki Nishimura, Kazuhiko Baba, Yoshiaki Yamanaka, Hideo Ohnishi, Yoichi Ueta, Akinori Sakai